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대한피부과학회> 대한피부과학회지> Original Article : Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

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Original Article : Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

Byung In Ro , Hyun Ok Son , Sin Wook Chun , Hang Cheol Shin
  • : 대한피부과학회
  • : 대한피부과학회지 54권3호
  • : 연속간행물
  • : 2016년 03월
  • : 184-189(6pages)
대한피부과학회지

DOI


목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES

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Background: Growth factor treatment in combination with microneedling in androgenetic alopecia (AGA) patients is safe and effective. However, there is a lack of studies examining the effect of treatment according to the depth of the microneedle. Objective: The aim was to evaluate differences in efficacy according to the depth of microneedle. Methods: This study was performed on 6 male and 5 female AGA patients who were treated with topical growth factor cocktail (GFC) with microneedling every 2 weeks for 3 months. The scalp was divided into right and left sides and treated with microneedle depths of 0.5 and 0.3 mm, respectively. GFC was topically applied using a microneedle medical device. Treatment efficacy was evaluated by phototrichogram and digital photograph analysis on 6 repeated treatments for 3 months. Results: Phototrichogram of the 0.5- and 0.3-mm-treated sides of the scalp showed 19 and 12 cm2 increase in hair density and 2.6- and 1.8-μm increase in hair diameter, respectively. These results were statistically significant (p< 0.05). In terms of density, the 0.5-mm depth was significantly more effective than the 0.3-mm depth (p<0.05). With regard to diameter, the effect according to microneedle depth was not significantly different (p>0.05). Conclusion: GFC treatment with microneedling is effective and safe and a microneedle depth of 0.5 mm appears to be more effective than that of 0.3 mm. More research is necessary to confirm these results and determine the most effective depth for microneedling by investigating various depths. (Korean J Dermatol 2016;54(3):184~189)

UCI(KEPA)

I410-ECN-0102-2016-510-000696062

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9674


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60권4호(2022년 05월) 수록논문
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1한국인 50세 이상 여성의 안면 피부 노화와 생활습관 간의 상관관계

저자 : 김승미 ( Seung-mee Kim ) , 이영윤 ( Young Yoon Lee ) , 황초롱 ( Cho-long Hwang ) , 신정민 ( Jung-min Shin ) , 권인선 ( In-sun Kwon ) , 박상현 ( Sang-hyun Park ) , 정경은 ( Kyung Eun Jung ) , 김창덕 ( Chang-deok Kim ) , 서영준 ( Young-joon Seo ) , 홍동균 ( Dongkyun Hong ) , 이영 ( Young L

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 201-208 (8 pages)

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Background: Skin aging can be divided into intrinsic and extrinsic processes, and occur due to several factors. Although the interest in skin youthfulness is increasing globally, research on facial skin youthfulness and lifestyle is limited.
Objective: This study aimed to evaluate the association between facial skin youthfulness and biophysical facial skin parameters in Korean women over 50 years of age. We further investigated lifestyle factors that make people appear younger than their chronological age.
Methods: We surveyed the essential information and lifestyle of subjects by questionnaires, and measured the biophysical parameters of the facial skin. We then performed clinical facial assessments, and the values were compared with the chronologic age. The associations between age differences, biophysical parameters, and living habits were evaluated.
Results: We identified a positive correlation between age and melanin index (r=0.245, p<0.001) and erythema index (r=0.119, p=0.002). The melanin index was statistically significantly lower in the group without regular outdoor activities (144.66±43.24 vs. 137.00±55.48, p=0.043). The melanin index and erythema index were the significant differences that defined younger perceived age than chronological age. The perceived age was younger in the group who wore a hat when performing outdoor activities than the group who did not (3.70±1.84 vs. 3.40±1.94, p=0.034).
Conclusion: To retain youthful skin, it is essential to reduce sun exposure, as this factor can affect the melanin and erythema indices by inducing photoaging. Therefore, avoiding the sun bia proper methods, such as wearing a hat and sunscreen during outdoor activities, is recommended to maintain skin youthfulness. (Korean J Dermatol 2022;60(4): 201∼208)

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2대상포진 예방접종이 고령에서 발생하는 대상포진의 임상양상 및 경과에 미치는 영향: 단일기관의 5년간 후향적 연구

저자 : 김중호 ( Joong Ho Kim ) , 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 209-219 (11 pages)

