논문 상세보기

대한당뇨병학회> 당뇨병(JKD)> 신체조성 분석에 있어서 생체전기저항분석을 이용한 방법의 유용성

신체조성 분석에 있어서 생체전기저항분석을 이용한 방법의 유용성

Utility of Bioelectrical Impedance Analysis for Body Composition Assessment

임수 ( Soo Lim )
  • : 대한당뇨병학회
  • : 당뇨병(JKD) 23권2호
  • : 연속간행물
  • : 2022년 06월
  • : 106-112(7pages)
당뇨병(JKD)

DOI


목차

서론
신체조성평가의 임상적 중요성
신체조성 추정 및 정량화 방법
생체전기저항분석
실제 적용
결론
REFERENCES

키워드 보기


초록 보기

People with obesity are at high risk of type 2 diabetes, cardiovascular diseases, and certain types of malignancy. A significant reduction in muscle mass is also associated with increased risk of developing sarcopenia. In general, body composition is affected by several factors, including ethnicity, environment, genetics, and lifestyle patterns. Assessment of body composition is an important tool for maintaining good general health and longevity, and is utilized by physicians and researchers to monitor disease severity and nutritional status. It can also be used to monitor the effectiveness of dietary and drug interventions. Dual energy X-ray absorptiometry is regarded as the gold standard method for analyzing body composition. However, there is an associated risk of a small amount of radiation exposure. In addition, severely obese people are not candidates for this method. Recently, bioelectrical impedance analysis (BIA) has been developed. BIA poses no radiation hazard, is easy applicable and relatively inexpensive. Thus, BIA is widely used in fitness centers as well as in hospitals. Several studies have been conducted to assess the effectiveness of BIA for measuring body composition, but most have focused on subjects of European descent. Of note, body composition differs among ethnic groups: Asians have a greater tendency toward obesity at a lower body mass index than Caucasians. Therefore, an ethnicityspecific approach is required for precise estimation of body composition using BIA. In conclusion, healthcare providers should have a thorough understanding of body composition assessment and the advantages and disadvantages of different measurement methods.

UCI(KEPA)

간행물정보

  • : 의약학분야  > 내과학
  • :
  • :
  • : 계간
  • : 2233-7431
  • : 2714-0547
  • : 학술지
  • : 연속간행물
  • : 2000-2022
  • : 1029


저작권 안내

한국학술정보㈜의 모든 학술 자료는 각 학회 및 기관과 저작권 계약을 통해 제공하고 있습니다.

이에 본 자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

23권3호(2022년 09월) 수록논문
최근 권호 논문
| | | |

1당뇨병 약제의 역할은 어디까지인가?

저자 : 홍준화 ( Jun Hwa Hong )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 153-156 (4 pages)

다운로드

(기관인증 필요)

초록보기

In management of diabetes, glucose lowering is the basic target of treatment. Insulin is essential to type 1 diabetes. Non-insulin therapy in type 2 diabetes is very diverse and continuously developing to improve glucose control and prevent diabetes-related complications. In the recent 30 years, recommended specifications of anti-diabetic drugs are high glucose-lowering efficacy, low risk of hypoglycemia, less burden of weight gain, and cardiovascular safety. With development of SGLT2 inhibitors (sodium glucose cotransporter 2 inhibitors) and GLP-1RA (glucagon-like peptide-1 receptor agonist), the clinical benefits also include risk reduction of diabetes-related complications (hospitalization for heart failure, chronic kidney disease, atherosclerotic cardiovascular disease), even in non-diabetic patients. Anti-diabetic medication can have a role in holistic management for prevention and treatment of diabetes and diabetes-related complications, as well as an improvement of mortality.

