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대한피부과학회> 대한피부과학회지> 두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

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두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

Clinicopathological Characteristics of H-Zone and Non-H-Zone Basal Cell Carcinoma in the Head and Neck Region

손우리 ( Uri Shon ) , 염규진 ( Kyujin Yeom ) , 윤대관 ( Dea Kwan Yun ) , 김명화 ( Myung Hwa Kim ) , 최미수 ( Mi Soo Choi ) , 박병철 ( Byung Cheol Park )
  • : 대한피부과학회
  • : 대한피부과학회지 59권10호
  • : 연속간행물
  • : 2021년 12월
  • : 735-741(7pages)
대한피부과학회지

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Background: Basal cell carcinoma (BCC) is the most common type of skin cancer. However, limited comparative data on the characteristics and prognosis of BCC in the H-zone and non-H-zone exist.
Objective: We aimed to compare the clinical, histopathological, and surgical characteristics of BCCs in the head and neck region between the H- and non-H-zones.
Methods: We retrospectively reviewed the clinical and histopathological characteristics of 292 head and neck BCC lesions in 275 patients and the characteristics of Mohs micrographic surgery (MMS) of 252 BCC lesions in 239 patients.
Results: In the H-zone, 226 lesions (77.4%) were found. Clinically, patients with H-zone BCC, compared to those with non-H-zone, were significantly older (71.6±11.4 years vs. 64.6±13.5 years) and smaller in diameter (10.1±7.1 mm vs. 12.4±9.9 mm). The noduloulcerative type was more frequent in the H-zone, while the superficial and morpheaform types in the non-H-zone. Histopathologically, the infiltrative subtype was particularly noted in the H-zone than the non-H-zone (7.5% vs. 1.5%). Out of 37 BCC patients with prior treatment history, 31 (83.8%) were in the H-zone. Two out of 252 lesions (0.8%) recurred after MMS at our institution. The mean stages of MMS were comparable between the H- and non-H-zones (1.59 vs. 1.45, p=0.135).
Conclusion: H-zone BCCs were associated with older age and smaller tumor size compared to the non-H-zone BCCs. The noduloulcerative clinical and nodulocystic pathologic subtypes were the most common in both H-zone and non-H-zone BCCs. (Korean J Dermatol 2021;59(10):735∼741)

UCI(KEPA)

I410-ECN-0102-2022-500-000963267

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9660


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1악성 흑색종에 대한 한국어 유튜브 동영상의 질 평가

저자 : 허근영 ( Keunyoung Hur ) , 하은서 ( Eun-seo Ha ) , 김동효 ( Dong Hyo Kim ) , 송원지 ( Won Ji Song ) , 문제호 ( Je-ho Mun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 143-150 (8 pages)

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Background: Disseminating public knowledge on malignant melanoma through YouTube is an important way to bridge the gap between physicians and patients. However, videos recorded on this topic in Korea are yet to be evaluated.
Objective: We aimed to evaluate the quality of YouTube videos on malignant melanoma recorded in Korea. We also investigated whether there was a difference in the quality of videos made by medical professionals (subdivided into dermatologists and non-dermatologists) and non-medical personnel.
Methods: We included all videos recorded in Korean by searching YouTube using the keywords “melanoma” or “malignant melanoma”. The search was performed on March 22, 2021. The inclusion criterion was videos in Korean language that contained medical information about malignant melanoma. The characteristics and content information were collected for each video. Video quality (DISCERN, Global Quality Scale [GQS], Journal of the American Medical Association [JAMA] benchmark criteria) was analyzed.
Results: Eighty-five videos met the inclusion criterion for the analysis. Fifty-six (66%) and 29 videos (34%) were made by medical and non-medical personnel, respectively. The videos made by medical professionals significantly contained more of the following information than those made by non-medical personnel: clinical information (p<0.001), symptoms and signs (p=0.001), risk factors (p<0.05), diagnosis (p<0.001). Videos made by medical professionals, videos with a length of more than 5 minutes, or videos with more than 10,000 views had significantly higher quality scores (DISCERN, GQS, JAMA).
Conclusion: Considering that YouTube is being used as a portal for medical information, the participation of medical professionals is essential for providing more accurate information. (Korean J Dermatol 2022;60(3):143∼150)

