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대한피부과학회> 대한피부과학회지> 약 20년간 지속된 림프부종에서 기인한 스튜어트-트리브스 증후군(Stewart-Treves Syndrome) 1예

KCI등재SCOUPUS

약 20년간 지속된 림프부종에서 기인한 스튜어트-트리브스 증후군(Stewart-Treves Syndrome) 1예

A Case of Stewart-Treves Syndrome Derived from Lymphedema Lasting for about 20 Years

권혁진 , 유동화 , 박경덕 , 김기호 , 윤정호
  • : 대한피부과학회
  • : 대한피부과학회지 60권7호
  • : 연속간행물
  • : 2022년 08월
  • : 453-454(2pages)
대한피부과학회지

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UCI(KEPA)

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  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9752


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60권9호(2022년 11월) 수록논문
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KCI등재 SCOPUS

1물집유사천포창 환자의 말초혈액 호산구 수치와 질환의 중증도 간의 상관관계: 20년간 단일기관 후향적 연구

저자 : 권혁진 ( Hyeok-jin Kwon ) , 윤정호 ( Jung-ho Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 549-558 (10 pages)

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Background: Bullous pemphigoid (BP) is an autoimmune blistering disease. Studies have focused on eosinophils for their significant role in the pathogenesis of BP, as they not only secrete proteases and proinflammatory cytokines but also recruit other inflammatory cells.
Objective: To investigate the correlation among peripheral eosinophil count, clinical severity, and laboratory findings in patients with BP.
Methods: A total of 59 patients with BP were included in this study. Correlation analyses between peripheral eosinophil count and bullous pemphigoid disease activity index (BPDAI) score, duration of hospitalization, anti-bullous pemphigoid antigen 180 (anti-BP180) immunoglobulin G (IgG) antibody, anti-bullous pemphigoid antigen 230 (anti-BP230) IgG antibody, immunoglobulin E (IgE), C-reactive protein, and procalcitonin levels were performed. Simple and multiple linear regression analyses were conducted to evaluate whether peripheral eosinophil counts could independently affect the BPDAI score and hospitalization duration.
Results: The peripheral eosinophil count was positively correlated with the initial skin, mucosa, total BPDAI score (p<0.001, p=0.027, and p<0.001, respectively), hospitalization days (p=0.032), anti-BP180 IgG antibody (p <0.001), anti-BP230 IgG antibody (p<0.001), and IgE (p<0.001). Furthermore, not only peripheral eosinophil count but also anti-BP180 IgG antibody, anti-BP230 IgG antibody, and IgE levels independently affected both the initial total BPDAI score (p<0.05) and hospitalization duration (p<0.05).
Conclusion: Based on our results, the peripheral eosinophil count can influence both clinical severity and laboratory findings. Additionally, it can indicate the clinical severity and prognosis of BP. Therefore, we suggest that the peripheral eosinophil count could be a useful marker for predicting clinical outcomes in patients with BP. (Korean J Dermatol 2022;60(9):549∼558)

KCI등재 SCOPUS

2중등증-중증의 한국인 건선 환자에서 Guselkumab의 효과와 안전성에 관한 연구

저자 : 신준오 ( Jun-oh Shin ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoonsoo Kim ) , 고현창 ( Hyunchang Ko ) , 김문범 ( Moon-bum Kim ) , 김병수 ( Byungsoo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 559-565 (7 pages)

