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대한피부과학회> 대한피부과학회지> 유방암과 연관된 림프관내조직구증식증

KCI등재SCOUPUS

유방암과 연관된 림프관내조직구증식증

A Case of Intralymphatic Histiocytosis Associated with Breast Cancer

김종규 ( Jong Kyu Kim ) , 김민성 ( Min Sung Kim ) , 나찬호 ( Chan Ho Na ) , 이예선 ( Yea Son Lee ) , 신봉석 ( Bong Seok Shin )
  • : 대한피부과학회
  • : 대한피부과학회지 55권8호
  • : 연속간행물
  • : 2017년 09월
  • : 522-525(4pages)
대한피부과학회지

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Intralymphatic histiocytosis (IH) is a rare disease with variable and nonspecific clinical features, but with characteristic histopathological findings. Histopathologically, dilated lymphatic vessels containing aggregates of mononuclear cells are observed near the reticular dermis. IH is often associated with other diseases, such as rheumatoid arthritis, osteoarthritis, joint metal implantation, and with breast cancer where it occurs over the mastectomy scar. Although the pathogenesis of IH is not defined, some authors have suggested that lymphatic vessel engorgement by histiocytes migrating from neighboring inflammatory reactions may play a key pathogenic role. We present a case of IH associated with breast cancer. A 50-year-old female developed multiple tender erythematous plaques on both breasts and the right shoulder 3 years after bilateral mastectomy. To our knowledge, this is the first case of IH in association with breast cancer in the Korean dermatologic literature. (Korean J Dermatol 2017;55(8):522∼525)

UCI(KEPA)

I410-ECN-0102-2018-500-000709404

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9620


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KCI등재 SCOPUS

1두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

저자 : 손우리 ( Uri Shon ) , 염규진 ( Kyujin Yeom ) , 윤대관 ( Dea Kwan Yun ) , 김명화 ( Myung Hwa Kim ) , 최미수 ( Mi Soo Choi ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 735-741 (7 pages)

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Background: Basal cell carcinoma (BCC) is the most common type of skin cancer. However, limited comparative data on the characteristics and prognosis of BCC in the H-zone and non-H-zone exist.
Objective: We aimed to compare the clinical, histopathological, and surgical characteristics of BCCs in the head and neck region between the H- and non-H-zones.
Methods: We retrospectively reviewed the clinical and histopathological characteristics of 292 head and neck BCC lesions in 275 patients and the characteristics of Mohs micrographic surgery (MMS) of 252 BCC lesions in 239 patients.
Results: In the H-zone, 226 lesions (77.4%) were found. Clinically, patients with H-zone BCC, compared to those with non-H-zone, were significantly older (71.6±11.4 years vs. 64.6±13.5 years) and smaller in diameter (10.1±7.1 mm vs. 12.4±9.9 mm). The noduloulcerative type was more frequent in the H-zone, while the superficial and morpheaform types in the non-H-zone. Histopathologically, the infiltrative subtype was particularly noted in the H-zone than the non-H-zone (7.5% vs. 1.5%). Out of 37 BCC patients with prior treatment history, 31 (83.8%) were in the H-zone. Two out of 252 lesions (0.8%) recurred after MMS at our institution. The mean stages of MMS were comparable between the H- and non-H-zones (1.59 vs. 1.45, p=0.135).
Conclusion: H-zone BCCs were associated with older age and smaller tumor size compared to the non-H-zone BCCs. The noduloulcerative clinical and nodulocystic pathologic subtypes were the most common in both H-zone and non-H-zone BCCs. (Korean J Dermatol 2021;59(10):735∼741)

KCI등재 SCOPUS

2수지점액낭종 환자에서 유형 및 치료 반응에 대한 후향적 연구

저자 : 정준우 ( Joon Woo Jung ) , 홍은혜 ( Eun Hye Hong ) , 백은주 ( Eun Joo Baek ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 742-748 (7 pages)

