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KCI등재SCOUPUS

아토피피부염의 치료

Treatment of Atopic Dermatitis

한태영 ( Tae-young Han ) , 나찬호 ( Chan Ho Na ) , 이지현 ( Ji Hyun Lee ) , 김혜원 ( Hye One Kim ) , 박창욱 ( Chang Ook Park ) , 서영준 ( Young Joon Seo ) , 손상욱 ( Sang Wook Son ) , 신민경 ( Min Kyung Shin ) , 안지영 ( Ji Young Ahn ) , 이양원 ( Yang Won Lee ) , 장용현 ( Yong Hyun Jang ) , 박영립 ( Young Lip Park ) , 유박린 ( Bark Lynn Lew )
  • : 대한피부과학회
  • : 대한피부과학회지 56권10호
  • : 연속간행물
  • : 2018년 12월
  • : 581-593(13pages)
대한피부과학회지

DOI


목차

서 론
아토피피부염의 기본 관리
국소치료
전신치료
항원특이면역치료(Allergen-specific immunotherapy)
광선치료(Phototherapy)
생물학적제제(Biologics)
Small molecule inhibitors
Adjunctive treatment
결 론
ORCID
REFERENCES

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Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and cyclosporine. Systemic steroids are not recommended by current guidelines and are commonly associated with disease rebound. Instead, clinicians choose from several off-label immunosuppressants. In 2018, the Korean FDA approved dupilumab for adults with moderate-to-severe AD whose disease is not adequately controlled with topical therapies. The implementation of treatment guidelines for AD is challenging. Herein, we review the several treatment modalities for AD and recommend a treatment algorithm. (Korean J Dermatol 2018;56(10):581∼593)

UCI(KEPA)

I410-ECN-0102-2019-500-001589273

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9660


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60권3호(2022년 03월) 수록논문
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KCI등재 SCOPUS

1악성 흑색종에 대한 한국어 유튜브 동영상의 질 평가

저자 : 허근영 ( Keunyoung Hur ) , 하은서 ( Eun-seo Ha ) , 김동효 ( Dong Hyo Kim ) , 송원지 ( Won Ji Song ) , 문제호 ( Je-ho Mun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 143-150 (8 pages)

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Background: Disseminating public knowledge on malignant melanoma through YouTube is an important way to bridge the gap between physicians and patients. However, videos recorded on this topic in Korea are yet to be evaluated.
Objective: We aimed to evaluate the quality of YouTube videos on malignant melanoma recorded in Korea. We also investigated whether there was a difference in the quality of videos made by medical professionals (subdivided into dermatologists and non-dermatologists) and non-medical personnel.
Methods: We included all videos recorded in Korean by searching YouTube using the keywords “melanoma” or “malignant melanoma”. The search was performed on March 22, 2021. The inclusion criterion was videos in Korean language that contained medical information about malignant melanoma. The characteristics and content information were collected for each video. Video quality (DISCERN, Global Quality Scale [GQS], Journal of the American Medical Association [JAMA] benchmark criteria) was analyzed.
Results: Eighty-five videos met the inclusion criterion for the analysis. Fifty-six (66%) and 29 videos (34%) were made by medical and non-medical personnel, respectively. The videos made by medical professionals significantly contained more of the following information than those made by non-medical personnel: clinical information (p<0.001), symptoms and signs (p=0.001), risk factors (p<0.05), diagnosis (p<0.001). Videos made by medical professionals, videos with a length of more than 5 minutes, or videos with more than 10,000 views had significantly higher quality scores (DISCERN, GQS, JAMA).
Conclusion: Considering that YouTube is being used as a portal for medical information, the participation of medical professionals is essential for providing more accurate information. (Korean J Dermatol 2022;60(3):143∼150)

KCI등재 SCOPUS

2중등도-중증의 한국인 건선 환자에서 Ustekinumab 장기 투여에 따른 효과 및 안전성 연구

저자 : 김연아 ( Yeona Kim ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoonsoo Kim ) , 고현창 ( Hyun-chang Ko ) , 김문범 ( Moon-bum Kim ) , 신봉석 ( Bong Seok Shin ) , 김병수 ( Byungsoo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 151-158 (8 pages)

