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조선대학교 치의학연구원> Oral Biology Research (OBR)> Treatment of pre-eruptive intracoronal resorption: Case report

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Treatment of pre-eruptive intracoronal resorption: Case report

So-young Kim , Sang-ho Lee , Nan-young Lee , Young-mi Yoon , Sung-ok Im
  • : 조선대학교 치의학연구원
  • : Oral Biology Research (OBR) 41권3호
  • : 연속간행물
  • : 2017년 09월
  • : 153-157(5pages)
Oral Biology Research (OBR)

DOI


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Pre-eruptive intracoronal resorption is a rare disease defined as an intracoronal radiolucent lesion. Most are revealed through casual radiological examinations, and are clinically identifiable after eruption. The possible causes of lesions include congenital abnormalities, systemic fluoride uptake, external factors after tooth formation, and eruption of the tooth; however, no definite etiology has been found. Early diagnosis through regular examination is therefore considered to be the best diagnostic method. Treatment may differ depending on the size and progression of the lesion, but conservative treatment is recommended. This case report describes two cases where the lesions were accidentally found while performing a radiologic examination addressing other issues. It is the clinician`s responsibility to identify the size of the lesion and the expected eruption time, and to execute the appropriate treatment.

UCI(KEPA)

I410-ECN-0102-2018-500-000694346

간행물정보

  • : 의약학분야  > 기초치의학
  • : KCI등재
  • :
  • : 계간
  • : 2508-2558
  • : 2508-2566
  • : 학술지
  • : 연속간행물
  • : 1978-2022
  • : 1503


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1Smad3 deficiency accelerates tongue wound healing via epithelial cell-extracellular matrix interactions

저자 : Chieko Taguchi , Fuyuki Sato , Chen Wang , Shigeru Nakamura , Kosuke Oikawa , Ujjal Kumar Bhawal , Hiroyuki Okada , Kazumune Arikawa

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 141-149 (9 pages)

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Aberrant wound closure occurs in a broad range of wounds and scars, and the altered regulation of transcription factors in wound areas can account for both of those conditions. This study aimed to explore the function of the transcription factor Smad3 in wound healing using a tongue wound model in Smad3 knockout (Smad3-/-) mice and with Smad3 small interfering RNA (siRNA) transfected human gingival fibroblasts (HGFs). Smad3-/- mice were used to examine the extent of repair in tongue wounds. Cell migration was evaluated in HGFs using wound healing assays. The mRNA expression levels of Sox2, E-cadherin, fibronectin, and vimentin were examined in HGFs using reverse transcription-quantitative polymerase chain reaction. Histopathological analysis of wound closure in Smad3-/- mice showed rapid re-epithelialization and remodeling in tongue wound repair compared with Smad3+/+ mice. Increased numbers of neutrophils were identified in the wounds of Smad3-/- mice. Sox2 and phospho-E-cadherin expression levels were increased in Smad3-/- mice. Smad3 knockdown by siRNA increased cell migration of HGFs. In addition, Sox2, E-cadherin, fibronectin, and vimentin mRNA levels were significantly increased in Smad3 siRNA-transfected HGFs compared with controls. Collectively, these findings demonstrate that a Smad3 deficiency can expedite wound healing and increase immune reactions and extracellular matrix formation after tongue injuries, boosting recovery through Sox2 and E-cadherin. Consequently, Smad3 inhibition would help stimulate tongue wound healing.

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2Case series of maxillary anterior bone augmentation with a novel biphasic calcium phosphate: a clinical and radiographic pilot study

저자 : Jae-hong Lee , Eun-hee Jung , Hyun-wook An , Jae-seung Im , Dong-won Lee , Jeong-ho Yun

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 150-157 (8 pages)

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The purpose of this pilot case series was to evaluate the clinical and radiographic outcomes of employing newly developed alloplastic biphasic calcium phosphate (BCP) in guided bone regeneration (GBR) for maxillary anterior peri-implant defects. Six peri-implant dehiscence defects were grafted with BCP. For all included treatment sites, clinical (defect width [DW] and defect height [DH]), radiographic (horizontal hard tissue thickness [HT]), patient discomfort, and early wound healing outcomes were evaluated. At reentry surgery, all surgical sites indicated a change in DW, DH, HT0, HT1, HT2, and HT3 from 4.08±1.39 mm to 1.13±1.76 mm, 3.57±1.42 mm to 0.58±1.09 mm, 2.18±0.66 mm to 1.50±0.53 mm, 2.11±0.57 mm to 1.73±0.28 mm, 2.22±0.54 mm to 1.75±0.26 mm, and 2.63±0.87 mm to 1.83±0.46 mm, respectively. Significant differences were discovered between paired DW and DH (p<0.05), whereas radiographic parameters had no significant differences. The severity of pain and swelling was 4.8±1.9 and 6.5±1.9, respectively, and the duration of pain and swelling was 4.5±3.8 and 5.8±2.9 days, respectively, according to early postoperative discomfort assessment. No adverse reactions occurred at any treatment site. In terms of clinical and radiographic outcomes, the newly developed BCP is acceptable biocompatible and suitable for the GBR of maxillary anterior peri-implant dehiscence defects within the limitations of this study.

