Purpose: Space planning to cope with the changing function of the hospital is essential in hospital architecture. In order to do so, it is vital that the paradigm shifts from hospital design focused on purpose toward hospital design focused on system. Not only space planning but also air-conditioning plan, which is most closely related to the operation and maintenance of hospital facilities; and the environment of hospital users, should be able to respond to changes with ease. Thus this study is to provide fundamental data of the air-conditioning plan for the hospital design focused on system by analyzing the concept and characteristics of the air-conditioning plan in the recent hospital architecture planning. Results: As a result of this study, in the air conditioning plan for the hospital architecture planning, the most important are the location relation among the departments the air handling unit room and the air handling unit manage and the air conditioning zoning setting according to the air conditioning system. Therefore, for the hospital architecture planning focused on system, it is necessary to establish the air conditioning setting that can accommodate changeable environment of departments and accordingly the appropriate area range of the air conditioning zoning and the plan for the location of the air handling unit should be considered. Implications: Thereby aims to provide fundamental data on air handling unit zoning planning in the hospital architecture planning.