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대한피부과학회> 대한피부과학회지> 급속소퇴성 선천혈관종 5예

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급속소퇴성 선천혈관종 5예

Rapidly Involuting Congenital Hemangioma: Five Case Reports

한만훈 ( Man-hoon Han ) , 정호윤 ( Ho Yun Chung ) , 이종민 ( Jong Min Lee ) , 허승 ( Seung Huh ) , 김준영 ( Jun Young Kim ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee )
  • : 대한피부과학회
  • : 대한피부과학회지 57권9호
  • : 연속간행물
  • : 2019년 11월
  • : 532-537(6pages)
대한피부과학회지

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Rapidly involuting congenital hemangioma (RICH), a subtype of congenital hemangioma (CH), is fully developed at birth and undergoes rapid involution by 6-14 months of age. Clinically, this vascular lesion differs from both non-involuting CH and infantile hemangiomas. It is important to distinguish between this rare condition and other vascular lesions to ensure appropriate management (active intervention vs. non-intervention). We describe 5 patients diagnosed with RICH based on clinicopathological and/or imaging studies. Three patients showed red-stippled bluish to purplish tense plaques and two showed slightly depressed red-stippled hypopigmented rubbery patches at their initial visit. Spontaneous involution commenced shortly after birth, and complete involution occurred by 16.0±9.9 months of age. Doppler ultrasonography and magnetic resonance imaging were performed for further evaluation. Histopathological examination revealed vascular lobules of various sizes without true arteriovenous microfistulae, and thickened intra- and interlobular vessels were prominent with glucose transporter isoform-1 protein negativity. (Korean J Dermatol 2019;57(9):532∼537)

UCI(KEPA)

I410-ECN-0102-2021-500-000122719

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9717


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60권7호(2022년 08월) 수록논문
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KCI등재 SCOPUS

1건선 치료 후 피부 병변에서 Th1과 Th17 염증성 사이토카인의 변화

저자 : 박효진 ( Hyo Jin Park ) , 장현준 ( Hyun Joon Chang ) , 김태근 ( Tae Geun Kim ) , 권미연 ( Mi Yeon Kwon ) , 임채윤 ( Chae Yoon Lim ) , 주현정 ( Hyun Jeong Ju ) , 이경호 ( Kyung Ho Lee ) , 박철종 ( Chul Jong Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 409-413 (5 pages)

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Background: Psoriasis is a T cell-mediated disorder. Appropriate treatment of psoriasis can result in a plethora of dynamic changes in the T cells and their cytokine production. Studies on the expression of Th1 and Th17 inflammatory cytokines after various treatments have reported inconsistent results.
Objective: This study aimed to investigate the changes in inflammatory cytokine expression in psoriasis skin lesions before and after psoriasis treatment.
Methods: Five patients with plaque psoriasis were enrolled in the study. The tissue mRNA and protein levels of interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22 in psoriatic skin lesions before and after psoriasis treatment were detected using real-time polymerase chain reaction and immunohistochemical staining, respectively.
Results: The decrease in the psoriasis area and severity index was accompanied by a reduction in IL-12 and IL-23 mRNA levels and a concomitant reduction of IL-2 and IL-17A protein levels in psoriasis skin lesions. Both mRNA and protein levels of IFN-γ in psoriatic skin lesions increased after treatment.
Conclusion: The mRNA levels of tissue inflammatory cytokines (IL-12 and IL-23) and the protein levels of tissue inflammatory cytokines (IL-2 and IL-17A) significantly decreased after psoriasis treatment. The mRNA and protein levels of IFN-γ increased, even after psoriasis treatment. (Korean J Dermatol 2022;60(7):409∼413)

KCI등재 SCOPUS

2구순열 수술 후 흉터를 가진 영유아 환자에서 흉터 복합 레이저요법의 효과 및 안전성에 대한 단일 기관, 후향적 연구

저자 : 이주희 ( Joo Hee Lee ) , 최수연 ( Sooyeon Choi ) , 김제민 ( Jemin Kim ) , 이영인 ( Young In Lee ) , 이주희 ( Ju Hee Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 414-419 (6 pages)

