논문 상세보기

대한피부과학회> 대한피부과학회지> Oxybutynin 치료에 상반된 반응을 보인 국소 다한증: 증례 보고

KCI등재SCOUPUS

Oxybutynin 치료에 상반된 반응을 보인 국소 다한증: 증례 보고

Paradoxical Responses to Oxybutynin Treatment in Localized Hyperhidrosis: Case Report

김민성 ( Min Sung Kim ) , 배인호 ( In Ho Bae ) , 최훈 ( Hoon Choi ) , 나찬호 ( Chan Ho Na ) , 신봉석 ( Bong Seok Shin )
  • : 대한피부과학회
  • : 대한피부과학회지 57권9호
  • : 연속간행물
  • : 2019년 11월
  • : 558-559(2pages)
대한피부과학회지

DOI


목차

ORCID
REFERENCES

키워드 보기


초록 보기


UCI(KEPA)

I410-ECN-0102-2021-500-000122779

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9769


저작권 안내

한국학술정보㈜의 모든 학술 자료는 각 학회 및 기관과 저작권 계약을 통해 제공하고 있습니다.

이에 본 자료를 상업적 이용, 무단 배포 등 불법적으로 이용할 시에는 저작권법 및 관계법령에 따른 책임을 질 수 있습니다.

60권10호(2022년 12월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCOPUS

1생물학적제제로 치료 받는 성인 중증 건선 환자에서 잠복결핵 감염에 대한 단일 기관 연구

저자 : 최기화 ( Ki Hwa Choi ) , 은대휘 ( Dae Hwi Eun ) , 이지연 ( Ji Yeoun Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 631-639 (9 pages)

다운로드

(기관인증 필요)

초록보기

Background: Biologics have been increasingly used in the treatment of severe psoriasis. However, evidence regarding the results of tuberculosis (TB) screening and risk of latent tuberculosis infection (LTBI) during treatment with biologics is conflicting.
Objective: We aimed to assess the prevalence of LTBI in patients with severe psoriasis who were treated with biologics (anti-tumor necrosis factor-α, interleukin [IL]-12/23, IL-17, and IL-23) and to evaluate the rate of conversion of interferon-gamma release assay (IGRA) during treatment with biologics at a single medical center.
Methods: We retrospectively reviewed the medical records of patients with severe psoriasis who were treated with biologics (n=118) and had results for ≥2 IGRA (n=76). Data including demographics, age, sex, previous therapy for psoriasis, and type of ongoing treatment were collected for each patient.
Results: Among the 118 patients included in the study, 30 (25.4%) were diagnosed with LTBI before the initiation of biologics, 25 (83.3%) were male, and only five patients were aged below 40 years. After treatment with biologics for an average duration of 2.4 years, there was no active tuberculosis infection in 76 patients, but eight patients (10.5%) showed positive conversion of IGRA.
Conclusion: Altogether, 10.5% of the patients with psoriasis who were undergoing treatment with biologics exhibited IGRA conversion. Periodic follow-up is crucial to avoid severe infectious complications during prolonged use of these agents, especially in patients with risk factors for tuberculosis or in patients aged above 50 years. (Korean J Dermatol 2022;60(10):631∼639)

KCI등재 SCOPUS

2각질형성세포의 염증 반응 및 분화에 미치는 Activating Transcription Factor 3의 영향

저자 : 김경민 ( Kyungmin Kim ) , 김도연 ( Doyeon Kim ) , 신정민 ( Jung-min Shin ) , 홍동균 ( Dongkyun Hong ) , 정경은 ( Kyung Eun Jung ) , 서영준 ( Young-joon Seo ) , 이영 ( Young Lee ) , 김창덕 ( Chang Deok Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 640-646 (7 pages)

다운로드

(기관인증 필요)