KCI등재 SCOPUS

2중등도-중증의 한국인 건선 환자에서 Ustekinumab 장기 투여에 따른 효과 및 안전성 연구

저자 : 김연아 ( Yeona Kim ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoonsoo Kim ) , 고현창 ( Hyun-chang Ko ) , 김문범 ( Moon-bum Kim ) , 신봉석 ( Bong Seok Shin ) , 김병수 ( Byungsoo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 151-158 (8 pages)

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Background: Ustekinumab is a humanized monoclonal antibody targeting interleukin (IL)-12 and IL-23. Although popular, data on its long-term efficacy and safety in Korean patients with psoriasis are limited.
Objective: To evaluate the long-term efficacy and safety of ustekinumab in Korean patients with psoriasis.
Methods: A retrospective study in patients with moderate-to-severe psoriasis who had been treated with ustekinumab for at least 5 years was conducted. The sex, age, body mass index, medical records, previous psoriasis therapy, psoriasis area and severity index (PASI) scores, and adverse events were evaluated.
Results: Twenty-five patients (median age 47.00 years) had been treated with ustekinumab for 5 years. The mean duration of psoriasis was 19.12±8.45 years, and the treatment duration with ustekinumab was 285.12±8.48 weeks. The baseline PASI was 17.52±7.38. PASI75 was achieved in 84% of the patients at week 28, and 96% of the patients maintained PASI75 during the 5-year follow-up period. Furthermore, 56% of patients reached PASI90 at 28 weeks, and 48% of patients maintained PASI90 for 5 years. No unexpected adverse events other than herpes zoster, herpes simplex, or elevated liver enzymes were reported.
Conclusion: Ustekinumab demonstrated long-lasting efficacy with an acceptable safety profile in Korean patients with moderate-to-severe psoriasis. (Korean J Dermatol 2022;60(3):151∼158)

KCI등재 SCOPUS

3흡입 수포의 체액과 혈청에서 측정한 지질들의 상관성 분석

저자 : 권일주 ( Il Joo Kwon ) , 최승재 ( Sung Jay Choe ) , 정승원 ( Seung Won Jeong ) , 전명수 ( Myungsoo Jun ) , 최응호 ( Eung Ho Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 159-166 (8 pages)

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Background: Several biomarkers are measured in the interstitial fluid (IF) obtained from suction blisters that are used by dermatologists. As abnormal lipid levels can cause health problems, several studies have investigated the composition and distribution of lipids and lipoproteins in IF. However, to date, no study has focused on examining lipid profiles in the postprandial state.
Objective: This study aimed to compare postprandial changes in serum lipid profiles and IF obtained from suction blisters and investigated their correlation.
Methods: Fasting and postprandial levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides were measured in paired serum samples. IF was obtained from suction blisters from 20 healthy men using enzymatic-colorimetric methods.
Results: The IF/serum ratios of TC, HDL-C, and LDL-C remained unchanged postoperatively. Postprandial levels of HDL-C and LDL-C decreased in the serum but not in IF. In both fasting and postprandial states, TC, HDL-C, and LDL-C levels in the serum were positively correlated with those in the IF.
Conclusion: The results of this study showed that lipoprotein cholesterol levels measured from suction blister fluids could be used as a biomarker to predict their serum levels regardless of food intake. Therefore, suction blister fluid sampling can be considered as a method to monitor serum lipid concentrations. (Korean J Dermatol 2022;60(3):159∼166)

KCI등재 SCOPUS

4일차성 호중구성 반흔성 탈모의 임상 및 조직학적 소견에 대한 비교 연구

저자 : 백은주 ( Eun Joo Baek ) , 형진혁 ( Jin Hyeok Hyeong ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 167-172 (6 pages)