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Background: Guselkumab, a human immunoglobulin-G1λ monoclonal antibody, selectively blocks the interleukin-23-mediated signaling pathway. It has emerged as a promising treatment option for moderate-to-severe psoriasis. However, no studies have reported real-world clinical data on guselkumab in patients with psoriasis in Korea.
Objective: To investigate the effectiveness and safety of guselkumab in Korean patients with moderate to severe plaque psoriasis.
Methods: We retrospectively reviewed patients with moderate-to-severe psoriasis who were treated with guselkumab at Pusan National University Hospital (Busan and Yangsan) from January 2019 to May 2021. Fifty-six patients with psoriasis who were treated with guselkumab were included in the study. Patient demographics, psoriasis area and severity index (PASI) scores, investigator's global assessment scores, and adverse events were assessed.
Results: The mean baseline PASI score (16.2±7.6) significantly decreased after 20 weeks of guselkumab treatment (p<0.05). In total, 76.8%, 78.6%, and 88.1% of patients achieved a PASI90 response at 20, 28, and 52 weeks, respectively. Of 56 patients, 52 had a PASI90 response at the last follow-up visit. No serious adverse events were observed. Four patients (7.1%) experienced mild adverse events, such as injection site reaction, upper respiratory tract infection, and headache.
Conclusion: This study reconfirmed the efficacy and safety of guselkumab in Korean patients with moderateto- severe psoriasis. (Korean J Dermatol 2022;60(9):559∼565)

KCI등재 SCOPUS

3두드러기 혈관염의 임상조직학적 연구: 65명의 환자를 대상으로 한 한국의 단일 기관 연구

저자 : 김지선 ( Ji Sun Kim ) , 구대원 ( Dae Won Koo ) , 이중선 ( Joong Sun Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 566-575 (10 pages)

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Background: Urticarial vasculitis (UV) is a rare disorder that can be diagnosed with clinical and histopathologic studies. There are classical clinical criteria; however, histopathological evidence is required for a definite diagnosis. Few studies have reported on the clinical and histological features of UV.
Objective: To analyze the clinical and histopathologic features of patients diagnosed with UV at a single center in the Republic of Korea.
Methods: We performed a retrospective study of the medical records, clinical photographs, and histopathological slides of patients who visited the Department of Dermatology at Daejeon Eulji Medical Center for urticarial wheals or purpuric plaques lasting more than 24 hours from January 2013 to October 2021.
Results: A total of 65 patients and 95 slides were analyzed. Clinically, most patients had wheal-like plaquedominant lesions (55 patients, 84.6%) rather than purpura and presented with pruritus. In the histopathological study, lymphocytic vasculitis (65 of 69 slides, 94.2%) was more dominant than leukocytoclastic vasculitis. However, its severity was milder than that of leukocytoclastic vasculitis.
Conclusion: This study performed a more in-depth clinical and histological analysis of UV, and histologically, it showed more diversity than previously known leukocytoclastic vasculitis. This might be used as basic research data for more large-scale studies of UV in the future. (Korean J Dermatol 2022;60(9):566∼575)

KCI등재 SCOPUS

4COVID-19 백신 접종 이후 발생한 피부증상: 국내 다기관 사례군 연구

저자 : 윤희정 ( Hee Jung Yoon ) , 권민정 ( Min Jung Kwon ) , 홍은지 ( Eun Ji Hong ) , 은윤수 ( Yun Su Eun ) , 정의현 ( Euy Hyun Chung ) , 김정은 ( Jung Eun Kim ) , 이상훈 ( Sanghoon Lee ) , 박영립 ( Young Lip Park ) , 이설희 ( Sul Hee Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 576-584 (9 pages)

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Background: During the coronavirus disease 2019 (COVID-19) pandemic, large-scale vaccinations have been performed worldwide without sufficient verification of safety profiles. So far, little is known about skin manifestations following COVID-19 vaccination in Korean patients.
Objective: We investigated the epidemiological and clinical characteristics of patients who had skin manifestations following COVID-19 vaccination in Korea.
Methods: We retrospectively reviewed the data of 123 patients that presented with skin manifestations within 1 month after COVID-19 vaccination from two tertiary referral hospitals in Korea. The types of COVID-19 vaccinations administered to the patients, demographics, comorbidities, and clinical course of the patients were obtained from the data. Statistical analyses of the extracted data were performed using Microsoft Excel.
Results: Skin manifestations following COVID-19 vaccination were mostly observed in patients in their 40s (23.6%), according to our data. Urticarial eruption was the most common manifestation, followed by macular rash (17.1%) and papulosquamous eruption (17.1%). Notably, 70% of the patients showed delayed reactions. More than half of the patients showed a good prognosis, and their symptoms were relieved with conservative treatment, including corticosteroids and antihistamines, even after additional vaccination.
Conclusion: We statistically analyzed the prevalence and characteristics of skin manifestations after COVID-19 vaccination. Urticarial eruptions are the most common skin manifestations associated with the COVID-19 vaccination. We believe that this real-world retrospective study will provide valuable information for doctors who treat patients with skin manifestations after COVID-19 vaccination by providing real-world experience in Korea. (Korean J Dermatol 2022;60(9):576∼584)

