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대한피부과학회> 대한피부과학회지> Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss

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Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss

Byung In Ro , Suk Young Lee , Jong Baik Kim , Hang Cheol Shin
  • : 대한피부과학회
  • : 대한피부과학회지 55권8호
  • : 연속간행물
  • : 2017년 09월
  • : 504-510(7pages)
대한피부과학회지

DOI


목차

INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
CONCLUSION
REFERENCES

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Background: A growth factor cocktail (GFC) including fibroblast growth factor 9 (FGF9) in combination with microneedling is an effective and safe treatment for patients with androgenetic alopecia (AGA). However, there is a lack of studies evaluating its effects based on microneedle depth.
Objective: This study aimed to evaluate the effects of a GFC including FGF9 on hair growth in patients with AGA, and compare the differences in efficacy according to microneedle depth.
Methods: The study was performed on patients with AGA who were treated with topical GFC including FGF9 with microneedling once every 2 weeks for 3 months. The scalp was divided into right and left sides, and treated with GFC including FGF9 (right side) and normal saline (left side). The microneedle depth was 0.8 mm for both sides. A total of 22 patients (11 males and 11 females) were enrolled. GFC including FGF9 was topically applied with a microneedle medical device. Treatment efficacy was evaluated through phototrichogram and digital photograph analyses after 6 repeated treatments for 3 months.
Results: The phototrichogram images showed that 3 months of treatment with GFC including FGF9 with microneedling increased hair density (27.4±4.4/cm2) and diameter (2.7±2.7 μm); increases in hair density (5.7±4.4/cm2) and diameter (2.2±2.3 μm) were also seen in the region of the scalp that received normal saline. These results were statistically significant (p<0.05). The treatment effect was not significantly different between microneedle depths of 0.8 mm (used in this study) and 0.5 mm (used in our previous study) in terms of both hair density and hair diameter.
Conclusion: GFC including FGF9 with microneedling is an effective and safe treatment for patients with AGA. According to the results of this study and our previous report, we believe that microneedle depths of 0.5∼0.8 mm can sufficiently stimulate the scalp to increase drug-delivery. (Korean J Dermatol 2017;55(8):504∼510)

UCI(KEPA)

I410-ECN-0102-2018-500-000709368

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9592


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59권8호(2021년 09월) 수록논문
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1단기간 피부과 의료봉사와 세계보건: 기후 변화 분석을 통한 후향적 연구

저자 : 함민석 ( Min Seok Ham ) , 김대연 ( Dae Yeon Kim ) , 김대현 ( Dai Hyun Kim ) , 서수홍 ( Soo Hong Seo ) , 안효현 ( Hyo Hyun Ahn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 581-586 (6 pages)

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Background: The coronavirus disease pandemic has directly impacted global health. In developing countries, health service problems are more serious because of the lack of healthcare infrastructure. In this situation, if medical needs could be predicted, it would be helpful to bridge the medical gap with the provision of appropriate medical support.
Objective: The aim of this study was to evaluate the association between climate change and skin diseases in developing countries to better prepare for medical missions.
Methods: From 2012 to 2016, except for 2014, we visited a mission site located in Luzon, Philippines, every July. We retrospectively reviewed 499 patient data as well as weather information.
Results: The total number of patients decreased each year. The climate change analysis using Pearson correlation showed that the temperature and ultraviolet index tended to increase every year (r2=0.99, 0.93, respectively; p< 0.05). Conversely, humidity and rainfall decreased (r2=-0.99, -0.96, respectively; p<0.05). The Cochran-Armitage test showed that the rate of infectious skin disease diagnoses decreased every year compared to that of eczematous diseases.
Conclusion: The total number of patients decreased by approximately 50% during medical service. We believe that the improvement in living standards and hygiene through continuous medical support has influenced the change in the incidence of skin diseases. Climate change was also thought to have affected the rate of skin disease diagnoses; in fact, the rate of infectious disease diagnoses tended to decrease compared to that of eczematous diseases. This analysis would be helpful for preparing for medical support. (Korean J Dermatol 2021;59(8):581∼586)

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2화농성 한선염 환자의 병변 평가와 중증도 설정을 위한 초음파 검사의 유용성

