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대한피부과학회> 대한피부과학회지> Prevalence of Onychomycosis in Korea over 10 Years (2006∼2015)

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Prevalence of Onychomycosis in Korea over 10 Years (2006∼2015)

Ji Hyun Lee , Kyung Do Han , Hyo Jung Kim , Ju Hee Han , Hyun Min Seo , Chul Hwan Bang , Jun Young Lee , Young Min Park
  • : 대한피부과학회
  • : 대한피부과학회지 56권10호
  • : 연속간행물
  • : 2018년 12월
  • : 655-657(3pages)
대한피부과학회지

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UCI(KEPA)

I410-ECN-0102-2019-500-001590874

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  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9620


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1두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

저자 : 손우리 ( Uri Shon ) , 염규진 ( Kyujin Yeom ) , 윤대관 ( Dea Kwan Yun ) , 김명화 ( Myung Hwa Kim ) , 최미수 ( Mi Soo Choi ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 735-741 (7 pages)

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Background: Basal cell carcinoma (BCC) is the most common type of skin cancer. However, limited comparative data on the characteristics and prognosis of BCC in the H-zone and non-H-zone exist.
Objective: We aimed to compare the clinical, histopathological, and surgical characteristics of BCCs in the head and neck region between the H- and non-H-zones.
Methods: We retrospectively reviewed the clinical and histopathological characteristics of 292 head and neck BCC lesions in 275 patients and the characteristics of Mohs micrographic surgery (MMS) of 252 BCC lesions in 239 patients.
Results: In the H-zone, 226 lesions (77.4%) were found. Clinically, patients with H-zone BCC, compared to those with non-H-zone, were significantly older (71.6±11.4 years vs. 64.6±13.5 years) and smaller in diameter (10.1±7.1 mm vs. 12.4±9.9 mm). The noduloulcerative type was more frequent in the H-zone, while the superficial and morpheaform types in the non-H-zone. Histopathologically, the infiltrative subtype was particularly noted in the H-zone than the non-H-zone (7.5% vs. 1.5%). Out of 37 BCC patients with prior treatment history, 31 (83.8%) were in the H-zone. Two out of 252 lesions (0.8%) recurred after MMS at our institution. The mean stages of MMS were comparable between the H- and non-H-zones (1.59 vs. 1.45, p=0.135).
Conclusion: H-zone BCCs were associated with older age and smaller tumor size compared to the non-H-zone BCCs. The noduloulcerative clinical and nodulocystic pathologic subtypes were the most common in both H-zone and non-H-zone BCCs. (Korean J Dermatol 2021;59(10):735∼741)

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2수지점액낭종 환자에서 유형 및 치료 반응에 대한 후향적 연구

저자 : 정준우 ( Joon Woo Jung ) , 홍은혜 ( Eun Hye Hong ) , 백은주 ( Eun Joo Baek ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 742-748 (7 pages)

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Background: Digital mucous cysts (DMCs) are benign, occurring mainly on the fingers but rarely on the toes. Although the exact cause of DMC has not been identified, it is classified into two different types based on its pathogenesis and location. Surgical and nonsurgical procedures, including aspiration, sclerotherapy, steroid injection, cryotherapy, and CO2 laser, can be used to treat DMC.
Objective: This study aimed to compare treatment response based on DMC type and evaluate its efficacy in surgical and nonsurgical (sclerotherapy) treatments.
Methods: We retrospectively reviewed the electronic medical records of patients with DMC who visited our dermatology department between January 2010 and November 2020.
Results: This study enrolled 39 patients having a mean age of 59.2 years. The proportion of female patients (21/39, 53.8%) was more than male (18/39, 46.2%). The DMC occurrence was more frequent in the fingers (32/39, 82.1%), especially in the index and middle fingers than in the toes (7/39, 17.9%). In sclerotherapy, DMC in the distal interphalangeal joint (DIPJ) required more treatment than that in the proximal nail fold (PNF) (p<0.05). The number of treatments using sclerotherapy was higher compared to that of surgical treatments (p<0.05).
Conclusion: The DIPJ type of DMC patients was more difficult to treat using sclerotherapy than the PNF type. Moreover, surgical treatment has a better response than sclerotherapy. (Korean J Dermatol 2021;59(10):742∼748)

