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대한피부과학회> 대한피부과학회지> 원저 : 건선 환자에서 경구 Cyclosporine 치료 후 재발인자에 대한 연구

KCI등재SCOUPUS

원저 : 건선 환자에서 경구 Cyclosporine 치료 후 재발인자에 대한 연구

Original Article : A Study on the Factors Causing Recurrence of Psoriasis after Cyclosporine Treatment

문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )
  • : 대한피부과학회
  • : 대한피부과학회지 53권4호
  • : 연속간행물
  • : 2015년 05월
  • : 277-283(7pages)
대한피부과학회지

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Background: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. Objective: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. Methods: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. Results: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. Conclusion: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact. (Korean J Dermatol 2015;53(4):277∼283)

UCI(KEPA)

I410-ECN-0102-2015-500-001976045

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9674


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60권4호(2022년 05월) 수록논문
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KCI등재 SCOPUS

1한국인 50세 이상 여성의 안면 피부 노화와 생활습관 간의 상관관계

저자 : 김승미 ( Seung-mee Kim ) , 이영윤 ( Young Yoon Lee ) , 황초롱 ( Cho-long Hwang ) , 신정민 ( Jung-min Shin ) , 권인선 ( In-sun Kwon ) , 박상현 ( Sang-hyun Park ) , 정경은 ( Kyung Eun Jung ) , 김창덕 ( Chang-deok Kim ) , 서영준 ( Young-joon Seo ) , 홍동균 ( Dongkyun Hong ) , 이영 ( Young L

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 201-208 (8 pages)

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Background: Skin aging can be divided into intrinsic and extrinsic processes, and occur due to several factors. Although the interest in skin youthfulness is increasing globally, research on facial skin youthfulness and lifestyle is limited.
Objective: This study aimed to evaluate the association between facial skin youthfulness and biophysical facial skin parameters in Korean women over 50 years of age. We further investigated lifestyle factors that make people appear younger than their chronological age.
Methods: We surveyed the essential information and lifestyle of subjects by questionnaires, and measured the biophysical parameters of the facial skin. We then performed clinical facial assessments, and the values were compared with the chronologic age. The associations between age differences, biophysical parameters, and living habits were evaluated.
Results: We identified a positive correlation between age and melanin index (r=0.245, p<0.001) and erythema index (r=0.119, p=0.002). The melanin index was statistically significantly lower in the group without regular outdoor activities (144.66±43.24 vs. 137.00±55.48, p=0.043). The melanin index and erythema index were the significant differences that defined younger perceived age than chronological age. The perceived age was younger in the group who wore a hat when performing outdoor activities than the group who did not (3.70±1.84 vs. 3.40±1.94, p=0.034).
Conclusion: To retain youthful skin, it is essential to reduce sun exposure, as this factor can affect the melanin and erythema indices by inducing photoaging. Therefore, avoiding the sun bia proper methods, such as wearing a hat and sunscreen during outdoor activities, is recommended to maintain skin youthfulness. (Korean J Dermatol 2022;60(4): 201∼208)

KCI등재 SCOPUS

2대상포진 예방접종이 고령에서 발생하는 대상포진의 임상양상 및 경과에 미치는 영향: 단일기관의 5년간 후향적 연구

저자 : 김중호 ( Joong Ho Kim ) , 이수경 ( Soo Kyung Lee ) , 김명신 ( Myoung Shin Kim ) , 이운하 ( Un Ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 209-219 (11 pages)