저자 : 김고은 ( Ko Eun Kim ) , 정재영 ( Jae Yeong Jeong ) , 박병근 ( Byeong Geun Park ) , 김일환 ( Il-hwan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 587-595 (9 pages)

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Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition characterized by recurrent abscesses, nodules, and fistulous tracts. Recently, novel staging systems, including sonographic scoring system of hidradenitis suppurativa (SOS-HS), have been widely introduced in HS.
Objective: To assess the efficacy of SOS-HS compared with Hurley staging and modified sartorius scoring (MSS) system and determine the necessity of ultrasound evaluation.
Methods: A radiologist performed an ultrasound evaluation, and three dermatologists reviewed the images and videos. Clinical characteristics, including staging and demographic data, were recorded by three dermatologists. The correlation of each staging system and the significance of vascularity (Doppler mode) and lesion depth on sonography were statistically analyzed.
Results: Among the 46 patients, 34.8% were classified as stage 1 and 3, and 30.4% were classified as stage 2 in the SOS-HS system, which was statistically higher than the Hurley staging (p<0.0005). MSS score increased according to the SOS-HS stages (p<0.0005, p=0.001). Vascularity and depth of involvement also increased with SOS-HS and Hurley staging.
Conclusion: Sonographic examination can be applied in HS severity assessment and documentation of the clinical characteristics of each lesion in detail. Special tools, such as Doppler mode and depth assessment, can also be useful in HS evaluation. (Korean J Dermatol 2021;59(8):587∼595)

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3최근 8년간(2012∼2020) 단일기관 피부과에서의 연조직염 입원환자에 대한 임상적 고찰

저자 : 정홍필 ( Hong Pil Jeong ) , 김창일 ( Chang Il Kim ) , 허은필 ( Eun Phil Heo ) , 고재완 ( Jae Wan Go )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 596-603 (8 pages)

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Background: Cellulitis is one of the most common infectious skin diseases treated by hospitalization, and presents with various clinical features and treatment responses. Therefore, more detailed analysis on this condition is required.
Objective: To investigate the clinical characteristics of cellulitis among dermatology inpatients in a single center.
Methods: We retrospectively reviewed the medical records of 84 patients hospitalized with cellulitis between January 2012 and August 2020. We analyzed the differences by dividing them into <60-year-old and >60-year-old age groups.
Results: The average age of the 84 inpatients in this study was 48.8 years with the peak incidence in fifties. Cellulitis was most prevalent in the calf (39.8%). Erythrocyte sedimentation rate (ESR) and risk factors such as obesity and smoking had positive correlations with duration of hospital stay (p<0.05). There was no significant difference in duration of hospital stay between those administered first-generation cephalosporin and other antibiotics.
Conclusion: Our data showed that ESR, obesity, and smoking were correlated to the hospitalization periods. In particular, it showed positive correlation of C-reactive protein and ESR with duration of hospital stay in those below the age of 60 years. (Korean J Dermatol 2021;59(8):596∼603)

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4스티븐스 존슨 증후군 및 독성표피괴사융해증 88예의 임상적 고찰

저자 : 홍정연 ( Jeong Yeon Hong ) , 정의현 ( Euy Hyun Chung ) , 양나경 ( Na Gyeong Yang ) , 김재윤 ( Jae Yun Kim ) , 허남훈 ( Nam Hun Heo ) , 이설희 ( Sul Hee Lee ) , 김정은 ( Jung Eun Kim ) , 이성열 ( Sung Yul Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 604-610 (7 pages)