KCI등재 SCOPUS

5Expression of Antimicrobial Peptides in Psoriasiform Mouse Models

저자 : Song-ee Kim , Sang Eun Lee , Soo-chan Kim , Jong Hoon Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 585-592 (8 pages)

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Background: Psoriasis is a chronic inflammatory skin disease. Despite the current focus on T cells in the pathogenesis of psoriasis, keratinocytes within the psoriatic epidermis are also abnormal in many respects including excessive production of antimicrobial peptides (AMPs). Recently, several studies have used imiquimod (IMQ)- and interleukin (IL)-23-induced mouse models to explore the immunological significance of psoriasis. However, the expression of AMPs in these models remains unclear.
Objective: In this study, we evaluated the protein and mRNA expression of AMPs, including cathelicidin-related antimicrobial peptides (CRAMP), mouse β-defensin 3 (mBD3), and psoriasin (S100 calcium-binding protein A7, S100A7) in IMQ- and IL-23-induced psoriasiform mouse models. In addition, we investigated whether ustekinumab, an inhibitor of IL-12 and IL-23, reduces the expression levels of AMPs in these mouse models.
Methods: We used IMQ- and IL-23-induced psoriasiform mouse models. Gene and protein expression levels of AMPs were evaluated using quantitative real-time polymerase chain reaction and immunofluorescence staining, respectively.
Results: We found that the protein and mRNA expression levels of CRAMP, mBD3, and S100A7 were increased in both mouse models. Ustekinumab decreased AMP expression levels in the two mouse models.
Conclusion: These data showed that the elevated expression of AMPs in the epidermis decreased following ustekinumab treatment in both psoriasiform mouse models. Therefore, AMP expression levels may be used as an indicator of treatment efficacy. (Korean J Dermatol 2022;60(9):585∼592)

KCI등재 SCOPUS

6다발성 전이를 동반한 투명세포육종 1예

저자 : 장현준 ( Hyun Joon Chang ) , 우유리 ( Yu Ri Woo ) , 조상현 ( Sang Hyun Cho ) , 이정덕 ( Jeong Deuk Lee ) , 김혜성 ( Hei Sung Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 593-596 (4 pages)

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Clear cell sarcoma is a rare malignant soft tissue tumor that grows slowly; however, recurrence and metastasis are common. Metastases to the lymph nodes, lungs, and bones are the most frequent; however, multiple metastases to the lungs and bones have not been reported in Korea. A 41-year-old man was referred for an erythematous hard mass measuring 5 cm on his left sole that appeared 5 years ago and gradually grew while he was hospitalized at the Department of Pulmonology for multiple lung nodules. Histopathological examination of the lesions on the sole and pleura revealed clear cell sarcoma. In addition to the lungs and pleurae, bony metastases to the sternum, cervical-thoracic-lumbar vertebrae, sacrum, scapulae, clavicles, pelvic bones, femurs, and humeri, with extensive lymph node metastases were also present. Herein, we report a rare case of a clear cell sarcoma with multiple metastases. (Korean J Dermatol 2022;60(9):593∼596)

KCI등재 SCOPUS

7우측 제1족지에 발생한 공격성 수지 유두상 선종

저자 : 노형래 ( Hyungrye Noh ) , 김희연 ( Hee Yeon Kim ) , 신동민 ( Dong Min Shin ) , 장동휘 ( Donghwi Jang ) , 심준호 ( Joonho Shim ) , 오세진 ( Se Jin Oh ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dong-youn Lee ) , 이주흥 ( Joo-heung Lee ) , 박지혜 ( Ji-hye Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 597-600 (4 pages)

