논문 상세보기

대한천식알레르기학회> Allergy asthma & respiratory disease> Interleukin-13으로 유도된 폐 병태생리에 대한 atorvastatin의 치료 효과

KCI등재

Interleukin-13으로 유도된 폐 병태생리에 대한 atorvastatin의 치료 효과

Therapeutic effect of atorvastatin on interleukin-13-induced lung pathology

모요셉 ( Yosep Mo ) , 배보람 ( Boram Bae ) , 김정현 ( Junghyun Kim ) , 김율담 ( Ruth Lee Kim ) , 손경희 ( Kyunghee Son ) , 강민종 ( Min-jong Kang ) , 이춘근 ( Chun-gen Lee ) , 조상헌 ( Sang-heon Cho ) , 강혜련 ( Hye-ryun Kang )
  • : 대한천식알레르기학회
  • : Allergy asthma & respiratory disease 9권2호
  • : 연속간행물
  • : 2021년 04월
  • : 76-83(8pages)
Allergy asthma & respiratory disease

DOI


목차

서 론
대상 및 방법
결 과
고 찰
알림(ACKNOWLEDGMENTS)
REFERENCES

키워드 보기


초록 보기

Purpose: Asthma is a common chronic lung disease, in which interleukin (IL)-13 is implicated as a central regulator of IgE synthesis, mucus hypersecretion, airway hyperresponsiveness (AHR), and fibrosis. This study was designed to determine the anti-inflammatory effect of atorvastatin, a widely used lipid-lowering agent, on the IL-13-induced lung pathology through the modulation of macrophages.
Methods: Atorvastatin (40 mg/kg) was given to transgenic mice overexpressing IL-13 (IL-13 TG mice) and their wild type littermates by oral gavage for 2 weeks. AHR, numbers of inflammatory cells in the airway, and cytokine levels in IL-13 TG mice were measured. Using the alveolar macrophage cell line CRL-2456, the direct effect of atorvastatin on macrophages activated by recombinant IL-13 was assessed.
Results: Significant reduction in total leukocytes and alleviation of AHR were observed with administration of atorvastatin in IL-13 TG mice compared to those without atorvastatin treatment (P<0.05). Atorvastatin administration resulted in upregulation of IL-10 in the lungs of IL-13 TG mice (P<0.05). In addition, mRNA expression of connective tissue growth factor, fibronectin, and type III collagen as well as chord length enhanced by IL-13 overexpression were reduced by atorvastatin administration (P<0.05). M2 macrophage markers, such as Ym-1 and CD206, were decreased, while M1 macrophage marker, inducible nitric oxide synthase, was increased upon atorvastatin treatment (P<0.05). Administration of atorvastatin resulted in improved removal of apoptotic cells (P<0.05).
Conclusion: The results of this study reveal a potential of atorvastatin as an effective antiasthmatic agent by reducing IL-13-induced lung inflammation via the modulation of macrophage polarization. (Allergy Asthma Respir Dis 2021;9:76-83)

UCI(KEPA)

간행물정보

  • : 의약학분야  > 내과학
  • : KCI등재
  • :
  • : 계간
  • : 2288-0402
  • : 2288-0410
  • : 학술지
  • : 연속간행물
  • : 2013-2021
  • : 533


저작권 안내

한국학술정보㈜의 모든 학술 자료는 각 학회 및 기관과 저작권 계약을 통해 제공하고 있습니다.

이에 본 자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

9권3호(2021년 07월) 수록논문
최근 권호 논문
| | | |

KCI등재

1한국 코로나바이러스감염증-19 환자의 특성과 경과; 국가 데이터베이스의 분석

저자 : 김상헌 ( Sang-heon Kim )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 113-114 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재

2Severe acute respiratory syndrome coronavirus-2 대유행 중 알레르기 환자의 진료

저자 : 이영수 ( Youngsoo Lee ) , 장재혁 ( Jae-hyuk Jang ) , 박해심 ( Hae-sim Park )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 115-123 (9 pages)

다운로드

(기관인증 필요)