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Background: Ustekinumab is a humanized monoclonal antibody targeting interleukin (IL)-12 and IL-23. Although popular, data on its long-term efficacy and safety in Korean patients with psoriasis are limited.
Objective: To evaluate the long-term efficacy and safety of ustekinumab in Korean patients with psoriasis.
Methods: A retrospective study in patients with moderate-to-severe psoriasis who had been treated with ustekinumab for at least 5 years was conducted. The sex, age, body mass index, medical records, previous psoriasis therapy, psoriasis area and severity index (PASI) scores, and adverse events were evaluated.
Results: Twenty-five patients (median age 47.00 years) had been treated with ustekinumab for 5 years. The mean duration of psoriasis was 19.12±8.45 years, and the treatment duration with ustekinumab was 285.12±8.48 weeks. The baseline PASI was 17.52±7.38. PASI75 was achieved in 84% of the patients at week 28, and 96% of the patients maintained PASI75 during the 5-year follow-up period. Furthermore, 56% of patients reached PASI90 at 28 weeks, and 48% of patients maintained PASI90 for 5 years. No unexpected adverse events other than herpes zoster, herpes simplex, or elevated liver enzymes were reported.
Conclusion: Ustekinumab demonstrated long-lasting efficacy with an acceptable safety profile in Korean patients with moderate-to-severe psoriasis. (Korean J Dermatol 2022;60(3):151∼158)

KCI등재 SCOPUS

3흡입 수포의 체액과 혈청에서 측정한 지질들의 상관성 분석

저자 : 권일주 ( Il Joo Kwon ) , 최승재 ( Sung Jay Choe ) , 정승원 ( Seung Won Jeong ) , 전명수 ( Myungsoo Jun ) , 최응호 ( Eung Ho Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 159-166 (8 pages)

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Background: Several biomarkers are measured in the interstitial fluid (IF) obtained from suction blisters that are used by dermatologists. As abnormal lipid levels can cause health problems, several studies have investigated the composition and distribution of lipids and lipoproteins in IF. However, to date, no study has focused on examining lipid profiles in the postprandial state.
Objective: This study aimed to compare postprandial changes in serum lipid profiles and IF obtained from suction blisters and investigated their correlation.
Methods: Fasting and postprandial levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides were measured in paired serum samples. IF was obtained from suction blisters from 20 healthy men using enzymatic-colorimetric methods.
Results: The IF/serum ratios of TC, HDL-C, and LDL-C remained unchanged postoperatively. Postprandial levels of HDL-C and LDL-C decreased in the serum but not in IF. In both fasting and postprandial states, TC, HDL-C, and LDL-C levels in the serum were positively correlated with those in the IF.
Conclusion: The results of this study showed that lipoprotein cholesterol levels measured from suction blister fluids could be used as a biomarker to predict their serum levels regardless of food intake. Therefore, suction blister fluid sampling can be considered as a method to monitor serum lipid concentrations. (Korean J Dermatol 2022;60(3):159∼166)

KCI등재 SCOPUS

4일차성 호중구성 반흔성 탈모의 임상 및 조직학적 소견에 대한 비교 연구

저자 : 백은주 ( Eun Joo Baek ) , 형진혁 ( Jin Hyeok Hyeong ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 167-172 (6 pages)

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Background: Folliculitis decalvans and dissecting cellulitis are types of primary neutrophilic cicatricial alopecia characterized by permanent hair loss. Clinicopathological differentiation is poorly described in literature.
Objective: This study aimed to determine the clinicopathological distinction between folliculitis decalvans and dissecting cellulitis.
Methods: A retrospective review was conducted in 45 patients diagnosed with dissecting cellulitis and folliculitis decalvans between 2011 and 2021. We reviewed the clinical features using electronic medical records, clinical photographs, and histopathologic features.
Results: Clinically, middle-aged men with folliculitis decalvans showed polytrichia (80%) and papulopustules (55%), while young men with dissecting cellulitis had deeply seated nodules (84%). Histopathologically, follicular plugging was more frequently observed in dissecting cellulitis (80%) than in folliculitis decalvans (50%). There was a difference in the depth of inflammation between the two types.
Conclusion: A difference in clinical manifestations was observed according to the depth of inflammation. These findings may contribute to the differential diagnosis of primary neutrophilic cicatricial alopecia. (Korean J Dermatol 2022;60(3):167∼172)