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Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are potentially fatal acute hypersensitivity reactions that involve the skin and mucous membranes. Because they are relatively rare diseases, it is difficult to obtain well-organized epidemiological data. The clinicodemographic characteristics, culprit drugs, and factors related to disease prognosis may vary.
Objective: To identify the characteristics of SJS/TEN by investigating patient clinicopathological characteristics, laboratory findings, suspected drugs, and mortality through a retrospective study using medical record data.
Methods: The clinical records of patients diagnosed with SJS/TEN between February 2009 and February 2019 at three medical institutions of Soonchunhyang University were retrospectively reviewed. Data pertaining to sex, age, history, suspected drugs, latent period, laboratory findings, and mortality were collected, and their correlations were analyzed.
Results: We identified SJS/TEN in 88 patients. Among the probable causative agents, antibiotics were the most common (29 cases, 33.0%), followed by nonsteroidal anti-inflammatory drugs (NSAIDs) in 20 cases (22.7%). The period between drug administration and symptom onset varied with the causative agent. Patients who died had high SCORTEN scores. In addition, hypertension, diabetes, renal failure, and cardiac disease had a statistically significant association with high SCORTEN.
Conclusion: Antibiotics, NSAIDs, antiepileptics and allopurinol were the most commonly implicated drugs in our retrospective study. There was a significant correlation between comorbidities. Because SJS/TEN is a life-threatening condition, early recognition of the suspected drug are important. The results of this study may provide insights that aid in the early diagnosis and prediction of disease outcomes of SJS/TEN in the Korean population. (Korean J Dermatol 2021;59(8):604∼610)

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5외국인 어업 노동자의 바닷물 첩포검사에 대한 보고

저자 : 서지민 ( Ji Min Seo ) , 윤소연 ( So Yeon Yoon ) , 구하예린 ( Ha Yeh Rin Koo ) , 김경문 ( Gyong Moon Kim ) , 유동수 ( Dong Soo Yu ) , 이영복 ( Young Bok Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 611-617 (7 pages)

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Background: Occupational allergic contact dermatitis accounts for about half of all occupational skin diseases. Patch testing is essential for establishing a diagnosis of occupational allergic contact dermatitis. To date, allergic contact dermatitis caused by seawater has rarely been reported.
Objective: The aim of this study was to investigate the patch test results of seawater in foreign maritime workers.
Methods: We retrospectively reviewed the clinical photos and medical records of patients who underwent the patch test with the Korean standard series and sea-water at Uijeongbu St. Mary's Hospital and St. Vincent's Hospital from January 2017 to August 2020.
Results: A total of 26 patients were enrolled in the study. All patients were men with a median age of 26.5 years. Twenty-five patients were Sri Lankan, and 25 patients (96.2%) showed a positive reaction to seawater. Patients showed positive reactions with multiple allergens (average: 4), and the positive rates were higher than those reported in previous studies. Atypical reactions, such as pricking patterns or erosive patches, have been observed. A marked erosive reaction was observed even at the site without allergen attachment in a patient who showed a negative reaction to seawater.
Conclusion: These results suggest the possibility of artificially inducing positive reactions to seawater in maritime workers. Therefore, it is necessary to identify atypical reactions and confirm the relationship between positive reactions and medical history when judging contact dermatitis with unknown substances such as seawater. This study emphasizes education on the standardization of the reading of results. (Korean J Dermatol 2021;59(8):611∼617)

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6조갑진균증에서 병리조직검사의 진단적 가치 및 Periodic Acid-Schiff와 Gomori's Methenamine Silver 염색의 민감도 비교

저자 : 백가연 ( Gayun Baek ) , 구태한 ( Taehan Koo ) , 이동훈 ( Donghoon Lee ) , 강현지 ( Hyun Ji Kang ) , 김민수 ( Min-soo Kim ) , 김영혜 ( Younghye Kim ) , 주민숙 ( Mihn-sook Jue )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 618-623 (6 pages)

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Background: A direct potassium hydroxide (KOH) smear is used to diagnose onychomycosis despite its broad sensitivity range. For a more accurate diagnosis, histopathologic examination can be used and consistently show high sensitivity.
Objective: We investigated the value of histopathologic examination of the nail plate as a diagnostic tool for onychomycosis. We proposed effective routine diagnostic staining to compare sensitivity between periodic acid-Schiff (PAS) and Gomori's methenamine silver (GMS) staining.
Methods: This retrospective study was conducted from January 1, 2019 to May 31, 2020, and included 97 patients who showed negative results on direct KOH smear but had clinical manifestations that implied onychomycosis. We performed nail plate biopsy and PAS or GMS staining to identify fungal hyphae missed in the direct KOH smear. Sensitivity comparison between PAS and GMS was performed in co-stained samples.
Results: Among 97 patients with 102 cases, 55 cases (53.9%) of onychomycosis were confirmed by histopathologic examination. A total of 68 patients (70.1%) had a previous medical history of antifungal agents within previous six months. PAS and GMS staining were concurrently performed in 73 cases, and onychomycosis was confirmed in 41 cases. The sensitivity of PAS was 100% (41/41), while that of GMS was 87.8% (36/41); this difference was not significant.
Conclusion: This study suggests that histologic examination of the nail plate is an effective tool to diagnose onychomycosis and can be performed with a direct KOH smear. Two staining methods, PAS and GMS, are recommended for concurrent performance to enhance the identification of fungal hyphae. (Korean J Dermatol 2021;59(8):618∼623)

