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대한피부과학회> 대한피부과학회지> A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

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A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

Kui Young Park , Jun Ki Hong , Sun Hye Shin , Young Gue Koh , Hye Sung Han , Nam Ju Moon , Gun Young Ahn , Seong Jun Seo
  • : 대한피부과학회
  • : 대한피부과학회지 60권4호
  • : 연속간행물
  • : 2022년 05월
  • : 242-253(12pages)
대한피부과학회지

DOI


목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
CONFLICTS OF INTEREST
ORCID
REFERENCES

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초록 보기

Background: The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
Objective: To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
Methods: From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
Results: The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
Conclusion: This is the first study to investigate the association of BST with genetic factors and environmental factors. (Korean J Dermatol 2022;60(4):242∼253)

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간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
최근 권호 논문
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1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

KCI등재 SCOPUS

2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

KCI등재 SCOPUS

3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

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4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

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5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

KCI등재 SCOPUS

6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

KCI등재 SCOPUS

7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

KCI등재 SCOPUS

8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

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9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

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10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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12
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1한국인 50세 이상 여성의 안면 피부 노화와 생활습관 간의 상관관계

저자 : 김승미 ( Seung-mee Kim ) , 이영윤 ( Young Yoon Lee ) , 황초롱 ( Cho-long Hwang ) , 신정민 ( Jung-min Shin ) , 권인선 ( In-sun Kwon ) , 박상현 ( Sang-hyun Park ) , 정경은 ( Kyung Eun Jung ) , 김창덕 ( Chang-deok Kim ) , 서영준 ( Young-joon Seo ) , 홍동균 ( Dongkyun Hong ) , 이영 ( Young L

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 201-208 (8 pages)

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Background: Skin aging can be divided into intrinsic and extrinsic processes, and occur due to several factors. Although the interest in skin youthfulness is increasing globally, research on facial skin youthfulness and lifestyle is limited.
Objective: This study aimed to evaluate the association between facial skin youthfulness and biophysical facial skin parameters in Korean women over 50 years of age. We further investigated lifestyle factors that make people appear younger than their chronological age.
Methods: We surveyed the essential information and lifestyle of subjects by questionnaires, and measured the biophysical parameters of the facial skin. We then performed clinical facial assessments, and the values were compared with the chronologic age. The associations between age differences, biophysical parameters, and living habits were evaluated.
Results: We identified a positive correlation between age and melanin index (r=0.245, p<0.001) and erythema index (r=0.119, p=0.002). The melanin index was statistically significantly lower in the group without regular outdoor activities (144.66±43.24 vs. 137.00±55.48, p=0.043). The melanin index and erythema index were the significant differences that defined younger perceived age than chronological age. The perceived age was younger in the group who wore a hat when performing outdoor activities than the group who did not (3.70±1.84 vs. 3.40±1.94, p=0.034).
Conclusion: To retain youthful skin, it is essential to reduce sun exposure, as this factor can affect the melanin and erythema indices by inducing photoaging. Therefore, avoiding the sun bia proper methods, such as wearing a hat and sunscreen during outdoor activities, is recommended to maintain skin youthfulness. (Korean J Dermatol 2022;60(4): 201∼208)

KCI등재SCOUPUS

2대상포진 예방접종이 고령에서 발생하는 대상포진의 임상양상 및 경과에 미치는 영향: 단일기관의 5년간 후향적 연구

저자 : 김중호 ( Joong Ho Kim ) , 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 209-219 (11 pages)

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Background: Herpes zoster (HZ) is a neurocutaneous disease caused by reactivation of the varicella zoster virus after primary infection. In Korea, it is recommended that all adults aged >60 be vaccinated against HZ. However, breakthrough infection with HZ can occur infrequently in vaccinated individuals.
Objective: This study aimed to investigate the effects of the HZ vaccine on the clinical manifestations and courses of HZ in immunocompetent elderly individuals aged 60 years and older.
Methods: Among 848 immunocompetent HZ patients, 52 were vaccinated and 796 were unvaccinated. From this cohort, we chose 156 unvaccinated patients through a 1:3 propensity score matching analysis using three parameters; age, sex, and involved dermatome. We subsequently compared the clinical manifestations and courses between the vaccinated (n=52) and unvaccinated (n=156) groups.
Results: The vaccinated group had a lower peak numeric rating scale pain score and a lower rate of consultation with the pain control clinic than the opposite. Additionally, mild skin lesions without vesicles were more frequent in the vaccinated group than in the opposite. The vaccinated group had a shorter duration of total follow-up, shorter antiviral treatment period, lower admission rate, and shorter hospital stay than the opposite. Although postherpetic neuralgia occurred more frequently in the unvaccinated group than in the unvaccinated group, the incidences of other HZ-related complications showed no significant difference between the two groups.
Conclusion: Despite the possibility of breakthrough infection, the HZ vaccine should be recommended in the elderly as it can weaken the clinical features and course of the disease. (Korean J Dermatol 2022;60(4):209∼219)