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3혈청 비타민 D 레벨 및 혈중 지질 농도와 건선: 단일 3차 의료기관에 내원한 한국인 건선 환자를 대상으로 한 임상적 고찰

저자 : 박현정 ( Hyeon Jeong Park ) , 이현주 ( Heun Joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 749-760 (12 pages)

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Background: Psoriasis is a chronic inflammatory autoimmune disease. Some studies have demonstrated a relationship of psoriasis with vitamin D (Vit D) deficiency or serum lipid levels.
Objective: We aimed to compare serum levels of Vit D and lipids in patients with active psoriasis and control subjects. Additionally, we analyzed the relationship of disease severity with serum Vit D and lipid levels.
Methods: A total of 243 patients were retrospectively analyzed. Statistical data were evaluated, and the values were considered significant at p<0.05.
Results: Statistically significant difference in Vit D levels between the psoriasis (n=117) and the control groups (n=126) was not found. In addition, an association between Vit D levels and the disease severity, using the psoriasis area and severity index (PASI) was not observed. The proportion of overweight patients (body mass index [BMI]≥ 23 kg/m2) was higher in the psoriasis group than in the control group, and there was a significant relationship between the increase in PASI and the serum triglycerides (TG) levels (p<0.05).
Conclusion: The psoriasis and control groups did not show a statistical difference in serum Vit D levels. In the subgroup analysis of cases with normal BMI, excluding the underlying disease, no significant difference in Vit D levels between the two groups was observed. However, the association of psoriasis with factors, such as BMI and TG, was found to be significant; hence, these could be therapeutic targets in patients with psoriasis to improve their quality of life. Controlled and well-designed studies are required in the future. (Korean J Dermatol 2021;59(10):749∼760)

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4박피 레이저 치료 후 발생하는 염증 후 홍반과 색소 침착에 대한 표피 성장 인자 함유 연고의 효과에 관한 연구

저자 : 송창화 ( Chang Hwa Song ) , 정유진 ( You Jin Jung ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro ) , 김정은 ( Jeong Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 761-769 (9 pages)

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Background: Epidermal growth factor (EGF) stimulates wound healing in various skin conditions, and EGFcontaining formulations can promote wound regeneration and help reduce complications after laser treatment.
Objective: To evaluate the effect of EGF-containing ointment on wound regeneration after ablative laser treatment and laser-induced postinflammatory erythema (PIE) and hyperpigmentation (PIH).
Methods: Twenty-five patients who required treatment with ablative laser on both sides of the face were enrolled and underwent one session of laser treatment. Postoperatively, all patients were instructed to apply the EGFcontaining ointment on the randomly assigned-hemifacial side, while gentamicin cream was applied on the opposite side. Investigators' global assessment (IGA), evaluating general wound condition, erythema, pigmentation, and scab shedding, and patient's global assessment (PGA), evaluating patient satisfaction with clinical improvement, were both measured at 1 week and 4 weeks after treatment. Objective assessments, including melanin index (MI), erythema index (EI), skin hydration, and transepidermal water loss (TEWL), were measured before treatment and at 1 week and 4 weeks after treatment.
Results: The EGF-containing ointment showed better outcomes with IGA (1 week; p=0.02, 4 weeks; p=0.002) and PGA (1 week; p=0.04, 4 weeks; p=0.01) scores compared to gentamicin cream. Compared to gentamicin cream, treatment with EGF-containing ointment resulted in significantly lower EI (p=0.044) and MI (p=0.023), but skin hydration and TEWL between the two groups exhibited nonsignificant differences.
Conclusion: EGF-containing ointment could be an effective adjuvant option for wound regeneration after ablative laser treatment and minimizing laser-induced PIE and PIH in Asian patients. (Korean J Dermatol 2021;59(10):761∼769)