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3Effect of alar base cinch suturing on preventing nasal deformation during orthognathic surgery with Le Fort I osteotomy

저자 : Kyung-min Lee , Jae-woo Jang , Young-wook Park

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 158-164 (7 pages)

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This retrospective study assessed changes in interalar width (IAW) resulting from the alar base cinch suturing in 17 patients who underwent Le Fort I osteotomy. After maxillary fixation, alar base cinch suturing was performed through levator labii superioris alaque nasi muscle, alar part of nasalis muscle, and fibroareolar tissues. The IAW was measured in all patients using a vernier caliper preoperatively (T0), one day postoperatively (T1), one week postoperatively (T2), one month postoperatively (T3), and six months postoperatively (T4). Results showed that the IAW at T1 was significantly narrower than at T0, and the measurement was not changed significantly after that. Therefore, effective alar base cinch suturing prevents horizontal nasal soft tissue from widening.

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4Effects of cimifugin on cell growth inhibition and cell apoptosis induction in fadu human pharyngeal squamous cell carcinoma

저자 : Jong-hyun Park , Do Kyung Kim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 165-170 (6 pages)

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Cimifugin is an important component of chromones in the dry roots of Saposhnikovia divaricata and is used in treating inflammatory diseases. However, the effect of cimifugin on cancer is unclear. The aim of this study was to investigate the effects of cimifugin on cell apoptosis induction in FaDu human pharyngeal carcinoma cells using MTT assay, live/dead cell assay, and western blot. Cimifugininduced FaDu cell death in a dose-dependent manner. Cimifugin-induced apoptosis in FaDu cells was mediated by the expression of Fas and activation of caspase-8, caspase-3, and poly (ADP-ribose) polymerase (PARP). Western blot results showed the downregulation of Bcl-2 and Bcl-xL but the upregulation of Bad and Bax by cimifugin in FaDu cells. These results suggest that cimifugin inhibits cell survival and induces apoptotic cell death in FaDu human pharyngeal carcinoma cells via both the death receptor-mediated extrinsic apoptotic pathway and the mitochondria-mediated intrinsic apoptotic pathway.

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5In vitro and in vivo analyses of the biocompatibility of sintered TCP-HA composite screws

저자 : Young-gon Sun , Myeong-seop Lim , Young-joon Kim , Jeong-in Choi

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 171-182 (12 pages)

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Biphasic calcium phosphate (BCP), which is a β-tricalcium phosphate (TCP) and hydroxyapatite (HA) composite, is used mainly as a bone graft material. However, it has recently been used for orthopedic, oral, and maxillofacial surgeries. The use of BCP to produce an absorbable screw and plate to reconstruct fractures has been suggested. Nevertheless, further research on using BCP in the surgical field will be needed. In particular, studies on the physical properties of BCP and in vivo analysis are essential. In this study, TCP and HA were mixed at a ratio of 7:3 and heat-treated to form BCP. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, and an MTT assay were conducted to evaluate the surface characteristics and physical and biological properties of each sample. In addition, BCP was used to produce a screw to be implanted into the mandible of beagles. An analysis of the physical properties of BCP confirmed the intermediate properties between TCP and HA. The cell viability was better with BCP than TCP, and significant differences were observed on days 1 and 3. Histological analysis at eight weeks after inserting the BCP screw into the mandible of beagles revealed osseointegration between the BCP screw and bone. The results showed that BCP had better mechanical properties than TCP and excellent biocompatibility, highlighting its potential clinical use. In addition, according to its processing, BCP may be used to produce screws and plates for fracture repair or as membranes and space-modeling tents for guided bone regeneration.

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6The etiology and possible molecular mechanisms underlying calcium channel blocker-induced gingival enlargement: a narrative review

저자 : Seul Lee , Hyung-keun You

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 183-188 (6 pages)

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Gingival enlargement, defined as the abnormal proliferation of gingival tissue, can be caused by exposure to poor oral hygiene, periodontal diseases, or systemic drugs such as antihypertensive, immunosuppressive, and anticonvulsant agents. Although numerous clinical studies have examined drug-induced gingival enlargement, there is limited evidence on the molecular mechanisms underlying this disease. Therefore, the current study aims to summarize the available literature on the effects of systemic drugs such as antihypertensive agents and calcium channel blockers used for the treatment of cardiac diseases on gingival enlargement expression, and to discuss possible molecular mechanisms underlying drug-induced gingival enlargement.