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Background: Herpes zoster (HZ) is a neurocutaneous disease caused by reactivation of the varicella zoster virus after primary infection. In Korea, it is recommended that all adults aged >60 be vaccinated against HZ. However, breakthrough infection with HZ can occur infrequently in vaccinated individuals.
Objective: This study aimed to investigate the effects of the HZ vaccine on the clinical manifestations and courses of HZ in immunocompetent elderly individuals aged 60 years and older.
Methods: Among 848 immunocompetent HZ patients, 52 were vaccinated and 796 were unvaccinated. From this cohort, we chose 156 unvaccinated patients through a 1:3 propensity score matching analysis using three parameters; age, sex, and involved dermatome. We subsequently compared the clinical manifestations and courses between the vaccinated (n=52) and unvaccinated (n=156) groups.
Results: The vaccinated group had a lower peak numeric rating scale pain score and a lower rate of consultation with the pain control clinic than the opposite. Additionally, mild skin lesions without vesicles were more frequent in the vaccinated group than in the opposite. The vaccinated group had a shorter duration of total follow-up, shorter antiviral treatment period, lower admission rate, and shorter hospital stay than the opposite. Although postherpetic neuralgia occurred more frequently in the unvaccinated group than in the unvaccinated group, the incidences of other HZ-related complications showed no significant difference between the two groups.
Conclusion: Despite the possibility of breakthrough infection, the HZ vaccine should be recommended in the elderly as it can weaken the clinical features and course of the disease. (Korean J Dermatol 2022;60(4):209∼219)

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3건선관절염을 동반한 중등증 및 중증 건선 환자에서 Secukinumab의 건강관련 삶의 질 개선 효과에 관한 후향적 연구

저자 : 홍용준 ( Yong Jun Hong ) , 고강민 ( Gang Min Go ) , 김미리 ( Miri Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 220-227 (8 pages)

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Background: Psoriasis is a relapsing inflammatory skin disorder that can affect the nails and joints. Psoriatic arthritis (PsA) occurs in up to 30% of patients with psoriasis, leading to chronic articular pain, and impairing quality of life. Secukinumab is a human monoclonal antibody targeting interleukin-17A that has been shown to effectively improve the clinical signs and symptoms of PsA.
Objective: To evaluate the effect of secukinumab on health-related quality of life (HRQOL) in Korean PsA patients.
Methods: We retrospectively investigated the medical records and psoriasis area and severity index (PASI) scores of 13 patients with PsA who completed the psoriatic arthritis impact of disease 12-item questionnaire (PsAID-12) before and 3 months after receiving secukinumab treatment between October 2019 and August 2021 in Yeouido St. Mary's Hospital.
Results: At week 12, significant reductions in the total and each item PsAID-12 and mean PASI score were observed (p<0.01). The mean decrease of total PsAID-12 score was 4.8 (95% confidence interval [CI], 3.74∼5.86), with the greatest improvement observed in the item of 'embarrassment' (7.15; 95% CI, 5.59∼8.72). Of the 13 patients, 11 (84.6%) and 5 (38.5%) achieved PASI75 and PASI90 response, respectively.
Conclusion: This study showed that secukinumab improves the HRQOL of patients with PsA, implying a positive influence of secukinumab on patients' physical and mental status in a real-world clinical setting. (Korean J Dermatol 2022;60(4):220∼227)

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4The Importance of Ultrasonography in the Diagnosis of Epidermal Cysts and Lipomas in the Field of Dermatology

저자 : Kihyuk Shin , Sang-hyeon Won , Chankue Park , Gun-wook Kim , Hoon-soo Kim , Hyun-chang Ko , Moon-bum Kim , Byung-soo Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 228-234 (7 pages)