KCI등재SCOUPUS

3건선관절염을 동반한 중등증 및 중증 건선 환자에서 Secukinumab의 건강관련 삶의 질 개선 효과에 관한 후향적 연구

저자 : 홍용준 ( Yong Jun Hong ) , 고강민 ( Gang Min Go ) , 김미리 ( Miri Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 220-227 (8 pages)

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Background: Psoriasis is a relapsing inflammatory skin disorder that can affect the nails and joints. Psoriatic arthritis (PsA) occurs in up to 30% of patients with psoriasis, leading to chronic articular pain, and impairing quality of life. Secukinumab is a human monoclonal antibody targeting interleukin-17A that has been shown to effectively improve the clinical signs and symptoms of PsA.
Objective: To evaluate the effect of secukinumab on health-related quality of life (HRQOL) in Korean PsA patients.
Methods: We retrospectively investigated the medical records and psoriasis area and severity index (PASI) scores of 13 patients with PsA who completed the psoriatic arthritis impact of disease 12-item questionnaire (PsAID-12) before and 3 months after receiving secukinumab treatment between October 2019 and August 2021 in Yeouido St. Mary's Hospital.
Results: At week 12, significant reductions in the total and each item PsAID-12 and mean PASI score were observed (p<0.01). The mean decrease of total PsAID-12 score was 4.8 (95% confidence interval [CI], 3.74∼5.86), with the greatest improvement observed in the item of 'embarrassment' (7.15; 95% CI, 5.59∼8.72). Of the 13 patients, 11 (84.6%) and 5 (38.5%) achieved PASI75 and PASI90 response, respectively.
Conclusion: This study showed that secukinumab improves the HRQOL of patients with PsA, implying a positive influence of secukinumab on patients' physical and mental status in a real-world clinical setting. (Korean J Dermatol 2022;60(4):220∼227)

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4The Importance of Ultrasonography in the Diagnosis of Epidermal Cysts and Lipomas in the Field of Dermatology

저자 : Kihyuk Shin , Sang-hyeon Won , Chankue Park , Gun-wook Kim , Hoon-soo Kim , Hyun-chang Ko , Moon-bum Kim , Byung-soo Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 228-234 (7 pages)

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Background: Ultrasonography (US) is a simple and reliable tool that can aid in the diagnosis of benign subcutaneous lesions such as epidermal cysts and lipomas.
Objective: This study aimed to determine the efficacy of US for the differential diagnosis of epidermal cysts and lipomas.
Methods: A retrospective study of 100 patients with epidermal cysts (n=45) or lipomas (n=55) who underwent US and then received a pathological diagnosis in the dermatology department of Pusan National University Hospital was conducted.
Results: US and clinical impressions accurately diagnosed the epidermal cysts in 90.0% and 88.0% of the patients, respectively, and the lipomas in 92.0% and 88.0% of the patients, respectively. US combined with clinical impression significantly increased the diagnostic yield of epidermal cysts (98%) and lipomas (99%). On US, the frequency of posterior acoustic enhancement was higher for the epidermal cysts than for the lipomas (82.2% and 29.1%, respectively; p<0.001), and striated echoes such as internal linear echogenic reflections and dark clefts were more frequently found in the lipomas than in the epidermal cysts (90.9% and 6.7%, respectively; p<0.001).
Conclusion: This study implies that the diagnostic role of US can be greatly enhanced by knowledge of the clinical presentation. (Korean J Dermatol 2022;60(4):228∼234)

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5Anxiety Sensitivity and Psychological Distress in Patients with Rosacea: A Questionnaire-Based Study

저자 : Hyo-eun Kwon , Hye-jin Ahn , Min Kyung Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 235-241 (7 pages)