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Aggressive digital papillary adenoma (ADPA) is a rare tumor of the sweat glands. They usually present as solitary masses, with or without pain, and are most commonly observed in the fingers. A 19-year-old man presented with a solitary, protruding lesion on the right big toe that had enlarged 6 months previously. The biopsy specimen revealed a well-marginated mass with papillary projections and tubular structures. On foot magnetic resonance imaging, there was no invasion, and chest radiography showed no metastasis. Based on these findings, the tumor was diagnosed as ADPA, and wide excision was performed. Herein, we report a rare sweat gland tumor on the toe that was diagnosed as an ADPA. (Korean J Dermatol 2022;60(9):597∼600)

KCI등재 SCOPUS

8케톤형성 식이요법으로 인해 발생한 색소침착가려움발진 2예

저자 : 양나경 ( Na Gyeong Yang ) , 김재윤 ( Jae Yun Kim ) , 은윤수 ( Yun Su Eun ) , 이성열 ( Sung Yul Lee ) , 정의현 ( Euy Hyun Chung ) , 이현주 ( Hyun Ju Lee ) , 김정은 ( Jung Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 601-605 (5 pages)

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Prurigo pigmentosa (PP) is a rare inflammatory skin disease that commonly affects Asian women. It is characterized by symmetric pruritic eruptions in a reticular pattern, primarily on the back, chest, or neck. The etiology of PP is unclear; however, it is estimated that neutrophil-mediated inflammation of the skin is induced by various exogenous stressors, such as friction from clothing and sweating. In addition to exogenous factors, some cases are thought to be related to ketosis, diabetes mellitus, fasting, or dieting to lose weight. With the increasing popularity of ketogenic diets, cases of PP are being more commonly reported. To raise awareness of this disease, we present two cases of PP that occurred after following a ketogenic diet. (Korean J Dermatol 2022;60(9):601∼605)

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9인터루킨-12/23 (Interleukin-12/23) 억제제로 치료 중인 건선 환자에서 발생한 전신형 고리육아종 1예

저자 : 김종욱 ( Jongwook Kim ) , 장봉석 ( Bongseok Jang ) , 김연아 ( Yeona Kim ) , 원상현 ( Sang-hyeon Won ) , 배경남 ( Kyung-nam Bae ) , 이정수 ( Jungsoo Lee ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoonsoo Kim ) , 고현창 ( Hyunchang Ko ) , 김문범 ( Oon-bum Kim ) , 김병수 ( Byungsoo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 606-610 (5 pages)

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Granuloma annulare is a relatively common inflammatory skin disease. The etiology is unknown; however, drugs have been considered as one of the predisposing conditions, and a few cases of granuloma annulare related to biologics have been recently reported. A 48-year-old man with a 25-year history of psoriasis visited our dermatological clinic. Ustekinumab was administered for the treatment of psoriasis. After 5 years of ustekinumab therapy, erythematous papules with an annular distribution appeared on his trunk and extremities. Skin biopsy supported the diagnosis of generalized granuloma annulare, and the patient continued to receive ustekinumab with oral methotrexate, cyclosporine, and steroids for 9 months. However, as the skin lesions aggravated, oral steroid treatment was continued, and secukinumab was administered instead of ustekinumab. The skin lesions improved and remained stable with the intermittent administration of oral steroids thereafter. (Korean J Dermatol 2022;60(9):606∼610)

KCI등재 SCOPUS

10Eczematous Vesicular Rruption and Exacerbation of Chronic Spontaneous Urticaria Associated with Secukinumab

저자 : Sang-min Choi , Bark-lynn Lew , Woo-young Sim , Soon-hyo Kwon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 9호 발행 연도 : 2022 페이지 : pp. 611-614 (4 pages)

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The pathogenesis of chronic spontaneous urticaria (CSU) is complex. Though the involvement of functional autoantibodies and imbalance of T helper (Th) cell subsets have been reported, the exact mechanism remains elusive. We report a case of eczematous vesicular eruption and exacerbation of CSU in a patient with psoriasis after treatment with secukinumab, an anti-interleukin (IL)-17 monoclonal antibody. The eczematoid eruption subsided after the administration of systemic steroids, but the exacerbation of CSU was not controlled. After switching the therapy to guselkumab, an anti-IL-23 monoclonal antibody, to supplement the control of the psoriasis lesions, the patient's urticaria flare-ups were well controlled with only H1 antihistamines. We hypothesize that the Th2-skewed immune response induced by anti-IL-17 treatment in predisposed patients might have resulted in the eczematous eruption and exacerbation of CSU. (Korean J Dermatol 2022;60(9):611∼614)