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5The Efficacy of Skin Care Habit Modifications on the Skin Barrier Function in Rosacea Patients

저자 : Jung Eun Seol , Gyeong Je Cho , Sang Woo Ahn , Seong Min Hong , So Hee Park , So Young Jung , Hyojin Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 770-777 (8 pages)

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Background: Patients with rosacea usually suffer from skin irritations, such as itching, stinging, burning, and pain. These symptoms may be related to the skin barrier function disruption.
Objective: We investigated the skin barrier functions in patients with mild to moderate rosacea and the associated improvements based on the skin care habit modifications and treatment modalities.
Methods: We analyzed the data on transepidermal water loss (TEWL) and stratum corneum hydration (SCH) of skin lesions in 27 patients with rosacea and healthy skin of 29 control subjects. We compared the results of TEWL and SCH based on sex, age, type of rosacea, skin care habits, and the treatment modalities.
Results: The skin in the patients with rosacea exhibited increased TEWL and decreased SCH compared with that in control subjects. Male patients showed increased TEWL and decreased SCH compared to female patients. Combination therapy with systemic minocycline and topical metronidazole improved the skin barrier functions. Patients with better skin care habits presented better skin barrier functions and clinical improvement.
Conclusion: Patients with rosacea, especially those with poor skin care habits, showed reduced skin barrier functions. Appropriate skin care habits with cleansers and moisturizers are recommended for the management of rosacea. (Korean J Dermatol 2021;59(10):770∼777)

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6A Clinical Study of Trichotillomania in 198 Cases: An Update and Cross-Time Comparison

저자 : Ji-hoon Lim , Ki-hun Kim , Soon-hyo Kwon , Woo-young Sim , Bark-lynn Lew

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 778-784 (7 pages)

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Background: Trichotillomania (TTM) is characterized by recurrent hair pulling, resulting in hair loss. TTM is typically encountered in dermatology settings; however, few reports on the clinical characteristics of TTM in a large population are available.
Objective: To evaluate the clinical characteristics of TTM.
Methods: We performed a retrospective chart review of patients diagnosed with TTM between 2006 and 2019.
Results: Clinical records of 198 patients were analyzed. The average age of TTM onset was 10.8 years, and 119 patients experienced childhood-onset (at <12 years). Sex prevalence showed a female predominance, and the proportion of females was lower in the childhood-onset TTM than in the late-onset TTM (onset at ≥12 years). Vertex was the most commonly involved site. A history of stressful situations was noted in 48 patients (24.2%). In the group with a poor prognosis, the number of patients with ≥25% scalp invasion was significantly more than the other group. The average duration of hair loss to more than 50% recovery was 4.88 months for childhood-onset TTM cases and 9.83 months for late-onset TTM cases. The prognosis was significantly better in the childhood-onset TTM than in the late-onset TTM. Nail biting and folliculitis were the most common co-occurring repetitive behavior and comorbid disease, respectively.
Conclusion: Unlike previous domestic studies, patients with childhood-onset TTM had a female preponderance. Moreover, the proportion of patients who experienced a stressful situation was higher than that reported in a previous study. In addition, patients with severe disease and late-onset TTM had a significantly poorer prognosis. (Korean J Dermatol 2021;59(10):778∼784)

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7Port-Wine Stains Confined to a Single Cosmetic Unit than on Multiple Cosmetic Units Respond Better to Pulsed Dye Laser Treatment: A Retrospective Study

저자 : Gyoo Huh , Jin Seop Kim , Heun Joo Lee , Young-jun Choi , Ga-young Lee , Won-serk Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 785-792 (8 pages)