KCI등재 SCOPUS

5비전형적인 조직소견을 보인 회음부의 색소성 정중솔기낭종 1예

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Eun Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 173-177 (5 pages)

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Median raphe cysts (MRCs) are rare benign lesions that occur as a result of congenital defects during the embryological development of the male genitalia in the fetal period. It can develop anywhere along the midline, from the meatus to the anus. Pigmented MRCs are rare subtypes that contain melanin pigments or melanocytes in the epithelium, and there are only eight such cases reported worldwide. We report herein a case of pigmented MRC in the perineum of a 3-year-old boy. The clinical features include a linear tubular structure and foreign body granuloma at the tip of the linear cystic lesion and rare histological findings of pigmented cuboidal epithelium and squamous epithelium. Immunohistochemical staining revealed strong positivity for c-kit in the pigmented cuboidal epithelium. In this report, we discuss a rare case of pigmented MRC with a mixed type of squamous epithelium and pigmented cuboidal epithelium and review the associated literature. (Korean J Dermatol 2022;60(3):173∼177)

KCI등재 SCOPUS

6Multiple Spider Angiomas as a Predictive Diagnostic Marker of Alcoholic Liver Cirrhosis

저자 : Jun Ki Hong , Hye Sung Han , Sun Hye Shin , Young Gue Koh , Kapsok Li , Beom Joon Kim , Kwang Ho Yoo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 178-181 (4 pages)

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Spider angioma (SA) may present as solitary or multiple lesions. Studies have shown that approximately 60% of pregnant women and 38% of healthy children have at least one spider telangiectasia. Hence, solitary SA in an otherwise healthy individual does not warrant further workup. However, multiple spider angiomas (MSAs) are usually suggestive of an underlying systemic disease. Physical examination for MSAs has been reported as the most reliable method to diagnose alcoholic liver cirrhosis; the presence of MSAs is more indicative of liver cirrhosis than just the history of alcohol use because a very low proportion of alcohol drinkers among the general population develop liver cirrhosis. We report a case of MSAs in a 42-year-old alcoholic woman suggesting that MSA is reliable indicator and a warning sign of liver cirrhosis, suggesting that further evaluation and management with the department of hepatology is necessary. (Korean J Dermatol 2022;60(3):178∼181)

KCI등재 SCOPUS

7A Drug-Induced Sarcoidosis-Like Reaction in Lung Cancer Patient Treated with Nivolumab and Ipilimumab: A Case Report and Literature Review

저자 : Soo Hyung Kim , Seo Gyeong Lee , Ji Yoon Kim , Hyun Jeong Ju , Gyong Moon Kim , Ji Hae Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 182-185 (4 pages)

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Immune checkpoint inhibitor (ICI), including programmed cell death protein 1 and cytotoxic T-lymphocyte-associated protein 4 inhibitors, has emerged as a pillar in the management of advanced malignancies. A drug-induced sarcoidosis-like reaction (DISR) is a rare cutaneous adverse event of ICI. A 47-year-old male presented with one-month history of a solitary erythematous nodule on his forehead. He had been diagnosed with metastatic adenocarcinoma of the lung and was treated with nivolumab and ipilimumab for three months. Histological findings revealed multinucleated giant cells forming non-caseating granulomas with moderate peripheral lymphocyte infiltration in the dermis. Also, new hilar lymphadenopathy of the lung was identified in a systemic evaluation. Given the temporal relationship with ICI treatment, the final diagnosis was ICI-induced sarcoidosis-like reaction. To our knowledge, this is the first report of a case of DISR that developed following ICI treatment in the dermatologic literature in Korea. (Korean J Dermatol 2022;60(3):182∼185)

KCI등재 SCOPUS

8Multiple Warty Dyskeratomas of the Scrotum: A Case Report and Review of the Literature