초록보기

A novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in China. The mutated coronavirus spread worldwide, and some patients infected with SARS-CoV-2 developed coronavirus disease 2019 (COVID-19) manifested with upper respiratory infection, pneumonia, or respiratory distress. Since the SARS-CoV-2 pandemic was declared with surging confirmed cases and mortality of COVID-19 worldwide, it has reshaped our way of living and how to manage patients with allergic diseases. The medical staff, including allergy specialists, has been at the forefront of fighting against the SARS-CoV-2 pandemic and is struggling to guarantee safety to themselves and their patients. Thanks to vigorous research into the relationship between SARS-CoV-2 and allergic diseases, we have become able to treat allergic patients with the best of evidence to date. The clinician should make a careful decision on each clinical situation with regard to patient characteristics, local and national circumstances as well as the knowledge we have, since it is still limited. We hope further efforts to identify the nature of SARS-CoV-2 and COVID-19 clearer and effective SARS-CoV-2 vaccination will soon remove the grim picture of the worldwide pandemic and bring us back to normal. (Allergy Asthma Respir Dis 2021;9:115-123)

KCI등재

3코로나바이러스감염증-19 (coronavirus disease 2019) 백신과 이상 반응

저자 : 정은희 ( Eun Hee Chung )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 124-135 (12 pages)

다운로드

(기관인증 필요)

초록보기

In order to overcome the global pandemic of the new pathogen, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), intensive research has been conducted to understand viral pathogenicity, establish effective treatment strategies, and develop vaccines against coronavirus disease 2019 (COVID-19). To prevent COVID-19, a variety of COVID-19 vaccines have been rapidly developed and are currently being administered worldwide. When developing new vaccines, monitoring for adverse events following immunization (AEFIs) has always been important, and some COVID-19 vaccines are particularly effective as new types of vaccines that have not been used before, thus attracting attention to AEFIs. Vaccine administration is carefully conducted while monitoring for AEFI that are being reported from time to time. AEFIs are largely divided into local reactions, systemic reactions, allergic reactions, and adverse reactions to specific diseases or disease- attributable events. In addition, it is classified according to causes, but it is very difficult to confirm the association with the vaccine. Anaphylaxis, which is a systemic reaction among serious allergic reactions, requires immediate treatment and may require testing to determine the cause. In order to increase the vaccination rate and secure herd immunity, there should be no fear of vaccination due to unidentified side effects. Therefore, monitoring of AEFIs is important and causal relationships must be well established based on reliable epidemiological investigations. Current data show that the benefits of a COVID-19 vaccine far outweigh the risk of AEFIs. Future studies should continue to understand the mechanisms and risk factors of identified adverse reactions. (Allergy Asthma Respir Dis 2021;9:124-135)

KCI등재

4한국 코로나바이러스감염증-19 환자 5,628명의 역학적, 임상적 특성: 전국단위 다기관 관찰 연구

저자 : 이승원 ( Seung Won Lee ) , 문성용 ( Sung Yong Moon ) , 연동건 ( Dong Keon Yon )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 136-140 (5 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: There are limited data on the epidemiological and clinical characteristics and outcomes in Korean patients with laboratory-confirmed coronavirus disease 2019 (COVID-19). We aimed to describe the epidemiological and clinical characteristics and outcomes of patients with COVID-19 using the Korean nationwide multicenter database.
Methods: In this nationwide multicenter study, we included all confirmed patients of COVID-19 in South Korea from February 1 to April 30, 2020. Subjects were classified into 3 age groups: those at younger than 10 years (children), 10 to 20 years (adolescents), and 20 years or more (adults). Cases were confirmed by laboratory testing using real-time reverse transcriptase-polymerase chain reaction assay and analyzed for epidemiological and clinical features and outcomes. Patents were followed up until April 30, 2020.
Results: Of 5,628 patients with COVID-19 (2,320 males [41.2%] and 3,308 females [58.8%]), there were 66 children (1.2%), 206 adolescents (3.7%), and 5,356 adults (95.2%). The common comorbidities were hypertension (1,201, 21.3%), diabetes (691, 12.3%), dementia (224, 4.0%), chronic heart disease (179, 3.2%), cancer (145, 2.6%), and asthma (128, 2.3%). The common presenting symptoms were cough (2,341, 41.6%), sputum (1,619, 28.8%), fever (1,305, 23.2%), headache (967, 17.2%), myalgia (926, 16.5%), and pharyngodynia (881, 15.7%). One hundred sixty-five patients (2.1%) were confirmed as having moderate or severe COVID-19 and 118 (2.1%) as having severe COVID-19.
Conclusion: Our descriptive study provides the epidemiological and clinical characteristics and outcomes of patients with laboratory-confirmed COVID-19 in South Korea. (Allergy Asthma Respir Dis 2021;9:136-140)