초록보기

Background: Pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune responses. Genetic background is one of the most important factors in disease pathogenesis. However, psoriasis-associated genes have not yet been fully identified. Activating transcription factor 3 (ATF3) is a member of the cyclic adenosine monophosphate responsive element-binding protein family of transcription factors, which may regulate epidermal keratinocytes.
Objective: We aimed to evaluate the effects of ATF3 on inflammation and differentiation of keratinocytes.
Methods: We evaluated the expression of ATF3 in polyinosinic:polycytidylic acid (poly[I:C])-treated keratinocytes. Subsequently, we compared ATF3 levels in psoriatic and normal skin using immunohistochemical staining. To illustrate the role of ATF3, we generated ATF3-overexpressing keratinocytes and ATF3-knockdown keratinocytes using a recombinant adenovirus. We investigated inflammation and differentiation of keratinocytes by measuring the mRNA levels of inflammatory cytokines and differentiation markers.
Results: Treatment of keratinocytes with poly(I:C) increased ATF3 expression in a time-dependent manner. Immunohistochemical staining showed that ATF3 expression was increased in the epidermis of psoriatic tissues. When ATF3 was overexpressed in keratinocytes using a recombinant adenovirus, poly(I:C)-induced inflammation was reduced. Conversely, ATF3 knockdown increased poly(I:C)-induced inflammation. Thus, ATF3 overexpression inhibited keratinocyte differentiation, while ATF3 knockdown promoted it.
Conclusion: ATF3 may be involved in the pathogenesis of psoriasis by influencing the inflammatory response and differentiation of keratinocytes. (Korean J Dermatol 2022;60(10):640∼646)

KCI등재 SCOPUS

3원반모양홍반루푸스 탈모 환자의 더모스코피 소견과 치료 반응의 상관관계에 관한 후향적 연구

저자 : 김나영 ( Na Young Kim ) , 허윤정 ( Yun Jung Huh ) , 주민숙 ( Mihn-sook Jue ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 647-656 (10 pages)

다운로드

(기관인증 필요)

초록보기

Background: Discoid lupus erythematosus (DLE) with alopecia of the scalp can result in permanent hair loss. Therefore, it is important to evaluate skin lesions and establish appropriate treatment plans for scalp DLE with alopecia.
Objective: We aimed to investigate the dermoscopic features of scalp DLE with alopecia and to determine the correlation between dermoscopic findings and treatment efficacy.
Methods: Thirty-one patients histopathologically diagnosed with scalp DLE and alopecia were included. We reviewed clinical photographs and dermoscopic findings of the patients and evaluated their treatment responses.
Results: The most frequent dermoscopic features of DLE with alopecia were follicular keratotic plugs (96.8%), white scales (71.0%), telangiectatic vessels (67.7%), and pigmentation (64.5%); followed by absent follicular openings (48.4%), white structureless areas (35.5%), follicular red dots (16.1%), and perifollicular whitish halo (12.9%). After at least 6 months of treatment, hair regrowth was observed in 22 patients (71.0%). Dermoscopic findings showed that white structureless areas, perifollicular whitish halo, absent follicular openings (especially when the alopecic patch involved >25% of the scalp), and moderate to severe telangiectatic vessels were associated with absence of hair regrowth.
Conclusion: Dermoscopy is a promising tool for evaluating lesions and predicting therapeutic outcomes in scalp DLE with alopecia. It may contribute to the establishment of appropriate treatment plan by determining whether hair loss is reversible. (Korean J Dermatol 2022;60(10):647∼656)

KCI등재 SCOPUS

4한국인 말단흑색종에서 Yes-Associated Protein의 면역조직화학적 발현 양상

저자 : 김승미 ( Seung-mee Kim ) , 김도연 ( Doyeon Kim ) , 권인선 ( In-sun Kwon ) , 신정민 ( Jung-min Shin ) , 홍동균 ( Dongkyun Hong ) , 정경은 ( Kyung Eun Jung ) , 김창덕 ( Chang-deok Kim ) , 이영 ( Young Lee ) , 서영준 ( Young-joon Seo ) , 박상현 ( Sanghyun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 657-665 (9 pages)

다운로드

(기관인증 필요)