저자 : Joon Ho Son , Yeong Ho Kim , Ju Hee Han , Chul Hwan Bang , Ji Hyun Lee , Young Min Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 186-189 (4 pages)

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Warty dyskeratoma (WD) is an uncommon skin tumor that histologically presents as focal acantholysis and dyskeratosis and is a common finding among acantholytic diseases such as Darier's disease. WD most commonly occurs on the head or neck of adults as an isolated papule or nodule. To our knowledge, only 6 cases of WD in the genital area have been previously reported in the literature, and no case have occurred on the scrotum to date. We report the first case of multiple WD that occurred on the scrotum successfully treated with 0.025% tretinoin cream. A 55-year-old male presented with asymptomatic, multiple, 0.1∼0.2-cm-sized, skin-colored papules on the scrotum for the previous 6 months. A skin punch biopsy and human papillomavirus (HPV) polymerase chain reaction test were performed for a clinical suspicion of genital warts or bowenoid papulosis. The histopathologic examination showed cup-shaped epidermal invaginations with central keratotic plug. Prominent villi, acantholytic clefting and corps ronds were also shown. The patient tested negative for HPV and was diagnosed with WD with typical pathologic findings. The patient was treated with 0.025% tretinoin cream for 2 weeks, and the lesions decreased in both size and number. (Korean J Dermatol 2022;60(3):186∼189)

KCI등재 SCOPUS

9급성 골수성 백혈병 재발과 연관된 결절홍반 1예

저자 : 윤지상 , 배경남 , 손진화 , 김훈수 , 고현창 , 김병수 , 김문범 , 신기혁

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 190-191 (2 pages)

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KCI등재 SCOPUS

10모낭 및 피지선 유도를 동반한 위축성 피부섬유종 1예

저자 : 한유진 , 김혜성 , 조상현 , 이정덕 , 우유리

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 192-193 (2 pages)

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12
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같은 권호 다른 논문
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KCI등재SCOUPUS

1아토피피부염의 치료

저자 : 한태영 ( Tae-young Han ) , 나찬호 ( Chan Ho Na ) , 이지현 ( Ji Hyun Lee ) , 김혜원 ( Hye One Kim ) , 박창욱 ( Chang Ook Park ) , 서영준 ( Young Joon Seo ) , 손상욱 ( Sang Wook Son ) , 신민경 ( Min Kyung Shin ) , 안지영 ( Ji Young Ahn ) , 이양원 ( Yang Won Lee ) , 장용현 ( Yong Hyun Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 581-593 (13 pages)

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Atopic dermatitis (AD) is a common, chronic, relapsing, inflammatory skin disease that affects both children and adults. AD is the cause of considerable morbidity including severe pruritus and impaired quality of life. Treatments for active disease include avoidance of triggering factors, barrier repair, topical medications including topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs), phototherapy, antibacterial agents, and systemic immunosuppressants including cyclosporine. Until recently, the only Food and Drug Administration (FDA)-approved systemic treatment options for patients with moderate-to-severe AD were steroids and cyclosporine. Systemic steroids are not recommended by current guidelines and are commonly associated with disease rebound. Instead, clinicians choose from several off-label immunosuppressants. In 2018, the Korean FDA approved dupilumab for adults with moderate-to-severe AD whose disease is not adequately controlled with topical therapies. The implementation of treatment guidelines for AD is challenging. Herein, we review the several treatment modalities for AD and recommend a treatment algorithm. (Korean J Dermatol 2018;56(10):581∼593)

KCI등재SCOUPUS

2급성전신발진농포증 환자의 임상 및 조직학적 분석

저자 : 정인순 ( In Soon Jung ) , 윤숙정 ( Sook Jung Yun ) , 이지범 ( Jee-bum Lee ) , 김성진 ( Seong-jin Kim ) , 이승철 ( Seung-chul Lee ) , 원영호 ( Young Ho Won )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 594-602 (9 pages)