2MODY 당뇨병

저자 : 박승신 ( Seung Shin Park ) , 곽수헌 ( Soo Heon Kwak )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 157-164 (8 pages)

다운로드

(기관인증 필요)

초록보기

앞으로 정밀의료는 개인별 특성에 맞게 당뇨병의 진단, 분류, 치료를 보다 구체화시키는 데 일조할 것이다. 단일유전자 당뇨병에 있어서는 이러한 변화가 이미 두드러지게 나타나고 있다. MODY 아형은 MODY의 원인 유전자에 따라 HNF1α-, GCK-, HNF4α-, HNF1β-MODY 등으로 구분되고 있으며 MODY 진단에 있어서도 원인 유전변이를 ACMG-AMP 지침을 통해 검증하는 것이 일반화되고 있다. 정확한 진단이 이루어지면 MODY 아형에 따라 설포닐유레아, GLP-1수용체 작용제, 인슐린, 혹은 치료 없이 경과 관찰 등 개별화된 치료 방법을 적용할 수 있다. MODY에서 적용되고 있는 이러한 정밀의료로의 변화는 단일유전자당뇨병뿐 아니라 전체 당뇨병의 분류, 진단, 치료에 있어서도 큰 변화를 가져올 수 있는 계기가 될 것으로 기대된다. 아직 국내에서는 MODY에 대한 진단 검사 및 발견이 적은 편이다. 이를 높이기 위해서는 임상에 널리 적용 가능한 분자유전학적 검사의 확대 및 보험 적용이 바탕이 되어야 하며 임상의를 대상으로 임상유전체의학에 대한 교육이 확대될 필요가 있다.


Precision medicine, which optimizes diagnosis and treatment of diseases according to individualized characteristics, is becoming a reality in the field of diabetes, especially for monogenic diabetes. Maturity-onset diabetes of the young (MODY) is a type of monogenic diabetes characterized by early onset, relative non-obesity, non-insulin dependence, and autosomal dominant inheritance. With the trend toward precision medicine and improvement in genetic testing, there have been advances in the classification, diagnosis, and treatment of MODY. MODY accounts for about 1% of diabetes in Korea, with GCK (glucokinase)-MODY, HNF1α (hepatocyte nuclear factor-1 alpha)-MODY, and HNF4α (hepatocyte nuclear factor-4 alpha)-MODY being most common. In the diagnosis of MODY, applying guidelines for interpretation of variant pathogenicity is important. For the treatment of MODY, individualized treatment strategies according to the causative gene of MODY should be applied when available. Still, the majority of MODY is misdiagnosed and more genetic testing is required in Korea. We review updates regarding the classification, diagnosis, and treatment of MODY.

3인지장애와 당뇨병

저자 : 정찬희 ( Chan-hee Jung ) , 목지오 ( Ji-oh Mok )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 165-177 (13 pages)

다운로드

(기관인증 필요)

초록보기

Diabetes mellitus and cognitive dysfunction are highly prevalent in the aging population. In the aging society, clinicians will be increasingly tasked with managing elderly patients who have both cognitive dysfunction and diabetes. A growing number of epidemiological and clinical studies confirmed that diabetes is associated with an increase in the risk of cognitive dysfunction and dementia. Cognitive dysfunction is of particular importance because it is associated with poor self-management ability, poor diabetes management with more frequent severe hypoglycemic episodes, and increased risk of cardiovascular morbidity and mortality. Current diabetes guidelines recommend screening for cognitive dysfunction in older and high-risk patients and providing individualized guidance for patients with cognitive dysfunction. Nonetheless, there is limited awareness among clinicians regarding this subject compared to other diabetic micro- and macrovascular complications. Recently, there has been increasing understanding in this field through multimodal neuroimaging and biomarkers for early detection of cognitive dysfunction in diabetes. In addition, new agents such as glucagon-like peptide 1 receptor agonists showed promising protective effects against cognitive dysfunction and dementia in patients with type 2 diabetes. In this review, we summarize the relationship between diabetes and cognitive dysfunction, especially dementia, and some contributing factors and pathogenesis of dementia in diabetes. We also review how anti-diabetic medications may influence cognitive dysfunction and clinical management guidance.