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KCI등재SCOUPUS

1건선 치료 후 피부 병변에서 Th1과 Th17 염증성 사이토카인의 변화

저자 : 박효진 ( Hyo Jin Park ) , 장현준 ( Hyun Joon Chang ) , 김태근 ( Tae Geun Kim ) , 권미연 ( Mi Yeon Kwon ) , 임채윤 ( Chae Yoon Lim ) , 주현정 ( Hyun Jeong Ju ) , 이경호 ( Kyung Ho Lee ) , 박철종 ( Chul Jong Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 409-413 (5 pages)

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Background: Psoriasis is a T cell-mediated disorder. Appropriate treatment of psoriasis can result in a plethora of dynamic changes in the T cells and their cytokine production. Studies on the expression of Th1 and Th17 inflammatory cytokines after various treatments have reported inconsistent results.
Objective: This study aimed to investigate the changes in inflammatory cytokine expression in psoriasis skin lesions before and after psoriasis treatment.
Methods: Five patients with plaque psoriasis were enrolled in the study. The tissue mRNA and protein levels of interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22 in psoriatic skin lesions before and after psoriasis treatment were detected using real-time polymerase chain reaction and immunohistochemical staining, respectively.
Results: The decrease in the psoriasis area and severity index was accompanied by a reduction in IL-12 and IL-23 mRNA levels and a concomitant reduction of IL-2 and IL-17A protein levels in psoriasis skin lesions. Both mRNA and protein levels of IFN-γ in psoriatic skin lesions increased after treatment.
Conclusion: The mRNA levels of tissue inflammatory cytokines (IL-12 and IL-23) and the protein levels of tissue inflammatory cytokines (IL-2 and IL-17A) significantly decreased after psoriasis treatment. The mRNA and protein levels of IFN-γ increased, even after psoriasis treatment. (Korean J Dermatol 2022;60(7):409∼413)

KCI등재SCOUPUS

2구순열 수술 후 흉터를 가진 영유아 환자에서 흉터 복합 레이저요법의 효과 및 안전성에 대한 단일 기관, 후향적 연구

저자 : 이주희 ( Joo Hee Lee ) , 최수연 ( Sooyeon Choi ) , 김제민 ( Jemin Kim ) , 이영인 ( Young In Lee ) , 이주희 ( Ju Hee Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 414-419 (6 pages)

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Background: Postoperative scars following cleft lip surgery are frequently accompanied by cosmetic and functional problems; therefore, patients with cleft lip scars usually undergo various long-term scar treatment courses. Currently, only a limited number of fractional laser treatment cases of cleft lip scars have been reported.
Objective: This study aimed to evaluate the safety and efficacy of the combination laser treatment for hypertrophic scar management following cleft lip surgery.
Methods: This single-center retrospective study included 27 patients who underwent cleft lip surgery before 12 months of age. The control group comprising 13 patients received only a silicone gel or sheet for the scars, while the treatment group comprising 14 patients underwent laser treatment with a 1,550 nm non-ablative fractional erbium-glass laser, followed by a 10,600 nm ablative fractional carbon dioxide laser. Intralesional triamcinolone injection (5∼10 mg/mL) was administered immediately after laser treatment. Scar improvement was assessed at 1, 3, and 6 months after surgery using the Vancouver Scar Scale.
Results: The mean total Vancouver scar scale showed a statistically significant improvement in the treatment group compared to that in the control group. In the sub-analysis of pigmentation, the vascularity, pliability, and height significantly improved in the treatment group. No differences in the patients' baseline characteristics between the two groups were noted. No significant adverse effects were observed during the follow-up.
Conclusion: Combination laser therapy using fractional lasers and intralesional triamcinolone injection is safe and effective for managing cleft lip surgery scars in infantile patients. (Korean J Dermatol 2022;60(7):414∼419)

