Objectives The purpose of this study was to examine the daily lifestyle of Vietnamese immigrant women and to find out if they could affect health-related quality of life improvement. Methods The subjects of this study were 273 women who immigrated to Korea from Vietnam. This study was conducted at Daejeon and nearby Healthy Family Support Centers from September 2019 to January 2020 with the cooperation of the Daejeon City Healthy Family Support Center. Correlation analysis was performed between lifestyle and quality of life, and ANOVA analysis was performed to confirm the difference in health-related quality of life scores for each subgroup of dietary nutrition, sleep quality, and physical activity. A regression analysis was conducted to investigate the contribution of dietary nutrition, sleep quality, and physical activity to the quality of life of Vietnamese immigrant women. The significance level was p<0.05. Results Physical activity showed significant correlations with Euro Quality of Life -Visual Analogue Scale (EQ VAS), sleep quality with EQ VAS and Euro Quality of Life-5Dimension (EQ-5D) Index, and dietary nutrition with EQ-5D Index. There were significant differences in EQ VAS and EQ-5D Index scores for each sleep quality subgroup, and a significant difference in EQ VAS scores for each activity subgroup. The quality of sleep was found to have the greatest effect on EQ VAS and EQ Index of Vietnamese immigrant women, and physical activity on EQ VAS and dietary nutrition had some influence on EQ-5D Index. Conclusions Quality of sleep is closely related to health-related quality of life, and plays an important role in health-related quality of life for Vietnamese immigrant women.