4우울장애와 당뇨병

저자 : 전언주 ( Eonju Jeon )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 178-184 (7 pages)

다운로드

(기관인증 필요)

초록보기

As a result of their increasing prevalence, diabetes and depression, together with population growth and aging, are growing public health concerns. Diabetes and depressive disorder may occur on the basis of a common pathophysiology and interact with each other. Complex environmental, social, behavioral, and emotional factors influence diabetes care. In particular, maintaining psychological well-being for people with diabetes is the foundation for achieving diabetes treatment goals and satisfactory quality of life. An improved understanding of depressive disorder and diabetes may potentially lead to early detection, and timely treatment planning may simultaneously prevent the onset of depression. Ultimately, this can build positive health behaviors and optimizing medical outcomes for living with diabetes.

5수면장애와 당뇨병

저자 : 이정안 ( Jung An Lee ) , 이정구 ( Jung Goo Lee )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 185-191 (7 pages)

다운로드

(기관인증 필요)

초록보기

Sleep problems and diabetes mellitus are increasing in prevalence. Although it is unclear if they are related, a number of related studies implicate such a relationship. A number of related studies implicate such a relationship. In this review, the significance of sleep in diabetes mellitus will be reviewed by summarizing the relationships between sleep, circadian rhythm, sleep disorders, and diabetes mellitus. Also, the mechanisms of influence will be reviewed. In addition, although the relationship between sleep and diabetes mellitus mainly has focused on type 2 diabetes mellitus, this review also summarizes the relationship between type 1 diabetes mellitus and sleep. In clinical practice, sleep problems have not been emphasized in management or prevention of diabetes mellitus. Considering their close relationship and impact on prognosis, mental health and physical health study will need to be integrated for treatment and prevention of diabetes mellitus.

6음주, 흡연과 당뇨병

저자 : 정우영 ( Wooyoung Jung )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 192-200 (9 pages)

다운로드

(기관인증 필요)

초록보기

Many patients with diabetes continue smoking and high-risk drinking during diabetes treatment. Some patients try and fail to stop alcohol drinking and smoking because of the addictive and habitual effects. Considering the high lifetime prevalence of alcohol and nicotine use disorders, the percentage of people who actively use treatment services is low. Smoking is related to increased vascular complications and mortality as well as development of diabetes. A small amount of alcohol is allowed in the diabetes treatment guidelines, but the limit can be difficult to maintain in reality. Therefore, it is necessary for a medical doctor to evaluate the alcohol and smoking problems of diabetic patients, and it may be helpful to use screening and evaluation tools such as AUDIT (alcohol use disorders identification test) for alcohol drinking and FTND (Fagerstrom Test for Nicotine Dependence) for smoking. It is important that patients are provided necessary information and a brief intervention and that they are recommended a professional treatment such as active treatment with anti-craving medications and structural psychosocial treatment programs. Many patients are worried about the harmful effects of alcohol drinking and smoking and think they should quit it, but at the same time, they may have their own reasons for not being able to quit drinking and smoking, and may be suffering from ambivalent ideas about alcohol drinking and smoking. Therefore, rather than criticizing the patient's alcohol drinking and smoking behavior, it is important to show understanding of patient difficulties and to encourage the patient to stop drinking and smoking.

7노인당뇨병 환자의 인슐린주사교육

저자 : 이기연 ( Gi Yeon Lee )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 201-205 (5 pages)

다운로드

(기관인증 필요)

초록보기

The number of elderly diabetes patients continues to increase. These patients experience decline in physical functions related to aging and various accompanying disease. These interrupt insulin self-injection and self-management of diabetes. Therefore, it is necessary to understand the characteristics of elderly diabetes patients in order to provide proper insulin injection education.

8비만한 당뇨병환자의 체중 조절을 위한 임상영양요법

저자 : 김미향 ( Mihyang Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 3호 발행 연도 : 2022 페이지 : pp. 206-212 (7 pages)

다운로드

(기관인증 필요)

초록보기

Clinical Practice Guidelines for Diabetes recommend that overweight or obese adults lose more than 5% of their body weight and reduce their total caloric intake to maintain the reduced body weight. In diabetic patients, the goal of weight control is not simply to lose weight, but to achieve health benefits by controlling blood sugar well and reducing the risk of complications and other comorbidities. An extremely calorie-restricted diet, whose long-term effectiveness has not been verified, is not recommended as it may increase the risk of hypoglycemia and ketoacidosis. For weight control in obese diabetic patients, it is important to follow diabetic diet guidelines while setting actionable energy goals that prevent hypoglycemia and do not increase health risks. The energy target should be adjusted in consideration of individual conditions such as daily intake, body size, and activity level.