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Background: Folliculitis decalvans and dissecting cellulitis are types of primary neutrophilic cicatricial alopecia characterized by permanent hair loss. Clinicopathological differentiation is poorly described in literature.
Objective: This study aimed to determine the clinicopathological distinction between folliculitis decalvans and dissecting cellulitis.
Methods: A retrospective review was conducted in 45 patients diagnosed with dissecting cellulitis and folliculitis decalvans between 2011 and 2021. We reviewed the clinical features using electronic medical records, clinical photographs, and histopathologic features.
Results: Clinically, middle-aged men with folliculitis decalvans showed polytrichia (80%) and papulopustules (55%), while young men with dissecting cellulitis had deeply seated nodules (84%). Histopathologically, follicular plugging was more frequently observed in dissecting cellulitis (80%) than in folliculitis decalvans (50%). There was a difference in the depth of inflammation between the two types.
Conclusion: A difference in clinical manifestations was observed according to the depth of inflammation. These findings may contribute to the differential diagnosis of primary neutrophilic cicatricial alopecia. (Korean J Dermatol 2022;60(3):167∼172)

KCI등재 SCOPUS

5비전형적인 조직소견을 보인 회음부의 색소성 정중솔기낭종 1예

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Eun Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 173-177 (5 pages)

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Median raphe cysts (MRCs) are rare benign lesions that occur as a result of congenital defects during the embryological development of the male genitalia in the fetal period. It can develop anywhere along the midline, from the meatus to the anus. Pigmented MRCs are rare subtypes that contain melanin pigments or melanocytes in the epithelium, and there are only eight such cases reported worldwide. We report herein a case of pigmented MRC in the perineum of a 3-year-old boy. The clinical features include a linear tubular structure and foreign body granuloma at the tip of the linear cystic lesion and rare histological findings of pigmented cuboidal epithelium and squamous epithelium. Immunohistochemical staining revealed strong positivity for c-kit in the pigmented cuboidal epithelium. In this report, we discuss a rare case of pigmented MRC with a mixed type of squamous epithelium and pigmented cuboidal epithelium and review the associated literature. (Korean J Dermatol 2022;60(3):173∼177)

KCI등재 SCOPUS

6Multiple Spider Angiomas as a Predictive Diagnostic Marker of Alcoholic Liver Cirrhosis

저자 : Jun Ki Hong , Hye Sung Han , Sun Hye Shin , Young Gue Koh , Kapsok Li , Beom Joon Kim , Kwang Ho Yoo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 178-181 (4 pages)

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Spider angioma (SA) may present as solitary or multiple lesions. Studies have shown that approximately 60% of pregnant women and 38% of healthy children have at least one spider telangiectasia. Hence, solitary SA in an otherwise healthy individual does not warrant further workup. However, multiple spider angiomas (MSAs) are usually suggestive of an underlying systemic disease. Physical examination for MSAs has been reported as the most reliable method to diagnose alcoholic liver cirrhosis; the presence of MSAs is more indicative of liver cirrhosis than just the history of alcohol use because a very low proportion of alcohol drinkers among the general population develop liver cirrhosis. We report a case of MSAs in a 42-year-old alcoholic woman suggesting that MSA is reliable indicator and a warning sign of liver cirrhosis, suggesting that further evaluation and management with the department of hepatology is necessary. (Korean J Dermatol 2022;60(3):178∼181)

KCI등재 SCOPUS

7A Drug-Induced Sarcoidosis-Like Reaction in Lung Cancer Patient Treated with Nivolumab and Ipilimumab: A Case Report and Literature Review

저자 : Soo Hyung Kim , Seo Gyeong Lee , Ji Yoon Kim , Hyun Jeong Ju , Gyong Moon Kim , Ji Hae Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 182-185 (4 pages)

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Immune checkpoint inhibitor (ICI), including programmed cell death protein 1 and cytotoxic T-lymphocyte-associated protein 4 inhibitors, has emerged as a pillar in the management of advanced malignancies. A drug-induced sarcoidosis-like reaction (DISR) is a rare cutaneous adverse event of ICI. A 47-year-old male presented with one-month history of a solitary erythematous nodule on his forehead. He had been diagnosed with metastatic adenocarcinoma of the lung and was treated with nivolumab and ipilimumab for three months. Histological findings revealed multinucleated giant cells forming non-caseating granulomas with moderate peripheral lymphocyte infiltration in the dermis. Also, new hilar lymphadenopathy of the lung was identified in a systemic evaluation. Given the temporal relationship with ICI treatment, the final diagnosis was ICI-induced sarcoidosis-like reaction. To our knowledge, this is the first report of a case of DISR that developed following ICI treatment in the dermatologic literature in Korea. (Korean J Dermatol 2022;60(3):182∼185)

