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대한피부과학회> 대한피부과학회지> Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

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Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

Byung In Ro , Hyun Ok Son , Sin Wook Chun , Hang Cheol Shin
  • : 대한피부과학회
  • : 대한피부과학회지 54권3호
  • : 연속간행물
  • : 2016년 03월
  • : 184-189(6pages)
대한피부과학회지

DOI


목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES

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초록 보기

Background: Growth factor treatment in combination with microneedling in androgenetic alopecia (AGA) patients is safe and effective. However, there is a lack of studies examining the effect of treatment according to the depth of the microneedle. Objective: The aim was to evaluate differences in efficacy according to the depth of microneedle. Methods: This study was performed on 6 male and 5 female AGA patients who were treated with topical growth factor cocktail (GFC) with microneedling every 2 weeks for 3 months. The scalp was divided into right and left sides and treated with microneedle depths of 0.5 and 0.3 mm, respectively. GFC was topically applied using a microneedle medical device. Treatment efficacy was evaluated by phototrichogram and digital photograph analysis on 6 repeated treatments for 3 months. Results: Phototrichogram of the 0.5- and 0.3-mm-treated sides of the scalp showed 19 and 12 cm2 increase in hair density and 2.6- and 1.8-μm increase in hair diameter, respectively. These results were statistically significant (p< 0.05). In terms of density, the 0.5-mm depth was significantly more effective than the 0.3-mm depth (p<0.05). With regard to diameter, the effect according to microneedle depth was not significantly different (p>0.05). Conclusion: GFC treatment with microneedling is effective and safe and a microneedle depth of 0.5 mm appears to be more effective than that of 0.3 mm. More research is necessary to confirm these results and determine the most effective depth for microneedling by investigating various depths. (Korean J Dermatol 2016;54(3):184~189)

UCI(KEPA)

I410-ECN-0102-2016-510-000696062

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
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1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

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2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

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3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

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4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

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5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

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6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

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7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

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8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

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9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

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10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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1소아에 발생한 선상 흑색손발톱의 임상적 고찰

저자 : 최윤선 ( Yun Seon Choe ) , 김진용 ( Jin Yong Kim ) , 최미라 ( Mi Ra Choi ) , 조광현 ( Kwang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 167-177 (11 pages)

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Background: Longitudinal melanonychia is characterized by pigmented bands on the nail plate. It is not unusual to encounter pediatric melanonychia patients in the dermatologic clinic. Objective: To assess the clinical manifestations of melanonychia in childhood in Korea, we reviewed the pediatric patient registry of a tertiary referral hospital in Korea. Methods: Patients under fifteen years of age with longitudinal melanonychia referred between January, 2001, and March, 2015, were enrolled in the study. All patients had clinical as well as photo records. Clinical characteristics including age, sex, location, disease duration, width and color of pigmentation, morphological change over time, underlying disease, and dermoscopic images or biopsy findings were evaluated where available. Results: A total of 92 patients had 158 pigmented nails, with more than one melanonychia identified in 14 patients. The patient sample included 43 male and 49 female patients with an average age of 6.1 years at diagnosis. A follow-up examination was performed for 132 nails in 80 patients with a mean period of 27.8 months and morphological changes were identified in 61 nails. Changes included remission or aggravation of pigmentation. In 48% and 17% of patients, nail plate dystrophy and Hutchinson's sign were observed, respectively. Dermoscopic image analysis was available for 79 nails. A nail biopsy was performed for 8 nails and none showed evidence of malignant melanoma. Conclusion: Pediatric longitudinal melanonychia generally presents a benign nature despite overt morphological changes, diffuse pigmentation, or Hutchinson's sign. Characteristically, melanonychia in childhood is frequently accompanied by nail dystrophy. Based on clinical reference of our study, aggressive nail biopsy may not be routinely necessary in pediatric melanonychia. (Korean J Dermatol 2016;54(3):167~177)

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2건선 및 건선관절염에서 손톱 병변에 대한 임상적 고찰

저자 : 오수진 ( Su Jin Oh ) , 고원선 ( Won Seon Koh ) , 권형일 ( Hyoung Il Kwon ) , 문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 178-183 (6 pages)