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Background: Acute generalized exanthematous pustulosis (AGEP) is typically a medication-induced acute febrile eruption. Few large-scale studies have reported clinical data regarding AGEP in Korea.
Objective: This study analyzed the clinical and histopathological features of AGEP in Koreans to identify recent trends in this context.
Methods: This study retrospectively reviewed 31 patients with AGEP. Age, sex, clinical features, etiologies, laboratory findings, histopathological features, and treatment outcomes were obtained from patients' medical records and photographs.
Results: The mean age of onset was 43.6 years, and the male:female ratio was 2.1:1. All patients showed non-follicular tiny pustules and erythema. Fever was reported in 13 patients and neutrophilia in 17 patients. Medications were considered the most common etiological contributors. Twenty patients showed drug-induced AGEP, and 11 of 20 patients showed antibiotic-induced AGEP. Serum C-reactive protein and lactate dehydrogenase levels increased in 93.8% and 77.8% of the patients, respectively. Histopathologically, all patients showed subcorneal or intraepidermal pustules, followed by exocytosis and neutrophilic dermal infiltrate. Twenty-five patients improved within a mean period of 7.5 days after the onset of the skin rash. The percentage of women in the drug-induced AGEP group was significantly higher than that in the non-drug-induced AGEP group.
Conclusion: This report describes a large-scale study that analyzed the clinical and histopathological features of AGEP in Koreans and seems to accurately reflect the recent trends in this context. Clinically, it is important to note that the percentage of women in the drug-induced AGEP group was higher than that in groups showing other etiologies of AGEP. (Korean J Dermatol 2018;56(10):594∼602)

KCI등재SCOUPUS

3고형 장기 이식 후 발생하는 피부암과 피부암 전구증으로 최근 22년간 단일 기관을 방문한 환자들에 대한 임상 양상과 인구통계학적 고찰(1995∼2017)

저자 : 박찬성 ( Chan Seong Park ) , 박지혜 ( Ji-hye Park ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dong-youn Lee ) , 이주흥 ( Joo-heung Lee ) , 양준모 ( Jun-mo Yang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 603-608 (6 pages)

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Background: It is well known that skin cancer and precancerous disease develop more frequently in patients undergoing solid organ transplantation than normal populations in the normal population in Western countries. However, to date, the clinical and demographic features of skin cancer and precancerous disease after solid organ transplantation are not established in Asian countries. We evaluated the clinical and demographic features of primary skin cancer and precancerous lesions after solid organ transplantation and compared these with the trends observed in Western countries.
Methods: We retrospectively reviewed the medical records of patients who underwent kidney, liver, heart, and lung transplantation between January 1995 and April 2017 and who developed skin cancer or precancerous lesions after transplantation. The various lesions observed were squamous and basal cell carcinoma, malignant melanoma, Kaposi sarcoma, Bowen's disease, and actinic keratosis.
Results: We identified 4604 patients who received organ transplant. The mean age of patients was 44.8 years (male, 64.6%; female, 35.4%), and the sum of the person-year of observation time was 31,024 person-years. The incidence rate per 100,000 person-years was 29.01 for squamous cell carcinoma, 19.34 for basal cell carcinoma, 6.45 for malignant melanoma 3.22 for Kaposi sarcoma, and 74.17 for Bowen's disease and actinic keratosis. The incidence rate per 100,000 person-years was the highest in patients undergoing heart transplantation (610.50), followed by those who underwent kidney transplantation (136.54) and liver transplantation (90.15). Koreans showed lower incidence rates than those observed in Westerners.
Conclusion: The incidence of primary skin cancer and precancerous lesions after solid organ transplantation in Koreans was lower than that in Westerners. Squamous cell carcinoma was the most common skin cancer in patients undergoing solid organ transplantation and the incidence rate of skin cancer and precancerous lesions was the highest in patients undergoing heart transplantation. (Korean J Dermatol 2018;56(10):603∼608)

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4이미퀴모드로 유발된 건선양 쥐 모델에서 건선 연관 유전자 발현에 대한 면역조직화학적 연구

저자 : 김지영 ( Ji-young Kim ) , 최미라 ( Mi-ra Choi ) , 최종원 ( Chong-won Choi ) , 박경덕 ( Kyung-duck Park ) , 이영 ( Young Lee ) , 김창덕 ( Chang-deok Kim ) , 서영준 ( Young-joon Seo ) , 이증훈 ( Jeung-hoon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 609-613 (5 pages)

