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대한소화기학회> 대한소화기학회지> 아시아 의사들의 바이오시밀러 단일 클론 항체에 대한 지식과 관점: 유럽 의사들과 비교

KCI등재

아시아 의사들의 바이오시밀러 단일 클론 항체에 대한 지식과 관점: 유럽 의사들과 비교

Knowledge and Viewpoints on Biosimilar Monoclonal Antibodies among Asian Physicians: Comparison with European Physicians

박수경 ( Soo-kyung Park ) , 문원 ( Won Moon ) , 김은수 ( Eun Soo Kim ) , 박상현 ( Sang Hyun Park ) , 박동일 ( Dong Il Park )
  • : 대한소화기학회
  • : 대한소화기학회지 74권6호
  • : 연속간행물
  • : 2019년 12월
  • : 333-346(14pages)
대한소화기학회지

DOI


목차

INTRODUCTION
SUBJECTS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
Supplementary Table 1. Multinational Survey of the 4th AOCC Meeting in Seoul
Supplementary Table 1. Continued
Supplementary Table 2. Results of the 17-question Multiple Choice Anonymous Web Survey of AOCC Members
Supplementary Table 2. Continued

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Background/Aims: Current knowledge and viewpoints regarding biosimilars among physicians in Asia are unknown, even though these were investigated by European Crohn’s and Colitis Organization (ECCO) members in 2013 and 2015. Thus, this study conducted a multinational survey to assess the awareness of biosimilar monoclonal antibodies among Asian physicians.
Methods: A 17-question multiple-choice anonymous web survey was conducted with the logistic support of the Asian Organization of Crohn’s and Colitis (AOCC). Randomly selected AOCC members were invited by e-mail to participate between February 24, 2017 and March 26, 2017.
Results: In total, 151 physicians from eight Asian countries responded to the survey. Most of the participants were gastroenterologists (96.6%), and 77.5% had cared for inflammatory bowel diseases (IBD) patients for more than 5 years. The majority of the respondents (66.2%) were aware that a biosimilar is similar but not equivalent to the originator. The majority of respondents (77.5%) considered cost saving to be the main advantage of biosimilars, but a high percentage of respondents (38.4%) were concerned about a different immunogenicity from that of the originator (92.4% and 27.1% respectively in ECCO 2015). Only 19.2% considered that the originator and biosimilars were interchangeable, and only 6.0% felt very confident in the use of biosimilars (44.4% and 28.8% respectively in ECCO 2015).
Conclusions: Asian gastroenterologists in 2017 are generally well informed about biosimilars. On the other hand, compared to the ECCO members surveyed in 2015, Asian gastroenterologists had more concerns and less confidence about the use of biosimilars in clinical practice. Thus, IBD-specific data on the comparison of the efficacy, safety, and immunogenicity in Asian patients are needed. (Korean J Gastroenterol 2019;74:333-340)

UCI(KEPA)

I410-ECN-0102-2021-500-000618152

간행물정보

  • : 의약학분야  > 내과학
  • : KCI등재
  • :
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 학술지
  • : 연속간행물
  • : 1968-2021
  • : 5774


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1비용-효과 분석에 기반한 간세포암종 감시 검사의 현재 및 진전된 전략

저자 : 안지현 ( Jihyun An )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 255-260 (6 pages)

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Detection of hepatocellular carcinoma (HCC) at an early stage enables patients to receive curative treatment with survival gains. Current international liver society guidelines recommend the enrollment of patients at high risk for HCC in surveillance programs. In Korea, surveillance for HCC advocated for patients with chronic hepatitis B, chronic hepatitis C, and liver cirrhosis. The established surveillance tool for HCC is liver ultrasonography plus serum alpha-fetoprotein measurement every 6 months. However, there would be obstacles to the improvement of efficacy and cost-effectiveness of the HCC surveillance test. Assessing who is at risk of developing HCC remains incompletely validated. Also, which surveillance tools to use according to patients' characteristics are controversial. The present paper reviews the latest knowledge regarding the strategies and cost-effectiveness of HCC surveillance. (Korean J Gastroenterol 2021;78:255-260)