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7주사 환자의 임상적 고찰 및 주사의 진단 분류 체계의 비교에 대한 연구

저자 : 임준수 ( Joon Soo Lim ) , 권은선 ( Eun Sun Kwon ) , 명기범 ( Ki Bum Myung ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 624-633 (10 pages)

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Background: Rosacea is a common chronic inflammatory skin disease, which primarily affects the central face. In 2002, the National Rosacea Society (NRS) committee developed the first diagnostic criteria for rosacea, based on its subtypes. The revised classification in 2017 prompted a proposal to transit from a subtyping to a phenotyping approach, reflecting current insights into rosacea pathogenesis, pathophysiology, and management.
Objective: This study aimed to elucidate the clinical features of rosacea and compare two diagnostic criteria in rosacea patients.
Methods: We performed a clinical study on 100 patients with rosacea diagnosed according to the 2002 NRS criteria. The age, sex, clinical features, subtypes, severity, and predisposing factors were evaluated using the questionnaire. In addition, we compared the 2002 and 2017 criteria, and evaluated patients if they met the revised criteria.
Results: According to the 2002 NRS classification, the erythematotelangiectatic type (88.0%) was the most frequent, followed by the papulopustular (43.0%), ocular (13.0%), and phymatous (6.0%) types. There were 44 overlapping cases, including 38 cases with 2 subtypes mixed and 6 cases with three subtypes. Six patients were diagnosed with rosacea using the 2002 NRS criteria but they did not satisfy the revised 2017 criteria.
Conclusion: We found that the diagnostic features of the 2002 criteria are too ambiguous for the diagnosis of rosacea. Therefore, we recommend that dermatologists recognize the necessity of a transition from a subtyping to a phenotyping approach, according to the 2017 criteria for the diagnosis of rosacea. (Korean J Dermatol 2021;59(8): 624∼633)

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8Histopathological and Immunohistochemical Differentiation between Psoriasis and Seborrheic Dermatitis of the Scalp: Based on Langerin and CD1a

저자 : Ji Ha Yoon , Hye Rim Park , Eun Joo Park , Kwang Joong Kim , Kwang Ho Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 634-639 (6 pages)

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Background: Psoriasis and seborrheic dermatitis are difficult to distinguish if the lesion is localized to the scalp.
Objective: To validify the use of langerin and CD1a as markers of Langerhans cells to distinguish scalp psoriasis from seborrheic dermatitis.
Methods: We retrospectively evaluated 25 seborrheic dermatitis cases and 17 psoriasis cases diagnosed at a tertiary medical center in Korea from 2010 to 2019. The histopathological features and expression of CD1a and langerin were analyzed by dermato-pathologists.
Results: Hyperkeratosis, parakeratosis, and the presence of neutrophils in the parakeratotic mound were observed more frequently in the psoriasis group than in the seborrheic dermatitis group (p=0.016, p=0.027, and p=0.021, respectively). Other features examined did not show statistically significant differences. Dermal expression of langerin occurred more frequently in the psoriasis group than in the seborrheic dermatitis group (76.5% vs. 36.0%, p=0.010). Additionally, stronger CD1a dermal expression was observed in the psoriasis group than in the seborrheic dermatitis group (p=0.049), although the difference in overall dermal CD1a expression regardless of strength was not significant. In contrast, the epidermal expressions of CD1a and langerin did not show significant differences. Similarly, the follicular expressions of CD1a and langerin did not demonstrate significant differences.
Conclusion: In this retrospective study, histopathological findings that favored psoriasis over seborrheic dermatitis included hyperkeratosis, parakeratosis, and the presence of neutrophils in the parakeratotic mound. The use of Langerhans cells, CD1a, and langerin as markers could help distinguish scalp psoriasis from seborrheic dermatitis. (Korean J Dermatol 2021;59(8):634∼639)