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3중등증 및 중증 한국인 건선 환자에서 생물학제제 변경 양상과 효과에 대한 분석

저자 : 이수민 ( Su Min Lee ) , 고병창 ( Byeong Chang Ko ) , 안상우 ( Sang Woo Ahn ) , 어지안 ( Ji An Uh ) , 설정은 ( Jung Eun Seol ) , 김효진 ( Hyojin Kim ) , 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee ) , 박소희 ( So Hee Park ) , 정소영 ( So Young Jung ) , 박혜진 (

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 420-428 (9 pages)

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Background: Biologics-experienced patients are more likely to show a lower response to biologics than that of biologic-naïve patients. However, no consensus on switching biologics exists.
Objective: We aimed to investigate the switching patterns and efficacy of the switched biologics in patients with moderate-to-severe psoriasis in actual clinical practice.
Methods: This multicenter retrospective study included 37 patients with a history of switching biologics. We analyzed the reasons for switching, the switching patterns, and psoriasis area and severity index (PASI) 75 response rates after switching biologics. We also analyzed the factors affecting the PASI75 response rate to the second biologic.
Results: The reasons for switching baseline biologics were primary failure in five patients (13.5%), secondary failure in 28 patients (75.7%), and adverse events in four patients (10.8%). The second biologics prescribed mostly include interleukin (IL)-23 inhibitor in twenty-four patients (64.9%), IL-17 inhibitor in eight patients (21.6%), tumor necrosis factor-α inhibitor in three patients (8.1%), and IL-12/23 inhibitor in two patients (5.4%). A total of 46% of patients (17/37) switched biologics from IL-12/23 inhibitors to IL-23 inhibitors. The PASI75 response rates at the primary endpoint of the second and third biologics were 89.2% and 88.8%, respectively. Our study found that female sex and obesity were associated with the primary failure of the second biologic.
Conclusion: Secondary failure was the most common reason for switching baseline biologics. Korean dermatologists prefer different classes of biologics while switching. The PASI75 response rates at the primary endpoints of the second and third biologics were relatively satisfactory. (Korean J Dermatol 2022;60(7):420∼428)

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4녹색손발톱증후군의 임상적 특징에 대한 연구

저자 : 이기욱 ( Gi-wook Lee ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byungsoo Kim ) , 김문범 ( Moon-bum Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 429-435 (7 pages)

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Background: Green nail syndrome (GNS) is characterized by a greenish discoloration of the nail with accompanying nail apparatus disorders, such as onycholysis or paronychia. To date, data on the clinical characteristics of GNS are limited, especially in Korea.
Objective: This study aimed to investigate the clinical characteristics of GNS.
Methods: We retrospectively reviewed the medical records and clinical photographs of 78 patients with 91 GNS lesions diagnosed at the Pusan National University Hospitals (Busan and Yangsan) from 2009 to 2021.
Results: Among 78 patients, 47 (60.3%) were female and 31 male (39.7%), with a mean age of 53.1 years (23∼82 years). This study included 56 fingernail (61.5%) and 35 toenail lesions (38.5%). Thumbnails and great toenails were the most common site, with 62 lesions (68.1%). Most patients presented predisposing conditions, such as frequent exposure to wet conditions (55.1%), immunosuppressive conditions (26.9%), and trauma history (29.5%). The most common colors, shapes, and eccentricities of GNS were blackish-green (31.9%), reverse triangle (53.8%), and distal eccentricity (42.9%), respectively. The GNS was accompanied by various nail diseases that mostly (80.2%) preceded the syndrome, and onycholysis was the most common (83.5%). Based on the involvement of the nail surface or subsurface, GNS can be divided into the superficial (15.4%), subungual (73.6%), and mixed (11.0%) subtypes, each of which shows different clinical features, such as multiplicity, color, shape, and eccentricity.
Conclusion: This is the largest-scale study showing the clinical characteristics of GNS and can be helpful for dermatologists who usually and primarily treat GNS. (Korean J Dermatol 2022;60(7):429∼435)