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Background: Digital mucous cysts (DMCs) are benign, occurring mainly on the fingers but rarely on the toes. Although the exact cause of DMC has not been identified, it is classified into two different types based on its pathogenesis and location. Surgical and nonsurgical procedures, including aspiration, sclerotherapy, steroid injection, cryotherapy, and CO2 laser, can be used to treat DMC.
Objective: This study aimed to compare treatment response based on DMC type and evaluate its efficacy in surgical and nonsurgical (sclerotherapy) treatments.
Methods: We retrospectively reviewed the electronic medical records of patients with DMC who visited our dermatology department between January 2010 and November 2020.
Results: This study enrolled 39 patients having a mean age of 59.2 years. The proportion of female patients (21/39, 53.8%) was more than male (18/39, 46.2%). The DMC occurrence was more frequent in the fingers (32/39, 82.1%), especially in the index and middle fingers than in the toes (7/39, 17.9%). In sclerotherapy, DMC in the distal interphalangeal joint (DIPJ) required more treatment than that in the proximal nail fold (PNF) (p<0.05). The number of treatments using sclerotherapy was higher compared to that of surgical treatments (p<0.05).
Conclusion: The DIPJ type of DMC patients was more difficult to treat using sclerotherapy than the PNF type. Moreover, surgical treatment has a better response than sclerotherapy. (Korean J Dermatol 2021;59(10):742∼748)

KCI등재 SCOPUS

3혈청 비타민 D 레벨 및 혈중 지질 농도와 건선: 단일 3차 의료기관에 내원한 한국인 건선 환자를 대상으로 한 임상적 고찰

저자 : 박현정 ( Hyeon Jeong Park ) , 이현주 ( Heun Joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 749-760 (12 pages)

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Background: Psoriasis is a chronic inflammatory autoimmune disease. Some studies have demonstrated a relationship of psoriasis with vitamin D (Vit D) deficiency or serum lipid levels.
Objective: We aimed to compare serum levels of Vit D and lipids in patients with active psoriasis and control subjects. Additionally, we analyzed the relationship of disease severity with serum Vit D and lipid levels.
Methods: A total of 243 patients were retrospectively analyzed. Statistical data were evaluated, and the values were considered significant at p<0.05.
Results: Statistically significant difference in Vit D levels between the psoriasis (n=117) and the control groups (n=126) was not found. In addition, an association between Vit D levels and the disease severity, using the psoriasis area and severity index (PASI) was not observed. The proportion of overweight patients (body mass index [BMI]≥ 23 kg/m2) was higher in the psoriasis group than in the control group, and there was a significant relationship between the increase in PASI and the serum triglycerides (TG) levels (p<0.05).
Conclusion: The psoriasis and control groups did not show a statistical difference in serum Vit D levels. In the subgroup analysis of cases with normal BMI, excluding the underlying disease, no significant difference in Vit D levels between the two groups was observed. However, the association of psoriasis with factors, such as BMI and TG, was found to be significant; hence, these could be therapeutic targets in patients with psoriasis to improve their quality of life. Controlled and well-designed studies are required in the future. (Korean J Dermatol 2021;59(10):749∼760)

KCI등재 SCOPUS

4박피 레이저 치료 후 발생하는 염증 후 홍반과 색소 침착에 대한 표피 성장 인자 함유 연고의 효과에 관한 연구

저자 : 송창화 ( Chang Hwa Song ) , 정유진 ( You Jin Jung ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro ) , 김정은 ( Jeong Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 761-769 (9 pages)

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Background: Epidermal growth factor (EGF) stimulates wound healing in various skin conditions, and EGFcontaining formulations can promote wound regeneration and help reduce complications after laser treatment.
Objective: To evaluate the effect of EGF-containing ointment on wound regeneration after ablative laser treatment and laser-induced postinflammatory erythema (PIE) and hyperpigmentation (PIH).
Methods: Twenty-five patients who required treatment with ablative laser on both sides of the face were enrolled and underwent one session of laser treatment. Postoperatively, all patients were instructed to apply the EGFcontaining ointment on the randomly assigned-hemifacial side, while gentamicin cream was applied on the opposite side. Investigators' global assessment (IGA), evaluating general wound condition, erythema, pigmentation, and scab shedding, and patient's global assessment (PGA), evaluating patient satisfaction with clinical improvement, were both measured at 1 week and 4 weeks after treatment. Objective assessments, including melanin index (MI), erythema index (EI), skin hydration, and transepidermal water loss (TEWL), were measured before treatment and at 1 week and 4 weeks after treatment.
Results: The EGF-containing ointment showed better outcomes with IGA (1 week; p=0.02, 4 weeks; p=0.002) and PGA (1 week; p=0.04, 4 weeks; p=0.01) scores compared to gentamicin cream. Compared to gentamicin cream, treatment with EGF-containing ointment resulted in significantly lower EI (p=0.044) and MI (p=0.023), but skin hydration and TEWL between the two groups exhibited nonsignificant differences.
Conclusion: EGF-containing ointment could be an effective adjuvant option for wound regeneration after ablative laser treatment and minimizing laser-induced PIE and PIH in Asian patients. (Korean J Dermatol 2021;59(10):761∼769)