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Background: Cosmetic units are designated based on their similarity in topographic anatomy, texture and color, solar exposure, hair density, and sebaceous features. The difference of such features in facial port-wine stain (PWS) cases can affect the response to pulsed dye laser (PDL) treatment.
Objective: To evaluate the response of facial PWS to PDL treatment based on the underlying cosmetic units.
Methods: A retrospective study was conducted on 18 patients with facial PWS who received PDL treatment. For clinical assessment, three dermatologists evaluated the photographs taken before each treatment session. The response grade was assigned according to the quartile grading scale. The lesion was classified based on the underlying cosmetic units.
Results: The cheek was the most (50%) commonly involved area. All PWS (6/6) confined to one cosmetic unit showed a marked improvement compared with 16% PWS (2/12) affecting two or more units (p<0.05). Patients with PWS within one cosmetic unit required fewer treatment sessions to achieve marked improvement.
Conclusion: PWS confined to a single cosmetic unit than that located in two or more units responded better to PDL treatment. Before PDL treatment for facial PWS, age, initial lesion size, as well as the number of cosmetic units affected by the lesion should be considered. (Korean J Dermatol 2021;59(10):785∼792)

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8크론병 환자에서 발생한 다발성 보웬병 1예

저자 : 조민아 ( Minah Cho ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 793-796 (4 pages)

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A 47-year-old man with a 25-year history of Crohn's disease, presenting asymptomatic erythematous scaly patches (size, 1∼3 cm in diameter) on his back, left hand, right wrist, left ankle, and left sole, visited our clinic. Histopathological examination of the lesions revealed Bowen's disease. Herein, we report a rare case of multiple Bowen's disease in the skin, away from the anogenital region, in a patient with Crohn's disease. (Korean J Dermatol 2021;59(10):793∼796)

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9간찰 부위에서 발생한 전신형 고리 육아종 1예

저자 : 허규 ( Gyoo Huh ) , 이현주 ( Heun-joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 797-800 (4 pages)

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Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

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10A Case of Lyme Disease Followed by Post-Treatment Lyme Disease Syndrome

저자 : Sung Ha Lim , Eung Ho Choi

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 801-804 (4 pages)

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Lyme disease caused by Borrelia species is transmitted via infected tick bites. Erythema migrans, a typical skin lesion on the tick-bitten site, is a hallmark of Lyme disease. A 63-year-old female presented an erythematous, semi-circular patch in the left inguinal area. It disappeared spontaneously without treatment. However, after 3 months, an erythematous patch with a diameter of 1 cm recurred on the left thigh. B. burgdorferi antibody testing revealed positive results. At the second visit, doxycycline was prescribed, and the skin lesion was resolved. However, the patient exhibited persistent systemic symptoms, including arthralgia and fatigue, and was diagnosed with post-treatment Lyme disease syndrome (PTLDS). The PTLDS prognosis is associated with delayed diagnosis. Thus, antibiotic treatment should be promptly initiated after suspecting Lyme disease to minimize the associated systemic symptoms. PTLDS diagnosis should be followed by proper medical care to alleviate the symptoms. (Korean J Dermatol 2021;59(10):801∼804)

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KCI등재SCOUPUS

1아토피피부염의 치료

저자 : 한태영 ( Tae-young Han ) , 나찬호 ( Chan Ho Na ) , 이지현 ( Ji Hyun Lee ) , 김혜원 ( Hye One Kim ) , 박창욱 ( Chang Ook Park ) , 서영준 ( Young Joon Seo ) , 손상욱 ( Sang Wook Son ) , 신민경 ( Min Kyung Shin ) , 안지영 ( Ji Young Ahn ) , 이양원 ( Yang Won Lee ) , 장용현 ( Yong Hyun Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 581-593 (13 pages)