1
권호별 보기
같은 권호 다른 논문
| | | | 다운로드

12형당뇨병에서의 정밀의료

저자 : 전언주 ( Eonju Jeon )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 77-82 (6 pages)

다운로드

(기관인증 필요)

초록보기

Precision medicine is an innovative approach to tailoring disease prevention and treatment that takes into account differences in people's genes, environments, and lifestyle patterns. The aim of such an approach is to lead a shift in the clinical treatment paradigm from a trial-and-error or perceptive approach to the right drug, for the right patient, at the right time. The characterization of human biology and behaviors is now possible at scale owing to advances in biomarkers, bioimaging, and wearable technologies. In addition, big data from electronic medical records, health insurance databases, and other platforms have become available. These have enabled the generation of new insights into the phenotype known as diabetes. Precision medicine in diabetes (PMD) refers to an approach to optimize the diagnosis, prediction, and prevention or treatment of diabetes by integrating multi-dimensional data accounting for individual differences. The potential for precision treatment in diabetes is vast and should be considered cost-effective. Compared to precision medicine of monogenic diabetes, precision medicine of type 2 diabetes is difficult due to the polygenic condition in which environment as well as thousands of etiological genetic variants play an important role. Although there are the great concerns about PMD, which is complex and difficult to do, is required much time, we look forward to clinical utility in the treatment of patients based on their effects on different classes of markers, including race, metabolic status, other phenotypic markers, and omics data for each class of antihyperglycemic medication in the near future.

2비알코올지방간질환의 약물치료: 당뇨병약

저자 : 김경수 ( Kyung-soo Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 83-88 (6 pages)

다운로드

(기관인증 필요)

초록보기

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorders and is associated with various metabolic diseases, including type 2 diabetes mellitus (T2DM). There are no approved drugs for NAFLD, and the only approved treatment option is weight reduction. However, it is not easy to maintain weight loss by lifestyle modification alone; pharmacological treatments are helpful in this regard. As insulin resistance plays an important role in the development of NAFLD, many antidiabetic drugs have been evaluated for treatment of NAFLD. Pioglitazone could be a first-line option to improve nonalcoholic steatohepatitis (NASH) in patients with T2DM to produce some improvement in fibrosis. Glucagonlike peptide-1 receptor agonists show evidence of improving NAFLD/NASH with fibrosis. Metformin and dipeptidyl peptidase-4 inhibitors are not recommended for treating NAFLD in patients with T2DM. Evidence that sodium-glucose cotransporter 2 inhibitors improve NAFLD/NASH with fibrosis in patients with T2DM is emerging.

3식욕조절 기전과 비만

저자 : 노은 ( Eun Roh )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 89-96 (8 pages)

다운로드

(기관인증 필요)

초록보기

Dysregulated energy homeostasis leads to obesity. The brain, particularly hypothalamus and brain stem, plays a key role in the control of food intake and homeostatic regulation of energy metabolism. Food reward-related hedonic controls integrate with homeostatic controls to regulate body weight. The brain determines energy status by receiving peripheral signals, such as nutrients, gut-derived satiety signals, and adiposity-related hormones, via the circulation or through afferent fibers of the vagus nerve. Significant advances in understanding of the molecular mechanisms of appetite control and energy metabolism drove the pursuit of anti-obesity drugs in recent years. The development of incretins as drugs for type 2 diabetes provided unprecedented results in body weight loss. Recently, clinical study results with incretin-based poly-agonists reported mean weight loss greater than 10%, inspiring confidence in development of anti-obesity medications. Here, I briefly review how brain and peripheral signals integrate and interact to regulate homeostatic and hedonic eating behavior and discuss the mechanism of action of recently developed anti-obesity drugs.