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Background: Postoperative scars following cleft lip surgery are frequently accompanied by cosmetic and functional problems; therefore, patients with cleft lip scars usually undergo various long-term scar treatment courses. Currently, only a limited number of fractional laser treatment cases of cleft lip scars have been reported.
Objective: This study aimed to evaluate the safety and efficacy of the combination laser treatment for hypertrophic scar management following cleft lip surgery.
Methods: This single-center retrospective study included 27 patients who underwent cleft lip surgery before 12 months of age. The control group comprising 13 patients received only a silicone gel or sheet for the scars, while the treatment group comprising 14 patients underwent laser treatment with a 1,550 nm non-ablative fractional erbium-glass laser, followed by a 10,600 nm ablative fractional carbon dioxide laser. Intralesional triamcinolone injection (5∼10 mg/mL) was administered immediately after laser treatment. Scar improvement was assessed at 1, 3, and 6 months after surgery using the Vancouver Scar Scale.
Results: The mean total Vancouver scar scale showed a statistically significant improvement in the treatment group compared to that in the control group. In the sub-analysis of pigmentation, the vascularity, pliability, and height significantly improved in the treatment group. No differences in the patients' baseline characteristics between the two groups were noted. No significant adverse effects were observed during the follow-up.
Conclusion: Combination laser therapy using fractional lasers and intralesional triamcinolone injection is safe and effective for managing cleft lip surgery scars in infantile patients. (Korean J Dermatol 2022;60(7):414∼419)

KCI등재 SCOPUS

3중등증 및 중증 한국인 건선 환자에서 생물학제제 변경 양상과 효과에 대한 분석

저자 : 이수민 ( Su Min Lee ) , 고병창 ( Byeong Chang Ko ) , 안상우 ( Sang Woo Ahn ) , 어지안 ( Ji An Uh ) , 설정은 ( Jung Eun Seol ) , 김효진 ( Hyojin Kim ) , 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee ) , 박소희 ( So Hee Park ) , 정소영 ( So Young Jung ) , 박혜진 (

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 420-428 (9 pages)

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Background: Biologics-experienced patients are more likely to show a lower response to biologics than that of biologic-naïve patients. However, no consensus on switching biologics exists.
Objective: We aimed to investigate the switching patterns and efficacy of the switched biologics in patients with moderate-to-severe psoriasis in actual clinical practice.
Methods: This multicenter retrospective study included 37 patients with a history of switching biologics. We analyzed the reasons for switching, the switching patterns, and psoriasis area and severity index (PASI) 75 response rates after switching biologics. We also analyzed the factors affecting the PASI75 response rate to the second biologic.
Results: The reasons for switching baseline biologics were primary failure in five patients (13.5%), secondary failure in 28 patients (75.7%), and adverse events in four patients (10.8%). The second biologics prescribed mostly include interleukin (IL)-23 inhibitor in twenty-four patients (64.9%), IL-17 inhibitor in eight patients (21.6%), tumor necrosis factor-α inhibitor in three patients (8.1%), and IL-12/23 inhibitor in two patients (5.4%). A total of 46% of patients (17/37) switched biologics from IL-12/23 inhibitors to IL-23 inhibitors. The PASI75 response rates at the primary endpoint of the second and third biologics were 89.2% and 88.8%, respectively. Our study found that female sex and obesity were associated with the primary failure of the second biologic.
Conclusion: Secondary failure was the most common reason for switching baseline biologics. Korean dermatologists prefer different classes of biologics while switching. The PASI75 response rates at the primary endpoints of the second and third biologics were relatively satisfactory. (Korean J Dermatol 2022;60(7):420∼428)

KCI등재 SCOPUS

4녹색손발톱증후군의 임상적 특징에 대한 연구

저자 : 이기욱 ( Gi-wook Lee ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byungsoo Kim ) , 김문범 ( Moon-bum Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 429-435 (7 pages)

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Background: Green nail syndrome (GNS) is characterized by a greenish discoloration of the nail with accompanying nail apparatus disorders, such as onycholysis or paronychia. To date, data on the clinical characteristics of GNS are limited, especially in Korea.
Objective: This study aimed to investigate the clinical characteristics of GNS.
Methods: We retrospectively reviewed the medical records and clinical photographs of 78 patients with 91 GNS lesions diagnosed at the Pusan National University Hospitals (Busan and Yangsan) from 2009 to 2021.
Results: Among 78 patients, 47 (60.3%) were female and 31 male (39.7%), with a mean age of 53.1 years (23∼82 years). This study included 56 fingernail (61.5%) and 35 toenail lesions (38.5%). Thumbnails and great toenails were the most common site, with 62 lesions (68.1%). Most patients presented predisposing conditions, such as frequent exposure to wet conditions (55.1%), immunosuppressive conditions (26.9%), and trauma history (29.5%). The most common colors, shapes, and eccentricities of GNS were blackish-green (31.9%), reverse triangle (53.8%), and distal eccentricity (42.9%), respectively. The GNS was accompanied by various nail diseases that mostly (80.2%) preceded the syndrome, and onycholysis was the most common (83.5%). Based on the involvement of the nail surface or subsurface, GNS can be divided into the superficial (15.4%), subungual (73.6%), and mixed (11.0%) subtypes, each of which shows different clinical features, such as multiplicity, color, shape, and eccentricity.
Conclusion: This is the largest-scale study showing the clinical characteristics of GNS and can be helpful for dermatologists who usually and primarily treat GNS. (Korean J Dermatol 2022;60(7):429∼435)