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2간세포암종의 영상 진단

저자 : 정우경 ( Woo Kyoung Jeong )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 261-267 (7 pages)

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간세포암종은 바이러스성 간염 외에도 다양한 원인에 의해 발생하며, 다른 암종과는 달리 영상의학적 진단만을 거쳐 치료 계획을 수립하는 경우가 많다. LI-RADS는 미국 영상의학회에서 간 영상 소견에 대한 확실한 의사소통과 표준화된 보고서 작성을 목적으로 만든 진단 시스템이며, 최근 미국간학회 가이드라인에 진단 기준으로 포함되었다. 이외에도 gadoxetic acid MRI의 활용이 보편화됨에 따라 간세포암종의 진단뿐만 아니라 간세포암종의 치료 후 예후 예측을 가능하게 하는 영상 소견들이 연구되고 있어, 앞으로 간세포암종의 영상의학 발달이 더욱 기대된다.


There are various causes of hepatocellular carcinoma, including viral hepatitis, and treatment strategies are often established based on the radiology diagnosis, unlike other carcinomas. The liver imaging reporting and data system (LI-RADS) is a diagnostic system developed by the American College of Radiologists for clear communication and standardized reports of the liver imaging findings. It was recently included in the clinical guidance of the American Association for the Study of Liver Diseases. In addition, the radiologic findings of hepatocellular carcinoma (HCC) enable a prediction of the prognosis after treatment and a diagnosis of diseases because the use of gadoxetic acid MRI has become more common. Thus, the role of radiology for the diagnosis and treatment of HCC is expected to be developed further. (Korean J Gastroenterol 2021;78:261-267)

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3간세포암종의 병리진단에 대한 최신 지견

저자 : 남지해 ( Ji Hae Nahm ) , 박영년 ( Young Nyun Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 268-283 (16 pages)

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Hepatocellular carcinoma (HCC) has heterogeneous molecular and pathological features and biological behavior. Large-scale genetic studies of HCC were accumulated, and a pathological-molecular classification of HCC was proposed. Approximately 35% of HCCs can be classified into distinct histopathological subtypes according to their molecular characteristics. Among recently identified subtypes, macrotrabecular massive HCC, neutrophil-rich HCC, vessels encapsulating tumor clusters HCC, and progenitor phenotype HCC (HCC with CK19 expression) are associated with a poor prognosis, whereas the lymphocyte-rich HCC subtype is related to a better prognosis. This review provides up-to-date knowledge on the pathological diagnosis of HCC according to the updated World Health Organization Classification of Digestive System Tumors 5th ed. (Korean J Gastroenterol 2021;78:268-283)

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4간세포암종 감시 검사에서 종양 표지자의 역할

저자 : 임영석 ( Young-suk Lim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 284-288 (5 pages)

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Biomarkers are key components of the clinical management of cancer patients because they have contributed to significant survival improvements in these patients. They allow the classification of patients based on common features and facilitate risk stratification, early detection, diagnosis, and prediction of the prognosis or treatment response. In hepatocellular carcinoma (HCC), there are few biomarkers incorporated in clinical practice. Despite this, this has been an extensive area of research in recent years, with increasing efforts to identify the biomarkers across the cancer care continuum from risk stratification to early detection to prognostication and treatment response. The heterogeneous nature of HCCs has restricted the performance of biomarkers. HCC biomarkers have limited roles in risk stratification, diagnosis, and treatment response. Currently, the main role of biomarkers is in the surveillance of HCC to detect it at an earlier stage and reduce mortality, which is the focus of this review. (Korean J Gastroenterol 2021;78:284-288)

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저자 : 강여울 ( Yeo Wool Kang ) , 김동균 ( Dong Kyun Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 289-294 (6 pages)

