In this study, the CO2 emission and economic efficiency of high-rise apartment houses were evaluated, and were analyzed as a way to establish database on the evaluation of environment-friendliness of high-rise buildings. To that end, standard of buildings to be evaluated were proposed through analysis of the designing guideline for high-rise apartment houses proposed by Seoul city, and CO2 emission of the subject buildings were evaluated based on the characteristics of materials admitted into each building and the amounts of energy consumed during lifecycle period. In addition, the initial costs in construction stage and annual costs in operation stage were set as analysis parameters, and along with calculation of direct cost by the consumption of construction materials and energy, the costs of CO2 emission were evaluated and analyzed. As a result, the CO2 emission and economic efficiencies of high-rise apartment houses by construction stage and operation stage could be analyzed quantitatively.