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대한본초학회> 대한본초학회지(본초분과학회지)> 한약재 함유 대두발효 추출물이 streptozotocin으로 유발된 당뇨 흰쥐의 혈당 및 조직형태학적 변화에 미치는 영향

KCI등재

한약재 함유 대두발효 추출물이 streptozotocin으로 유발된 당뇨 흰쥐의 혈당 및 조직형태학적 변화에 미치는 영향

Effect of Fermented Soy Bean Extract Containing Herbal Medicines (Godjang) on Blood Glucose Levels and Histomorphology in Streptozotocin-induced Diabetic Rat

조창숙 ( Chang Suk Jo ) , 김소영 ( So Young Kim ) , 최문열 ( Moon-yeol Choi ) , 김미형 ( Mi Hyung Kim ) , 김미려 ( Mi Ryeo Kim ) , 서부일 ( Bu-il Seo )
  • : 대한본초학회
  • : 대한본초학회지(본초분과학회지) 37권1호
  • : 연속간행물
  • : 2022년 01월
  • : 1-9(9pages)
대한본초학회지(본초분과학회지)

DOI


목차

Ⅰ. 서 론
Ⅱ. 재료 및 방법
Ⅲ. 결 과
Ⅳ. 고 찰
Ⅴ. 결 론
감사의 글
References

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초록 보기

Objective : This study was designed to investigate anti-diabetic effects of fermented soy bean extract with herbal medicines (Godjang) in diabetic rat models induced by streptozotocin (STZ) injection.
Method : Changes in body weight, drinking water, and food intake were observed for 4 weeks before and after induction of diabetes mellitus in rats. The anti-diabetic capacity of Godjang was analyzed by fasting blood glucose (FBG) every week. Also, after 4 weeks of administration, the oral glucose tolerance test (OGTT) was performed, and then blood levels of insulin were checked. And serum levels of total cholesterol and triglycerides were determined. Histomorphological changes of liver, kidney and pancreatic tissues were also observed in STZ-induced diabetic rats and Godjang administered rats.
Result : In Godjang administered group, body weight and water intake were more lower than that of STZ-induced diabetic rats. FBG was decreased in the Godjang administered group than STZ-induced diabetic group. According to OGTT, blood glucose levels at 30 minutes and 60 minutes significantly decreased in Godjang administered group than in STZ-induced diabetic control group. Administration of Godjang extract for 4W significantly decreased levels of serum glucose, total cholesterol (TC), triglycerides (TG) in diabetic rats. In histomorphological analysis of kidney, liver, Godjang administrated groups showed the inhibition of pathological damage.
Conclusion : These results suggest that Godjang extract has an anti-diabetic action through decrease in serum glucose, TC, TG levels and recovery of the morphological changes in kidney and liver in STZ-induced diabetic rats.1)

UCI(KEPA)

I410-ECN-0102-2022-500-001034358

간행물정보

  • : 의약학분야  > 기초한의학
  • : KCI등재
  • :
  • : 격월
  • : 1229-1765
  • : 2288-7199
  • : 학술지
  • : 연속간행물
  • : 1986-2023
  • : 1697


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이에 본 자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

38권1호(2023년 01월) 수록논문
최근 권호 논문
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KCI등재

1바이칼레인(baicalein)이 peptidoglycan으로 자극된 RAW 264.7 mouse macrophages의 hydrogen peroxide 생성에 미치는 영향

저자 : 박완수 ( Wansu Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 38권 1호 발행 연도 : 2023 페이지 : pp. 1-9 (9 pages)

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Objectives : The aim of this study was to investigate the effect of baicalein (BA) on the production of hydrogen peroxide in peptidoglycan-stimulated RAW 264.7 mouse macrophages.
Methods : Peptidoglycan-stimulated RAW 264.7 were incubated with baicalein at concentrations of 50 and 100 μM. Incubation time is 30 min, 2 h, 12 h, and 18 h. After incubation, The production of hydrogen peroxide in RAW 264.7 was measured with dihydrorhodamine 123 assay. Berberine and gallic acid were used as the comparative materials.
Results : BA at the concentration of 50 and 100 μM did not show cytotoxicity on RAW 264.7 for 24 h incubation. For 30 min, 2 h, 12 h, and 18 h incubation, BA at the concentration of 50 and 100 μM significantly inhibited the production of hydrogen peroxide in RAW 264.7 stimulated by peptidoglycan (p < 0.05). In details, production of hydrogen peroxide in peptidoglycan-stimulated RAW 264.7 treated for 30 min with BA at concentrations of 50 and 100 μM was 93.91% and 93.52% of the control group treated with peptidoglycan only, respectively; the production of hydrogen peroxide for 2 h was 93.8% and 92.71%, respectively; production of hydrogen peroxide for 12 h was 94.86% and 95.93%, respectively; production of hydrogen peroxide for 18 h was 95.37% and 96.48%, respectively.
Conclusions : BA might have anti-oxidative activity related to its inhibition of hydrogen peroxide production in peptidoglycan-stimulated RAW 264.7 macrophages.