초록보기

Background: Acral melanoma is the most common subtype of melanoma among Koreans, and regional or distant metastasis is an indicator of poor prognosis. Yes-associated protein (YAP), a key effector of the Hippo pathway, is known to induce tumor progression and metastasis in various cancers.
Objective: We aimed to analyze the clinical and histopathological characteristics of acral melanoma among Koreans and to evaluate their association with YAP expression.
Methods: This retrospective review included 27 patients with acral melanoma. Clinical features including age, sex, lesion site, and stage were obtained from the medical records and images. Biopsy slides of patients with acral melanoma were reviewed, and immunohistochemical staining for YAP was performed.
Results: The rate of YAP expression was significantly higher in patients having acral melanoma with regional or distant lymph node (LN) metastasis than in those without metastasis (n=4/5, 80.0% vs. n=2/22, 9.1%; p=0.004). Histopathologically, the rate of YAP expression was higher in patients having acral melanoma with lymphovascular invasion than in those without lymphovascular invasion (n=4/8, 50.0% vs. n=2/19, 10.5%; p=0.044). Among the 27 lesions, 14 (51.9%) were on stress-bearing sites such as the forefoot and heel. However, the rate of YAP expression did not differ significantly between weight-bearing and non-weight-bearing locations (p=0.834).
Conclusion: YAP expression is significantly associated with metastasis, especially LN metastasis, in patients with acral melanoma. Therefore, YAP expression may be used as a prognostic factor for LN metastasis and a target for novel treatments in patients with melanoma. (Korean J Dermatol 2022;60(10):657∼665)

KCI등재 SCOPUS

5The Distinctive Immunologic Pathogenesis Differentiates Atopic Comorbidity Status in Prurigo Nodularis

저자 : Howard Chu , Wan Jin Kim , Su Min Kim , Seo Hyeong Kim , Ji Hye Kim , Kelun Zhang , Hye Li Kim , Ryeo Won Kim , Kwang Hoon Lee , Chang Ook Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 666-674 (9 pages)

다운로드

(기관인증 필요)

초록보기

Background: Prurigo nodularis (PN) is a chronic pruritic skin disorder with a large number of hyperkeratotic nodules. The precise mechanisms of its pathogenesis remain unknown. PN has been linked to atopic dermatitis (AD), but its association remains unclear.
Objective: We aimed to investigate the clinical, histological, and immunohistochemical characteristics of patients with PN and PN underlying AD (PN-AD).
Methods: Eight patients were recruited for PN, PN-AD, and eight normal subjects, respectively. Skin tissues were obtained from patients and healthy subjects for histological and immunohistochemical analyses.
Results: Histological examination showed increased epidermal thickness and dermal inflammatory cell counts in the PN-AD and PN groups compared to normal subjects. Immunohistochemical analyses revealed that the expression of interleukin (IL)-4, IL-13, IL-18, IL-31, IL-33, interferon (IFN)-γ, stromal-derived factor (SDF) 1-α and thymic stromal lymphopoietin (TSLP) was increased in the tissues of PN-AD and PN groups, in which the staining intensities of IL-4, IL-13, SDF1-α and TSLP in the PN-AD group were higher than those in the PN group, but the differences were not statistically significant. Conversely, the staining intensities of IL-18, IL-33 and IFN-γ were significantly higher in the PN group than those in the PN-AD group.
Conclusion: The pathogenesis of PN may differ from that of PN-AD, in which IL-18, IL-33 and IFN-γ may be associated, implying that epidermal injury is the initial cause of IL-18 and IL-33 induction, which then increases IFN-γ, resulting in the inflammatory process of PN. (Korean J Dermatol 2022;60(10):666∼674)

KCI등재 SCOPUS

6역 T 절개와 방추형 절제로 호전을 보인 조갑만곡증 1예

저자 : 정연주 ( Yeon Joo Jung ) , 배재희 ( Jai Hee Bae ) , 장동휘 ( Donghwi Jang ) , 심준호 ( Joonho Shim ) , 오세진 ( Se Jin Oh ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dongyoun Lee ) , 이주흥 ( Joo-heung Lee ) , 박지혜 ( Ji-hye Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 675-678 (4 pages)

다운로드

(기관인증 필요)

초록보기

Onychogryphosis is a disorder of nail plate growth, which most commonly involves the toenails. It is characterized by opaque, yellow-brown thickening of the nail plate with associated marked convexity and elongation. Treatment for onychogryphosis can be conservative or operative depending on the cause and medical status of the patient. A 30-year-old male presented with onychogryphosis of the right and left toenails. Since the patient had shown recurrence after simple nail avulsion several years ago, the inverted T incision method and fusiform excision of the hypertrophic hyponychium were performed. No recurrence was observed during the 3-year follow-up period. Our results showed that nail avulsion combined with traction osteophyte removal is a suitable surgical method for treating onychogryphosis. (Korean J Dermatol 2022;60(10):675∼678)

KCI등재 SCOPUS

7구셀쿠맙 첫 번째 투여 후 사이클로스포린 중단에 의한 반동현상으로 악화된 건선 1예

저자 : 박소희 ( So Hee Park ) , 정소영 ( So Young Jung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 679-682 (4 pages)