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Background: Ultrasonography (US) is a simple and reliable tool that can aid in the diagnosis of benign subcutaneous lesions such as epidermal cysts and lipomas.
Objective: This study aimed to determine the efficacy of US for the differential diagnosis of epidermal cysts and lipomas.
Methods: A retrospective study of 100 patients with epidermal cysts (n=45) or lipomas (n=55) who underwent US and then received a pathological diagnosis in the dermatology department of Pusan National University Hospital was conducted.
Results: US and clinical impressions accurately diagnosed the epidermal cysts in 90.0% and 88.0% of the patients, respectively, and the lipomas in 92.0% and 88.0% of the patients, respectively. US combined with clinical impression significantly increased the diagnostic yield of epidermal cysts (98%) and lipomas (99%). On US, the frequency of posterior acoustic enhancement was higher for the epidermal cysts than for the lipomas (82.2% and 29.1%, respectively; p<0.001), and striated echoes such as internal linear echogenic reflections and dark clefts were more frequently found in the lipomas than in the epidermal cysts (90.9% and 6.7%, respectively; p<0.001).
Conclusion: This study implies that the diagnostic role of US can be greatly enhanced by knowledge of the clinical presentation. (Korean J Dermatol 2022;60(4):228∼234)

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5Anxiety Sensitivity and Psychological Distress in Patients with Rosacea: A Questionnaire-Based Study

저자 : Hyo-eun Kwon , Hye-jin Ahn , Min Kyung Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 235-241 (7 pages)

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Background: Rosacea is a common chronic inflammatory disorder that affects the skin of the central face. Anxiety sensitivity (AS) refers to the fear of sensations and symptoms arising from an expected experience of anxiety. High AS can cause anxiety disorders. Several studies have evaluated depression in patients with rosacea; however, AS has not yet been investigated.
Objective: We aimed to investigate AS, depression, and quality of life in patients with rosacea.
Methods: Eighty-five patients with rosacea and 85 controls (aged>18 years) were enrolled in the study. The severity of rosacea was evaluated according to the standard guidelines of the National Rosacea Society. Patients with rosacea and controls were asked to complete the Korean version of the anxiety sensitivity index-revised (ASI-R), beck depression inventory (BDI), and dermatology life quality index (DLQI).
Results: The ASI, BDI, and DLQI scores were significantly higher in patients with rosacea than in controls (p< 0.001). In particular, the cardiovascular subscale of the ASI was significantly increased in patients with rosacea. The ASI and BDI scores were significantly correlated. DLQI scores were weakly correlated with ASI compared with BDI scores in patients with rosacea.
Conclusion: Our study is the first to report that AS is elevated in patients with rosacea. It is necessary to consider the anxiety-related symptoms of patients with rosacea, as they may benefit from psychological intervention to alleviate distress. (Korean J Dermatol 2022;60(4):235∼241)

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6A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

저자 : Kui Young Park , Jun Ki Hong , Sun Hye Shin , Young Gue Koh , Hye Sung Han , Nam Ju Moon , Gun Young Ahn , Seong Jun Seo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 242-253 (12 pages)

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Background: The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
Objective: To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
Methods: From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
Results: The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
Conclusion: This is the first study to investigate the association of BST with genetic factors and environmental factors. (Korean J Dermatol 2022;60(4):242∼253)

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7전완부의 덩이로 발견된 근육내 전이성 투명세포신세포암 1예

저자 : 최연구 ( Yeon-gu Choi ) , 이현주 ( Heun Joo Lee ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee ) , 최영준 ( Young Jun Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 254-257 (4 pages)

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Cutaneous metastases from renal cell carcinoma (RCC) present as rapidly growing erythematous or purple-round nodules. An 88-year-old male presented with a solitary, deep-seated firm mass on his left forearm that had persisted for 3 years. Ultrasonography revealed an hypervascular mass with rich vessels. Magnetic resonance imaging revealed a 1.6×1.6×3.3 cm sized, high T2-weighted signal intensity mass at brachioradialis muscle. Histopathologic examination revealed cells with atypical, pleomorphic, oval to spindle-shaped nuclei, and clear cytoplasm with an alveolar pattern within an unencapsulated, lobulated mass. Immunohistochemical analysis showed that the tumor cells were positive for PAX8, CD10, epithelial membrane antigen, and vimentin. Ultrasonography of the urinary tract revealed a lesion suspected to be RCC, which was thought to be the primary tumor. As our patient showed peculiar clinical symptoms and the primary tumor was later diagnosed as a metastatic lesion inversely, we report a rare case of metastatic RCC with an intramuscular mass on the forearm. (Korean J Dermatol 2022;60(4):254∼257)

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8가족력이 있으면서 임상적 진단이 어려웠던 결절흑색종 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 윤태진 ( Tae Jin Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 258-261 (4 pages)