KCI등재 SCOPUS

8Multiple Warty Dyskeratomas of the Scrotum: A Case Report and Review of the Literature

저자 : Joon Ho Son , Yeong Ho Kim , Ju Hee Han , Chul Hwan Bang , Ji Hyun Lee , Young Min Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 186-189 (4 pages)

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Warty dyskeratoma (WD) is an uncommon skin tumor that histologically presents as focal acantholysis and dyskeratosis and is a common finding among acantholytic diseases such as Darier's disease. WD most commonly occurs on the head or neck of adults as an isolated papule or nodule. To our knowledge, only 6 cases of WD in the genital area have been previously reported in the literature, and no case have occurred on the scrotum to date. We report the first case of multiple WD that occurred on the scrotum successfully treated with 0.025% tretinoin cream. A 55-year-old male presented with asymptomatic, multiple, 0.1∼0.2-cm-sized, skin-colored papules on the scrotum for the previous 6 months. A skin punch biopsy and human papillomavirus (HPV) polymerase chain reaction test were performed for a clinical suspicion of genital warts or bowenoid papulosis. The histopathologic examination showed cup-shaped epidermal invaginations with central keratotic plug. Prominent villi, acantholytic clefting and corps ronds were also shown. The patient tested negative for HPV and was diagnosed with WD with typical pathologic findings. The patient was treated with 0.025% tretinoin cream for 2 weeks, and the lesions decreased in both size and number. (Korean J Dermatol 2022;60(3):186∼189)

KCI등재 SCOPUS

9급성 골수성 백혈병 재발과 연관된 결절홍반 1예

저자 : 윤지상 , 배경남 , 손진화 , 김훈수 , 고현창 , 김병수 , 김문범 , 신기혁

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 190-191 (2 pages)

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10모낭 및 피지선 유도를 동반한 위축성 피부섬유종 1예

저자 : 한유진 , 김혜성 , 조상현 , 이정덕 , 우유리

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 192-193 (2 pages)

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KCI등재SCOUPUS

1두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

저자 : 손우리 ( Uri Shon ) , 염규진 ( Kyujin Yeom ) , 윤대관 ( Dea Kwan Yun ) , 김명화 ( Myung Hwa Kim ) , 최미수 ( Mi Soo Choi ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 735-741 (7 pages)

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Background: Basal cell carcinoma (BCC) is the most common type of skin cancer. However, limited comparative data on the characteristics and prognosis of BCC in the H-zone and non-H-zone exist.
Objective: We aimed to compare the clinical, histopathological, and surgical characteristics of BCCs in the head and neck region between the H- and non-H-zones.
Methods: We retrospectively reviewed the clinical and histopathological characteristics of 292 head and neck BCC lesions in 275 patients and the characteristics of Mohs micrographic surgery (MMS) of 252 BCC lesions in 239 patients.
Results: In the H-zone, 226 lesions (77.4%) were found. Clinically, patients with H-zone BCC, compared to those with non-H-zone, were significantly older (71.6±11.4 years vs. 64.6±13.5 years) and smaller in diameter (10.1±7.1 mm vs. 12.4±9.9 mm). The noduloulcerative type was more frequent in the H-zone, while the superficial and morpheaform types in the non-H-zone. Histopathologically, the infiltrative subtype was particularly noted in the H-zone than the non-H-zone (7.5% vs. 1.5%). Out of 37 BCC patients with prior treatment history, 31 (83.8%) were in the H-zone. Two out of 252 lesions (0.8%) recurred after MMS at our institution. The mean stages of MMS were comparable between the H- and non-H-zones (1.59 vs. 1.45, p=0.135).
Conclusion: H-zone BCCs were associated with older age and smaller tumor size compared to the non-H-zone BCCs. The noduloulcerative clinical and nodulocystic pathologic subtypes were the most common in both H-zone and non-H-zone BCCs. (Korean J Dermatol 2021;59(10):735∼741)