KCI등재

5소아의 메타콜린 기관지유발검사에서 PC20-FEF25%-75% 및 △FVC에 대한 분석

저자 : 김현아 ( Hyeon A Kim ) , 권정은 ( Jung Eun Kwon ) , 안지영 ( Ji Young Ahn ) , 최재영 ( Jae Young Choe ) , 김동섭 ( Dong Sub Kim ) , 박숙현 ( Sook Hyun Park ) , 현명철 ( Myung Chul Hyun ) , 최봉석 ( Bong Seok Choi )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 141-147 (7 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Forced expiratory flow between 25% and 75% (FEF25%-75%) is known to sensitively reflect bronchial obstruction. Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity (FVC) with the reduction in forced expiratory volume in 1 second (FEV1) in asthma. The aim of this study was to evaluate the clinical implication of provocative concentration causing a 20% fall in FEF25%-75% (PC20-FEF25%-75%) and the percentage fall in FVC at the PC20 dose of methacholine (△FVC).
Methods: A total of 194 children who visited the hospital due to respiratory symptoms and underwent MCT were analyzed retrospectively. The patients were divided into 3 groups. Group I had both PC20-FEV1 and PC20-FEF25%-75% above 16 mg/mL; group II had a PC20-FEF25%-75% that fell below 16 mg/mL but PC20-FEV1 was 16 mg/mL or above; group III had a PC20-FEV1 and a PC20-FEF25%-75% that both fell below 16 mg/mL.
Results: In group II, PC20-FEV1 was lower (P=0.026) and the rate of change in FEV1 and FEF25%-75% from baseline to 16 mg/mL of methacholine concentration was greater than in group I (both P<0.001). Levels of PC20-FEF25%-75% were higher in group II compared to group III (P<0.001). △FVC showed a correlation with PC20-FEV1 (P<0.001) only in the whole group.
Conclusion: In asthmatic children, PC20-FEF25%-75% may be associated with bronchial hyperresponsiveness. △FVC was not associated with other parameters in either group. For subjects with a positive finding of PC20-FEF25%-75% and a negative finding of MCT, the progression to asthma can be suspected. (Allergy Asthma Respir Dis 2021;9:141-147)

KCI등재

6천식 및 알레르기비염으로 진단된 소아, 청소년 및 성인에서의 흡입 알레르겐에 대한 감작률 비교

저자 : 이나겸 ( Na Gyeom Lee ) , 김희규 ( Hee-kyoo Kim ) , 최길순 ( Gil Soon Choi )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 148-155 (8 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Inhalant allergens are known as a major factor for respiratory allergic diseases. There are many differences in sensitization rates of inhalant allergens, depending on the environment and demographic factors. This study aimed to compare the cross-sectional differences in sensitivity patterns to inhalant allergen between children, adolescents, and adults.
Methods: We analyzed the results of 449 patients with asthma or allergic rhinitis who underwent the inhalant allergen skin prick test at our university hospital in 2016. The subjects were classified 5 groups according to age: children (≤12 years), adolescents (13-17 years), young adults (18-30 years), middle adults (31-64 years), and elderly group (≥65 years). Positive responses skin prick test for allergens were defined as allergen-to-histamine wheal ratio ≥1.
Results: The sensitization rate (SR) to house dust mites (HDM) was 52.1% on average, showing the highest SR in all groups, especially in children (64.2%). Children and adolescents showed high SRs to cockroach along with tree pollen, animal fur, and adults showed high SR to weed pollen along with them. Among the tree pollen, the SRs to oak, alder, birch, and beech were high in all groups; in children, the SR to plain and willow tended to be high, and in adults the SR to hazel was high. SRs to Timothy pollen (9.9%) and Alternaria (8.6%) tended to be higher in children than in the other groups.
Conclusion: Although HDM is still the major allergen in children and adults with respiratory allergy, our study suggests various differences in the sensitization pattern to inhalant allergens according to age even in the same area. Further studies are needed to explain these differences in sensitization patterns. (Allergy Asthma Respir Dis 2021;9:148-155)