KCI등재 SCOPUS

5국소 안면 진피 이형성증 3형: Setleis 증후군

저자 : 신준오 ( Jun-oh Shin ) , 배경남 ( Kyung-nam Bae ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byungsoo Kim ) , 김문범 ( Moon-bum Kim ) , 신기혁 ( Kihyuk Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 436-439 (4 pages)

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Setleis syndrome, also known as the focal facial dermal dysplasia type 3, is characterized by atrophic scar-like lesions in both the temporal regions and other facial abnormalities. The syndrome is associated with a mutation in the TWIST2 gene and is inherited as an autosomal recessive pattern. Here, we describe a case of an 18-year-old woman and her 10-year-old brother with bitemporal depressed patches. The lesions were observed at birth, but they were replaced by atrophic patches after several months. No abnormalities in growth or development were observed. Histopathologic findings showed atrophy of the epidermis and loss of appendages, such as hair follicles and adnexal glands, in the atrophic patches compared to that of the adjacent normal skin. (Korean J Dermatol 2022;60(7):436∼ 439)

KCI등재 SCOPUS

6A Case of Locally Recurring Multiple Fibrocollagenous Dermatofibromas on the Forearm

저자 : Sang-min Choi , Bark-lynn Lew , Woo-young Sim , Soon-hyo Kwon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 440-443 (4 pages)

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Dermatofibroma (DF) is one of the most common benign soft tissue tumors. Various histological variants of DF have been described, and it is important to discern the different variants to evaluate the prognosis. A 43-year-old female patient with no specific medical history presented with multiple brown-colored nodules on the right arm for 5 years. Biopsy specimens showed a predominance of collagen and fibroblasts in a whorled arrangement with moderate cellularity, findings that were consistent with fibrocollagenous DF. The patient underwent excision of the largest lesion and revisited our department 3 months after surgery with local recurrence at the excision site. We report a rare case of multiple fibrocollagenous DF with local recurrence at the excision site. (Korean J Dermatol 2022;60(7):440∼443)

KCI등재 SCOPUS

7Two Case Reports of Leukocytoclastic Vasculitis after ChAdOx1 nCoV-19 Vaccine

저자 : Hae Eun Park , Ju Hee Han , Yeong Ho Kim , Ji Hyun Lee , Young Min Park , Hwa Young Lee , Chul Hwan Bang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 444-448 (5 pages)

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Leukocytoclastic vasculitis after the BNT162b2 vaccine and ChAdOx1 nCoV-19 Corona Virus vaccine [recombinant] has been observed. Herein, we report two cases of leukocytoclastic vasculitis that developed after the ChAdOx1-S [recombinant] vaccination. A 61-year-old and a 52-year-old woman presented with pruritic purpuric macules and papules on both lower legs. The patients had been vaccinated with the ChAdOx1-S [recombinant] vaccine. The histopathological analyses were consistent with a diagnosis of leukocytoclastic vasculitis. They were treated with oral prednisolone and improved within 1 month of treatment. We assume that the rash had arisen from the deposition of spike protein at the skin tissue induced by the viral vector of the COVID-19 vaccine or hyperimmune responses by excipients present in vaccine preparations. To our knowledge, our cases would be the first Korean cases of leukocytoclastic vasculitis after the ChAdOx1-S [recombinant] vaccination. (Korean J Dermatol 2022;60(7):444∼ 448)

KCI등재 SCOPUS

8입술에 발생한 색소성 스피츠 모반 1예

저자 : 어지안 , 김중호 , 이재호 , 이수경 , 김명신 , 이운하

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 449-450 (2 pages)