KCI등재 SCOPUS

5The Efficacy of Skin Care Habit Modifications on the Skin Barrier Function in Rosacea Patients

저자 : Jung Eun Seol , Gyeong Je Cho , Sang Woo Ahn , Seong Min Hong , So Hee Park , So Young Jung , Hyojin Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 770-777 (8 pages)

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Background: Patients with rosacea usually suffer from skin irritations, such as itching, stinging, burning, and pain. These symptoms may be related to the skin barrier function disruption.
Objective: We investigated the skin barrier functions in patients with mild to moderate rosacea and the associated improvements based on the skin care habit modifications and treatment modalities.
Methods: We analyzed the data on transepidermal water loss (TEWL) and stratum corneum hydration (SCH) of skin lesions in 27 patients with rosacea and healthy skin of 29 control subjects. We compared the results of TEWL and SCH based on sex, age, type of rosacea, skin care habits, and the treatment modalities.
Results: The skin in the patients with rosacea exhibited increased TEWL and decreased SCH compared with that in control subjects. Male patients showed increased TEWL and decreased SCH compared to female patients. Combination therapy with systemic minocycline and topical metronidazole improved the skin barrier functions. Patients with better skin care habits presented better skin barrier functions and clinical improvement.
Conclusion: Patients with rosacea, especially those with poor skin care habits, showed reduced skin barrier functions. Appropriate skin care habits with cleansers and moisturizers are recommended for the management of rosacea. (Korean J Dermatol 2021;59(10):770∼777)

KCI등재 SCOPUS

6A Clinical Study of Trichotillomania in 198 Cases: An Update and Cross-Time Comparison

저자 : Ji-hoon Lim , Ki-hun Kim , Soon-hyo Kwon , Woo-young Sim , Bark-lynn Lew

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 778-784 (7 pages)

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Background: Trichotillomania (TTM) is characterized by recurrent hair pulling, resulting in hair loss. TTM is typically encountered in dermatology settings; however, few reports on the clinical characteristics of TTM in a large population are available.
Objective: To evaluate the clinical characteristics of TTM.
Methods: We performed a retrospective chart review of patients diagnosed with TTM between 2006 and 2019.
Results: Clinical records of 198 patients were analyzed. The average age of TTM onset was 10.8 years, and 119 patients experienced childhood-onset (at <12 years). Sex prevalence showed a female predominance, and the proportion of females was lower in the childhood-onset TTM than in the late-onset TTM (onset at ≥12 years). Vertex was the most commonly involved site. A history of stressful situations was noted in 48 patients (24.2%). In the group with a poor prognosis, the number of patients with ≥25% scalp invasion was significantly more than the other group. The average duration of hair loss to more than 50% recovery was 4.88 months for childhood-onset TTM cases and 9.83 months for late-onset TTM cases. The prognosis was significantly better in the childhood-onset TTM than in the late-onset TTM. Nail biting and folliculitis were the most common co-occurring repetitive behavior and comorbid disease, respectively.
Conclusion: Unlike previous domestic studies, patients with childhood-onset TTM had a female preponderance. Moreover, the proportion of patients who experienced a stressful situation was higher than that reported in a previous study. In addition, patients with severe disease and late-onset TTM had a significantly poorer prognosis. (Korean J Dermatol 2021;59(10):778∼784)

KCI등재 SCOPUS

7Port-Wine Stains Confined to a Single Cosmetic Unit than on Multiple Cosmetic Units Respond Better to Pulsed Dye Laser Treatment: A Retrospective Study

저자 : Gyoo Huh , Jin Seop Kim , Heun Joo Lee , Young-jun Choi , Ga-young Lee , Won-serk Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 785-792 (8 pages)