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Acupuncture is a representative treatment field in oriental medicine that is used widely in various medical conditions. Although acupuncture is considered a safe procedure, it can cause complications. This paper reports the case of a 44-year-old quadriplegic woman who received a percutaneous gastrostomy (PEG) tube and was referred for the endoscopic removal of swallowed acupuncture needles. The needles were removed successfully by endoscopy through the PEG tube using the rendezvous technique without significant complications. (Korean J Gastroenterol 2021;78:289-294)

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6자발적으로 소실된 특발성 후복막 혈종 1예

저자 : 황유정 ( Yu Jeong Hwang ) , 진석재 ( Suk Je Jin ) , 정용진 ( Yong Jin Jeong ) , 명형준 ( Hyung Joon Myung ) , 신혜영 ( Hae Young Shin ) , 김호동 ( Ho Dong Kim ) , 주영은 ( Young Eun Joo )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 295-299 (5 pages)

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A 54-year-old man was transferred from another hospital due to a hematoma in the third portion of the duodenum on abdomen CT. He had been admitted for 2 weeks due to vomiting at another hospital. He had abdominal discomfort and nausea without abdominal pain when he visited the Gwangyang Sarang Hospital. Other than a distended abdomen and mild general abdominal tenderness, the results of physical examination were unremarkable. Abdominal CT revealed an approximately 9 cm thick walled hematoma at the anteroinferior site of the duodenal third portion. Upper endoscopy revealed stenosis of the third portion of the duodenum without mucosal lesions. The endoscope was not advanced through the narrowed duodenal lumen. A retroperitoneal hematoma was diagnosed, and his state was classified as subacute rather than acute based on the duration. The surgeon did not recommend surgical treatment. Urgent treatment was unnecessary; he was managed conservatively. The size of the hematoma decreased from 9.0 cm to 5.8 cm on the following CT. He could begin to eat food on the 26th admission day, and he was discharged on the 31st admission day. The hematoma disappeared entirely on the following CT. This paper describes a rare case of idiopathic retroperitoneal hematoma with a spontaneous resolution. (Korean J Gastroenterol 2021;78:295-299)

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7낭성 원발간신경내분비종양 1예

저자 : 김진모 ( Jin Mo Kim ) , 이원애 ( Won Ae Lee ) , 신현덕 ( Hyun Deok Shin ) , 송일한 ( Il Han Song ) , 김석배 ( Suk Bae Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 300-304 (5 pages)

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Neuroendocrine tumors (NETs) can arise throughout the body. Most NETs in the liver are metastatic tumors; primary hepatic NET (PHNET) is extremely rare. A diagnosis of PHNET is very difficult. No single modality can diagnose PHNET by itself, and it often resembles other hypervascular masses of the liver. This paper reports the case of a 51-year old female with a large hepatic mass. Unlike most of PHNETs reported previously, it was composed of a solid mass with mainly multiple cystic lesions, which led to an erroneous diagnosis of hepatic mucinous cystadenoma or cystadenocarcinoma. PHNET with cystic lesions is extremely rare, and the features are not well studied. This case may help physicians suspect PHNET in a differential diagnosis of an atypical hepatic mass. (Korean J Gastroenterol 2021;78:300-304)

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8위와 대장을 동시에 침범한 거대세포바이러스 위장관 감염

저자 : 양희찬 ( Hee Chan Yang ) , 김상욱 ( Sang Wook Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 305-307 (3 pages)

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9내시경역행성담췌관조영술 후 발생하는 급성 췌장염의 예방

저자 : 조인래 ( In Rae Cho )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 78권 5호 발행 연도 : 2021 페이지 : pp. 308-310 (3 pages)

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1염증성 장질환에서 바이오시밀러에 대한 아시아 의사들의 관점 - 우리는 사용할 준비가 되어 있는가?