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Nodular melanoma is a malignant melanoma which presents as blackish-brown or colorless nodules. Nodular melanoma shows rapid growth compared to other melanoma subtypes, and often exhibits clinical features that do not correspond to the ABCD rules, which is key in differentiating melanoma. This makes nodular melanoma difficult to differentiate from the initially suspected melanoma. As such, diagnosis of nodular melanoma is commonly delayed, and is therefore often identified at an advanced stage. Here, we report a case of nodular melanoma in a young man with a family history of melanoma. We emphasize the importance of early diagnosis through biopsy for malignant melanoma, which is difficult to differentiate based on clinical features. (Korean J Dermatol 2022;60(4):258∼261)

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9면역기능 정상 성인에서 겨드랑 부위에 발생한 모낭염 양상의 전염성 연속종

저자 : 김동성 , 허재영 , 박태흠 , 김우일 , 조문균 , 김수영

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 262-263 (2 pages)

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10저절로 호전된 원인 불명의 붉은 에크린색한증 1예

저자 : 이상균 , 홍승필

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 264-265 (2 pages)

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12
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같은 권호 다른 논문
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1원저 : 소아에 발생한 선상 흑색손발톱의 임상적 고찰

저자 : 최윤선 ( Yun Seon Choe ) , 김진용 ( Jin Yong Kim ) , 최미라 ( Mi Ra Choi ) , 조광현 ( Kwang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 167-177 (11 pages)

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Background: Longitudinal melanonychia is characterized by pigmented bands on the nail plate. It is not unusual to encounter pediatric melanonychia patients in the dermatologic clinic. Objective: To assess the clinical manifestations of melanonychia in childhood in Korea, we reviewed the pediatric patient registry of a tertiary referral hospital in Korea. Methods: Patients under fifteen years of age with longitudinal melanonychia referred between January, 2001, and March, 2015, were enrolled in the study. All patients had clinical as well as photo records. Clinical characteristics including age, sex, location, disease duration, width and color of pigmentation, morphological change over time, underlying disease, and dermoscopic images or biopsy findings were evaluated where available. Results: A total of 92 patients had 158 pigmented nails, with more than one melanonychia identified in 14 patients. The patient sample included 43 male and 49 female patients with an average age of 6.1 years at diagnosis. A follow-up examination was performed for 132 nails in 80 patients with a mean period of 27.8 months and morphological changes were identified in 61 nails. Changes included remission or aggravation of pigmentation. In 48% and 17% of patients, nail plate dystrophy and Hutchinson's sign were observed, respectively. Dermoscopic image analysis was available for 79 nails. A nail biopsy was performed for 8 nails and none showed evidence of malignant melanoma. Conclusion: Pediatric longitudinal melanonychia generally presents a benign nature despite overt morphological changes, diffuse pigmentation, or Hutchinson's sign. Characteristically, melanonychia in childhood is frequently accompanied by nail dystrophy. Based on clinical reference of our study, aggressive nail biopsy may not be routinely necessary in pediatric melanonychia. (Korean J Dermatol 2016;54(3):167~177)

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2원저 : 건선 및 건선관절염에서 손톱 병변에 대한 임상적 고찰

저자 : 오수진 ( Su Jin Oh ) , 고원선 ( Won Seon Koh ) , 권형일 ( Hyoung Il Kwon ) , 문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 178-183 (6 pages)

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Background: It has been reported that nail psoriasis is common in psoriatic arthritis (PsA) patients, however, studies on the prevalence of PsA with nail psoriasis and the relationship between the severity of the diseases has not previously been reported in Korea. Objective: The aim of this study was to investigate nail psoriasis and its relation to psoriasis and PsA. Methods: After researching past medical records, 48 patients with nail psoriasis and 247 patients without nail psoriasis were enrolled in this study. Nail psoriasis was classified according to the morphologic types of nails and severity was evaluated using the modified nail psoriasis severity score index (mNAPSI). We assessed the severity of psoriasis and PsA by psoriasis area and severity index (PASI), and swollen and tender joint counts (STJC), respectively. Finally, we analyzed the relationship between mNAPSI, PASI, and STJC. Results: Nail involvement was observed in 48 (16.3%) of 295 patients. Prevalence of PsA was higher in nail psoriasis (31.3%) than in uncomplicated psoriasis (9.3%, p<0.001). mNAPSI showed a positive correlation with STJC (p=0.002, Pearson correlation=0.427), but not with PASI (p=0.094, Pearson correlation=0.202). Conclusion: The results show that PsA is more common and severe in psoriatic patients with nail involvement than in uncomplicated psoriasis. Clinicians should be alert to nail involvement in psoriatic patients, as it could be related to the disease course and prognosis of PsA. (Korean J Dermatol 2016;54(3):178~183)