KCI등재

7소아 스와이어-제임스-맥레오드증후군의 임상 양상 및 폐기능에 대한 단일기관 연구

저자 : 김은지 ( Eunji Kim ) , 김소리나 ( Sorina Kim ) , 이승현 ( Seunghyun Lee ) , 김우선 ( Woo Sun Kim ) , 서동인 ( Dong In Suh )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 156-163 (8 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Swyer-James-Macleod syndrome (SJMS) is a rare disorder characterized by the hyperlucency of a unilateral lung due to ipsilaterally arrested lung growth. No sufficient information on progressive lung function changes during growth is available in SJMS.
Methods: We retrospectively reviewed SJMS cases using a clinical database from January 2000 to August 2018.
Results: A total of 40 patients were enrolled in this study. The median age of the patients was 4.8 years (interquartile range [IQR], 2.7-9.0 years), boys (n=21, 52.5%) were more affected, and left lungs (n=27, 67.5%) were more involved. The interval between infection and diagnosis was 1.8 years (IQR, 0.7-6.4 years). Mycoplasma pneumoniae (n=14) and adenovirus (n=5) were most prevalent among the 21 subjects with presumably identifiable causes. Most of the 16 patients with available pulmonary function data presented moderate obstructive lung function (z-score, median; FEV1: -4.320 [IQR, -5.955 to -3.400] and FVC: -2.600 [IQR, -3.590 to -1.570], respectively) with the more decreased median in forced expiratory flow between 25% and 75% of FVC (FEF25%-75%) (z-score, -4.470; IQR, -5.330 to -3.170). Linear mixed effect models indicated that younger age at first infectious insult was significantly related to decreased FEV1 z-score (P=0.041), and that the FEV1/FVC and FEF25%-75% z-scores were reduced by 0.082 (P=0.005) and 0.069 (P≤0.001) per year.
Conclusion: In children with SJMS, the initial infectious insult occurs in the early life with M. pneumoniae being the most common pathogen. Lung function may deteriorate with an obstructive pattern during growth. The impairment can progress slowly not in the FEV1, but in the FEV1/FVC or FEF25%-75%. (Allergy Asthma Respir Dis 2021;9:156-163)

KCI등재

8요오드화 조영제 이상반응 전산 관리시스템의 영향

저자 : 조은정 ( Eun-jung Jo ) , 박혜경 ( Hye-kyung Park )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 164-170 (7 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: In 2014, Pusan National University Hospital developed an electronic system for the monitoring and management of adverse drug reactions (ADRs) to iodinated contrast media (ICM) and premedication. We analyzed the prevalence of hypersensitivity reactions (HRs) and the effect of premedication after system development.
Methods: We analyzed immediate HRs to ICM recorded from January 2015 to September 2018 and the annual incidences were compared.
Results: Patients with immediate HRs to ICM were at a mean age of 54.6±14.3 years and 53.8% were female. The overall frequency of HRs was 0.328%. In the classification according to the degree of severity, 87.2% of the cases were mild, 11.0% were moderate, and 1.8% were severe. The ICM most commonly inducing an HR was iomeprol (0.529%), followed by iohexol (0.371%), ioversol (0.359%), iobitridol (0.310%), iopamidol (0.152%), iopromide (0.128%), and iodixanol (0.036%). ICM was readministered to 49.2% of the patients, and immediate HRs recurred in 16.2%. There was no correlation between premedication with an antihistamine and HR recurrence, but premedication with corticosteroids reduced the rate significantly. After development of the electronic monitoring and management system, the HR incidence increased 1.25-fold per year, but most cases were mild and the rate of severe reactions tended to decrease.
Conclusion: Because ADRs to ICM are difficult to predict, appropriate strategies to prevent their development are needed. A system that documents ADRs to ICM can improve patient management. (Allergy Asthma Respir Dis 2021;9:164-170)