KCI등재

2LPS로 인해 활성화된 BV2 Microglia에서 발효 복합버섯-곡물 숙성균주 배양 紅蔘의 뇌신경염증 보호효과

저자 : 권빛나 ( Bitna Kweon ) , 오진영 ( Jin-young Oh ) , 김동욱 ( Dong-uk Kim ) , 장미경 ( Mi-kyung Jang ) , 조준형 ( Jun-hyoung Cho ) , 박성주 ( Sung-joo Park ) , 배기상 ( Gi-sang Bae )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 38권 1호 발행 연도 : 2023 페이지 : pp. 11-19 (9 pages)

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Objectives : Neuroinflammation is a common pathological mechanism of neurodegenerative diseases, and the development of therapeutic agents is urgently needed. Red ginseng has been known to be good for the immune stimulation in Eastern Asia. Although the immuno-stimulatory activity of red ginseng are already known, the neuro-protective effects of cultivated red ginseng with fermented complex mushroom-cereal mycelium (RGFM) have not been conducted. Thus, in this study, we tried to investigate the anti-neuroinflammatory effect of RGFM water extract on lipopolysaccharide (LPS) stimulated BV2 cells.
Methods : BV2 cells were pretreated with RGFM 1 h prior to LPS exposure. To determine the neuro-protective effects of RGFM water extract, we measured the expression of inflammatory mediators including inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2 and nitric oxide (NO) and pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in LPS-stimulated BV2 cells. In addition, to find out the regulatory mechanism of RGFM water extract, we assessed the protein levels of mitogen-activated protein kinases (MAPKs) and inhibitory κBα (IκBα) by western blotting.
Results : In our study, treatment of RGFM reduced the mRNA expression of iNOS and COX-2 and suppressed NO production in LPS-stimulated BV2 cells. Additionally, the secretion of IL-1β and TNF-α but not IL-6 was significantly inhibited by RGFM. Furthermore, RGFM water extract inhibited the phosphorylation of c-Jun N-terminal kinase (JNK).
Conclusions : Taken together, these findings suggest that RGFM water extract has a protective effect on neuroinflammation through inhibition of JNK.

KCI등재

3산화스트레스를 유발한 위 상피세포에서 수치 치자의 세포 보호 효과

저자 : 이종록 ( Jong Rok Lee ) , 김상찬 ( Sang Chan Kim ) , 박숙자 ( Sook Jahr Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 38권 1호 발행 연도 : 2023 페이지 : pp. 21-30 (10 pages)

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Objective : Gardeniae Fructus (GF) has bitter and cold nature. Thus, it has been traditionally prescribed in processed form roasted with ginger juice for patients with a weak stomach. This study investigated the effects of processed GF in tert-butyl hydroperoxide (tBHP)-treated gastric epithelial cells.
Methods : Processed GF was made by applying 40% ginger juice or 10% ethanol for 24 h and then roasting at 150℃ for 5 minutes. Apoptosis was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Mitochondrial membrane potential (MMP) was monitored by flow cytometry using the membrane permeable fluorescent dye Rh123. Protein expression was measured by Western blot analysis.
Results : Cell viability was reduced by tBHP and restored by ethanol extract of GF (GFE). In the TUNEL assay, it was found that cell death by tBHP was due to apoptosis, and GFE had an anti-apoptotic effect. Processed GF roasted with ginger juice showed the best anti-apoptotic effect. Processed GF also inhibited MMP loss and restored tBHPinduced changes in expression levels of apoptosis-related proteins. Increased ROS production and GSH depletion after tBHP treatment were significantly reduced by processed GF. In addition, tBHP-induced activation of mitogen-activated protein kinase (MAPK) was inhibited by processed GF.
Conclusion : These results demonstrate that the processed GF is able to protect gastric epithelial cells from oxidative stress-induced cell death with antiapoptotic and antioxidant activity. In addition, it shows that the processing of GF, which have been traditionally used for gastrointestinal protection, partially have scientific validity.