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9BNT162b2 mRNA COVID-19 백신 접종 후 발생한 동창 모양의 피부병변 1예

저자 : 윤지상 , 배경남 , 손진화 , 김훈수 , 고현창 , 김병수 , 김문범 , 신기혁

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 451-452 (2 pages)

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10약 20년간 지속된 림프부종에서 기인한 스튜어트-트리브스 증후군(Stewart-Treves Syndrome) 1예

저자 : 권혁진 , 유동화 , 박경덕 , 김기호 , 윤정호

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 7호 발행 연도 : 2022 페이지 : pp. 453-454 (2 pages)

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1두피 건선 환자의 삶의 질에 미치는 국소 스테로이드제 단독 요법과 경구 사이클로스포린 병합 요법의 효과 비교

저자 : 김민수 ( Minsu Kim ) , 양승걸 ( Seungkeol Yang ) , 김보리 ( Bo Ri Kim ) , 윤상웅 ( Sang Woong Youn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 513-518 (6 pages)

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Background: Scalp psoriasis severely affects patients' quality of life, and patients may occasionally be refractory to topical steroid application. Although systemic therapy combined with topical steroid application is recommended for treatment-resistant scalp psoriasis, previous research has not reported whether such combination treatment improves patients' quality of life.
Objective: This study investigated whether combination therapy using oral cyclosporine and topical steroid reduces the severity of scalp psoriasis and improves patients' quality of life compared with the use of topical steroid alone.
Methods: The study included 23 patients with scalp psoriasis who were categorized as patients who received topical steroid therapy alone vs. those who received combination therapy with topical steroid and oral cyclosporine for 12 weeks. The severity of psoriasis and quality of life were evaluated at 4, 8, and 12 weeks of treatment.
Results: No significant improvement was observed in the severity of psoriasis or in patients' quality of life during the treatment period in patients receiving topical steroid alone. Patients treated with a combination of topical steroid and oral cyclosporine showed a reduction in the severity of psoriasis from the 4th week of treatment and their quality of life improved from the 12th week of treatment.
Conclusion: Combination therapy with oral cyclosporine and topical steroid may reduce the severity of scalp psoriasis and improve patients' quality of life. (Korean J Dermatol 2019;57(9):513∼518)

KCI등재SCOUPUS

2재발성 카포시수두양발진의 임상적 특징과 유발요인에 대한 분석

저자 : 배경남 ( Kyung-nam Bae ) , 김태욱 ( Taewook Kim ) , 박성민 ( Sungmin Park ) , 이현주 ( Hyun Joo Lee ) , 진현주 ( Hyunju Jin ) , 유향석 ( Hyangsuk You ) , 심우행 ( Woo-haing Shim ) , 김건욱 ( Gun-wook Kim ) , 김훈수 ( Hoon-soo Kim ) , 고현창 ( Hyun-chang Ko ) , 김병수 ( Byung Soo Kim ) , 김

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 519-526 (8 pages)

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Background: Kaposi varicelliform eruption (KVE) is a disseminated viral infection primarily caused by the herpes simplex virus in the setting of an underlying chronic skin disease. Few studies have reported the clinical characteristics and predisposing factors for recurrent KVE.
Objectives: To characterize the clinical features and predisposing factors for recurrent KVE.
Methods: This retrospective comparative study of recurrent vs. single-episode KVE was performed at the Pusan National University Hospital between 2004 and 2017.
Results: A total of 84 episodes occurred in 60 patients, and of these, 13 patients developed recurrence (21.7%). No statistically significant intergroup difference was observed in the mean age and sex distribution. The face was the most common site of involvement in both groups, followed by the trunk and the upper and lower extremities. Atopic dermatitis was the most common pre-existing disease in both groups; however, Darier's disease was more common in the recurrent KVE group, and this difference was statistically significant. Most patients with KVE (66.7%) showed aggravation of the underlying skin disease within 3 months of KVE onset. This finding was more prominent in patients with recurrent episodes (91.7%) than in those with single-episode KVE (58.3%), (p=0.040).
Conclusion: This study can contribute to a better understanding of recurrent KVE and guide clinicians in treating patients with conditions predisposing to KVE. (Korean J Dermatol 2019;57(9):519∼526)

KCI등재SCOUPUS

3Clinical Analysis of Serial (Staged) Excision for Congenital Melanocytic Nevi: A Single-center Experience