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Background: Psoriasis is a chronic inflammatory skin disease with an incidence of 0.5∼3% of the worldwide population. The pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune reactions. Notably, genetic factors are considered important etiological contributors. Globally, several researchers have recently performed genome-wide association studies (GWAS) to identify the genes related with psoriasis.
Objective: We aimed to investigate the expression pattern of 2 candidate genes that were identified by GWAS. These include interleukin 28 receptor alpha (IL28RA) and CUB and Sushi multiple domains 1 (CSMD1).
Methods: We applied imiquimod cream to develop a psoriasis-like mouse model and obtained skin tissue. We performed immunohistochemistry to detect the expression of IL-28A and CSMD1.
Results: IL28RA expression increased at an early time point such as 1 day after the topical application of 5% imiquimod cream. However, its expression returned to baseline levels 2 weeks after the topical application of imiquimod cream. CSMD1 expression also increased after the topical application of imiquimod, with increased expression particularly observed in the upper epidermal layer. Notably, CSMD1 expression decreased 7 days after imiquimod cream application.
Conclusion: These results suggest that IL28RA and CSMD1 may play key roles in the pathogenesis of psoriasis. (Korean J Dermatol 2018;56(10):609∼613)

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5전북지역 옴 감염의 임상양상에 대한 연구

저자 : 김도현 ( Do Hyeon Kim ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 614-619 (6 pages)

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Background: Scabies is a contagious skin infestation primarily observed in poor or overcrowded environments. However, an individual may be affected regardless of hygiene and/or socioeconomic status, and/or age.
Objective: To investigate the characteristics and epidemiology of scabies in patients visiting a single tertiary hospital in Jeonbuk province.
Methods: We retrospectively reviewed the medical records of 194 patients with scabies who visited the Dermatology clinic at Wonkwang University Hospital between June 2015 and May 2018.
Results: Of the 194 patients investigated, 82 (42.3%) were men and 112 (57.7%) were women. The mean age of men was 46.3 years and that of women was 60.1 years. Scabies was diagnosed in patients most commonly in autumn. The most common symptom of scabies was the occurrence of papules (83.5%) followed by the presence of burrows (23.2%). The most common route of infection was a nursing hospital (26.3%), except unknown (29.4%). Medications used to treat scabies included 5% permethrin cream, 10% crotamiton ointment, and 1% gamma benzene hexachloride lotion. The mean duration of treatment was 33.9 days using 5% permethrin cream, 34.8 days using 10% crotamiton ointment, and 34.6 days using 1% gamma benzene hexachloride lotion. Conclusion: This study could help in the prevention and management of scabies, by guiding clinicians in choosing optimal therapeutic agents based on patients' condition. (Korean J Dermatol 2018;56(10):614∼619)

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6전신홍반루푸스 환자에서 병발한 백반증 1예

저자 : 권형일 ( Hyoung Il Kwon ) , 오의현 ( Eui Hyun Oh ) , 정연도 ( Yun Do Jung ) , 고주연 ( Joo Yeon Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 620-623 (4 pages)

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Vitiligo is a multifactorial disorder. Neural, biochemical, and autoimmune mechanisms have been hypothetically suggested as etiopathological contributors to this condition. Autoimmunity focuses primarily on genetic factors and the association between vitiligo and other autoimmune disorders including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, pernicious anemia, and Addison's disease. We describe a 35-year-old man with systemic lupus erythematosus who developed concurrent vitiligo and discoid lupus erythematosus suggesting the possible autoimmune association between these 2 different diseases. (Korean J Dermatol 2018;56(10):620∼623)

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7Ofloxacin 안연고에 의해 유발된 눈주위 알레르기접촉피부염

저자 : 조정원 ( Jeong Won Jo ) , 정해봉 ( Hae Bong Jeong ) , 신영빈 ( Young Bin Shin ) , 강기련 ( Kee Ryeon Kang ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 624-627 (4 pages)