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Background: Cosmetic units are designated based on their similarity in topographic anatomy, texture and color, solar exposure, hair density, and sebaceous features. The difference of such features in facial port-wine stain (PWS) cases can affect the response to pulsed dye laser (PDL) treatment.
Objective: To evaluate the response of facial PWS to PDL treatment based on the underlying cosmetic units.
Methods: A retrospective study was conducted on 18 patients with facial PWS who received PDL treatment. For clinical assessment, three dermatologists evaluated the photographs taken before each treatment session. The response grade was assigned according to the quartile grading scale. The lesion was classified based on the underlying cosmetic units.
Results: The cheek was the most (50%) commonly involved area. All PWS (6/6) confined to one cosmetic unit showed a marked improvement compared with 16% PWS (2/12) affecting two or more units (p<0.05). Patients with PWS within one cosmetic unit required fewer treatment sessions to achieve marked improvement.
Conclusion: PWS confined to a single cosmetic unit than that located in two or more units responded better to PDL treatment. Before PDL treatment for facial PWS, age, initial lesion size, as well as the number of cosmetic units affected by the lesion should be considered. (Korean J Dermatol 2021;59(10):785∼792)

KCI등재 SCOPUS

8크론병 환자에서 발생한 다발성 보웬병 1예

저자 : 조민아 ( Minah Cho ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 793-796 (4 pages)

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A 47-year-old man with a 25-year history of Crohn's disease, presenting asymptomatic erythematous scaly patches (size, 1∼3 cm in diameter) on his back, left hand, right wrist, left ankle, and left sole, visited our clinic. Histopathological examination of the lesions revealed Bowen's disease. Herein, we report a rare case of multiple Bowen's disease in the skin, away from the anogenital region, in a patient with Crohn's disease. (Korean J Dermatol 2021;59(10):793∼796)

KCI등재 SCOPUS

9간찰 부위에서 발생한 전신형 고리 육아종 1예

저자 : 허규 ( Gyoo Huh ) , 이현주 ( Heun-joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 797-800 (4 pages)

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Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

KCI등재 SCOPUS

10A Case of Lyme Disease Followed by Post-Treatment Lyme Disease Syndrome

저자 : Sung Ha Lim , Eung Ho Choi

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 801-804 (4 pages)

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Lyme disease caused by Borrelia species is transmitted via infected tick bites. Erythema migrans, a typical skin lesion on the tick-bitten site, is a hallmark of Lyme disease. A 63-year-old female presented an erythematous, semi-circular patch in the left inguinal area. It disappeared spontaneously without treatment. However, after 3 months, an erythematous patch with a diameter of 1 cm recurred on the left thigh. B. burgdorferi antibody testing revealed positive results. At the second visit, doxycycline was prescribed, and the skin lesion was resolved. However, the patient exhibited persistent systemic symptoms, including arthralgia and fatigue, and was diagnosed with post-treatment Lyme disease syndrome (PTLDS). The PTLDS prognosis is associated with delayed diagnosis. Thus, antibiotic treatment should be promptly initiated after suspecting Lyme disease to minimize the associated systemic symptoms. PTLDS diagnosis should be followed by proper medical care to alleviate the symptoms. (Korean J Dermatol 2021;59(10):801∼804)

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KCI등재SCOUPUS

1단일 기관에서 시행한 피부과 전문의에 대한 인식도 조사

저자 : 이준범 ( Joon-bum Lee ) , 오병호 ( Byung-ho Oh ) , 류영욱 ( Young-wook Ryoo ) , 김성애 ( Sung-ae Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 483-489 (7 pages)

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Background: Currently, physicians from different medical specialties treat patients` skin conditions, especially for cosmetic purposes. Although diagnosis and treatment made by non-dermatologists may sometimes be improper, many patients are unable to distinguish a non-dermatologist from a dermatologist.
Objective: The aim of this study was to evaluate public`s perception of dermatologists.
Methods: A total of 515 participants completed the online survey. The questionnaire consisted of three main parts: information regarding respondents, experience of dermatological treatments, and awareness of skin treatments performed by dermatologists, and by medical specialties.
Results: Overall, 48% of respondents were unable to distinguish a dermatologist from a non-dermatologist; however, 93% of respondents responded that they were willing to visit a dermatologist for treatment. A fair number of respondents identified dermatologists by signboards, professional biographies, and licenses. However, some nondermatologists` signboards and biographies were considered misleading and confused patients.
Conclusion: Many patients intend to visit a dermatologist for their dermatological treatments. However, half could not distinguish dermatologists from non-dermatologists. For this reason, we underline the importance of increasing public awareness of the dermatologist`s expertise in helping patients in choosing their clinics. (Korean J Dermatol 2017;55(8):483∼489)