KCI등재

4알코올성 간 손상 동물 모델에서 芍藥 葛根 복합물의 간 손상 보호 효과

저자 : 최정원 ( Jeong Won Choi ) , 김진영 ( Jin Young Kim ) , 신미래 ( Mi-rae Shin ) , 박해진 ( Hae-jin Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 38권 1호 발행 연도 : 2023 페이지 : pp. 31-43 (13 pages)

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Objective : Alcoholic liver disease (ALD) is caused by excess alcohol intake. In the liver, alcohol breakdown results formation of toxic byproducts that lead to damage to tissue. This study is to investigate the therapeutic effects of Paeoniae Radix Alba and Puerariae Radix combination (PP) on ALD.
Methods : PP was analyzed for polyphenolic compounds and free radical scavenging activity. ALD mouse model was induced by feeding ethanol and water (Control), silymarin (50 mg/kg), low-dose (PP: 100 mg/kg) or high-dose (PP: 200 mg/kg) was orally administrated to ALD mice for 14 days. The serum was assessed with levels of AST, ALT, total bilirubin, total cholesterol, and triglyceride. Liver tissues were evaluated for ROS levels, degree of liver damage and protein expression.
Results : The 3:1 (Paeoniae Radix Alba:Puerariae Radix) ratio showed the best antioxidant values for the experiment. In ALD model, levels of AST, ALT, total bilirubin, total cholesterol, and triglyceride were significantly increased in the Control and the levels were decreased by treatment of PP. In addition, increased ROS, ONOO- and MDA levels in the Control were reduced in the PP groups. Western blot analysis figured out that proteins related to ROS and cholesterol metabolism were higher in ALD than in PP-treated ALD. Antioxidant enzyme expression was low in the control group and increased by PP treatment.
Conclusion : Our results suggest that PP has the potential to be a medicine in ALD in terms of regulating oxidative stress and adjusting lipid metabolism.

KCI등재

5네트워크 약리학을 통한 황기의 항비만 효능 및 작용기전 예측 연구

저자 : 김미혜 ( Mi Hye Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 38권 1호 발행 연도 : 2023 페이지 : pp. 45-53 (9 pages)

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Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis.
Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM.
Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity. Based on GO biological process and KEGG Pathway, 'Response to lipid', 'Cellular response to lipid', 'Lipid metabolic process', 'Regulation of chemokine production', 'Regulation of lipase activity', 'Chemokine signaling pathway', 'Regulation of lipolysis in adipocytes' and 'PPAR signaling pathway' were predicted as functional pathways of AM on obesity.
Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.

1
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KCI등재

1한약재 함유 대두발효 추출물이 streptozotocin으로 유발된 당뇨 흰쥐의 혈당 및 조직형태학적 변화에 미치는 영향

저자 : 조창숙 ( Chang Suk Jo ) , 김소영 ( So Young Kim ) , 최문열 ( Moon-yeol Choi ) , 김미형 ( Mi Hyung Kim ) , 김미려 ( Mi Ryeo Kim ) , 서부일 ( Bu-il Seo )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 1-9 (9 pages)

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Objective : This study was designed to investigate anti-diabetic effects of fermented soy bean extract with herbal medicines (Godjang) in diabetic rat models induced by streptozotocin (STZ) injection.
Method : Changes in body weight, drinking water, and food intake were observed for 4 weeks before and after induction of diabetes mellitus in rats. The anti-diabetic capacity of Godjang was analyzed by fasting blood glucose (FBG) every week. Also, after 4 weeks of administration, the oral glucose tolerance test (OGTT) was performed, and then blood levels of insulin were checked. And serum levels of total cholesterol and triglycerides were determined. Histomorphological changes of liver, kidney and pancreatic tissues were also observed in STZ-induced diabetic rats and Godjang administered rats.
Result : In Godjang administered group, body weight and water intake were more lower than that of STZ-induced diabetic rats. FBG was decreased in the Godjang administered group than STZ-induced diabetic group. According to OGTT, blood glucose levels at 30 minutes and 60 minutes significantly decreased in Godjang administered group than in STZ-induced diabetic control group. Administration of Godjang extract for 4W significantly decreased levels of serum glucose, total cholesterol (TC), triglycerides (TG) in diabetic rats. In histomorphological analysis of kidney, liver, Godjang administrated groups showed the inhibition of pathological damage.
Conclusion : These results suggest that Godjang extract has an anti-diabetic action through decrease in serum glucose, TC, TG levels and recovery of the morphological changes in kidney and liver in STZ-induced diabetic rats.1)