4만성질환 관리에서 이중에너지방사선흡수측정기 사용

저자 : 김태년 ( Tae Nyun Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 97-105 (9 pages)

다운로드

(기관인증 필요)

초록보기

Aging and chronic disease are often accompanied by changes in body composition that lead to decreased muscle mass and increased fat mass, even in weight-stable individuals. Both obesity and sarcopenia are important causes of frailty, disability, morbidity, and mortality. Diminished skeletal muscle and expanded visceral fat can act synergistically, which might maximize their effects on physical impairments and metabolic disorders. Dual-energy X-ray absorptiometry (DEXA) was regarded as one of the most versatile imaging techniques for evaluation of sarcopenia and obesity as well as osteoporosis. Whole-body DEXA allows total and regional assessment of the three compartments for fat mass, non-bone lean mass, and bone mineral content. Moreover, DEXA is accurate, reproducible, fast, relatively inexpensive, and involves very low radiation dose to the patient. Developments in DEXA equipment and software allow an accurate and differential estimate of visceral adipose tissue. This review summarizes the clinical practical application of whole-body DEXA values, with use of muscle and fat mass indices in the diagnostic workup of low muscle mass, sarcopenia, and sarcopenic obesity according to the most recent studies and guidelines.

5신체조성 분석에 있어서 생체전기저항분석을 이용한 방법의 유용성

저자 : 임수 ( Soo Lim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 106-112 (7 pages)

다운로드

(기관인증 필요)

초록보기

People with obesity are at high risk of type 2 diabetes, cardiovascular diseases, and certain types of malignancy. A significant reduction in muscle mass is also associated with increased risk of developing sarcopenia. In general, body composition is affected by several factors, including ethnicity, environment, genetics, and lifestyle patterns. Assessment of body composition is an important tool for maintaining good general health and longevity, and is utilized by physicians and researchers to monitor disease severity and nutritional status. It can also be used to monitor the effectiveness of dietary and drug interventions. Dual energy X-ray absorptiometry is regarded as the gold standard method for analyzing body composition. However, there is an associated risk of a small amount of radiation exposure. In addition, severely obese people are not candidates for this method. Recently, bioelectrical impedance analysis (BIA) has been developed. BIA poses no radiation hazard, is easy applicable and relatively inexpensive. Thus, BIA is widely used in fitness centers as well as in hospitals. Several studies have been conducted to assess the effectiveness of BIA for measuring body composition, but most have focused on subjects of European descent. Of note, body composition differs among ethnic groups: Asians have a greater tendency toward obesity at a lower body mass index than Caucasians. Therefore, an ethnicityspecific approach is required for precise estimation of body composition using BIA. In conclusion, healthcare providers should have a thorough understanding of body composition assessment and the advantages and disadvantages of different measurement methods.

6비만 약물치료의 최신지견

저자 : 손장원 ( Jang Won Son )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 113-127 (15 pages)

다운로드

(기관인증 필요)

초록보기

Obesity is a chronic, complex, and heterogeneous disease that is affected by genetic, developmental, biological, and environmental factors; thus, it is necessary to approach obesity with an integrated and comprehensive treatment strategy. Because it is difficult to achieve and maintain successful long-term weight loss through lifestyle modifications in most obese patients, a pharmacological approach to the treatment of obesity should be considered as adjuvant therapy. According to the Korean Society for the Study of Obesity guidelines, patients who fail to lose weight with comprehensive lifestyle modifications and who have a body mass index of ≥ 25 kg/m2 are eligible for weight loss medication treatment. Four drugs (orlistat, naltrexone extended-release [ER]/bupropion ER, phentermine/topiramate controlledrelease, and liraglutide) have been approved for long-term use (> 12 weeks) to promote weight loss in Korea. Here, I will discuss these currently available anti-obesity agents as well as upcoming anti-obesity agents including semaglutide, setmelanotide, and tirzepatide in terms of obesity management.