저자 : Min Young Lee , Ji Yeon Byun , Kyu Kwang Whang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 527-531 (5 pages)

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Background: Serial (staged) excision of congenital melanocytic nevi (CMN) is an important treatment option for medium-sized CMN. However, few studies have investigated the outcomes of serial excision in detail.
Objective: We report our experience regarding serial excision of CMN, including methods to effectively reduce the procedural stages and scar length. Methods: We retrospectively reviewed medical records of patients with CMN treated between 2008 and 2015; 33 patients (7 men and 26 women) underwent serial excision.
Results: The CMN were located on the face (n=11), arms (n=6), legs (n=11), and other areas of the body (n=11), including the back (n=2), chest (n=1), deltoid region (n=1), and buttocks (n=1). The mean CMN area was 19.7 cm2. The mean number of surgical stages was 2.2. The mean interval between surgeries was 10.6 months. A marginal S-shaped incision along both edges of the nevus was preferred over elliptical excision, to reduce scarring. Pulsed dye, erbium:yttrium-aluminum-garnet (YAG), neodymium-doped:YAG, and carbon dioxide fractional lasers were used to improve the final outcomes and minimize scarring.
Conclusion: Serial excision is an effective treatment option associated with greater patient satisfaction, particularly for medium-sized and hairy CMN. Conventional elliptical serial excision is associated with the formation of elongated scars and sacrifices normal skin adjacent to the lesion. The marginal S-shaped incision reduces scarring by dispersing mechanical tension on the scar without skin wastage. Compared with the elliptical excision method, the marginal S-shaped incision reduces the number of surgical stages and results in a cosmetically superior scar. Performing a marginal S-shaped incision is technically challenging in certain anatomical locations, such as the eyes, nose, and mouth. Therefore, it is necessary to combine this procedure with erbium:YAG and neodymium-doped:YAG ablation. (Korean J Dermatol 2019;57(9):527∼531)

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4급속소퇴성 선천혈관종 5예

저자 : 한만훈 ( Man-hoon Han ) , 정호윤 ( Ho Yun Chung ) , 이종민 ( Jong Min Lee ) , 허승 ( Seung Huh ) , 김준영 ( Jun Young Kim ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 532-537 (6 pages)

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Rapidly involuting congenital hemangioma (RICH), a subtype of congenital hemangioma (CH), is fully developed at birth and undergoes rapid involution by 6-14 months of age. Clinically, this vascular lesion differs from both non-involuting CH and infantile hemangiomas. It is important to distinguish between this rare condition and other vascular lesions to ensure appropriate management (active intervention vs. non-intervention). We describe 5 patients diagnosed with RICH based on clinicopathological and/or imaging studies. Three patients showed red-stippled bluish to purplish tense plaques and two showed slightly depressed red-stippled hypopigmented rubbery patches at their initial visit. Spontaneous involution commenced shortly after birth, and complete involution occurred by 16.0±9.9 months of age. Doppler ultrasonography and magnetic resonance imaging were performed for further evaluation. Histopathological examination revealed vascular lobules of various sizes without true arteriovenous microfistulae, and thickened intra- and interlobular vessels were prominent with glucose transporter isoform-1 protein negativity. (Korean J Dermatol 2019;57(9):532∼537)

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5다수의 경부림프절과 연부조직을 동시에 침범한 두피의 랑게르한스세포육종 1예

저자 : 한만훈 ( Man-hoon Han ) , 김준영 ( Jun Young Kim ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 538-543 (6 pages)

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Currently, the World Health Organization classifies Langerhans cell tumors into Langerhans cell histiocytosis and Langerhans cell sarcoma (LCS). LCS is a neoplastic proliferation of Langerhans cells showing malignant cytological features and aggressive clinical behavior with grave prognosis. Only a few cases have been reported in the available literature; therefore, to date, no definitive treatment has been established. A 64-year-old woman presented with a 1-year history of an asymptomatic, slow-growing erythematous nodule measuring 0.7 cm on her scalp. The patient also reported a 3-month history of a painful swelling on the right side of her neck. Histopathological examination of a scalp biopsy specimen revealed sheets of atypical cells with hyperchromatic nucleoli and clear cytoplasm. Immunohistochemical studies revealed malignant cells positive for CD1a, CD31, CD68, and S-100 expression. Additionally, positron emission tomography-computed tomography and fine-needle aspiration revealed LCS of the cervical lymph nodes and surrounding soft tissue. We recommended surgical excision and adjunctive chemotherapy; however, the patient refused treatment and died of the disease 28 months later. (Korean J Dermatol 2019;57(9):538∼543)