KCI등재SCOUPUS

2수지점액낭종 환자에서 유형 및 치료 반응에 대한 후향적 연구

저자 : 정준우 ( Joon Woo Jung ) , 홍은혜 ( Eun Hye Hong ) , 백은주 ( Eun Joo Baek ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 742-748 (7 pages)

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Background: Digital mucous cysts (DMCs) are benign, occurring mainly on the fingers but rarely on the toes. Although the exact cause of DMC has not been identified, it is classified into two different types based on its pathogenesis and location. Surgical and nonsurgical procedures, including aspiration, sclerotherapy, steroid injection, cryotherapy, and CO2 laser, can be used to treat DMC.
Objective: This study aimed to compare treatment response based on DMC type and evaluate its efficacy in surgical and nonsurgical (sclerotherapy) treatments.
Methods: We retrospectively reviewed the electronic medical records of patients with DMC who visited our dermatology department between January 2010 and November 2020.
Results: This study enrolled 39 patients having a mean age of 59.2 years. The proportion of female patients (21/39, 53.8%) was more than male (18/39, 46.2%). The DMC occurrence was more frequent in the fingers (32/39, 82.1%), especially in the index and middle fingers than in the toes (7/39, 17.9%). In sclerotherapy, DMC in the distal interphalangeal joint (DIPJ) required more treatment than that in the proximal nail fold (PNF) (p<0.05). The number of treatments using sclerotherapy was higher compared to that of surgical treatments (p<0.05).
Conclusion: The DIPJ type of DMC patients was more difficult to treat using sclerotherapy than the PNF type. Moreover, surgical treatment has a better response than sclerotherapy. (Korean J Dermatol 2021;59(10):742∼748)

KCI등재SCOUPUS

3혈청 비타민 D 레벨 및 혈중 지질 농도와 건선: 단일 3차 의료기관에 내원한 한국인 건선 환자를 대상으로 한 임상적 고찰

저자 : 박현정 ( Hyeon Jeong Park ) , 이현주 ( Heun Joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 749-760 (12 pages)

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Background: Psoriasis is a chronic inflammatory autoimmune disease. Some studies have demonstrated a relationship of psoriasis with vitamin D (Vit D) deficiency or serum lipid levels.
Objective: We aimed to compare serum levels of Vit D and lipids in patients with active psoriasis and control subjects. Additionally, we analyzed the relationship of disease severity with serum Vit D and lipid levels.
Methods: A total of 243 patients were retrospectively analyzed. Statistical data were evaluated, and the values were considered significant at p<0.05.
Results: Statistically significant difference in Vit D levels between the psoriasis (n=117) and the control groups (n=126) was not found. In addition, an association between Vit D levels and the disease severity, using the psoriasis area and severity index (PASI) was not observed. The proportion of overweight patients (body mass index [BMI]≥ 23 kg/m2) was higher in the psoriasis group than in the control group, and there was a significant relationship between the increase in PASI and the serum triglycerides (TG) levels (p<0.05).
Conclusion: The psoriasis and control groups did not show a statistical difference in serum Vit D levels. In the subgroup analysis of cases with normal BMI, excluding the underlying disease, no significant difference in Vit D levels between the two groups was observed. However, the association of psoriasis with factors, such as BMI and TG, was found to be significant; hence, these could be therapeutic targets in patients with psoriasis to improve their quality of life. Controlled and well-designed studies are required in the future. (Korean J Dermatol 2021;59(10):749∼760)

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4박피 레이저 치료 후 발생하는 염증 후 홍반과 색소 침착에 대한 표피 성장 인자 함유 연고의 효과에 관한 연구

저자 : 송창화 ( Chang Hwa Song ) , 정유진 ( You Jin Jung ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro ) , 김정은 ( Jeong Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 761-769 (9 pages)