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9아랫입술에 발생한 육종성 편평세포암

저자 : 남경화 ( Kyung-hwa Nam ) , 이일재 ( Il-jae Lee ) , 이상경 ( Sang-kyung Lee ) , 박진 ( Jin Park ) , 김한욱 ( Han-uk Kim ) , 윤석권 ( Seok-kweon Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 640-643 (4 pages)

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Sarcomatoid squamous cell carcinoma (SSCC) is a rare malignancy with distinct carcinomatous and sarcomatous features. SSCCs involving the lung, esophagus bladder, and skin have been reported as rare case reports. It may also occur infrequently in the oral region. Moreover, the lower lip is still one of the rare sites, and such a case has not been reported in Korean literature. An 82-year-old man presented an exophytic protruding, huge, warty crusted lesion on the entire lower lip. The lesion started as a small, tender, erosive papule and suddenly enlarged in recent months. His medical history was unremarkable. A biopsy revealed atypical squamous and sarcomatous components with transition zones between the two cell types. These two cell types also showed characteristic immunohistochemical features. Based on these findings, the lesion was diagnosed as SSCC. The study, including positron emission tomography-computed tomography, showed no metastasis. We recommended surgical excision, but the patient refused therapy. (Korean J Dermatol 2021;59(8):640∼643)

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10Cutaneous Adverse Events of Anti-Programmed Cell Death Receptor-1 Antibody: Two Case Reports and a Literature Review

저자 : Joon Soo Lim , Hyun Hee Kim , Eun Sun Kwon , Ki Bum Myung , Seung Hyun Cheong

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 8호 발행 연도 : 2021 페이지 : pp. 644-648 (5 pages)

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The introduction of immune checkpoint inhibitors, including anti-programmed cell death receptor-1 antibodies (anti-PD-1 Ab), such as nivolumab and pembrolizumab, represents a major breakthrough in cancer therapy. The PD-1 pathway inhibits T cell activation, maintaining a normal and balanced immune response. Anti-PD-1 Ab induces T cell activity by inhibiting the suppressive effect of PD-1 signaling on T cells. Excessive stimulation of T cells represents a potential mechanism for multiple skin lesions. To the best of our knowledge, reports on cutaneous adverse effects during treatment with anti-PD-1 Ab are limited in the dermatological literature of Korea. Herein, we report two rare cases of nivolumab-induced lichenoid drug eruption and pembrolizumab-induced psoriasis. (Korean J Dermatol 2021;59(8):644∼648)

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1단일 기관에서 시행한 피부과 전문의에 대한 인식도 조사

저자 : 이준범 ( Joon-bum Lee ) , 오병호 ( Byung-ho Oh ) , 류영욱 ( Young-wook Ryoo ) , 김성애 ( Sung-ae Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 483-489 (7 pages)

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Background: Currently, physicians from different medical specialties treat patients` skin conditions, especially for cosmetic purposes. Although diagnosis and treatment made by non-dermatologists may sometimes be improper, many patients are unable to distinguish a non-dermatologist from a dermatologist.
Objective: The aim of this study was to evaluate public`s perception of dermatologists.
Methods: A total of 515 participants completed the online survey. The questionnaire consisted of three main parts: information regarding respondents, experience of dermatological treatments, and awareness of skin treatments performed by dermatologists, and by medical specialties.
Results: Overall, 48% of respondents were unable to distinguish a dermatologist from a non-dermatologist; however, 93% of respondents responded that they were willing to visit a dermatologist for treatment. A fair number of respondents identified dermatologists by signboards, professional biographies, and licenses. However, some nondermatologists` signboards and biographies were considered misleading and confused patients.
Conclusion: Many patients intend to visit a dermatologist for their dermatological treatments. However, half could not distinguish dermatologists from non-dermatologists. For this reason, we underline the importance of increasing public awareness of the dermatologist`s expertise in helping patients in choosing their clinics. (Korean J Dermatol 2017;55(8):483∼489)