KCI등재

2녹두 추출물이 생쥐에 유발된 접촉피부염의 피부 증상과 조직병리학적 소견에 미치는 영향

저자 : 장선경 ( Seonkyung Jang ) , 강윤형 ( Yoonhyoung Kang ) , 오승엽 ( Seongyeop Oh ) , 강윤태 ( Yuntae Kang ) , 김소연 ( Soyeon Kim ) , 류지효 ( Ji-hyo Lyu ) , 김형우 ( Hyungwoo Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 11-18 (8 pages)

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Objectives : Green gram (mung bean) has a cold nature and has been known to detoxify against various side effects that belong to hot in nature. In particular, since it has the effect of detoxifying fever and detoxification to treat swelling, it was also used externally to treat febrile dermatological diseases such as erysipelas and rubella. This study was designed to determine whether green gram exhibits anti-inflammatory effects on contact dermatitis in mice.
Methods : We investigated the effects of green gram extract (70% ethanol extract) on skin lesion, skin thickness and weights, melanin and erythema index and spleen body weight ratio in mice with contact dermatitis induced by repeated application of 1-Fluoro-2,4-dinitrobenzene.
Results : Topical application of green gram extract ameliorates skin lesions of contact dermatitis such as scale and roughness induces by 1-Fluoro-2,4-dinitrobenzene. green gram extract also suppressed enlargement of skin thicknesses and weights significantly. In addition, green gram extract treatment also lowered erythema index significantly compared to those in the control group. In the histopathological observation, green gram extract prevented epidermal hyperplasia and hyperkeratosis in inflamed tissues. Finally, green gram extract did not affect changes in body weights and the spleen body weight ratio, unlike dexamethasone, which significantly prevented body weight gain and lowered the spleen body weight ratio.
Conclusions : These results imply that green gram, which is known to have a detoxifying effect in Korean medicine, can be used in the treatment of contact dermatitis.

KCI등재

3백출(白朮)의 항산화 효과가 DSS 유발 궤양성 대장염 모델에 미치는 영향

저자 : 박석만 ( Seok Man Park ) , 이세희 ( Se Hui Lee ) , 정다운 ( Da Un Jeong ) , 조수정 ( Su-jung Cho ) , 신미래 ( Mi-rae Shin ) , 박해진 ( Hae-jin Park ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 19-29 (11 pages)

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Objectives : Although the pharmacological effects of anti-inflammatory and antioxidant action of Atractylodes macrocephala Koidzumi water extract (AM) have been proven from many studies, reports on the antioxidant effect of AM on ulcerative colitis (UC) are scarce. Therefore, we aimed at evaluating the anti-oxidant effect of AM on the DSS-induced UC model.
Methods : To induce ulcerative colitis, 8-week-old male Balb/c mice received 5% DSS in drinking water for 1 week. After 1 week of adaptation, mice were divided into four groups (n=8 each) for use as normal (Normal), DSS Control (Control), DSS + AM 100 ㎎/kg (AM100)-treatment, DSS + AM 200 ㎎/kg (AM200)-treatment. After 1 week of the experiment, the animals were sacrificed, and the extracted colon tissue was analyzed for protein through western blot.
Results : As a result of confirming the macroscopic changes in colon tissues to confirm the therapeutic effects of AM, the decrease in colon length was suppressed in the AM treatment group compared to the control group. In addition, as a result of biochemical analysis, AM administration significantly reduced serum glutamic oxalacetic transaminase, glutamic pyruvate transaminase levels and tissue malondialdehyde levels. As a result of confirming the protein expression level through western blot, AM administration significantly decreased the expression of NADPH-related proteins such as NOX2, p22phox, and iNOS, but significantly increased the expression of SOD, catalase, and GPx-1/2.
Conclusions : AM may improve DSS-induced UC in mice by modulating NADPH and antioxidant-related proteins. In conclusion, AM showed an antioxidant effect through the improvement of oxidative stress on UC.

KCI등재

4《상한론》 탕제에서 복용량을 부피로 표기한 약의 특징과 무게로 환산한 값

저자 : 김인락 ( In-rak Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 31-39 (9 pages)

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Objectives : It is very important to know the exact dosage of the Decoctions in 《Treatise on Cold Damage Diseases》. This study identified the characteristics of 15 Medicinal marked in volume and calculated their dosages in weight.
Methods : The origin, processing methods, and properties of 15 Medicinal were identified. The shape of the appropriate container that measures the volume of one seung was estimated, and the dosage in volume was converted into weight. These were compared with the dosages indicated by weight or count.
Results : The 15 Medicinal were categorized into liquids, powders, and grains. Ten items had only one dosage, of which three items had one seung, and seven items had 0.5 seung. Five items had two different dosages, of which four items had one or 0.5 seung, and only Suis Fel was 0.2 or 0.1 seung. Pinelliae Tuber and Urine were marked as 0.5 seung for convenience of measurement, although 0.4 seung were accurate. There were 20 different dosages in total, and when converted into weight, they matched 1, 2, 3, 4, 6, 8, or 16 Ryang, with none of 5 Ryang. Some exceptions that did not fit in the above were indicated by weight or count.
Conclusions : In the Decoctions of 《Treatise on Cold Damage Diseases》, dosages of 15 Medicinal were easy to measure by volume, and when converted into weight, they were consistent with the dosages originally indicated in weight or count.