다운로드

(기관인증 필요)

초록보기

Cyclosporine is one of the main therapeutic agents for psoriasis. It is known that psoriasis relapses 2∼3 months after discontinuation of cyclosporine, and exacerbation due to abrupt discontinuation of cyclosporine is uncommon. We report a case of psoriasis that was aggravated by cyclosporine cessation for guselkumab treatment, but improved with continuous administration of guselkumab. A 55-year-old man with a history of psoriasis presented with erythematous scaly plaques on the whole body. He had been treated with cyclosporine for 18 months and had received a subcutaneous injection of guselkumab 1 month previously. Two weeks after the first injection, the patient experienced exacerbation of the lesions. Considering the aggravation caused by abrupt discontinuation of cyclosporine, guselkumab administration was continued. The aggravated psoriatic lesions improved after additional guselkumab injections. At 16 weeks, the Psoriasis Area and Severity Index score was 0, which remained constant thereafter. (Korean J Dermatol 2022;60(10):679∼682)

KCI등재 SCOPUS

8시클로스포린 투여 후 호전된 모공홍색비강진 2예

저자 : 김지선 ( Ji Sun Kim ) , 이중선 ( Joong Sun Lee ) , 구대원 ( Dae Won Koo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 683-686 (4 pages)

다운로드

(기관인증 필요)

초록보기

Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous disease of the skin. Its exact pathogenesis and incidence are not yet known. Clinically, it presents as palmoplantar keratoderma, hyperkeratotic follicular papules, and plaques. PRP can be diagnosed by histopathological examination, and the characteristic histopathological features include alternating orthokeratosis and parakeratosis, hypergranulosis, psoriasiform acanthosis with short and broad rete ridges, thick suprapapillary plates of the epidermis, and superficial perivascular inflammatory cell infiltrates. There are six subtypes of PRP based on clinical manifestations and age of onset. PRP is known to respond to acitretin, and treatment with other medications such as isotretinoin, methotrexate, and biologics results in symptomatic improvement. We present two cases of patients who developed type 2 and type 4 PRP following treatment with cyclosporine. (Korean J Dermatol 2022;60(10):683∼686)

KCI등재 SCOPUS

9두필루맙 치료로 호전을 보인 결절성 양진 1예

저자 : 이동훈 ( Donghoon Lee ) , 백가연 ( Gayun Baek ) , 백지윤 ( Jiyoon Baek ) , 강현지 ( Hyun Ji Kang ) , 김민수 ( Min-soo Kim ) , 주민숙 ( Mihn-sook Jue )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 687-691 (5 pages)

다운로드

(기관인증 필요)

초록보기

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by multiple nodules and papules, which are accompanied by intense pruritus. Treatment is challenging and requires a diverse approach. Recently, a few reports have described successful treatment of PN with dupilumab. We report a case of a patient with treatment-resistant PN who was successfully treated with dupilumab. Dupilumab was administered at the standard dose: an initial induction dose of 600 mg, followed by 300 mg every 14 days. Pruritus reduced after 2 weeks and almost completely disappeared after 4 weeks of treatment. (Korean J Dermatol 2022;60(10):687∼691)

KCI등재 SCOPUS

10A Case of Pleomorphic Dermal Sarcoma Showing Characteristics of Myxoinflammatory Fibroblastic Sarcoma

저자 : Ji Sun Kim , Joong Sun Lee , Dae Won Koo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 10호 발행 연도 : 2022 페이지 : pp. 692-696 (5 pages)

다운로드

(기관인증 필요)

초록보기

Pleomorphic sarcoma is a mesenchymal neoplasm and divided into several groups based on histologic differentiation features, including stroma and infiltrated cells. Undifferentiated pleomorphic sarcoma is a rare type of pleomorphic sarcoma. It is called pleomorphic dermal sarcoma when the origin of tumor is the skin. The term of this tumor is confusing, and it has been changed continuously. In histopathologic study, it presents as well circumscribed tumor in which several pleomorphic and atypical cells are mixed. Herein, we report a rare pleomorphic dermal sarcoma showing characteristics of myxoinflammatory fibroblastic sarcoma. (Korean J Dermatol 2022;60(10):692∼696)