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2DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) 증후군에 대한 15년간의 후향적 연구: 단일 기관에서의 경험

저자 : 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee ) , 박혜진 ( Hai Jin Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 490-496 (7 pages)

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Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a syndrome involving multiple organs. Due to a variable clinical presentation and uncertain definition, diagnosis is often delayed or misdiagnosed.
Objective: The purpose of this study was to investigate the common causative drugs of DRESS and differences according to drugs, clinical features, and prognosis of DRESS, and secondly to compare the differences between steroid use group versus non-use group.
Methods: Medical records of hospitalized patients at the Sanggye Paik Hospital from January 2001 to December 2015 were collected. DRESS patients were enrolled retrospectively using the RegiSCAR diagnostic criteria.
Results: A total of 65 patients were included. The four most common causative drug groups were antibiotics (27.7%), anticonvulsants (20%), antituberculosis agents (16.9%), and allopurinol (16.9%). The mean incubation period was 4 weeks, significantly shorter in antibiotics (2 weeks, p<0.001) and significantly longer in anticonvulsants (6.5 weeks, p=0.033). Sixty-three patients fully recovered with a mean recovery time of 3.1 (standard deviation 2.2) weeks, one patient had sequelae, and one patient died. Recovery time tended to increase with longer duration of diagnosis from rash onset (p<0.001, correlation coefficient=0.419) and higher serum aspartate aminotransferase levels (p=0.024, correlation coefficient=0.297). The mean recovery time was 1 week shorter for the systemic steroid use group, but it was not statistically significant (p=0.056).
Conclusion: DRESS may be a heterogeneous syndrome with specific characteristics related to different drugs. The prognosis of DRESS is relatively good and the role of systemic steroid therapy is unclear. Prompt diagnosis and immediate discontinuation of the causative drug are essential for early recovery. (Korean J Dermatol 2017;55(8):490 ∼496)

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3피부과로 의뢰된 경남지역암센터 입원 환자에 대한 분석

저자 : 정해봉 ( Hae Bong Jeong ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 497-503 (7 pages)

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Background: The number of patients diagnosed with cancer has increased, and so has the number of dermatological consultations for related skin diseases.
Objective: To purposes of this study was to analyze the frequency and characteristics of dermatologic consultations at the Gyeongnam Cancer Center over a 9-year period.
Methods: We reviewed the records of 1,273 cases referred for dermatologic consultation at the Gyeongnam Cancer Center from 2007 to 2015.
Results: Dermatologic consultations increased over the 9-year period, with overall trends increasing in spring and summer. The most common age group comprised the 60∼69-year-old group (27.34%) and the male-to-female ratio was 1:0.6. Lung cancer was the most common underlying disease (25.53%). The most frequent skin disorder was infectious disease (33.78%), followed by drug eruption, erythema and urticaria (20.42%), and eczema (19.48%). The most common procedure was dressing or wet dressing (25.95%) followed by the KOH test (22.79%). The main reasons for dermatologic consultations were dermatologic disease or conditions (81.23%), followed by skin lesions related to the treatment of underlying disease (16.81%).
Conclusion: This study analyzed skin disease in cancer center inpatients. In conclusion, dermatologists should be responsible for the management of skin disease in cancer patients for more accurate examination and treatment. (Korean J Dermatol 2017;55(8):497∼503)

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4Therapeutic Effects of Growth Factor Cocktail Including Fibroblast Growth Factor 9 in Patients with Pattern Hair Loss

저자 : Byung In Ro , Suk Young Lee , Jong Baik Kim , Hang Cheol Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 504-510 (7 pages)