KCI등재SCOUPUS

2DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) 증후군에 대한 15년간의 후향적 연구: 단일 기관에서의 경험

저자 : 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee ) , 박혜진 ( Hai Jin Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 490-496 (7 pages)

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Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome involving multiple organs. Due to a variable clinical presentation and uncertain definition, diagnosis is often delayed or misdiagnosed.
Objective: The purpose of this study was to investigate the common causative drugs of DRESS and differences according to drugs, clinical features, and prognosis of DRESS, and secondly to compare the differences between steroid use group versus non-use group.
Methods: Medical records of hospitalized patients at the Sanggye Paik Hospital from January 2001 to December 2015 were collected. DRESS patients were enrolled retrospectively using the RegiSCAR diagnostic criteria.
Results: A total of 65 patients were included. The four most common causative drug groups were antibiotics (27.7%), anticonvulsants (20%), antituberculosis agents (16.9%), and allopurinol (16.9%). The mean incubation period was 4 weeks, significantly shorter in antibiotics (2 weeks, p<0.001) and significantly longer in anticonvulsants (6.5 weeks, p=0.033). Sixty-three patients fully recovered with a mean recovery time of 3.1 (standard deviation 2.2) weeks, one patient had sequelae, and one patient died. Recovery time tended to increase with longer duration of diagnosis from rash onset (p<0.001, correlation coefficient=0.419) and higher serum aspartate aminotransferase levels (p=0.024, correlation coefficient=0.297). The mean recovery time was 1 week shorter for the systemic steroid use group, but it was not statistically significant (p=0.056).
Conclusion: DRESS may be a heterogeneous syndrome with specific characteristics related to different drugs. The prognosis of DRESS is relatively good and the role of systemic steroid therapy is unclear. Prompt diagnosis and immediate discontinuation of the causative drug are essential for early recovery. (Korean J Dermatol 2017;55(8):490 ∼496)

KCI등재SCOUPUS

3피부과로 의뢰된 경남지역암센터 입원 환자에 대한 분석

저자 : 정해봉 ( Hae Bong Jeong ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 497-503 (7 pages)

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Background: The number of patients diagnosed with cancer has increased, and so has the number of dermatological consultations for related skin diseases.
Objective: To purposes of this study was to analyze the frequency and characteristics of dermatologic consultations at the Gyeongnam Cancer Center over a 9-year period.
Methods: We reviewed the records of 1,273 cases referred for dermatologic consultation at the Gyeongnam Cancer Center from 2007 to 2015.
Results: Dermatologic consultations increased over the 9-year period, with overall trends increasing in spring and summer. The most common age group comprised the 60∼69-year-old group (27.34%) and the male-to-female ratio was 1:0.6. Lung cancer was the most common underlying disease (25.53%). The most frequent skin disorder was infectious disease (33.78%), followed by drug eruption, erythema and urticaria (20.42%), and eczema (19.48%). The most common procedure was dressing or wet dressing (25.95%) followed by the KOH test (22.79%). The main reasons for dermatologic consultations were dermatologic disease or conditions (81.23%), followed by skin lesions related to the treatment of underlying disease (16.81%).
Conclusion: This study analyzed skin disease in cancer center inpatients. In conclusion, dermatologists should be responsible for the management of skin disease in cancer patients for more accurate examination and treatment. (Korean J Dermatol 2017;55(8):497∼503)

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4Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss

저자 : Byung In Ro , Suk Young Lee , Jong Baik Kim , Hang Cheol Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 504-510 (7 pages)