저자 : 나수영 ( Soo-young Na )

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The stomach is the most common primary site of an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type, which is characterized by an indolent clinical course. A diagnosis of gastric MALT lymphoma requires an endoscopic biopsy that should be confirmed by an experienced pathologist. Gastric MALT lymphoma shows a variable endoscopic appearance, including erosion, erythema, discoloration, atrophy, ulcer, and subepithelial lesion. The distribution is often multifocal. Therefore, clinical suspicion and multiple biopsies are essential for an accurate diagnosis. Gastric MALT lymphoma is almost invariably associated with a Helicobacter pylori (H. pylori) infection. H. pylori eradication therapy is the mainstay of treatment, which must be delivered to all patients regardless of the H. pylori infection status or stage. For patients who have failed to achieve remission following eradication therapy, radiotherapy or chemotherapy can be considered. Radiotherapy is an effective treatment modality for a localized stage and shows excellent outcomes. In the presence of disseminated or advanced disease, chemotherapy and/or immunotherapy with the anti-CD20 monoclonal antibody, rituximab, can be applied. Treatment should be individualized according to the stage and symptoms, as well as the patients' preference. Given that the clinical course of gastric MALT lymphoma is usually indolent, watchful waiting may be an adequate strategy in selected cases where scheduled follow-up is guaranteed. (Korean J Gastroenterol 2019;74:304-313)

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3Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies

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발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 314-320 (7 pages)

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Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors. The human intestine harbors hundreds of trillions of bacteria, as well as bacteriophage particles, viruses, fungi, and archaea, which constitute a complex and dynamic ecosystem referred to as the gut microbiota. Increasing evidence has indicated changes in the gut microbiota composition or function in type 2 diabetic patients. An analysis of 'dysbiosis' enables the detection of alterations in the specific bacteria, clusters of bacteria, or bacterial functions associated with the occurrence of type 2 diabetes. These bacteria are involved predominantly in the control of inflammation and energy homeostasis. This review attempts to show that the gut microbiota are important factors for the occurrence of type 2 diabetes and are important for the treatment of gut microbiota dysbiosis through bariatric surgery, fecal microbiota transplantation, prebiotics, and probiotics. (Korean J Gastroenterol 2019;74:314-320)

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발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 321-325 (5 pages)

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Gastroesophageal reflux disease (GERD) is diagnosed according to the medical history or in response to proton pump inhibitor therapy. However, the need for further testing is always appropriate. The decisive evidence for the current diagnosis of GERD is severe erosive esophagitis of Los Angeles grade C or D, long-segment Barrett's mucosa or peptic strictures seen on endoscopy or an acid exposure time >6% on ambulatory pH or pH impedance monitoring. If ambulatory reflux monitoring correlates between reflux and the symptoms, then the diagnosis and treatment are certain. If it is difficult to clearly diagnose this malady as seen upon endoscopy and ph/pH impedance monitoring, then this review recommends the biopsy findings, motor evaluation and novel impedance metrics. Novel impedance metrics include the baseline impedance and the post reflux swallow-induced peristaltic wave index. Therefore, making a future GERD diagnosis should focus on defining the patient's phenotype. The phenotype is determined by the level of reflux exposure, clearance efficacy, anatomy of the esophageal gastric junction, and the psychological state of the patient. The purpose of this review is to clarify the diagnostic guideline for GERD according to several test methods. (Korean J Gastroenterol 2019;74:321-325)

KCI등재

5대장 폴립절제술 후 예방적 클립 사용 없이 발생한 지연 출혈: 단일기관에서의 관찰 연구

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발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 326-332 (7 pages)