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Background: A growth factor cocktail (GFC) including fibroblast growth factor 9 (FGF9) in combination with microneedling is an effective and safe treatment for patients with androgenetic alopecia (AGA). However, there is a lack of studies evaluating its effects based on microneedle depth.
Objective: This study aimed to evaluate the effects of a GFC including FGF9 on hair growth in patients with AGA, and compare the differences in efficacy according to microneedle depth.
Methods: The study was performed on patients with AGA who were treated with topical GFC including FGF9 with microneedling once every 2 weeks for 3 months. The scalp was divided into right and left sides, and treated with GFC including FGF9 (right side) and normal saline (left side). The microneedle depth was 0.8 mm for both sides. A total of 22 patients (11 males and 11 females) were enrolled. GFC including FGF9 was topically applied with a microneedle medical device. Treatment efficacy was evaluated through phototrichogram and digital photograph analyses after 6 repeated treatments for 3 months.
Results: The phototrichogram images showed that 3 months of treatment with GFC including FGF9 with microneedling increased hair density (27.4±4.4/cm2) and diameter (2.7±2.7 μm); increases in hair density (5.7±4.4/cm2) and diameter (2.2±2.3 μm) were also seen in the region of the scalp that received normal saline. These results were statistically significant (p<0.05). The treatment effect was not significantly different between microneedle depths of 0.8 mm (used in this study) and 0.5 mm (used in our previous study) in terms of both hair density and hair diameter.
Conclusion: GFC including FGF9 with microneedling is an effective and safe treatment for patients with AGA. According to the results of this study and our previous report, we believe that microneedle depths of 0.5∼0.8 mm can sufficiently stimulate the scalp to increase drug-delivery. (Korean J Dermatol 2017;55(8):504∼510)

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5성게 가시 자상과 동반된 이상 감각 1예

저자 : 김영호 ( Yeong Ho Kim ) , 이지현 ( Ji Hyun Lee ) , 박영민 ( Young Min Park ) , 이준영 ( Jun Young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 511-513 (3 pages)

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Sea urchins are marine invertebrates commonly found in coastal areas around the world. The potential mechanisms of injury are primary puncture wounds, envenomation, and the foreign body reaction. A 20-year-old woman presented with multiple, 0.2 to 0.3 cm-sized, erythematous papules with central blackish particles accompanied by numbness and pain on the dorsum of the right foot and ankle for 7 days. She had been injured by a sea urchin 7 days prior at the seaside in Guam. A skin biopsy of the lesion showed inflammation with foreign body reaction. The attending physician removed all the blackish particles and applied mupirocin ointment. Although skin lesions improved over time, numbness and pain still remained. There have been only six reported cases of sea urchin granuloma in Korea, but no reports of sea urchin injury with neurologic symptoms. Herein, we report a rare case of sea urchin injury accompanied by paresthesia. (Korean J Dermatol 2017;55(8):511∼513)

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6얼굴백선과 유사한 양상으로 나타난 다륜형 소방성 혈관종

저자 : 오의현 ( Eui Hyun Oh ) , 한성수 ( Sung Soo Han ) , 박형권 ( Hyung Kwon Park ) , 김정수 ( Joung Soo Kim ) , 유희준 ( Hee Joon Yu )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 514-517 (4 pages)

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Tufted angioma is a rare benign vascular neoplasm that usually occurs in children. It appears as an erythematous, purplish, indurated papule or plaque on the trunk or neck. Although it can have variable clinical manifestations, the annular or serpiginous configuration of lesions resembling tinea infections has rarely been reported. A 47-year-old woman presented with an erythematous plaque enlarging by peripheral extension to form polycyclic or serpiginous figures on her left chin and buccal cheek for 7 months without any subjective symptoms. Tinea faciale was considered as the initial clinical diagnosis, but repeated KOH tests were all negative; therefore, skin biopsy was performed. Histopathology revealed discrete circumscribed foci of capillaries scattered throughout the dermis showing a cannon ball appearance, compatible with tufted angioma. Clinical features showed considerable improvement after 2 sessions of intense pulsed light and pulsed-dye laser (5 repetitions) without any complications. Herein, we report a rare case of polycyclic variant of tufted angioma, which developed in a woman in her 5th decade. (Korean J Dermatol 2017;55(8):514∼517)

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7이산화탄소 레이저로 치료한 Papular Acantholytic Dyskeratosis 1예

저자 : 이수경 ( Soo Kyung Lee ) , 김동주 ( Dong Joo Kim ) , 서중헌 ( Joong Heon Suh ) , 이운하 ( Un Ha Lee ) , 김명신 ( Myoung Shin Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 518-521 (4 pages)