KCI등재

940세 이상 건강한 성인에서 시간에 따른 체지방량과 복부지방률 변화가 폐기능 감소에 미치는 영향

저자 : 안경민 ( Kyung-min Ahn ) , 이소희 ( So-hee Lee ) , 김선신 ( Sun-sin Kim )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 171-179 (9 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Many studies have shown that obesity is one of the major causes of lung function decline. However, a longitudinal study of the correlation between changes in obesity degree and lung function is still lacking. This study aimed to analyze alterations in lung function according to changes in body and abdominal fat amount over time in healthy individuals.
Methods: A retrospective cohort study of individuals who received annual health screening was performed. Individuals who underwent health screening at least 3 times with follow-up periods more than 5 years were included. Using a linear mixed model, we analyzed associations between the change in total body fat amount/abdominal fat ratio and lung function decline over time by dividing each quartile according to the fat change rate.
Results: A total of 15,484 individuals over 40 years old was enrolled prospectively. A longitudinal increase in total body fat amount over time was associated with a predicted value of forced expiratory volume in 1 second (FEV1p; %) and predicted value of forced vital capacity (FVCp; %) declines, regardless of sex. A similar phenomenon was observed between an increase in abdominal fat ratio and FEV1p/FVCp decline, which was predominant in males. In addition, the change in abdominal fat ratio showed a significant correlation with differences in the initial values of FEV1p and FVCp after 40 years old.
Conclusion: Increases in total body fat amount and abdominal fat ratio may cause lung function decline over time. (Allergy Asthma Respir Dis 2021;9:171-179)

KCI등재

10Icatibant로 급성 악화를 치료한 제2형 유전성혈관부종 1예

저자 : 황유경 ( Yu-kyoung Hwang ) , 안경민 ( Kyeong Min An ) , 김용현 ( Yong Hyun Kim ) , 김세훈 ( Sae-hoon Kim ) , 장윤석 ( Yoon-seok Chang )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 3호 발행 연도 : 2021 페이지 : pp. 180-183 (4 pages)

다운로드

(기관인증 필요)

초록보기

Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by genetic deficiency or decreased function of C1-esterase inhibitor. It is characterized by swelling of subcutaneous and submucosal tissues of the extremities, gastrointestinal tract, and upper airways which can be life-threatening. Thus, early recognition and treatment of the disease are important. Short- and long-term prophylaxes are used to decrease the severity and frequency of attacks. Icatibant is a selective bradykinin B2-receptor antagonist, earlier treatment of acute attacks and hospital admission. The authors present a case of 47-year-old woman who was diagnosed with type II HAE, danazol as a long term. Her symptoms improved dramatically after drug treatment. The unpredictability and recurrence of HAE attacks could have a negative impact on social life and quality of life. This case shows that timely and proper treatment could improve quality of life and reduce morbidity and mortality. (Allergy Asthma Respir Dis 2021;9:180-183)

12
권호별 보기
같은 권호 다른 논문
| | | | 다운로드

KCI등재

1성인 폐기능 저하; 언제 시작되나?