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Background: It has been reported that nail psoriasis is common in psoriatic arthritis (PsA) patients, however, studies on the prevalence of PsA with nail psoriasis and the relationship between the severity of the diseases has not previously been reported in Korea. Objective: The aim of this study was to investigate nail psoriasis and its relation to psoriasis and PsA. Methods: After researching past medical records, 48 patients with nail psoriasis and 247 patients without nail psoriasis were enrolled in this study. Nail psoriasis was classified according to the morphologic types of nails and severity was evaluated using the modified nail psoriasis severity score index (mNAPSI). We assessed the severity of psoriasis and PsA by psoriasis area and severity index (PASI), and swollen and tender joint counts (STJC), respectively. Finally, we analyzed the relationship between mNAPSI, PASI, and STJC. Results: Nail involvement was observed in 48 (16.3%) of 295 patients. Prevalence of PsA was higher in nail psoriasis (31.3%) than in uncomplicated psoriasis (9.3%, p<0.001). mNAPSI showed a positive correlation with STJC (p=0.002, Pearson correlation=0.427), but not with PASI (p=0.094, Pearson correlation=0.202). Conclusion: The results show that PsA is more common and severe in psoriatic patients with nail involvement than in uncomplicated psoriasis. Clinicians should be alert to nail involvement in psoriatic patients, as it could be related to the disease course and prognosis of PsA. (Korean J Dermatol 2016;54(3):178~183)

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3Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

저자 : Byung In Ro , Hyun Ok Son , Sin Wook Chun , Hang Cheol Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 184-189 (6 pages)

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Background: Growth factor treatment in combination with microneedling in androgenetic alopecia (AGA) patients is safe and effective. However, there is a lack of studies examining the effect of treatment according to the depth of the microneedle. Objective: The aim was to evaluate differences in efficacy according to the depth of microneedle. Methods: This study was performed on 6 male and 5 female AGA patients who were treated with topical growth factor cocktail (GFC) with microneedling every 2 weeks for 3 months. The scalp was divided into right and left sides and treated with microneedle depths of 0.5 and 0.3 mm, respectively. GFC was topically applied using a microneedle medical device. Treatment efficacy was evaluated by phototrichogram and digital photograph analysis on 6 repeated treatments for 3 months. Results: Phototrichogram of the 0.5- and 0.3-mm-treated sides of the scalp showed 19 and 12 cm2 increase in hair density and 2.6- and 1.8-μm increase in hair diameter, respectively. These results were statistically significant (p< 0.05). In terms of density, the 0.5-mm depth was significantly more effective than the 0.3-mm depth (p<0.05). With regard to diameter, the effect according to microneedle depth was not significantly different (p>0.05). Conclusion: GFC treatment with microneedling is effective and safe and a microneedle depth of 0.5 mm appears to be more effective than that of 0.3 mm. More research is necessary to confirm these results and determine the most effective depth for microneedling by investigating various depths. (Korean J Dermatol 2016;54(3):184~189)

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4증례 : 복층 박리 코근 도경 피판술을 이용한 콧등의 큰 결손부위의 복원

저자 : 김지석 ( Ji Seok Kim ) , 최미수 ( Mi Soo Choi ) , 남찬희 ( Chan Hee Nam ) , 김지영 ( Jee Young Kim ) , 홍승필 ( Seung Phil Hong ) , 김명화 ( Myung Hwa Kim ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 190-193 (4 pages)

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Reconstruction of defects on the lower third of the nose is always a challenge, as dissection of tissues in this area is not simple due to both a lack of elasticity and the structural complexity of the mid-facial area. When the defect size is less than 1.5 cm on the nose, primary closure or a bilobed flap is widely-used, while a skin graft is required for reconstruction of larger defects. Here we present two cases of a nasalis myocutaneous island pedicle flap with bilevel undermining with a relatively large nasal dorsum defect (>2 cm). The nasalis myocutaneous island pedicle flap with bilevel undermining was performed in order to maximize the movement of skin flaps and minimize the secondary movement of flaps after surgery. The nasal tip showed a slight upward movement immediately after surgery that subsequently moved down to a normal level. This technique can be utilized for reconstruction of the lower part of the nose for defects 2 cm or larger in size by maximizing the movement of the flap within the nasal structure. A major advantage is a higher flap survival rate due to proper arterial supply and the procedure results  in relatively reduced secondary motion of the flap after the surgery. (Korean J Dermatol 2016;54(3):190~193

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5증례 : Nocardia farcinica에 의한 일차성 피부 노카르디아증

저자 : 최현석 ( Hyun Seok Choi ) , 신재민 ( Jae Min Shin ) , 문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 노영석 ( Young Suck Ro ) , 고주연 ( Joo Yeon Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 194-198 (5 pages)