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Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and cyclosporine. Systemic steroids are not recommended by current guidelines and are commonly associated with disease rebound. Instead, clinicians choose from several off-label immunosuppressants. In 2018, the Korean FDA approved dupilumab for adults with moderate-to-severe AD whose disease is not adequately controlled with topical therapies. The implementation of treatment guidelines for AD is challenging. Herein, we review the several treatment modalities for AD and recommend a treatment algorithm. (Korean J Dermatol 2018;56(10):581∼593)

KCI등재SCOUPUS

2급성전신발진농포증 환자의 임상 및 조직학적 분석

저자 : 정인순 ( In Soon Jung ) , 윤숙정 ( Sook Jung Yun ) , 이지범 ( Jee-bum Lee ) , 김성진 ( Seong-jin Kim ) , 이승철 ( Seung-chul Lee ) , 원영호 ( Young Ho Won )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 594-602 (9 pages)

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Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea.
Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context.
Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients' medical records and photographs.
Results: The mean age of onset was 43.6 years, and the male:female ratio was 2.1:1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group.
Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP. (Korean J Dermatol 2018;56(10):594∼602)

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3고형 장기 이식 후 발생하는 피부암과 피부암 전구증으로 최근 22년간 단일 기관을 방문한 환자들에 대한 임상 양상과 인구통계학적 고찰(1995∼2017)

저자 : 박찬성 ( Chan Seong Park ) , 박지혜 ( Ji-hye Park ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dong-youn Lee ) , 이주흥 ( Joo-heung Lee ) , 양준모 ( Jun-mo Yang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 603-608 (6 pages)

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Background: It is well known that skin cancer and precancerous disease develop more frequently in patients undergoing solid organ transplantation than normal populations in the normal population in Western countries. However, to date, the clinical and demographic features of skin cancer and precancerous disease after solid organ transplantation are not established in Asian countries. We evaluated the clinical and demographic features of primary skin cancer and precancerous lesions after solid organ transplantation and compared these with the trends observed in Western countries.
Methods: We retrospectively reviewed the medical records of patients who underwent kidney, liver, heart, and lung transplantation between January 1995 and April 2017 and who developed skin cancer or precancerous lesions after transplantation. The various lesions observed were squamous and basal cell carcinoma, malignant melanoma, Kaposi sarcoma, Bowen's disease, and actinic keratosis.
Results: We identified 4604 patients who received organ transplant. The mean age of patients was 44.8 years (male, 64.6%; female, 35.4%), and the sum of the person-year of observation time was 31,024 person-years. The incidence rate per 100,000 person-years was 29.01 for squamous cell carcinoma, 19.34 for basal cell carcinoma, 6.45 for malignant melanoma 3.22 for Kaposi sarcoma, and 74.17 for Bowen's disease and actinic keratosis. The incidence rate per 100,000 person-years was the highest in patients undergoing heart transplantation (610.50), followed by those who underwent kidney transplantation (136.54) and liver transplantation (90.15). Koreans showed lower incidence rates than those observed in Westerners.
Conclusion: The incidence of primary skin cancer and precancerous lesions after solid organ transplantation in Koreans was lower than that in Westerners. Squamous cell carcinoma was the most common skin cancer in patients undergoing solid organ transplantation and the incidence rate of skin cancer and precancerous lesions was the highest in patients undergoing heart transplantation. (Korean J Dermatol 2018;56(10):603∼608)

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4이미퀴모드로 유발된 건선양 쥐 모델에서 건선 연관 유전자 발현에 대한 면역조직화학적 연구

저자 : 김지영 ( Ji-young Kim ) , 최미라 ( Mi-ra Choi ) , 최종원 ( Chong-won Choi ) , 박경덕 ( Kyung-duck Park ) , 이영 ( Young Lee ) , 김창덕 ( Chang-deok Kim ) , 서영준 ( Young-joon Seo ) , 이증훈 ( Jeung-hoon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 609-613 (5 pages)