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Background: Epidermal growth factor (EGF) stimulates wound healing in various skin conditions, and EGFcontaining formulations can promote wound regeneration and help reduce complications after laser treatment.
Objective: To evaluate the effect of EGF-containing ointment on wound regeneration after ablative laser treatment and laser-induced postinflammatory erythema (PIE) and hyperpigmentation (PIH).
Methods: Twenty-five patients who required treatment with ablative laser on both sides of the face were enrolled and underwent one session of laser treatment. Postoperatively, all patients were instructed to apply the EGFcontaining ointment on the randomly assigned-hemifacial side, while gentamicin cream was applied on the opposite side. Investigators' global assessment (IGA), evaluating general wound condition, erythema, pigmentation, and scab shedding, and patient's global assessment (PGA), evaluating patient satisfaction with clinical improvement, were both measured at 1 week and 4 weeks after treatment. Objective assessments, including melanin index (MI), erythema index (EI), skin hydration, and transepidermal water loss (TEWL), were measured before treatment and at 1 week and 4 weeks after treatment.
Results: The EGF-containing ointment showed better outcomes with IGA (1 week; p=0.02, 4 weeks; p=0.002) and PGA (1 week; p=0.04, 4 weeks; p=0.01) scores compared to gentamicin cream. Compared to gentamicin cream, treatment with EGF-containing ointment resulted in significantly lower EI (p=0.044) and MI (p=0.023), but skin hydration and TEWL between the two groups exhibited nonsignificant differences.
Conclusion: EGF-containing ointment could be an effective adjuvant option for wound regeneration after ablative laser treatment and minimizing laser-induced PIE and PIH in Asian patients. (Korean J Dermatol 2021;59(10):761∼769)

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5The Efficacy of Skin Care Habit Modifications on the Skin Barrier Function in Rosacea Patients

저자 : Jung Eun Seol , Gyeong Je Cho , Sang Woo Ahn , Seong Min Hong , So Hee Park , So Young Jung , Hyojin Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 770-777 (8 pages)

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Background: Patients with rosacea usually suffer from skin irritations, such as itching, stinging, burning, and pain. These symptoms may be related to the skin barrier function disruption.
Objective: We investigated the skin barrier functions in patients with mild to moderate rosacea and the associated improvements based on the skin care habit modifications and treatment modalities.
Methods: We analyzed the data on transepidermal water loss (TEWL) and stratum corneum hydration (SCH) of skin lesions in 27 patients with rosacea and healthy skin of 29 control subjects. We compared the results of TEWL and SCH based on sex, age, type of rosacea, skin care habits, and the treatment modalities.
Results: The skin in the patients with rosacea exhibited increased TEWL and decreased SCH compared with that in control subjects. Male patients showed increased TEWL and decreased SCH compared to female patients. Combination therapy with systemic minocycline and topical metronidazole improved the skin barrier functions. Patients with better skin care habits presented better skin barrier functions and clinical improvement.
Conclusion: Patients with rosacea, especially those with poor skin care habits, showed reduced skin barrier functions. Appropriate skin care habits with cleansers and moisturizers are recommended for the management of rosacea. (Korean J Dermatol 2021;59(10):770∼777)

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6A Clinical Study of Trichotillomania in 198 Cases: An Update and Cross-Time Comparison

저자 : Ji-hoon Lim , Ki-hun Kim , Soon-hyo Kwon , Woo-young Sim , Bark-lynn Lew

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 778-784 (7 pages)

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Background: Trichotillomania (TTM) is characterized by recurrent hair pulling, resulting in hair loss. TTM is typically encountered in dermatology settings; however, few reports on the clinical characteristics of TTM in a large population are available.
Objective: To evaluate the clinical characteristics of TTM.
Methods: We performed a retrospective chart review of patients diagnosed with TTM between 2006 and 2019.
Results: Clinical records of 198 patients were analyzed. The average age of TTM onset was 10.8 years, and 119 patients experienced childhood-onset (at <12 years). Sex prevalence showed a female predominance, and the proportion of females was lower in the childhood-onset TTM than in the late-onset TTM (onset at ≥12 years). Vertex was the most commonly involved site. A history of stressful situations was noted in 48 patients (24.2%). In the group with a poor prognosis, the number of patients with ≥25% scalp invasion was significantly more than the other group. The average duration of hair loss to more than 50% recovery was 4.88 months for childhood-onset TTM cases and 9.83 months for late-onset TTM cases. The prognosis was significantly better in the childhood-onset TTM than in the late-onset TTM. Nail biting and folliculitis were the most common co-occurring repetitive behavior and comorbid disease, respectively.
Conclusion: Unlike previous domestic studies, patients with childhood-onset TTM had a female preponderance. Moreover, the proportion of patients who experienced a stressful situation was higher than that reported in a previous study. In addition, patients with severe disease and late-onset TTM had a significantly poorer prognosis. (Korean J Dermatol 2021;59(10):778∼784)