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7Headache disorders in dental practice

저자 : Jin-kyu Kang , Jin-han Lee

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 189-194 (6 pages)

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Headache is a common pain disorder. Primary headaches constitute most headache disorders, with migraine and tension headaches being the most common. In contrast, secondary headaches are rare and accompanied by the underlying disease. Headaches due to dental diseases and temporomandibular disorders have also been reported. Patients complaining of headaches are often observed in dental clinics, so distinguishing each headache is crucial for specific management. Therefore, dentists should be familiar with the diagnostic criteria for primary and secondary headaches. Moreover, some secondary headaches can be life-threatening or red flags of serious diseases such as cerebral hemorrhage and brain tumor, so it is necessary to differentiate them and take emergency management or refer the patient to the appropriate department.

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8Diagnosis and treatment of maxillary molar with abnormality

저자 : Kkot-byeol Bae , Bin-na Lee , Hoon-sang Chang , In-nam Hwang , Won-mann Oh , Yun-chan Hwang

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 195-199 (5 pages)

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Endodontic treatment of an abnormally shaped tooth is complicated by irregular tooth morphology. Furthermore, root canal fusions are known to occur in abnormal teeth. The placement of canal orifices is unusual and due to their depth, they are sometimes invisible to the naked eye. As a result of the difficulty in instrumentations and obturation, root canal treatment of teeth with an abnormality is difficult. When performing root canal treatment on abnormal teeth, complex anatomic variations of the root canal system should be investigated as thoroughly as possible. Cone-beam computed tomography is an effective method for assessing the morphology of the root canal by visualizing the canal of the tooth. The case reports that follow each describe a case of root canal treatment in a maxillary molar with an abnormality.

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9A case report of nonsurgical treatment of maxillary anterior peri-implantitis

저자 : Min-cheol Yang , Seok-hwan Jeong , Kyu-man Lee , Byung-ock Kim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 200-204 (5 pages)

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Peri-implantitis is defined as an inflammatory reaction associated with bone loss beyond the initial biologic bone remodeling around a functional implant. This study aims to report the clinical and radiographic outcomes of nonsurgical peri-implantitis treatment in the maxillary anterior area. Subgingival irrigation with normal saline and antiseptics, systemic antibiotics, laser decontamination, and biofilm decontamination approach in department of periodontics and water irrigation as home care were conducted. Nonsurgical treatment of peri-implantitis resulted in healing, such as improvements in bleeding tendency, pus discharge, bad odor, and gingival recession, and resulted in a little bit bone changes around implants with severe bone resorption and shallow pocket probing depth over a 5-yr maintenance period. We confirmed that nonsurgical therapy with regular follow-up maintained peri-implantitis with an initial shallow pocket probing depth in the maxillary anterior area.

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10Removable partial denture restoration using implant-supported surveyed crowns

저자 : Yu-ri Heo

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 4호 발행 연도 : 2022 페이지 : pp. 205-209 (5 pages)

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Conventional dentures and implant-fixed prostheses are the treatment of choice for patients with multiple missing teeth. Implantassisted removable partial dentures (IARPD) represent a viable treatment option that combines these two treatment modalities to provide greater retention and stability compared to dentures alone. IARPDs also offer enhanced esthetic characteristics in patients with severe bone loss, and treatment outcomes can be improved further through careful diagnosis taking the degree of bone loss and the patient's facial features into consideration. Accurate implant placement that is compatible with the partial denture design and the opposing dentition is also crucial for success. The current clinical series includes patients that underwent partial denture treatment using implant-supported surveyed crowns, and presented satisfactory functional and esthetic treatment outcomes.

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1Alcohol ingestion reduced acetylcholine-binding protein in the submandibular gland of the rat

저자 : Bo Hyun Jung , Ki-yeon Yoo

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 107-113 (7 pages)

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Continuous alcohol ingestion may lead to various dental diseases because a hyposalivation. In this study, we investigated changes in pathology and choline acetyltransferase (ChAT, an enzyme for synthesis of acetylcholine) in the brain and acetylcholine-binding protein (AchBP, a protein responsible for modulation of synaptic transmission in cholinergic synapses) in the submandibular gland after alcohol ingestion. There was no change in neuronal death and expression of ChAT in superior salivary nucleus after alcohol ingestion. In the submandibular gland, expression of AchBP were significantly reduced after alcohol ingestion. Therefore, decrease of saliva secretion by alcohol ingestion is less related to damage of neurons in the superior salivary nucleus and decrease of acetylcholine synthesis or cholinergic neurotransmission.