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Background: Psoriasis is a chronic inflammatory skin disease with an incidence of 0.5∼3% of the worldwide population. The pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune reactions. Notably, genetic factors are considered important etiological contributors. Globally, several researchers have recently performed genome-wide association studies (GWAS) to identify the genes related with psoriasis.
Objective: We aimed to investigate the expression pattern of 2 candidate genes that were identified by GWAS. These include interleukin 28 receptor alpha (IL28RA) and CUB and Sushi multiple domains 1 (CSMD1).
Methods: We applied imiquimod cream to develop a psoriasis-like mouse model and obtained skin tissue. We performed immunohistochemistry to detect the expression of IL-28A and CSMD1.
Results: IL28RA expression increased at an early time point such as 1 day after the topical application of 5% imiquimod cream. However, its expression returned to baseline levels 2 weeks after the topical application of imiquimod cream. CSMD1 expression also increased after the topical application of imiquimod, with increased expression particularly observed in the upper epidermal layer. Notably, CSMD1 expression decreased 7 days after imiquimod cream application.
Conclusion: These results suggest that IL28RA and CSMD1 may play key roles in the pathogenesis of psoriasis. (Korean J Dermatol 2018;56(10):609∼613)

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5전북지역 옴 감염의 임상양상에 대한 연구

저자 : 김도현 ( Do Hyeon Kim ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 614-619 (6 pages)

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Background: Scabies is a contagious skin infestation primarily observed in poor or overcrowded environments. However, an individual may be affected regardless of hygiene and/or socioeconomic status, and/or age.
Objective: To investigate the characteristics and epidemiology of scabies in patients visiting a single tertiary hospital in Jeonbuk province.
Methods: We retrospectively reviewed the medical records of 194 patients with scabies who visited the Dermatology clinic at Wonkwang University Hospital between June 2015 and May 2018.
Results: Of the 194 patients investigated, 82 (42.3%) were men and 112 (57.7%) were women. The mean age of men was 46.3 years and that of women was 60.1 years. Scabies was diagnosed in patients most commonly in autumn. The most common symptom of scabies was the occurrence of papules (83.5%) followed by the presence of burrows (23.2%). The most common route of infection was a nursing hospital (26.3%), except unknown (29.4%). Medications used to treat scabies included 5% permethrin cream, 10% crotamiton ointment, and 1% gamma benzene hexachloride lotion. The mean duration of treatment was 33.9 days using 5% permethrin cream, 34.8 days using 10% crotamiton ointment, and 34.6 days using 1% gamma benzene hexachloride lotion. Conclusion: This study could help in the prevention and management of scabies, by guiding clinicians in choosing optimal therapeutic agents based on patients' condition. (Korean J Dermatol 2018;56(10):614∼619)

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6전신홍반루푸스 환자에서 병발한 백반증 1예

저자 : 권형일 ( Hyoung Il Kwon ) , 오의현 ( Eui Hyun Oh ) , 정연도 ( Yun Do Jung ) , 고주연 ( Joo Yeon Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 620-623 (4 pages)

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Vitiligo is a multifactorial disorder. Neural, biochemical, and autoimmune mechanisms have been hypothetically suggested as etiopathological contributors to this condition. Autoimmunity focuses primarily on genetic factors and the association between vitiligo and other autoimmune disorders including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, pernicious anemia, and Addison's disease. We describe a 35-year-old man with systemic lupus erythematosus who developed concurrent vitiligo and discoid lupus erythematosus suggesting the possible autoimmune association between these 2 different diseases. (Korean J Dermatol 2018;56(10):620∼623)

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7Ofloxacin 안연고에 의해 유발된 눈주위 알레르기접촉피부염

저자 : 조정원 ( Jeong Won Jo ) , 정해봉 ( Hae Bong Jeong ) , 신영빈 ( Young Bin Shin ) , 강기련 ( Kee Ryeon Kang ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 624-627 (4 pages)