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5국소 안면 진피 이형성증 3형: Setleis 증후군

저자 : 신준오 ( Jun-oh Shin ) , 배경남 ( Kyung-nam Bae ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byungsoo Kim ) , 김문범 ( Moon-bum Kim ) , 신기혁 ( Kihyuk Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 436-439 (4 pages)

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Setleis syndrome, also known as the focal facial dermal dysplasia type 3, is characterized by atrophic scar-like lesions in both the temporal regions and other facial abnormalities. The syndrome is associated with a mutation in the TWIST2 gene and is inherited as an autosomal recessive pattern. Here, we describe a case of an 18-year-old woman and her 10-year-old brother with bitemporal depressed patches. The lesions were observed at birth, but they were replaced by atrophic patches after several months. No abnormalities in growth or development were observed. Histopathologic findings showed atrophy of the epidermis and loss of appendages, such as hair follicles and adnexal glands, in the atrophic patches compared to that of the adjacent normal skin. (Korean J Dermatol 2022;60(7):436∼ 439)

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6A Case of Locally Recurring Multiple Fibrocollagenous Dermatofibromas on the Forearm

저자 : Sang-min Choi , Bark-lynn Lew , Woo-young Sim , Soon-hyo Kwon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 440-443 (4 pages)

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Dermatofibroma (DF) is one of the most common benign soft tissue tumors. Various histological variants of DF have been described, and it is important to discern the different variants to evaluate the prognosis. A 43-year-old female patient with no specific medical history presented with multiple brown-colored nodules on the right arm for 5 years. Biopsy specimens showed a predominance of collagen and fibroblasts in a whorled arrangement with moderate cellularity, findings that were consistent with fibrocollagenous DF. The patient underwent excision of the largest lesion and revisited our department 3 months after surgery with local recurrence at the excision site. We report a rare case of multiple fibrocollagenous DF with local recurrence at the excision site. (Korean J Dermatol 2022;60(7):440∼443)

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7Two Case Reports of Leukocytoclastic Vasculitis after ChAdOx1 nCoV-19 Vaccine

저자 : Hae Eun Park , Ju Hee Han , Yeong Ho Kim , Ji Hyun Lee , Young Min Park , Hwa Young Lee , Chul Hwan Bang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 444-448 (5 pages)

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Leukocytoclastic vasculitis after the BNT162b2 vaccine and ChAdOx1 nCoV-19 Corona Virus vaccine [recombinant] has been observed. Herein, we report two cases of leukocytoclastic vasculitis that developed after the ChAdOx1-S [recombinant] vaccination. A 61-year-old and a 52-year-old woman presented with pruritic purpuric macules and papules on both lower legs. The patients had been vaccinated with the ChAdOx1-S [recombinant] vaccine. The histopathological analyses were consistent with a diagnosis of leukocytoclastic vasculitis. They were treated with oral prednisolone and improved within 1 month of treatment. We assume that the rash had arisen from the deposition of spike protein at the skin tissue induced by the viral vector of the COVID-19 vaccine or hyperimmune responses by excipients present in vaccine preparations. To our knowledge, our cases would be the first Korean cases of leukocytoclastic vasculitis after the ChAdOx1-S [recombinant] vaccination. (Korean J Dermatol 2022;60(7):444∼ 448)

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8입술에 발생한 색소성 스피츠 모반 1예

저자 : 어지안 , 김중호 , 이재호 , 이수경 , 김명신 , 이운하

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 449-450 (2 pages)

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9BNT162b2 mRNA COVID-19 백신 접종 후 발생한 동창 모양의 피부병변 1예

저자 : 윤지상 , 배경남 , 손진화 , 김훈수 , 고현창 , 김병수 , 김문범 , 신기혁

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 451-452 (2 pages)

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10약 20년간 지속된 림프부종에서 기인한 스튜어트-트리브스 증후군(Stewart-Treves Syndrome) 1예

저자 : 권혁진 , 유동화 , 박경덕 , 김기호 , 윤정호

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 453-454 (2 pages)

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