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2The susceptibility of antibiotics for intracanal bacteria removal using E. faecalis biofilm model

저자 : Su-hee Go , So-hee Kim , In-chol Kang , In-nam Hwang , Won-mann Oh , Yun-chan Hwang

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 114-119 (6 pages)

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Most root canal procedures are anatomically complex, resulting in insufficient removal of the necrotic pulp by mechanical root canal shaping. This study evaluated the use of antibiotics as canal irrigants for removal of susceptible intracanal bacteria, using an Enterococcus faecalis biofilm model. Enterococcus faecalis biofilm was developed in the root canal and test tube. For the experiments, sodium hypochlorite (NaOCl), augmentin and erythromycin were used as intracanal irrigants. The test tubes and canals were prepared and irrigated with phosphate buffered saline (PBS), NaOCl, augmentin and erythromycin. Bacterial samples were collected after irrigation in the test tube models on day 1, and from the tooth model on days 1, 4 and 7. The surface of each sample and attached pattern of the bacteria was also analyzed by examining under scanning electron microscopy (SEM). The antibacterial study using 10 ml test tubes (n=10) revealed that 5% NaOCl, augmentin and erythromycin inhibited bacterial growth relative to PBS. In the tooth model, NaOCl, augmentin and erythromycin inhibited bacterial growth significantly (all p<0.05) at days 4 and 7, relative to PBS. Compared to day 1, bacterial density of all groups reduced at day 7, and changes in cell morphology were observed in all experimental groups. Our studies revealed evidence of significant differences in the antimicrobial efficacy at days 4 and 7, upon irrigation with augmentin and erythromycin versus PBS, in root canals infected with E. faecalis.

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3Periodontal disease and vasculogenic erectile dysfunction: a longitudinal health-examinee cohort study in South Korea

저자 : Jae-hong Lee , Yeon-tae Kim , Jung-kyu Choi , Seong-nyum Jeong , Seong-ho Choi

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 120-126 (7 pages)

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Data was collected for the period 2002 and 2013, from The National Health Insurance Service Health-Examinee Cohort Database, to evaluate the association between periodontal disease (PD) and vasculogenic erectile dysfunction (VED). Univariate and multivariate logistic regression models applied to a longitudinal retrospective database assessed the association between PD and VED, while adjusting for confounders of socio-demographic factors (age, household income, insurance status, health status, residence area, and smoking status) and systemic disease (cerebral infarction, myocardial infarction, angina pectoris, hypertension, diabetes mellitus, osteoporosis, lipid metabolism disturbances, and obesity). The univariate analysis revealed that VED was positively and significantly related to PD (OR = 2.07; 95% CI 1.73-2.49; P < 0.001). This was confirmed in the multivariate analysis, after adjusting for socio-demographic and systemic disease (OR = 1.45; 95% CI 1.21-1.75; P < 0.001). Using information from a longitudinal retrospective cohort database and considering the limitations of this study, we found positive and significant associations between PD and VED. Further studies are required to assess the mechanism underlying the association between PD and VED.

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4Suggestion for understanding and activation of the nursing home dentist system

저자 : Jung-min Kwag , Inn-im Park , Mee-kyoung Son

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 127-133 (7 pages)

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Various medical policies for elderly patients have been introduced in the era of aging. Recent implementation of nursing home dentist systems is a positive opportunity to recognize the significance of oral health care in managing general healthcare and improving the quality of life for elderly people. In addition, it is necessary to strengthen dentists` competencies and key roles in recovering oral function and rehabilitation with changes in the customer-oriented dental care paradigm. This study suggests the path towards stabilizing and activating nursing home dentist systems by understanding the background and current status of nursing home dentist systems, and identifying ways of improving the systems.

KCI등재

5The study on the participation of Korean dentists in public posts

저자 : Ja-won Cho , Su-hyun Shim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 134-140 (7 pages)

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There have been few reports about the manpower planning of dentists in the public sector in Korea. The purpose of this study was to research dentists` opinions about the public posts, and to suggest public health policies for the new dental manpower position. A total of 536 dentists were asked to fill out questionnaires inquiring about their opinions of public posts. We used an online survey methodology to involve 500 participants. The chi-square tests and frequency distributions were implemented to analyze the dentists` opinions about the public posts. The significance level of 0.05 was applied. A statistical package SPSS 21.0 was used for the analysis. An overwhelming majority of dentists (95.6%) answered that it is necessary to set up public posts for dentists. Respondents pointed out that the Korean Dental Association (35.5%) and the Ministry of Health and Welfare (33.2%) were the main institutes that should carry out this process. Especially, 47.4% of dentists answered they would quit their job if they had opportunities to fill public posts. Most dentists wanted to work as administrative officials (36.3%) in the public sector. Many dentists (62.4%) wanted to contribute to public welfare as health care professionals in public posts. Most of all, respondents (95.6%) answered that it is imperative to improve the manpower system of dentists in public posts.