저자 : 박흥우 ( Heung-woo Park )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 57-58 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재

2소아 아토피피부염의 최신 치료

저자 : 전유훈 ( You Hoon Jeon ) , 김정희 ( Jeong Hee Kim )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 59-68 (10 pages)

다운로드

(기관인증 필요)

초록보기

Atopic dermatitis is the most common chronic inflammatory skin disease in children. It usually develops in infancy and early childhood and is an entry point of 'atopic march', which may progress to other allergic diseases, including allergic rhinitis and asthma. Although there is no disagreement on the importance of early treatment of atopic dermatitis, it is difficult to treat children with moderate to severe atopic dermatitis due to concerns about treatment-related side effects and age restrictions for effective drugs in real world. As recent researches have extend our understanding of pathogenesis, new agents targeted key pathologic mechanisms have been developed. Therefore, it is time to establish a new paradigm of treatment for children with atopic dermatitis since new biologics have been demonstrated to be effective and safe in children. The objective of this article is to review the clinical characteristics, severity classification, pathogenesis, and treatment, in particular, biologics already approved/undergoing clinical trials for children with atopic dermatitis. (Allergy Asthma Respir Dis 2021;9:59-68)

KCI등재

3미숙아로 출생한 학동기 소아에서 폐기능과 임상 양상 사이의 관련성

저자 : 김영환 ( Young Hwan Kim ) , 정지은 ( Ji Eun Jeong ) , 정혜리 ( Hai Lee Chung ) , 장윤영 ( Yoon Young Jang )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 69-75 (7 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Survivors of preterm birth are at high risk of chronic pulmonary disease. We examined lung function in the school-age children born preterm and investigated the relationship between lung function and clinical parameters.
Methods: Thirty children born preterm were enrolled and divided into 2 groups: 14 very preterm (<32-week gestational age [GA]) and 16 moderate-to-late preterm (32- to 36-week GA). Pulmonary function tests (PFTs) were performed repeatedly during school-age and PFT parameters were compared with age-matched controls. The relationship between PFT and clinical parameters was also studied.
Results: PFT parameters in the very preterm group were persistently reduced compared with age-matched controls (P<0.05). Half of the children had been diagnosed with asthma at the visit for the first PFT. Seventy-seven percent of patients in the very preterm group had bronchial hyperresposiveness. Birth weight, duration of oxygen therapy and mechanical ventilation in the neonatal intensive care unit, and body weight at age 1 were associated with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), or forced expiratory flow between 25% and 75% of expired vital capacity (FEF25%-75%) z-scores. Multiple regression analysis revealed that body weight at age 1 was an independent predictor of FEV1 and FVC z-scores, and duration of oxygen therapy was independently associated with FEF25%-75% z-scores (P<0.01 for all).
Conclusion: No catch-up in lung function was observed in school-age children born very preterm. Lower body weight at age 1 might be an independent risk factor for reduced FEV1 and FVC, whereas long-term oxygen therapy might be associated with reduced FEF25%-75%. (Allergy Asthma Respir Dis 2021;9:69-75)

KCI등재

4Interleukin-13으로 유도된 폐 병태생리에 대한 atorvastatin의 치료 효과

저자 : 모요셉 ( Yosep Mo ) , 배보람 ( Boram Bae ) , 김정현 ( Junghyun Kim ) , 김율담 ( Ruth Lee Kim ) , 손경희 ( Kyunghee Son ) , 강민종 ( Min-jong Kang ) , 이춘근 ( Chun-gen Lee ) , 조상헌 ( Sang-heon Cho ) , 강혜련 ( Hye-ryun Kang )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 76-83 (8 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Asthma is a common chronic lung disease, in which interleukin (IL)-13 is implicated as a central regulator of IgE synthesis, mucus hypersecretion, airway hyperresponsiveness (AHR), and fibrosis. This study was designed to determine the anti-inflammatory effect of atorvastatin, a widely used lipid-lowering agent, on the IL-13-induced lung pathology through the modulation of macrophages.
Methods: Atorvastatin (40 mg/kg) was given to transgenic mice overexpressing IL-13 (IL-13 TG mice) and their wild type littermates by oral gavage for 2 weeks. AHR, numbers of inflammatory cells in the airway, and cytokine levels in IL-13 TG mice were measured. Using the alveolar macrophage cell line CRL-2456, the direct effect of atorvastatin on macrophages activated by recombinant IL-13 was assessed.
Results: Significant reduction in total leukocytes and alleviation of AHR were observed with administration of atorvastatin in IL-13 TG mice compared to those without atorvastatin treatment (P<0.05). Atorvastatin administration resulted in upregulation of IL-10 in the lungs of IL-13 TG mice (P<0.05). In addition, mRNA expression of connective tissue growth factor, fibronectin, and type III collagen as well as chord length enhanced by IL-13 overexpression were reduced by atorvastatin administration (P<0.05). M2 macrophage markers, such as Ym-1 and CD206, were decreased, while M1 macrophage marker, inducible nitric oxide synthase, was increased upon atorvastatin treatment (P<0.05). Administration of atorvastatin resulted in improved removal of apoptotic cells (P<0.05).
Conclusion: The results of this study reveal a potential of atorvastatin as an effective antiasthmatic agent by reducing IL-13-induced lung inflammation via the modulation of macrophage polarization. (Allergy Asthma Respir Dis 2021;9:76-83)