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6Eruptive Keratoacanthoma en Plaque Confirmed by Complete Spontaneous Regression: A Case Report and Review of the Literature

저자 : Seok-jong Lee , Tae In Park , Joon Soo Park , Jae Bok Jun , Hye Won Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 544-547 (4 pages)

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Here we present a case of an unusual variant of keratoacanthoma, eruptive keratoacanthoma en plaque, occurring on the upper lip of a 58-year-old man. The lesion was a flesh-colored nodular plaque measuring 1.5×1.0 cm that rapidly grew within 2 months. After two biopsies, the cutaneous lesion grew more rapidly for 1 month, covering the entire cutaneous surface of the upper lip and measuring 6.0×2.0 cm. Thereafter, it disappeared without any treatment within 3 months, resulting in mild scarring with a cobblestone-like surface similar to the stereotypical involuting course of ordinary keratoacanthoma. In addition to the clinical features, the present case displayed essential diagnostic features of eruptive keratoacanthoma by showing typical spontaneous involution not reported in previous reports. Furthermore, it also revealed histopathology suggestive of squamous cell carcinoma, at least focally in addition to that of keratoacanthoma, which may evoke the potential for a misdiagnosis of malignancy. (Korean J Dermatol 2019;57(9):544∼547)

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7Severe Hyperhidrosis in Apert Syndrome: A Case Report

저자 : Hanjae Lee , Sungjun Choi , Ji Hoon Yang , Jungyoon Moon , Dae Hun Suh

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 548-550 (3 pages)

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Apert syndrome is a rare genetic disorder characterized by malformations of the skull, face, hands, and feet. We report a case of severe hyperhidrosis in a 13-month-old female infant with Apert syndrome who was born with craniosynostosis, midface hypoplasia, and syndactyly of both hands. She had a history of excessive sweating since birth and this was confirmed using the iodine-starch test. Hyperhidrosis was first reported as a key cutaneous manifestation of Apert syndrome in 1993. However, the main focus in the field of dermatology is on antibiotic-refractory acne, which serves as another cutaneous hallmark of the disease. This is the first report in the Korean literature that describes hyperhidrosis in Apert syndrome. We highlight the presentation of hyperhidrosis as a key cutaneous manifestation in Apert syndrome. (Korean J Dermatol 2019;57(9):548∼550)

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8Lichen Planus Developed During the Treatment with Nivolumab in a Patient with Lung Cancer: A Case Report and Literature Review

저자 : Eunjung Park , Taehan Koo , Mingyul Jo , Jisook Yoo , Jiho Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 551-555 (5 pages)

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Nivolumab is a fully-humanized IgG4 monoclonal antibody that competitively binds to the programmed cell death receptor-1 protein (an immune check-point molecule) present on activated T cells. Nivolumab is approved for the treatment of advanced melanoma, lung cancer, and renal cell carcinoma. It attenuates the inactivation of cytotoxic CD8+ T cells and, produces an antitumor effect; however it may be associated with immune-related adverse events, including the development of lichen planus (LP). A 72-year-old man presented with a 2-month history of multiple, polygonal, purplish papules on the dorsal aspect of both hands. He was diagnosed with large cell neuroendocrine carcinoma (LCNEC) of the lung 4 years earlier and was treated with nivolumab (3 mg/kg every 2 weeks) for 9 months. By the 14th course of nivolumab therapy, the patient developed multiple rashes on the dorsal aspect of both hands, and biopsy was consistent with findings of LP. We report a rare case of LP in a patient with lung cancer treated with nivolumab. (Korean J Dermatol 2019;57(9):551∼555)

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9광선 치료 후 박탈피부염으로 진행된 농포건선 1예

저자 : 박수정 ( Su Jung Park ) , 정국진 ( Guk Jin Jeong ) , 홍준기 ( Jun Ki Hong ) , 서성준 ( Seong Jun Seo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 556-557 (2 pages)

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10Oxybutynin 치료에 상반된 반응을 보인 국소 다한증: 증례 보고

저자 : 김민성 ( Min Sung Kim ) , 배인호 ( In Ho Bae ) , 최훈 ( Hoon Choi ) , 나찬호 ( Chan Ho Na ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 57권 9호 발행 연도 : 2019 페이지 : pp. 558-559 (2 pages)

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