KCI등재

5배초향이 RAW 264.7의 염증인자 생성에 미치는 영향

저자 : 박완수 ( Wansu Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 41-50 (10 pages)

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Objectives : The aim of this study was to investigate the effect of water extract of Agastache rugosa (AR) on productions of inflammatory mediators in lipopolysaccharide (LPS)-stimulated RAW 264.7 mouse macrophages.
Methods : Cell viabilities were measured with MTT assay. The production of nitric oxide (NO) from RAW 264.7 cells was measured with Griess reagent assay. The production of cytokines in RAW 264.7 cells was measured with multiplex cytokine assay.
Results : AR showed no cytotoxicity on RAW 264.7 cells. AR at concentrations of 25, 50, 100, and 200 μg/mL significantly inhibited NO production in LPS-stimulated RAW 264.7 cells. AR at concentrations of 50, 100, and 200 μg/mL significantly inhibited productions of TNF-α and IL-1β in LPS-stimulated RAW 264.7 cells; AR at concentrations of 50 and 200 μg/mL significantly inhibited productions of RANTES (CCL5) in LPS-stimulated RAW 264.7 cells; AR at concentrations of 100 μg/mL significantly inhibited productions of macrophage inflammatory protein-1β in LPS-stimulated RAW 264.7 cells; AR at concentrations of 50, 100, and 200 μg/mL significantly increased productions of IP-10 (CXCL10) in LPS-stimulated RAW 264.7 cells; AR at concentrations of 100 and 200 μg/mL significantly increased MCP-1 (CCL-2) in LPS-stimulated RAW 264.7 cells; AR at concentrations of 50 and 100 μg/mL significantly increased productions of IL-10 in LPS-stimulated RAW 264.7 cells.
Conclusions : AR might have immunomodulatory effects on productions of NO, cytokines, and chemokines in LPSstimulated RAW 264.7 mouse macrophages.

KCI등재

6오가피(Eleutherococcus sessiliflorus )의 전연골성 ATDC5 세포의 분화 유도

저자 : 스레스타사로즈쿠마 ( Saroj Kumar Shrestha ) , 송정빈 ( Jungbin Song ) , 이성현 ( Sung Hyun Lee ) , 이동헌 ( Donghun Lee ) , 김호철 ( Hocheol Kim ) , 소윤조 ( Yunjo Soh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 1호 발행 연도 : 2022 페이지 : pp. 51-59 (9 pages)

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Objectives : The process through which mesenchymal cells condense and differentiate into chondrocytes to form new bone is known as endochondral bone formation. Chondrogenic differentiation and hypertrophy are essential steps in bone formation and are influenced by various factors. The stem bark and root bark of Eleutherococcus sessiliflorus (ES) have been widely used to treat growth retardation and arthritis in traditional Korean Medicine. In this study, we aimed to investigate the possible role of the stem bark of ES in the stimulation of chondrogenic differentiation in clonal murine chondrogenic ATDC5 cells.
Methods : In ATDC5 cells treated with ES extract, cell viability and extracellular matrix production were determined using CCK-8 assay and Alcian blue staining, respectively, and alkaline phosphatase activity was measured. We also examined mRNA and protein expression levels of genes related to chondrogenic expression in ATDC5 cells using reverse transcription-polymerase chain reaction and western blot analyses.
Results : ES extract increased the accumulation of Alcian blue-stained cartilage nodules and alkaline phosphatase activity in ATDC5 cells. It increased the mRNA expressions of chondrogenic markers including bone sialoprotein (BSP), cartilage collagens, Runt-related transcription factor-2 (RUNX-2), osteocalcin (OCN), β-catenin, and bone morphogenetic protein-2 (BMP-2), as well as the protein expressions of β-catenin, RUNX-2, BMP-2, and alkaline phosphatase (ALP).
Conclusion : Taken together, these results suggest that ES extract exhibits a chondromodulating activity and therefore may be a possible agent for the treatment of bone growth disorders.

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자료제공: 네이버학술정보
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자료제공: 네이버학술정보

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