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Background: A growth factor cocktail (GFC) including fibroblast growth factor 9 (FGF9) in combination with microneedling is an effective and safe treatment for patients with androgenetic alopecia (AGA). However, there is a lack of studies evaluating its effects based on microneedle depth.
Objective: This study aimed to evaluate the effects of a GFC including FGF9 on hair growth in patients with AGA, and compare the differences in efficacy according to microneedle depth.
Methods: The study was performed on patients with AGA who were treated with topical GFC including FGF9 with microneedling once every 2 weeks for 3 months. The scalp was divided into right and left sides, and treated with GFC including FGF9 (right side) and normal saline (left side). The microneedle depth was 0.8 mm for both sides. A total of 22 patients (11 males and 11 females) were enrolled. GFC including FGF9 was topically applied with a microneedle medical device. Treatment efficacy was evaluated through phototrichogram and digital photograph analyses after 6 repeated treatments for 3 months.
Results: The phototrichogram images showed that 3 months of treatment with GFC including FGF9 with microneedling increased hair density (27.4±4.4/cm2) and diameter (2.7±2.7 μm); increases in hair density (5.7±4.4/cm2) and diameter (2.2±2.3 μm) were also seen in the region of the scalp that received normal saline. These results were statistically significant (p<0.05). The treatment effect was not significantly different between microneedle depths of 0.8 mm (used in this study) and 0.5 mm (used in our previous study) in terms of both hair density and hair diameter.
Conclusion: GFC including FGF9 with microneedling is an effective and safe treatment for patients with AGA. According to the results of this study and our previous report, we believe that microneedle depths of 0.5∼0.8 mm can sufficiently stimulate the scalp to increase drug-delivery. (Korean J Dermatol 2017;55(8):504∼510)

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5성게 가시 자상과 동반된 이상 감각 1예

저자 : 김영호 ( Yeong Ho Kim ) , 이지현 ( Ji Hyun Lee ) , 박영민 ( Young Min Park ) , 이준영 ( Jun Young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 511-513 (3 pages)

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Sea urchins are marine invertebrates commonly found in coastal areas around the world. The potential mechanisms of injury are primary puncture wounds, envenomation, and the foreign body reaction. A 20-year-old woman presented with multiple, 0.2 to 0.3 cm-sized, erythematous papules with central blackish particles accompanied by numbness and pain on the dorsum of the right foot and ankle for 7 days. She had been injured by a sea urchin 7 days prior at the seaside in Guam. A skin biopsy of the lesion showed inflammation with foreign body reaction. The attending physician removed all the blackish particles and applied mupirocin ointment. Although skin lesions improved over time, numbness and pain still remained. There have been only six reported cases of sea urchin granuloma in Korea, but no reports of sea urchin injury with neurologic symptoms. Herein, we report a rare case of sea urchin injury accompanied by paresthesia. (Korean J Dermatol 2017;55(8):511∼513)

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6얼굴백선과 유사한 양상으로 나타난 다륜형 소방성 혈관종

저자 : 오의현 ( Eui Hyun Oh ) , 한성수 ( Sung Soo Han ) , 박형권 ( Hyung Kwon Park ) , 김정수 ( Joung Soo Kim ) , 유희준 ( Hee Joon Yu )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 514-517 (4 pages)

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Tufted angioma is a rare benign vascular neoplasm that usually occurs in children. It appears as an erythematous, purplish, indurated papule or plaque on the trunk or neck. Although it can have variable clinical manifestations, the annular or serpiginous configuration of lesions resembling tinea infections has rarely been reported. A 47-year-old woman presented with an erythematous plaque enlarging by peripheral extension to form polycyclic or serpiginous figures on her left chin and buccal cheek for 7 months without any subjective symptoms. Tinea faciale was considered as the initial clinical diagnosis, but repeated KOH tests were all negative; therefore, skin biopsy was performed. Histopathology revealed discrete circumscribed foci of capillaries scattered throughout the dermis showing a cannon ball appearance, compatible with tufted angioma. Clinical features showed considerable improvement after 2 sessions of intense pulsed light and pulsed-dye laser (5 repetitions) without any complications. Herein, we report a rare case of polycyclic variant of tufted angioma, which developed in a woman in her 5th decade. (Korean J Dermatol 2017;55(8):514∼517)

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7이산화탄소 레이저로 치료한 Papular Acantholytic Dyskeratosis 1예