7노인당뇨병 관리

저자 : 김선영 ( Sun Young Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 128-132 (5 pages)

다운로드

(기관인증 필요)

초록보기

As the aging population increases, the number of elderly diabetic patients continues to increase. Elderly diabetic patients are more likely to develop cardiovascular and cerebrovascular diseases than other age groups because of the increased susceptibility to other diseases caused by diabetes. As a result, the quality of life is reduced and the death rate is increasing, which is considered a social problem. Therefore, in order to manage such patients, it is necessary to understand the characteristics of the elderly and solve problems that can occur in elderly diabetic patients.

8탄수화물계산을 활용한 임상영양요법

저자 : 김미라 ( Mi Ra Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 133-137 (5 pages)

다운로드

(기관인증 필요)

초록보기

Improved postprandial glucose management requires careful monitoring of carbohydrate counting and consideration of the blood glucose response to dietary carbohydrate. Furthermore, learning how to use insulin-to-carbohydrate ratios for meal planning might help people successfully adjust insulin dose from meal to meal to enhance glycemic control. Regular education to raise knowledge of the link between carbohydrate intake and insulin requirements is critical for those whose meal schedules or carbohydrate consumption are unpredictable. Medical nutrition therapy is an important part of total diabetes management, and each person with diabetes should participate actively in education, self-management, and treatment planning with their health care team, including creation of a personalized food plan.

9당뇨병 환자 건강관리의 사회적 결정요인

저자 : 유빈 ( Been Yoo )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 138-143 (6 pages)

다운로드

(기관인증 필요)

초록보기

Diabetic patients must exert continuous self-management in areas such as diet, exercise, and medications to control blood sugar. However, such habits are greatly influenced by lifestyle; socioeconomic, cultural, and environmental conditions; as well as individual will. In vulnerable groups, the prevalence of diabetes is higher than in non-vulnerable groups, and difficulties in diabetes management are more common. Health is impacted by age; gender; genetics; lifestyle; social and community networks; living and working conditions; and socioeconomic, cultural, and environmental conditions. Among these various factors, five 'social determinants of health' highly affect the health management of diabetic patients: socioeconomic status, physical environment (housing environment, transportation), food insecurity, family and social support, and health literacy. It is important address these social determinants of health, starting with identification of individualized social needs of patients. Efforts should be made to improve quality of life through use of community resources and to further contribute to alleviating health inequality.

10소적혈구성 빈혈을 동반한 2형당뇨병 환자에서 진단된 무세룰로플라스민혈증

저자 : 박범균 ( Beomkyun Pak ) , 유은애 ( Eun Ae Yoo ) , 박효숙 ( Hyo Sook Park ) , 김지혜 ( Ji Hye Kim )

발행기관 : 대한당뇨병학회 간행물 : 당뇨병(JKD) 23권 2호 발행 연도 : 2022 페이지 : pp. 144-152 (9 pages)

다운로드

(기관인증 필요)

초록보기

Aceruloplasminemia (ACP) is a rare genetic disorder characterized by the triad of diabetes mellitus, retinal degeneration, and neurological symptoms. The patient's clinical and biochemical features highlight substantial phenotype heterogeneity, contributing to the difficulties and delay in diagnosing ACP. We described a patient presenting with diabetes and abnormal iron studies due to ACP with typical neuroradiologic abnormality. A 56-year-old female patient visited our hospital with complaints of weight loss and anxiety. The leading cause of unintentional weight loss was uncontrolled diabetes. She was treated with oral hypoglycemic agents. Initial blood tests revealed unexplained microcytic anemia and high ferritin levels. We performed magnetic resonance imaging (MRI) of the brain to alleviate her excessive concerns about normal memory loss. We suspected that she might have ACP, based on the results of cortical pencil lining sign of the brain MRI and microcytic anemia with decreased ceruloplasmin (CP) and increased ferritin levels. Sequence analysis of the CP gene revealed homozygosity for c.2630 G>A, confirming the clinical diagnosis of ACP. The patient was started on deferasirox with progressive normalization of ferritin. In conclusion, unexplained anemia, often with microcytosis, diabetes, and typical neuroradiologic findings, is the best clue for early diagnosis of ACP.

1
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기