KCI등재

5요오드화 조영제 부작용: 성분별 발생 빈도 비교

저자 : 고은실 ( Eunsil Koh ) , 김유진 ( Yu Jin Kim ) , 강노을 ( Noeul Kang ) , 진성례 ( Seong-rye Jin ) , 이진영 ( Jin-young Lee ) , 어홍 ( Hong Eo ) , 최동철 ( Dong-chull Choi ) , 이병재 ( Byung-jae Lee )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 84-92 (9 pages)

다운로드

(기관인증 필요)

초록보기

Purpose: Contrast media is one of the most common cause of adverse drug reaction (ADR) in adult. However, there was little data reported about differences in ADR ratio and severity among iodinated contrast media (ICM).
Methods: Medical records of 627,049 patients who performed computed tomography scan using low-osmolar nonionic iodinated contrast media from January 2015 to December 2018 were retrospectively reviewed. A total of 6 ICMs including iomeprol, iohexol, iopromide, iobitridol, ioversol, and iopamidol were used in this period. The incidence of ADR was compared to their total usage and dosage between each contrast media.
Results: The incidence of ADR of iopromide (1.36%) and iomeprol (1.27%) was the highest when compared with the average incidence of 1% of 6 ICMs. Ioversol (0.67%), iohexol, and iobitridol (0.74%) had the lower incidence of ADR. The order of results adjusted by actual administered dosage, the use of premedication, and the prior exposure history of ICMs was similar. The fraction of moderate and severe ADR in overall ADR was slightly different, but not proportional to the incidence of ADR.
Conclusion: The incidence of ADR among 6 low-osmolar nonionic ICMs was significantly different when compared by the total number of usage and the total volume of dose. The incidence of ADR varied by nearly 2-fold depending on ICMs. Further study might need to explore the reason for the difference of incidence. (Allergy Asthma Respir Dis 2021;9:84-92)

KCI등재

6과호산구증가증을 동반한 Sézary 증후군

저자 : 이윤찬 ( Yoonchan Lee ) , 심경아 ( Gyeongah Sim ) , 김병수 ( Byung-su Kim ) , 현정원 ( Jungwon Hyun ) , 김현철 ( Hyunchul Kim ) , 백문성 ( Moon Seong Baek ) , 김철홍 ( Cheol-hong Kim ) , 현인규 ( In-gyu Hyun ) , 최정희 ( Jeong-hee Choi )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 93-98 (6 pages)

다운로드

(기관인증 필요)

초록보기

The Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma characterized by the presence of erythroderma covering at least 80% of the body-surface area, lymphadenopathy, and the presence of clonally related neoplastic T cells with cerebriform nuclei (Sézary cells) in the blood, skin, and lymph nodes. Hypereosinophilia can be caused by hematologic malignancy with clonal abnormality, which is often associated with Sézary syndrome. Sézary syndrome has rarely been reported in Korea. However, hypereosinophilia in the Sézary syndrome has not been reported in Korea. Here, we report a case of 75-year-old man with hypereosinophila, erythroderma, and cutaneous T-cell lymphoma which was finally diagnosed as Sézary syndrome. (Allergy Asthma Respir Dis 2021;9:93-98)