12
권호별 보기
같은 권호 다른 논문
| | | | 다운로드

KCI등재SCOUPUS

1두피 건선 환자의 삶의 질에 미치는 국소 스테로이드제 단독 요법과 경구 사이클로스포린 병합 요법의 효과 비교

저자 : 김민수 ( Minsu Kim ) , 양승걸 ( Seungkeol Yang ) , 김보리 ( Bo Ri Kim ) , 윤상웅 ( Sang Woong Youn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 513-518 (6 pages)

다운로드

(기관인증 필요)

초록보기

Background: Scalp psoriasis severely affects patients' quality of life, and patients may occasionally be refractory to topical steroid application. Although systemic therapy combined with topical steroid application is recommended for treatment-resistant scalp psoriasis, previous research has not reported whether such combination treatment improves patients' quality of life.
Objective: This study investigated whether combination therapy using oral cyclosporine and topical steroid reduces the severity of scalp psoriasis and improves patients' quality of life compared with the use of topical steroid alone.
Methods: The study included 23 patients with scalp psoriasis who were categorized as patients who received topical steroid therapy alone vs. those who received combination therapy with topical steroid and oral cyclosporine for 12 weeks. The severity of psoriasis and quality of life were evaluated at 4, 8, and 12 weeks of treatment.
Results: No significant improvement was observed in the severity of psoriasis or in patients' quality of life during the treatment period in patients receiving topical steroid alone. Patients treated with a combination of topical steroid and oral cyclosporine showed a reduction in the severity of psoriasis from the 4th week of treatment and their quality of life improved from the 12th week of treatment.
Conclusion: Combination therapy with oral cyclosporine and topical steroid may reduce the severity of scalp psoriasis and improve patients' quality of life. (Korean J Dermatol 2019;57(9):513∼518)

KCI등재SCOUPUS

2재발성 카포시수두양발진의 임상적 특징과 유발요인에 대한 분석

저자 : 배경남 ( Kyung-nam Bae ) , 김태욱 ( Taewook Kim ) , 박성민 ( Sungmin Park ) , 이현주 ( Hyun Joo Lee ) , 진현주 ( Hyunju Jin ) , 유향석 ( Hyangsuk You ) , 심우행 ( Woo-haing Shim ) , 김건욱 ( Gun-wook Kim ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byung Soo Kim ) , 김

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 519-526 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background: Kaposi varicelliform eruption (KVE) is a disseminated viral infection primarily caused by the herpes simplex virus in the setting of an underlying chronic skin disease. Few studies have reported the clinical characteristics and predisposing factors for recurrent KVE.
Objectives: To characterize the clinical features and predisposing factors for recurrent KVE.
Methods: This retrospective comparative study of recurrent vs. single-episode KVE was performed at the Pusan National University Hospital between 2004 and 2017.
Results: A total of 84 episodes occurred in 60 patients, and of these, 13 patients developed recurrence (21.7%). No statistically significant intergroup difference was observed in the mean age and sex distribution. The face was the most common site of involvement in both groups, followed by the trunk and the upper and lower extremities. Atopic dermatitis was the most common pre-existing disease in both groups; however, Darier's disease was more common in the recurrent KVE group, and this difference was statistically significant. Most patients with KVE (66.7%) showed aggravation of the underlying skin disease within 3 months of KVE onset. This finding was more prominent in patients with recurrent episodes (91.7%) than in those with single-episode KVE (58.3%), (p=0.040).
Conclusion: This study can contribute to a better understanding of recurrent KVE and guide clinicians in treating patients with conditions predisposing to KVE. (Korean J Dermatol 2019;57(9):519∼526)

KCI등재SCOUPUS

3Clinical Analysis of Serial (Staged) Excision for Congenital Melanocytic Nevi: A Single-center Experience

저자 : Min Young Lee , Ji Yeon Byun , Kyu Kwang Whang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 527-531 (5 pages)

다운로드

(기관인증 필요)