저자 : 이수경 ( Soo Kyung Lee ) , 김동주 ( Dong Joo Kim ) , 서중헌 ( Joong Heon Suh ) , 이운하 ( Un Ha Lee ) , 김명신 ( Myoung Shin Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 518-521 (4 pages)

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Papular acantholytic dyskeratosis is a collection of papular skin lesions that occur in the intertriginous and genital area. They show a characteristic histology of focal suprabasal acantholysis that distinguishes it from Hailey-Hailey disease or Darier disease. We describe a 50-year-old man with an asymptomatic papular eruption on the perianal area for several years. Histologically, a biopsy specimen showed diffuse hyperkeratosis and irregular acantholysis throughout the epidermis. We used carbon dioxide laser therapy as a therapeutic option. Despite causing a long and painful healing process, a considerable reduction of the symptoms was achieved. Although we do not know the precise nature or the incidence of this disease, papular acantholytic dyskeratosis should be included in the differential diagnosis of verrucous papules in perineal or perianal areas and carbon dioxide laser may represent a good therapeutic option. (Korean J Dermatol 2017;55(8):518∼521)

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8유방암과 연관된 림프관내조직구증식증

저자 : 김종규 ( Jong Kyu Kim ) , 김민성 ( Min Sung Kim ) , 나찬호 ( Chan Ho Na ) , 이예선 ( Yea Son Lee ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 522-525 (4 pages)

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Intralymphatic histiocytosis (IH) is a rare disease with variable and nonspecific clinical features, but with characteristic histopathological findings. Histopathologically, dilated lymphatic vessels containing aggregates of mononuclear cells are observed near the reticular dermis. IH is often associated with other diseases, such as rheumatoid arthritis, osteoarthritis, joint metal implantation, and with breast cancer where it occurs over the mastectomy scar. Although the pathogenesis of IH is not defined, some authors have suggested that lymphatic vessel engorgement by histiocytes migrating from neighboring inflammatory reactions may play a key pathogenic role. We present a case of IH associated with breast cancer. A 50-year-old female developed multiple tender erythematous plaques on both breasts and the right shoulder 3 years after bilateral mastectomy. To our knowledge, this is the first case of IH in association with breast cancer in the Korean dermatologic literature. (Korean J Dermatol 2017;55(8):522∼525)

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9Tranilast로 치료한 소아 외음부 비립종양 한관종 1예

저자 : 권원주 ( Won Joo Kwon ) , 신요섭 ( Yo Sup Shin ) , 박복원 ( Bok Won Park ) , 조은별 ( Eun Byul Cho ) , 박은주 ( Eun Joo Park ) , 김광호 ( Kwang Ho Kim ) , 김광중 ( Kwang Joong Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 526-528 (3 pages)

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Syringoma is the most common type of benign intraepidermal eccrine sweat gland tumor in Korea, and is usually found in women in their forties. It presents mostly as a localized lesion, preferring the lower eyelid, cheek, or forehead, and rarely invades the vulval area, and in the case of children, vulvar invasion is even more rare. Tranilast is an antihistamine used for atopic dermatitis and asthma, and has recently been used for the treatment of keloid. A few previous studies have reported both localized and generalized forms of syringoma being effectively resolved with tranilast. Herein, we report a rare and interesting case of milium-like syringoma, which manifested on the vulval area of 10-year old girl that was successfully treated with tranilast. (Korean J Dermatol 2017;55(8):526∼ 528)

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10A Case of Cutaneous Sinus Tract of Odontogenic Origin

저자 : Kimin Sohn , Hei Sung Kim , Sang Hyun Cho , Jeong Deuk Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 529-532 (4 pages)

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A cutaneous sinus tract of odontogenic origin occurs when purulent by-products of dental pulp necrosis spread along the path of least resistance from the root apex to the skin on the face. Patients presenting with this condition usually visit a dermatologist first, as the lesion can mimic various dermatologic pathologies, ranging from an epidermal cyst to basal cell carcinoma. The location of the sinus in the head and neck region should lead the dermatologist to seek a dental origin in order to avoid misdiagnosis. The lesion may persist for long periods before a correct diagnosis is made and the odontogenic source is treated appropriately. Herein, we report a case of a cutaneous sinus tract of odontogenic origin. (Korean J Dermatol 2017;55(8):529∼532)

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