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7Port-Wine Stains Confined to a Single Cosmetic Unit than on Multiple Cosmetic Units Respond Better to Pulsed Dye Laser Treatment: A Retrospective Study

저자 : Gyoo Huh , Jin Seop Kim , Heun Joo Lee , Young-jun Choi , Ga-young Lee , Won-serk Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 785-792 (8 pages)

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Background: Cosmetic units are designated based on their similarity in topographic anatomy, texture and color, solar exposure, hair density, and sebaceous features. The difference of such features in facial port-wine stain (PWS) cases can affect the response to pulsed dye laser (PDL) treatment.
Objective: To evaluate the response of facial PWS to PDL treatment based on the underlying cosmetic units.
Methods: A retrospective study was conducted on 18 patients with facial PWS who received PDL treatment. For clinical assessment, three dermatologists evaluated the photographs taken before each treatment session. The response grade was assigned according to the quartile grading scale. The lesion was classified based on the underlying cosmetic units.
Results: The cheek was the most (50%) commonly involved area. All PWS (6/6) confined to one cosmetic unit showed a marked improvement compared with 16% PWS (2/12) affecting two or more units (p<0.05). Patients with PWS within one cosmetic unit required fewer treatment sessions to achieve marked improvement.
Conclusion: PWS confined to a single cosmetic unit than that located in two or more units responded better to PDL treatment. Before PDL treatment for facial PWS, age, initial lesion size, as well as the number of cosmetic units affected by the lesion should be considered. (Korean J Dermatol 2021;59(10):785∼792)

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8크론병 환자에서 발생한 다발성 보웬병 1예

저자 : 조민아 ( Minah Cho ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 793-796 (4 pages)

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A 47-year-old man with a 25-year history of Crohn's disease, presenting asymptomatic erythematous scaly patches (size, 1∼3 cm in diameter) on his back, left hand, right wrist, left ankle, and left sole, visited our clinic. Histopathological examination of the lesions revealed Bowen's disease. Herein, we report a rare case of multiple Bowen's disease in the skin, away from the anogenital region, in a patient with Crohn's disease. (Korean J Dermatol 2021;59(10):793∼796)

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9간찰 부위에서 발생한 전신형 고리 육아종 1예

저자 : 허규 ( Gyoo Huh ) , 이현주 ( Heun-joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 797-800 (4 pages)

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Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

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10A Case of Lyme Disease Followed by Post-Treatment Lyme Disease Syndrome

저자 : Sung Ha Lim , Eung Ho Choi

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 801-804 (4 pages)

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Lyme disease caused by Borrelia species is transmitted via infected tick bites. Erythema migrans, a typical skin lesion on the tick-bitten site, is a hallmark of Lyme disease. A 63-year-old female presented an erythematous, semi-circular patch in the left inguinal area. It disappeared spontaneously without treatment. However, after 3 months, an erythematous patch with a diameter of 1 cm recurred on the left thigh. B. burgdorferi antibody testing revealed positive results. At the second visit, doxycycline was prescribed, and the skin lesion was resolved. However, the patient exhibited persistent systemic symptoms, including arthralgia and fatigue, and was diagnosed with post-treatment Lyme disease syndrome (PTLDS). The PTLDS prognosis is associated with delayed diagnosis. Thus, antibiotic treatment should be promptly initiated after suspecting Lyme disease to minimize the associated systemic symptoms. PTLDS diagnosis should be followed by proper medical care to alleviate the symptoms. (Korean J Dermatol 2021;59(10):801∼804)

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