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The Nocardia species are aerobic Gram-positive filamentous bacteria found worldwide in soil and decaying organic plant matter. Primary cutaneous nocardiosis is a rare entity and most commonly caused by Nocardia brasiliensis (N. brasiliensis). However, it can rarely be caused by N. farcinica, which is recognized as a human pathogen. Here we report a case of a 54-year-old female patient who presented with erythematous nodules on her abdomen for 1 week. She had been treated with methotrexate and prednisolone due to systemic lupus erythematosus and rheumatoid arthritis. By bacterial culture and 16S ribosomal RNA gene sequencing, the patient was diagnosed with a primary cutaneous nocardiosis caused by N. farcinica, which has not previously been reported in the Korean dermatological literature. (Korean J Dermatol 2016;54(3):194~198)

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6증례 : 피부 전이를 보인 목척수의 조직구육종

저자 : 박형권 ( Hyung Kwon Park ) , 최현석 ( Hyun Seok Choi ) , 김영균 ( Young Gyun Kim ) , 오영하 ( Young Ha Oh ) , 유희준 ( Hee Joon Yu ) , 김정수 ( Joung Soo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 199-202 (4 pages)

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Histiocytic sarcoma is a rare, lymphohematopoietic malignant tumor comprised of tumor cells with the morphological and immunophenotypic features of mature histiocytes. A 35-year-old man presented with a disseminated histiocytic sarcoma that first occurred in the spinal cord and metastasized to the skin and lymph nodes. The tumor cells of the primary histiocytic sarcoma of the spinal cord were very large epithelioid cells with abundant eosinophilic cytoplasms and large, round-to-oval nuclei. In contrast, the metastatic histiocytic sarcoma of the skin was composed of relatively small polygonal cells with well-defined cell borders and high N/C (nucleus/cytoplasm) ratios. Immunohistochemically, both tumors were diffusely positive for histiocyte-associated antigens; but negative for epithelial, melanocyte, lymphoid, and dendritic cell antigens. It is important to recognize the morphological features and immunohistochemical characteristics of metastatic cells in order to ensure accurate diagnoses. (Korean J Dermatol 2016;54(3):199~202)

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7증례 : 냉동 치료 후 발생한 심각한 합병증 1예

저자 : 김준환 ( Jun Hwan Kim ) , 오승환 ( Seung Hwan Oh ) , 전지영 ( Ji-young Jun ) , 심준호 ( Joon Ho Shim ) , 박지혜 ( Ji-hye Park ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dong-youn Lee ) , 이주흥 ( Joo-heung Lee ) , 양준모 ( Jun-mo Yang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 203-205 (3 pages)

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Cryotherapy is a simple, relatively inexpensive therapeutic modality that is widely-used in clinical practice. It is especially appropriate for patients with an intolerance to anesthesia as well as high risk factors for developing hypertrophic scars after surgery. It can be applied to skin lesions located close to vital structures such as vessels and nerves. Potential side effects include pain, hemorrhage, edema, blisters, infection, hypopigmentation, and sensory damage. There are a numerous reports in the literature describing the side effects of cryotherapy. However, cases with severe complications have rarely been reported as yet. Herein, we report a case of serious complications of cryotherapy, a result of the course of treatment for linear porokeratosis. (Korean J Dermatol 2016;54(3):203~205)

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8Case Report : A Rare Cutaneous Presentation of Metastatic Orbital Adenocarcinoma

저자 : Ji Hee Kim , Jimyung Seo , Sang Ho Oh , Su Hee Kim , Kee Yang Chung

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 206-209 (4 pages)

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Primary ductal adenocarcinoma of the lacrimal gland (PDALG) is a rare tumor accounting for less than 2% of all tumors arising within the orbit. It is classified as a high-grade malignant epithelial tumor due to its variable biologic behavior and aggressive clinical course. Due to its rare incidence, the clinicopathologic profile is poorly identified and generally dependent on the few available reports and case series. Metastatic lesion of PDALG presenting as a skin lesion is very rare with only one previously reported case. We report here a case of metastatic PDALG that presented with cutaneous features. This case illustrates that such a rare malignant tumor may present to dermatologists, requiring prompt diagnosis and management with a multidisciplinary approach. (Korean J Dermatol 2016; 54(3):206~209)

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9유방암 치료 후에 발생한 림프관확장증 1예

저자 : 설정은 , 이원경 , 김도형 , 강미선 , 성호석 , 김효진

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 210-211 (2 pages)

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10중년 남성에서 발생한 모반양 유두유륜 과각화증 1예

저자 : 오승준 , 김유찬 , 이승헌

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 212-214 (3 pages)

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