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6Future perspective of new tooth creation

저자 : Mouetaz Kheirallah

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 141-146 (6 pages)

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Currently, outcomes of dental stem cells studies indicate that the tooth is an available source for clinical application. Finding a universal cell that can morph into many several types of oral tissues is a key for new tooth creation. If dental stem cells are isolated to form new tooth buds, with creation of an imitative condition to the embryonic jaw, this will be a revolutionary new way to replace a missing tooth. Although investigators have created tooth-like structures in studies, so far, later dental stem cells investigations will be able to create a workable vascularized implant in the human body. This review study discusses current challenges in creating a biological environment that mimics the condition of teeth as they form in an embryo.

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7The prognosis of autotransplanted tooth on molar region: 5 years follow up cases

저자 : Yong Yoon , Yong-gun Kim , Jo-young Suh , Jae-mok Lee

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 147-152 (6 pages)

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Tooth autotransplantation is the transplantation of embedded, impacted, or erupted teeth from one site to surgically prepared sockets or extraction sites within the same individual. Tooth autotransplantation is a valuable method to replace missing teeth, instead of other procedures like dental implants or prosthetic replacements. Discrimination of indication and consideration of delicate factors affecting the results is important to success in the procedure. This study reports a 5 year clinical observation of two different cases.

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8Treatment of pre-eruptive intracoronal resorption: Case report

저자 : So-young Kim , Sang-ho Lee , Nan-young Lee , Young-mi Yoon , Sung-ok Im

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 153-157 (5 pages)

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Pre-eruptive intracoronal resorption is a rare disease defined as an intracoronal radiolucent lesion. Most are revealed through casual radiological examinations, and are clinically identifiable after eruption. The possible causes of lesions include congenital abnormalities, systemic fluoride uptake, external factors after tooth formation, and eruption of the tooth; however, no definite etiology has been found. Early diagnosis through regular examination is therefore considered to be the best diagnostic method. Treatment may differ depending on the size and progression of the lesion, but conservative treatment is recommended. This case report describes two cases where the lesions were accidentally found while performing a radiologic examination addressing other issues. It is the clinician`s responsibility to identify the size of the lesion and the expected eruption time, and to execute the appropriate treatment.

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9Maxillary total arch distalization using midpalatal mini-implant: Case report

저자 : Chang-bok Song , Sung-hoon Lim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 158-166 (9 pages)

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Orthodontic mini-implant is usually placed in the buccal interdental area for molar distalization or total arch distalization. However, this requires timely replacement of the mini-implant to prevent contact between root and mini-implant and ensuing root resorption. Alternatively, midpalate may be considered as the mini-implant placement site because it has considerably dense bone and there is no interference with roots. Also, distalization forces may be designed to pass through the center of resistance of dentition for translatory distal movement. In this case report, end-on Class II occlusion with lip protrusion was successfully treated by applying distal forces from a transpalatal arch to a lever attached to two midpalatal mini-implants. Anti-rotation bends were bent on transpalatal arch to prevent mesial rotation of first molars during distalization. Another benefit of this approach is that molar distalization may be initiated at the beginning of treatment because distal tipping of molars can be prevented by applying distal force at the level of the center of resistance of molars thus eliminating the need of stiff rectangular archwire. With this approach, time-consuming molar distalization may be initiated at the beginning of treatment and therefore, overall treatment duration can be reduced.

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10Numb chin syndrome with metastatic malignancy in hyperparathyroidism: Case report

저자 : Byung-yoon Roh , Jong-mo Ahn , Jin-soo Kim , Yo-seob Seo

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 41권 3호 발행 연도 : 2017 페이지 : pp. 167-172 (6 pages)

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Numb chin syndrome (NCS) is sensory neuropathy characterized by numbness in the chin and lower lip, involving distribution of the mental nerve. Causes of NCS may be of regional origin, a systemic disease, and malignancy. In this study, we report a case of NCS occurring as a first symptom of malignant metastasis in a 57-year-old female patient diagnosed with hyperparathyroidism.

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자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

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