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3Original Article : Therapeutic Effects of Growth Factor Cocktail Treatment in Patients with Androgenetic Alopecia According to the Depth of Microneedle

저자 : Byung In Ro , Hyun Ok Son , Sin Wook Chun , Hang Cheol Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 184-189 (6 pages)

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Background: Growth factor treatment in combination with microneedling in androgenetic alopecia (AGA) patients is safe and effective. However, there is a lack of studies examining the effect of treatment according to the depth of the microneedle. Objective: The aim was to evaluate differences in efficacy according to the depth of microneedle. Methods: This study was performed on 6 male and 5 female AGA patients who were treated with topical growth factor cocktail (GFC) with microneedling every 2 weeks for 3 months. The scalp was divided into right and left sides and treated with microneedle depths of 0.5 and 0.3 mm, respectively. GFC was topically applied using a microneedle medical device. Treatment efficacy was evaluated by phototrichogram and digital photograph analysis on 6 repeated treatments for 3 months. Results: Phototrichogram of the 0.5- and 0.3-mm-treated sides of the scalp showed 19 and 12 cm2 increase in hair density and 2.6- and 1.8-μm increase in hair diameter, respectively. These results were statistically significant (p< 0.05). In terms of density, the 0.5-mm depth was significantly more effective than the 0.3-mm depth (p<0.05). With regard to diameter, the effect according to microneedle depth was not significantly different (p>0.05). Conclusion: GFC treatment with microneedling is effective and safe and a microneedle depth of 0.5 mm appears to be more effective than that of 0.3 mm. More research is necessary to confirm these results and determine the most effective depth for microneedling by investigating various depths. (Korean J Dermatol 2016;54(3):184~189)

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4증례 : 복층 박리 코근 도경 피판술을 이용한 콧등의 큰 결손부위의 복원

저자 : 김지석 ( Ji Seok Kim ) , 최미수 ( Mi Soo Choi ) , 남찬희 ( Chan Hee Nam ) , 김지영 ( Jee Young Kim ) , 홍승필 ( Seung Phil Hong ) , 김명화 ( Myung Hwa Kim ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 190-193 (4 pages)

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Reconstruction of defects on the lower third of the nose is always a challenge, as dissection of tissues in this area is not simple due to both a lack of elasticity and the structural complexity of the mid-facial area. When the defect size is less than 1.5 cm on the nose, primary closure or a bilobed flap is widely-used, while a skin graft is required for reconstruction of larger defects. Here we present two cases of a nasalis myocutaneous island pedicle flap with bilevel undermining with a relatively large nasal dorsum defect (>2 cm). The nasalis myocutaneous island pedicle flap with bilevel undermining was performed in order to maximize the movement of skin flaps and minimize the secondary movement of flaps after surgery. The nasal tip showed a slight upward movement immediately after surgery that subsequently moved down to a normal level. This technique can be utilized for reconstruction of the lower part of the nose for defects 2 cm or larger in size by maximizing the movement of the flap within the nasal structure. A major advantage is a higher flap survival rate due to proper arterial supply and the procedure results  in relatively reduced secondary motion of the flap after the surgery. (Korean J Dermatol 2016;54(3):190~193

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5증례 : Nocardia farcinica에 의한 일차성 피부 노카르디아증

저자 : 최현석 ( Hyun Seok Choi ) , 신재민 ( Jae Min Shin ) , 문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 노영석 ( Young Suck Ro ) , 고주연 ( Joo Yeon Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 194-198 (5 pages)

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The Nocardia species are aerobic Gram-positive filamentous bacteria found worldwide in soil and decaying organic plant matter. Primary cutaneous nocardiosis is a rare entity and most commonly caused by Nocardia brasiliensis (N. brasiliensis). However, it can rarely be caused by N. farcinica, which is recognized as a human pathogen. Here we report a case of a 54-year-old female patient who presented with erythematous nodules on her abdomen for 1 week. She had been treated with methotrexate and prednisolone due to systemic lupus erythematosus and rheumatoid arthritis. By bacterial culture and 16S ribosomal RNA gene sequencing, the patient was diagnosed with a primary cutaneous nocardiosis caused by N. farcinica, which has not previously been reported in the Korean dermatological literature. (Korean J Dermatol 2016;54(3):194~198)