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Allergic contact dermatitis is an inflammatory condition associated with periorbital erythema, edema, and pruritus. The periorbital skin is relatively thin compared with the skin over other facial areas; therefore, it is vulnerable to allergen penetration and may show a variety of cutaneous manifestations. Recently, vision enhancement surgery is a widely performed procedure, and the prevalence of senile cataract and glaucoma is increasing. The prevalence of periocular allergic contact dermatitis is increasing secondary to the growing use of topical ophthalmic medications. Several studies in Korea have reported periocular allergic contact dermatitis secondary to the use of topical ophthalmic medications including latanoprost (Latano®), fluorometholone (Tolon®), polymyxin B (Terramycin®), atropine sulfate (Atropine®), neomycin sulfate (Cambison®), and befunolol hydrochloride (Bentos®), among others. However, ofloxacin (Effexin®)-induced allergic contact dermatitis has not been reported in the domestic and/or foreign literature. We report a case of periocular allergic contact dermatitis secondary to the use of ofloxacin ophthalmic ointment. (Korean J Dermatol 2018;56(10):624∼627)

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8파종얕은광선땀구멍각화증에서 발생한 다양한 피부종양

저자 : 정해봉 ( Hae Bong Jeong ) , 조정원 ( Jeong Won Jo ) , 신영빈 ( Young Bin Shin ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 628-630 (3 pages)

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Disseminated superficial actinic porokeratosis (DSAP) is a rare keratinization disorder. It is histopathologically characterized by the presence of coronoid lamellae and clinically by lesions showing central atrophy with elevated borders. Squamous cell carcinoma originating in the classical Mibelli subtype of porokeratosis is well-documented; however, few reports have described squamous cell carcinoma in DSAP lesions. We report the case of a 76-year-old woman with DSAP who developed Bowen's disease, actinic keratosis, and keratoacanthoma on her face. (Korean J Dermatol 2018;56(10):628∼630)

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9초기 단계의 카포시육종과 임상조직학적으로 유사한 다발성미세소정맥혈관종 1예

저자 : 은동혁 ( Dong Hyuk Eun ) , 김석민 ( Seok Min Kim ) , 김준영 ( Jun Young Kim ) , 한만훈 ( Man-hoon Han ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 631-635 (5 pages)

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Microvenular hemangioma (MVH) is a rare acquired benign vascular neoplasm, which presents commonly as a solitary purple-to-red nodule or plaque measuring approximately 10 mm in diameter. MVH occurs primarily on the extremities or the trunk. Most lesions are solitary, and multiple lesions are rare. Histopathological features of MVH include numerous, scattered, thin and irregularly branching small vessels in the dermis and endothelial cells without atypia. Owing to similarities in clinical morphology and histopathological features, MVH may often be indistinguishable from the early patch stage of Kaposi sarcoma. Immunohistochemical (IHC) analysis helps differentiate between the 2 diseases. The results of IHC tests in patients with MVH show positive staining for CD31 and smooth muscle actin and typically, negative staining for the human herpes virus 8 antigen. We report a rare case of multiple MVH clinically mimicking the early patch stage of Kaposi sarcoma in a 63-year-old woman who presented with a 3-year history of slowly growing, compressible, soft, bluish-purple macules and plaques on the trunk and right arm. (Korean J Dermatol 2018;56(10):631∼653)

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10Mycosis Fungoides Responsive to Oral Alitretinoin and Ultraviolet B Phototherapy: A Case Report

저자 : Song Hee Han , Ji Youn Hong , Joo Ran Hong , Min Seok Hur , Hae Jeong Youn , Yang Won Lee , Yong Beom Choe , Kyu Joong Ahn

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 56권 10호 발행 연도 : 2018 페이지 : pp. 636-639 (4 pages)

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Mycosis fungoides is the most common type of cutaneous T-cell lymphoma. Patients with early stage disease usually respond well to conventional therapies, with a relatively favorable prognosis. However, a few patients are refractory to treatment and need alternative strategies, even at the patch and plaque stages. We report the case of a middle-aged woman with long-standing and refractory mycosis fungoides that responded to combination therapy with the 308-nm excimer laser and oral alitretinoin. (Korean J Dermatol 2018;56(10):636∼639)

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