초록보기

Background: Serial (staged) excision of congenital melanocytic nevi (CMN) is an important treatment option for medium-sized CMN. However, few studies have investigated the outcomes of serial excision in detail.
Objective: We report our experience regarding serial excision of CMN, including methods to effectively reduce the procedural stages and scar length. Methods: We retrospectively reviewed medical records of patients with CMN treated between 2008 and 2015; 33 patients (7 men and 26 women) underwent serial excision.
Results: The CMN were located on the face (n=11), arms (n=6), legs (n=11), and other areas of the body (n=11), including the back (n=2), chest (n=1), deltoid region (n=1), and buttocks (n=1). The mean CMN area was 19.7 cm2. The mean number of surgical stages was 2.2. The mean interval between surgeries was 10.6 months. A marginal S-shaped incision along both edges of the nevus was preferred over elliptical excision, to reduce scarring. Pulsed dye, erbium:yttrium-aluminum-garnet (YAG), neodymium-doped:YAG, and carbon dioxide fractional lasers were used to improve the final outcomes and minimize scarring.
Conclusion: Serial excision is an effective treatment option associated with greater patient satisfaction, particularly for medium-sized and hairy CMN. Conventional elliptical serial excision is associated with the formation of elongated scars and sacrifices normal skin adjacent to the lesion. The marginal S-shaped incision reduces scarring by dispersing mechanical tension on the scar without skin wastage. Compared with the elliptical excision method, the marginal S-shaped incision reduces the number of surgical stages and results in a cosmetically superior scar. Performing a marginal S-shaped incision is technically challenging in certain anatomical locations, such as the eyes, nose, and mouth. Therefore, it is necessary to combine this procedure with erbium:YAG and neodymium-doped:YAG ablation. (Korean J Dermatol 2019;57(9):527∼531)

KCI등재SCOUPUS

4급속소퇴성 선천혈관종 5예

저자 : 한만훈 ( Man-hoon Han ) , 정호윤 ( Ho Yun Chung ) , 이종민 ( Jong Min Lee ) , 허승 ( Seung Huh ) , 김준영 ( Jun Young Kim ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 532-537 (6 pages)

다운로드

(기관인증 필요)

초록보기

Rapidly involuting congenital hemangioma (RICH), a subtype of congenital hemangioma (CH), is fully developed at birth and undergoes rapid involution by 6-14 months of age. Clinically, this vascular lesion differs from both non-involuting CH and infantile hemangiomas. It is important to distinguish between this rare condition and other vascular lesions to ensure appropriate management (active intervention vs. non-intervention). We describe 5 patients diagnosed with RICH based on clinicopathological and/or imaging studies. Three patients showed red-stippled bluish to purplish tense plaques and two showed slightly depressed red-stippled hypopigmented rubbery patches at their initial visit. Spontaneous involution commenced shortly after birth, and complete involution occurred by 16.0±9.9 months of age. Doppler ultrasonography and magnetic resonance imaging were performed for further evaluation. Histopathological examination revealed vascular lobules of various sizes without true arteriovenous microfistulae, and thickened intra- and interlobular vessels were prominent with glucose transporter isoform-1 protein negativity. (Korean J Dermatol 2019;57(9):532∼537)

KCI등재SCOUPUS

5다수의 경부림프절과 연부조직을 동시에 침범한 두피의 랑게르한스세포육종 1예

저자 : 한만훈 ( Man-hoon Han ) , 김준영 ( Jun Young Kim ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 538-543 (6 pages)

다운로드

(기관인증 필요)

초록보기

Currently, the World Health Organization classifies Langerhans cell tumors into Langerhans cell histiocytosis and Langerhans cell sarcoma (LCS). LCS is a neoplastic proliferation of Langerhans cells showing malignant cytological features and aggressive clinical behavior with grave prognosis. Only a few cases have been reported in the available literature; therefore, to date, no definitive treatment has been established. A 64-year-old woman presented with a 1-year history of an asymptomatic, slow-growing erythematous nodule measuring 0.7 cm on her scalp. The patient also reported a 3-month history of a painful swelling on the right side of her neck. Histopathological examination of a scalp biopsy specimen revealed sheets of atypical cells with hyperchromatic nucleoli and clear cytoplasm. Immunohistochemical studies revealed malignant cells positive for CD1a, CD31, CD68, and S-100 expression. Additionally, positron emission tomography-computed tomography and fine-needle aspiration revealed LCS of the cervical lymph nodes and surrounding soft tissue. We recommended surgical excision and adjunctive chemotherapy; however, the patient refused treatment and died of the disease 28 months later. (Korean J Dermatol 2019;57(9):538∼543)

KCI등재SCOUPUS

6Eruptive Keratoacanthoma en Plaque Confirmed by Complete Spontaneous Regression: A Case Report and Review of the Literature