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Background: Rosacea is a common chronic inflammatory disorder that affects the skin of the central face. Anxiety sensitivity (AS) refers to the fear of sensations and symptoms arising from an expected experience of anxiety. High AS can cause anxiety disorders. Several studies have evaluated depression in patients with rosacea; however, AS has not yet been investigated.
Objective: We aimed to investigate AS, depression, and quality of life in patients with rosacea.
Methods: Eighty-five patients with rosacea and 85 controls (aged>18 years) were enrolled in the study. The severity of rosacea was evaluated according to the standard guidelines of the National Rosacea Society. Patients with rosacea and controls were asked to complete the Korean version of the anxiety sensitivity index-revised (ASI-R), beck depression inventory (BDI), and dermatology life quality index (DLQI).
Results: The ASI, BDI, and DLQI scores were significantly higher in patients with rosacea than in controls (p< 0.001). In particular, the cardiovascular subscale of the ASI was significantly increased in patients with rosacea. The ASI and BDI scores were significantly correlated. DLQI scores were weakly correlated with ASI compared with BDI scores in patients with rosacea.
Conclusion: Our study is the first to report that AS is elevated in patients with rosacea. It is necessary to consider the anxiety-related symptoms of patients with rosacea, as they may benefit from psychological intervention to alleviate distress. (Korean J Dermatol 2022;60(4):235∼241)

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6A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

저자 : Kui Young Park , Jun Ki Hong , Sun Hye Shin , Young Gue Koh , Hye Sung Han , Nam Ju Moon , Gun Young Ahn , Seong Jun Seo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 242-253 (12 pages)

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Background: The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
Objective: To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
Methods: From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
Results: The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
Conclusion: This is the first study to investigate the association of BST with genetic factors and environmental factors. (Korean J Dermatol 2022;60(4):242∼253)

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7전완부의 덩이로 발견된 근육내 전이성 투명세포신세포암 1예

저자 : 최연구 ( Yeon-gu Choi ) , 이현주 ( Heun Joo Lee ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee ) , 최영준 ( Young Jun Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 254-257 (4 pages)

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Cutaneous metastases from renal cell carcinoma (RCC) present as rapidly growing erythematous or purple-round nodules. An 88-year-old male presented with a solitary, deep-seated firm mass on his left forearm that had persisted for 3 years. Ultrasonography revealed an hypervascular mass with rich vessels. Magnetic resonance imaging revealed a 1.6×1.6×3.3 cm sized, high T2-weighted signal intensity mass at brachioradialis muscle. Histopathologic examination revealed cells with atypical, pleomorphic, oval to spindle-shaped nuclei, and clear cytoplasm with an alveolar pattern within an unencapsulated, lobulated mass. Immunohistochemical analysis showed that the tumor cells were positive for PAX8, CD10, epithelial membrane antigen, and vimentin. Ultrasonography of the urinary tract revealed a lesion suspected to be RCC, which was thought to be the primary tumor. As our patient showed peculiar clinical symptoms and the primary tumor was later diagnosed as a metastatic lesion inversely, we report a rare case of metastatic RCC with an intramuscular mass on the forearm. (Korean J Dermatol 2022;60(4):254∼257)

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8가족력이 있으면서 임상적 진단이 어려웠던 결절흑색종 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 윤태진 ( Tae Jin Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 258-261 (4 pages)

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Nodular melanoma is a malignant melanoma which presents as blackish-brown or colorless nodules. Nodular melanoma shows rapid growth compared to other melanoma subtypes, and often exhibits clinical features that do not correspond to the ABCD rules, which is key in differentiating melanoma. This makes nodular melanoma difficult to differentiate from the initially suspected melanoma. As such, diagnosis of nodular melanoma is commonly delayed, and is therefore often identified at an advanced stage. Here, we report a case of nodular melanoma in a young man with a family history of melanoma. We emphasize the importance of early diagnosis through biopsy for malignant melanoma, which is difficult to differentiate based on clinical features. (Korean J Dermatol 2022;60(4):258∼261)

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9면역기능 정상 성인에서 겨드랑 부위에 발생한 모낭염 양상의 전염성 연속종

저자 : 김동성 , 허재영 , 박태흠 , 김우일 , 조문균 , 김수영

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 262-263 (2 pages)

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10저절로 호전된 원인 불명의 붉은 에크린색한증 1예

저자 : 이상균 , 홍승필

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 264-265 (2 pages)

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