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Allergic contact dermatitis is an inflammatory condition associated with periorbital erythema, edema, and pruritus. The periorbital skin is relatively thin compared with the skin over other facial areas; therefore, it is vulnerable to allergen penetration and may show a variety of cutaneous manifestations. Recently, vision enhancement surgery is a widely performed procedure, and the prevalence of senile cataract and glaucoma is increasing. The prevalence of periocular allergic contact dermatitis is increasing secondary to the growing use of topical ophthalmic medications. Several studies in Korea have reported periocular allergic contact dermatitis secondary to the use of topical ophthalmic medications including latanoprost (Latano®), fluorometholone (Tolon®), polymyxin B (Terramycin®), atropine sulfate (Atropine®), neomycin sulfate (Cambison®), and befunolol hydrochloride (Bentos®), among others. However, ofloxacin (Effexin®)-induced allergic contact dermatitis has not been reported in the domestic and/or foreign literature. We report a case of periocular allergic contact dermatitis secondary to the use of ofloxacin ophthalmic ointment. (Korean J Dermatol 2018;56(10):624∼627)

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8파종얕은광선땀구멍각화증에서 발생한 다양한 피부종양

저자 : 정해봉 ( Hae Bong Jeong ) , 조정원 ( Jeong Won Jo ) , 신영빈 ( Young Bin Shin ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 628-630 (3 pages)

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Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder. It is histopathologically characterized by the presence of coronoid lamellae and clinically by lesions showing central atrophy with elevated borders. Squamous cell carcinoma originating in the classical Mibelli subtype of porokeratosis is well-documented; however, few reports have described squamous cell carcinoma in DSAP lesions. We report the case of a 76-year-old woman with DSAP who developed Bowen's disease, actinic keratosis, and keratoacanthoma on her face. (Korean J Dermatol 2018;56(10):628∼630)

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9초기 단계의 카포시육종과 임상조직학적으로 유사한 다발성미세소정맥혈관종 1예

저자 : 은동혁 ( Dong Hyuk Eun ) , 김석민 ( Seok Min Kim ) , 김준영 ( Jun Young Kim ) , 한만훈 ( Man-hoon Han ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 631-635 (5 pages)

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Microvenular hemangioma (MVH) is a rare acquired benign vascular neoplasm, which presents commonly as a solitary purple-to-red nodule or plaque measuring approximately 10 mm in diameter. MVH occurs primarily on the extremities or the trunk. Most lesions are solitary, and multiple lesions are rare. Histopathological features of MVH include numerous, scattered, thin and irregularly branching small vessels in the dermis and endothelial cells without atypia. Owing to similarities in clinical morphology and histopathological features, MVH may often be indistinguishable from the early patch stage of Kaposi sarcoma. Immunohistochemical (IHC) analysis helps differentiate between the 2 diseases. The results of IHC tests in patients with MVH show positive staining for CD31 and smooth muscle actin and typically, negative staining for the human herpes virus 8 antigen. We report a rare case of multiple MVH clinically mimicking the early patch stage of Kaposi sarcoma in a 63-year-old woman who presented with a 3-year history of slowly growing, compressible, soft, bluish-purple macules and plaques on the trunk and right arm. (Korean J Dermatol 2018;56(10):631∼653)

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10Mycosis Fungoides Responsive to Oral Alitretinoin and Ultraviolet B Phototherapy: A Case Report

저자 : Song Hee Han , Ji Youn Hong , Joo Ran Hong , Min Seok Hur , Hae Jeong Youn , Yang Won Lee , Yong Beom Choe , Kyu Joong Ahn

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 636-639 (4 pages)

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Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. Patients with early stage disease usually respond well to conventional therapies, with a relatively favorable prognosis. However, a few patients are refractory to treatment and need alternative strategies, even at the patch and plaque stages. We report the case of a middle-aged woman with long-standing and refractory mycosis fungoides that responded to combination therapy with the 308-nm excimer laser and oral alitretinoin. (Korean J Dermatol 2018;56(10):636∼639)

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