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Background/Aims: Bleeding is one of the major complications of a colorectal polypectomy. The aim of this study was to identify the risk of delayed bleeding, particularly after a colorectal endoscopic mucosal resection (EMR) without prophylactic clipping.
Methods: Between April 2014 and August 2014, patients who underwent colorectal EMR (≥6 mm and <2 cm) without prophylactic clipping were included. This study evaluated the incidence of delayed bleeding and the associated factors after colorectal EMR without prophylactic clipping.
Results: A total of 717 colorectal polyps (≥6 mm and <2 cm) of 243 patients resected by colorectal EMR in the study period were evaluated. The mean age of the patients was 63 years; 165 patients were men and 78 patients were women. The mean polyp size removed by colorectal EMR was 9.0 mm (range 6.0-19.0), and the number of polyps larger than 1 cm was 212 (29.6%). Delayed bleeding after colorectal EMR occurred in 12 polyps (1.7%) in eight patients (3.3%), and there were no significant risk factors affecting delayed bleeding.
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KCI등재

6아시아 의사들의 바이오시밀러 단일 클론 항체에 대한 지식과 관점: 유럽 의사들과 비교

저자 : 박수경 ( Soo-kyung Park ) , 문원 ( Won Moon ) , 김은수 ( Eun Soo Kim ) , 박상현 ( Sang Hyun Park ) , 박동일 ( Dong Il Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 333-346 (14 pages)

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Background/Aims: Current knowledge and viewpoints regarding biosimilars among physicians in Asia are unknown, even though these were investigated by European Crohn's and Colitis Organization (ECCO) members in 2013 and 2015. Thus, this study conducted a multinational survey to assess the awareness of biosimilar monoclonal antibodies among Asian physicians.
Methods: A 17-question multiple-choice anonymous web survey was conducted with the logistic support of the Asian Organization of Crohn's and Colitis (AOCC). Randomly selected AOCC members were invited by e-mail to participate between February 24, 2017 and March 26, 2017.
Results: In total, 151 physicians from eight Asian countries responded to the survey. Most of the participants were gastroenterologists (96.6%), and 77.5% had cared for inflammatory bowel diseases (IBD) patients for more than 5 years. The majority of the respondents (66.2%) were aware that a biosimilar is similar but not equivalent to the originator. The majority of respondents (77.5%) considered cost saving to be the main advantage of biosimilars, but a high percentage of respondents (38.4%) were concerned about a different immunogenicity from that of the originator (92.4% and 27.1% respectively in ECCO 2015). Only 19.2% considered that the originator and biosimilars were interchangeable, and only 6.0% felt very confident in the use of biosimilars (44.4% and 28.8% respectively in ECCO 2015).
Conclusions: Asian gastroenterologists in 2017 are generally well informed about biosimilars. On the other hand, compared to the ECCO members surveyed in 2015, Asian gastroenterologists had more concerns and less confidence about the use of biosimilars in clinical practice. Thus, IBD-specific data on the comparison of the efficacy, safety, and immunogenicity in Asian patients are needed. (Korean J Gastroenterol 2019;74:333-340)

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7만성 B형간염, 비알코올성 지방간 질환 환자에서 혈청 Asialo-α1-acid Glycoprotein의 진행성 간섬유화, 간경변증 예측력 연구

저자 : 김승업 ( Seung Up Kim ) , 전미영 ( Mi Young Jeon ) , 임태섭 ( Tae Seop Lim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 341-348 (8 pages)