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Papular acantholytic dyskeratosis is a collection of papular skin lesions that occur in the intertriginous and genital area. They show a characteristic histology of focal suprabasal acantholysis that distinguishes it from Hailey-Hailey disease or Darier disease. We describe a 50-year-old man with an asymptomatic papular eruption on the perianal area for several years. Histologically, a biopsy specimen showed diffuse hyperkeratosis and irregular acantholysis throughout the epidermis. We used carbon dioxide laser therapy as a therapeutic option. Despite causing a long and painful healing process, a considerable reduction of the symptoms was achieved. Although we do not know the precise nature or the incidence of this disease, papular acantholytic dyskeratosis should be included in the differential diagnosis of verrucous papules in perineal or perianal areas and carbon dioxide laser may represent a good therapeutic option. (Korean J Dermatol 2017;55(8):518∼521)

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8유방암과 연관된 림프관내조직구증식증

저자 : 김종규 ( Jong Kyu Kim ) , 김민성 ( Min Sung Kim ) , 나찬호 ( Chan Ho Na ) , 이예선 ( Yea Son Lee ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 522-525 (4 pages)

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Intralymphatic histiocytosis (IH) is a rare disease with variable and nonspecific clinical features, but with characteristic histopathological findings. Histopathologically, dilated lymphatic vessels containing aggregates of mononuclear cells are observed near the reticular dermis. IH is often associated with other diseases, such as rheumatoid arthritis, osteoarthritis, joint metal implantation, and with breast cancer where it occurs over the mastectomy scar. Although the pathogenesis of IH is not defined, some authors have suggested that lymphatic vessel engorgement by histiocytes migrating from neighboring inflammatory reactions may play a key pathogenic role. We present a case of IH associated with breast cancer. A 50-year-old female developed multiple tender erythematous plaques on both breasts and the right shoulder 3 years after bilateral mastectomy. To our knowledge, this is the first case of IH in association with breast cancer in the Korean dermatologic literature. (Korean J Dermatol 2017;55(8):522∼525)

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9Tranilast로 치료한 소아 외음부 비립종양 한관종 1예

저자 : 권원주 ( Won Joo Kwon ) , 신요섭 ( Yo Sup Shin ) , 박복원 ( Bok Won Park ) , 조은별 ( Eun Byul Cho ) , 박은주 ( Eun Joo Park ) , 김광호 ( Kwang Ho Kim ) , 김광중 ( Kwang Joong Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 526-528 (3 pages)

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Syringoma is the most common type of benign intraepidermal eccrine sweat gland tumor in Korea, and is usually found in women in their forties. It presents mostly as a localized lesion, preferring the lower eyelid, cheek, or forehead, and rarely invades the vulval area, and in the case of children, vulvar invasion is even more rare. Tranilast is an antihistamine used for atopic dermatitis and asthma, and has recently been used for the treatment of keloid. A few previous studies have reported both localized and generalized forms of syringoma being effectively resolved with tranilast. Herein, we report a rare and interesting case of milium-like syringoma, which manifested on the vulval area of 10-year old girl that was successfully treated with tranilast. (Korean J Dermatol 2017;55(8):526∼ 528)

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10A Case of Cutaneous Sinus Tract of Odontogenic Origin

저자 : Kimin Sohn , Hei Sung Kim , Sang Hyun Cho , Jeong Deuk Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 55권 8호 발행 연도 : 2017 페이지 : pp. 529-532 (4 pages)

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A cutaneous sinus tract of odontogenic origin occurs when purulent by-products of dental pulp necrosis spread along the path of least resistance from the root apex to the skin on the face. Patients presenting with this condition usually visit a dermatologist first, as the lesion can mimic various dermatologic pathologies, ranging from an epidermal cyst to basal cell carcinoma. The location of the sinus in the head and neck region should lead the dermatologist to seek a dental origin in order to avoid misdiagnosis. The lesion may persist for long periods before a correct diagnosis is made and the odontogenic source is treated appropriately. Herein, we report a case of a cutaneous sinus tract of odontogenic origin. (Korean J Dermatol 2017;55(8):529∼532)

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