KCI등재

7정제 알약 내 미량의 포비돈이 원인으로 추정되는 아나필락시스 1예

저자 : 김성현 ( Sung Hyun Kim ) , 김미영 ( Mi-yeong Kim )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 99-103 (5 pages)

다운로드

(기관인증 필요)

초록보기

Povidone, also known as polyvinylpyrrolidone has high sterilizing power and low toxicity, and has been widely used in disinfectants, ointments, gels, shampoos, soap, and pharmaceutical tablet additives. Povidone-iodine (Betadine) is a rare cause of IgE-mediated allergy, and to our best of knowledge there have been no reports in Korea. We report the first case of anaphylaxis in Korea presumably caused by a trace amount of povidone contained in a tablet pill. An 18-year-old man experienced severe rhinorrhea, nasal congestion, eyelid swelling, cough, and dyspnea after taking multiple drugs at the same time for abdominal pain and diarrhea 20 days before the hospital visit. Symptoms disappeared after the treatment. He experienced similar symptoms after applying povidone to skin wounds 2 years ago. Among the drugs taken, these symptoms were assumed to be caused by a drug containing a trace amount of povidone. The remaining drug was tested by oral provocation, and there were no adverse reactions. He has avoided drugs containing povidone and has not experienced similar reactions for more than 1 year since then. Therefore, it is presumed that a systemic hypersensitivity reaction may occur due to a very small amount of povidone in a tablet pill. (Allergy Asthma Respir Dis 2021;9:99-103)

KCI등재

8건강한 4개월 영아에서 기흉으로 발현된 거대세포바이러스 폐렴 1예

저자 : 강동희 ( Dong Hee Kang ) , 김수연 ( Su Yeon Kim ) , 김영은 ( Young Eun Kim ) , 고효정 ( Hyo Jung Koh ) , 안연화 ( Yeon Hwa Ahn )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 104-108 (5 pages)

다운로드

(기관인증 필요)

초록보기

Cytomegalovirus (CMV) is the most common agent of congenital infections and opportunistic infections in an immunocompromised host. CMV in an immunocompetent host has inapparent infections, which are usually asymptomatic or cause mild mononucleosis-like symptoms. However, severe CMV diseases, such as pneumonia, hepatitis, gastrointestinal disease, often occur in a healthy infant. The association of CMV pneumonia with the development of pneumothorax has rarely been reported. We experienced a case of CMV pneumonia presenting as pneumothorax in a 4-month-old healthy infant, who was successfully treated with supportive care. CMV was confirmed by using CMV polymerase chain reaction of tracheal aspirates. This case suggested that CMV should be considered as a cause of viral pneumonia during the infant period. (Allergy Asthma Respir Dis 2021;9:104-108)

KCI등재

9반복적인 아나필락시스를 경험한 36세 여성의 증례: Lipid transfer protein 증후군

저자 : 강재빈 ( Jae Been Kang ) , 황윤하 ( Yoon Ha Hwang )

발행기관 : 대한천식알레르기학회 간행물 : Allergy asthma & respiratory disease 9권 2호 발행 연도 : 2021 페이지 : pp. 109-112 (4 pages)

다운로드

(기관인증 필요)

초록보기

Lipid transfer protein (LTP) is a widely cross-reacting allergen in vegetables, fruits, nuts, or cereals. The amino acids sequence of LTP shows high structural similarity in various foods and thus acts as a pan-allergen. LTP syndrome is a new term for the pattern of clinical symptoms and natural course of allergy caused by LTP antigens. It is frequently reported by peaches mainly in the Mediterranean region, and reports in East Asia are rare. Therefore, this case report introduces a 36-year-old female Asian who experienced recurrent anaphylaxis and oral allergy syndrome, and finally diagnosed with LTP syndrome. (Allergy Asthma Respir Dis 2021;9:109-112)

1
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기