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Background/Aims: The utility of asialo-α1-acid glycoprotein (AsAGP) for assessing the fibrotic burden is unknown. This study examined the diagnostic performance of the AsAGP level for advanced liver fibrosis or cirrhosis in patients with chronic hepatitis B (CHB) or nonalcoholic fatty liver disease (NAFLD).
Methods: From July to December 2018, 48 patients with CHB and 75 with NAFLD were recruited prospectively. Transient elastography was used as the reference standard for liver fibrosis, and the cutoff liver stiffness values were defined as 10.0 kilopascal (kPa) for ≥F3 and 12.0 kPa for F4 in CHB patients, and 9.0 kPa for ≥F3 and 11.8 kPa for F4 in NAFLD patients.
Results: To predict stage ≥F3 and F4 fibrosis, the areas under the receiver operating characteristic curves of the AsAGP level in patients with CHB were 0.788 (95% CI 0.647-0.930; p=0.005) and 0.825 (95% CI 0.674-0.976; p=0.004), respectively. The cutoff AsAGP levels in patients with CHB that maximized the sum of the sensitivity and specificity values were 1.31 (sensitivity 100.0%, specificity 52.6%) and 1.55 (sensitivity 75.0%, specificity 80.0%), respectively. In contrast, the AsAGP level was similar regardless of the fibrosis stage in patients with NAFLD (all p>0.05 between the stages).
Conclusions: The AsAGP level showed acceptable diagnostic accuracy in predicting advanced liver fibrosis and cirrhosis in patients with CHB but not in those with NAFLD. Further studies will be needed to validate the diagnostic performance of the AsAGP level in patients with NALFD. (Korean J Gastroenterol 2019;74:341-348)

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8같은 종양에서 깊이에 따라 분포된 혼합형 신경내분비-비신경내분비 암의 증례: 2010년 세계보건기구에서 정의한 혼합형 샘-신경내분비 암 정의에 부합하지 않는 암

저자 : 정준호 ( Joonnho Jeong ) , 정경원 ( Kyoungwon Jung ) , 김재현 ( Jae Hyun Kim ) , 김성은 ( Sung Eun Kim ) , 문원 ( Won Moon ) , 박무인 ( Moo In Park ) , 박선자 ( Seun Ja Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 349-355 (7 pages)

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A mixed adenoneuroendocrine carcinoma (MANEC) of the stomach is a rare disease entity that was first defined by the World Health Organization (WHO) classification (2010) for tumors of the digestive system. According to the WHO classification (2010), MANEC is referred to as a tumor with both neuroendocrine and non-neuroendocrine neoplasms; each component of the tumor should be at least 30%. On the other hand, this cut-off value lacks clinical evidence and does not explain the characteristics and heterogeneity of this tumor. A 66-year-old male diagnosed with early gastric cancer (EGC) at a community hospital was referred to the Kosin University Gospel Hospital for further evaluation of gastric cancer. Esophagogastroduodenoscopy and EUS performed at the Kosin University Gospel Hospital revealed a sub-mucosal tumor-like component. In addition, a re-biopsy revealed a neuroendorine tumor at different depths of the same tumor. The final pathologic-diagnosis through surgery revealed a mixed neuroendocrine- non-neuroendocrine neoplasm, which is inconsistent with the definition of MANEC. Clinicians should consider EUS when a tumor has atypical endoscopic findings, even if EGC has already been diagnosed. (Korean J Gastroenterol 2019;74:349 -355)

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9담도선섬유종의 자기공명영상 소견

저자 : 이선영 ( Sunyoung Lee ) , 김경원 ( Kyoung Won Kim ) , 정우경 ( Woo Kyoung Jeong ) , 유은실 ( Eunsil Yu ) , 장기택 ( Kee-taek Jang )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 356-361 (6 pages)

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Biliary adenofibroma is a rare tumor with a bile duct origin characterized by a complex tubulocystic non-mucin secreting biliary epithelium with abundant fibrous stroma. The MRI features of biliary adenofibroma are not well established. The authors encountered two patients with biliary adenofibroma and reviewed the literature focusing on the MRI findings. A well-circumscribed multicystic tumor with septal enhancement and no intrahepatic bile duct communication may be the characteristic MRI findings of biliary adenofibroma. (Korean J Gastroenterol 2019;74:356-361)

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10상부위장관 대량 출혈로 나타난 췌장 가성낭종

저자 : 양서희 ( Seo Hee Yang ) , 손준혁 ( Jun Hyuk Son ) , 이윤석 ( Yoon Suk Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 74권 6호 발행 연도 : 2019 페이지 : pp. 362-364 (3 pages)

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