저자 : Seok-jong Lee , Tae In Park , Joon Soo Park , Jae Bok Jun , Hye Won Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 544-547 (4 pages)

다운로드

(기관인증 필요)

초록보기

Here we present a case of an unusual variant of keratoacanthoma, eruptive keratoacanthoma en plaque, occurring on the upper lip of a 58-year-old man. The lesion was a flesh-colored nodular plaque measuring 1.5×1.0 cm that rapidly grew within 2 months. After two biopsies, the cutaneous lesion grew more rapidly for 1 month, covering the entire cutaneous surface of the upper lip and measuring 6.0×2.0 cm. Thereafter, it disappeared without any treatment within 3 months, resulting in mild scarring with a cobblestone-like surface similar to the stereotypical involuting course of ordinary keratoacanthoma. In addition to the clinical features, the present case displayed essential diagnostic features of eruptive keratoacanthoma by showing typical spontaneous involution not reported in previous reports. Furthermore, it also revealed histopathology suggestive of squamous cell carcinoma, at least focally in addition to that of keratoacanthoma, which may evoke the potential for a misdiagnosis of malignancy. (Korean J Dermatol 2019;57(9):544∼547)

KCI등재SCOUPUS

7Severe Hyperhidrosis in Apert Syndrome: A Case Report

저자 : Hanjae Lee , Sungjun Choi , Ji Hoon Yang , Jungyoon Moon , Dae Hun Suh

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 548-550 (3 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

Apert syndrome is a rare genetic disorder characterized by malformations of the skull, face, hands, and feet. We report a case of severe hyperhidrosis in a 13-month-old female infant with Apert syndrome who was born with craniosynostosis, midface hypoplasia, and syndactyly of both hands. She had a history of excessive sweating since birth and this was confirmed using the iodine-starch test. Hyperhidrosis was first reported as a key cutaneous manifestation of Apert syndrome in 1993. However, the main focus in the field of dermatology is on antibiotic-refractory acne, which serves as another cutaneous hallmark of the disease. This is the first report in the Korean literature that describes hyperhidrosis in Apert syndrome. We highlight the presentation of hyperhidrosis as a key cutaneous manifestation in Apert syndrome. (Korean J Dermatol 2019;57(9):548∼550)

KCI등재SCOUPUS

8Lichen Planus Developed During the Treatment with Nivolumab in a Patient with Lung Cancer: A Case Report and Literature Review

저자 : Eunjung Park , Taehan Koo , Mingyul Jo , Jisook Yoo , Jiho Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 551-555 (5 pages)

다운로드

(기관인증 필요)

초록보기

Nivolumab is a fully-humanized IgG4 monoclonal antibody that competitively binds to the programmed cell death receptor-1 protein (an immune check-point molecule) present on activated T cells. Nivolumab is approved for the treatment of advanced melanoma, lung cancer, and renal cell carcinoma. It attenuates the inactivation of cytotoxic CD8+ T cells and, produces an antitumor effect; however it may be associated with immune-related adverse events, including the development of lichen planus (LP). A 72-year-old man presented with a 2-month history of multiple, polygonal, purplish papules on the dorsal aspect of both hands. He was diagnosed with large cell neuroendocrine carcinoma (LCNEC) of the lung 4 years earlier and was treated with nivolumab (3 mg/kg every 2 weeks) for 9 months. By the 14th course of nivolumab therapy, the patient developed multiple rashes on the dorsal aspect of both hands, and biopsy was consistent with findings of LP. We report a rare case of LP in a patient with lung cancer treated with nivolumab. (Korean J Dermatol 2019;57(9):551∼555)

KCI등재SCOUPUS

9광선 치료 후 박탈피부염으로 진행된 농포건선 1예

저자 : 박수정 ( Su Jung Park ) , 정국진 ( Guk Jin Jeong ) , 홍준기 ( Jun Ki Hong ) , 서성준 ( Seong Jun Seo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 556-557 (2 pages)

다운로드

(기관인증 필요)

초록보기

KCI등재SCOUPUS

10Oxybutynin 치료에 상반된 반응을 보인 국소 다한증: 증례 보고

저자 : 김민성 ( Min Sung Kim ) , 배인호 ( In Ho Bae ) , 최훈 ( Hoon Choi ) , 나찬호 ( Chan Ho Na ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 558-559 (2 pages)

다운로드

(기관인증 필요)

초록보기
123
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기