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6증례 : 피부 전이를 보인 목척수의 조직구육종

저자 : 박형권 ( Hyung Kwon Park ) , 최현석 ( Hyun Seok Choi ) , 김영균 ( Young Gyun Kim ) , 오영하 ( Young Ha Oh ) , 유희준 ( Hee Joon Yu ) , 김정수 ( Joung Soo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 199-202 (4 pages)

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Histiocytic sarcoma is a rare, lymphohematopoietic malignant tumor comprised of tumor cells with the morphological and immunophenotypic features of mature histiocytes. A 35-year-old man presented with a disseminated histiocytic sarcoma that first occurred in the spinal cord and metastasized to the skin and lymph nodes. The tumor cells of the primary histiocytic sarcoma of the spinal cord were very large epithelioid cells with abundant eosinophilic cytoplasms and large, round-to-oval nuclei. In contrast, the metastatic histiocytic sarcoma of the skin was composed of relatively small polygonal cells with well-defined cell borders and high N/C (nucleus/cytoplasm) ratios. Immunohistochemically, both tumors were diffusely positive for histiocyte-associated antigens; but negative for epithelial, melanocyte, lymphoid, and dendritic cell antigens. It is important to recognize the morphological features and immunohistochemical characteristics of metastatic cells in order to ensure accurate diagnoses. (Korean J Dermatol 2016;54(3):199~202)

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7증례 : 냉동 치료 후 발생한 심각한 합병증 1예

저자 : 김준환 ( Jun Hwan Kim ) , 오승환 ( Seung Hwan Oh ) , 전지영 ( Ji-young Jun ) , 심준호 ( Joon Ho Shim ) , 박지혜 ( Ji-hye Park ) , 이종희 ( Jong Hee Lee ) , 이동윤 ( Dong-youn Lee ) , 이주흥 ( Joo-heung Lee ) , 양준모 ( Jun-mo Yang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 203-205 (3 pages)

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Cryotherapy is a simple, relatively inexpensive therapeutic modality that is widely-used in clinical practice. It is especially appropriate for patients with an intolerance to anesthesia as well as high risk factors for developing hypertrophic scars after surgery. It can be applied to skin lesions located close to vital structures such as vessels and nerves. Potential side effects include pain, hemorrhage, edema, blisters, infection, hypopigmentation, and sensory damage. There are a numerous reports in the literature describing the side effects of cryotherapy. However, cases with severe complications have rarely been reported as yet. Herein, we report a case of serious complications of cryotherapy, a result of the course of treatment for linear porokeratosis. (Korean J Dermatol 2016;54(3):203~205)

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8Case Report : A Rare Cutaneous Presentation of Metastatic Orbital Adenocarcinoma

저자 : Ji Hee Kim , Jimyung Seo , Sang Ho Oh , Su Hee Kim , Kee Yang Chung

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 206-209 (4 pages)

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Primary ductal adenocarcinoma of the lacrimal gland (PDALG) is a rare tumor accounting for less than 2% of all tumors arising within the orbit. It is classified as a high-grade malignant epithelial tumor due to its variable biologic behavior and aggressive clinical course. Due to its rare incidence, the clinicopathologic profile is poorly identified and generally dependent on the few available reports and case series. Metastatic lesion of PDALG presenting as a skin lesion is very rare with only one previously reported case. We report here a case of metastatic PDALG that presented with cutaneous features. This case illustrates that such a rare malignant tumor may present to dermatologists, requiring prompt diagnosis and management with a multidisciplinary approach. (Korean J Dermatol 2016; 54(3):206~209)

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9유방암 치료 후에 발생한 림프관확장증 1예

저자 : 설정은 , 이원경 , 김도형 , 강미선 , 성호석 , 김효진

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 210-211 (2 pages)

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10중년 남성에서 발생한 모반양 유두유륜 과각화증 1예

저자 : 오승준 , 김유찬 , 이승헌

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 54권 3호 발행 연도 : 2016 페이지 : pp. 212-214 (3 pages)

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