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Background: Herpes zoster (HZ) is a neurocutaneous disease caused by reactivation of the varicella zoster virus after primary infection. In Korea, it is recommended that all adults aged >60 be vaccinated against HZ. However, breakthrough infection with HZ can occur infrequently in vaccinated individuals.
Objective: This study aimed to investigate the effects of the HZ vaccine on the clinical manifestations and courses of HZ in immunocompetent elderly individuals aged 60 years and older.
Methods: Among 848 immunocompetent HZ patients, 52 were vaccinated and 796 were unvaccinated. From this cohort, we chose 156 unvaccinated patients through a 1:3 propensity score matching analysis using three parameters; age, sex, and involved dermatome. We subsequently compared the clinical manifestations and courses between the vaccinated (n=52) and unvaccinated (n=156) groups.
Results: The vaccinated group had a lower peak numeric rating scale pain score and a lower rate of consultation with the pain control clinic than the opposite. Additionally, mild skin lesions without vesicles were more frequent in the vaccinated group than in the opposite. The vaccinated group had a shorter duration of total follow-up, shorter antiviral treatment period, lower admission rate, and shorter hospital stay than the opposite. Although postherpetic neuralgia occurred more frequently in the unvaccinated group than in the unvaccinated group, the incidences of other HZ-related complications showed no significant difference between the two groups.
Conclusion: Despite the possibility of breakthrough infection, the HZ vaccine should be recommended in the elderly as it can weaken the clinical features and course of the disease. (Korean J Dermatol 2022;60(4):209∼219)

KCI등재 SCOPUS

3건선관절염을 동반한 중등증 및 중증 건선 환자에서 Secukinumab의 건강관련 삶의 질 개선 효과에 관한 후향적 연구

저자 : 홍용준 ( Yong Jun Hong ) , 고강민 ( Gang Min Go ) , 김미리 ( Miri Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 220-227 (8 pages)

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Background: Psoriasis is a relapsing inflammatory skin disorder that can affect the nails and joints. Psoriatic arthritis (PsA) occurs in up to 30% of patients with psoriasis, leading to chronic articular pain, and impairing quality of life. Secukinumab is a human monoclonal antibody targeting interleukin-17A that has been shown to effectively improve the clinical signs and symptoms of PsA.
Objective: To evaluate the effect of secukinumab on health-related quality of life (HRQOL) in Korean PsA patients.
Methods: We retrospectively investigated the medical records and psoriasis area and severity index (PASI) scores of 13 patients with PsA who completed the psoriatic arthritis impact of disease 12-item questionnaire (PsAID-12) before and 3 months after receiving secukinumab treatment between October 2019 and August 2021 in Yeouido St. Mary's Hospital.
Results: At week 12, significant reductions in the total and each item PsAID-12 and mean PASI score were observed (p<0.01). The mean decrease of total PsAID-12 score was 4.8 (95% confidence interval [CI], 3.74∼5.86), with the greatest improvement observed in the item of 'embarrassment' (7.15; 95% CI, 5.59∼8.72). Of the 13 patients, 11 (84.6%) and 5 (38.5%) achieved PASI75 and PASI90 response, respectively.
Conclusion: This study showed that secukinumab improves the HRQOL of patients with PsA, implying a positive influence of secukinumab on patients' physical and mental status in a real-world clinical setting. (Korean J Dermatol 2022;60(4):220∼227)

KCI등재 SCOPUS

4The Importance of Ultrasonography in the Diagnosis of Epidermal Cysts and Lipomas in the Field of Dermatology

저자 : Kihyuk Shin , Sang-hyeon Won , Chankue Park , Gun-wook Kim , Hoon-soo Kim , Hyun-chang Ko , Moon-bum Kim , Byung-soo Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 228-234 (7 pages)

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Background: Ultrasonography (US) is a simple and reliable tool that can aid in the diagnosis of benign subcutaneous lesions such as epidermal cysts and lipomas.
Objective: This study aimed to determine the efficacy of US for the differential diagnosis of epidermal cysts and lipomas.
Methods: A retrospective study of 100 patients with epidermal cysts (n=45) or lipomas (n=55) who underwent US and then received a pathological diagnosis in the dermatology department of Pusan National University Hospital was conducted.
Results: US and clinical impressions accurately diagnosed the epidermal cysts in 90.0% and 88.0% of the patients, respectively, and the lipomas in 92.0% and 88.0% of the patients, respectively. US combined with clinical impression significantly increased the diagnostic yield of epidermal cysts (98%) and lipomas (99%). On US, the frequency of posterior acoustic enhancement was higher for the epidermal cysts than for the lipomas (82.2% and 29.1%, respectively; p<0.001), and striated echoes such as internal linear echogenic reflections and dark clefts were more frequently found in the lipomas than in the epidermal cysts (90.9% and 6.7%, respectively; p<0.001).
Conclusion: This study implies that the diagnostic role of US can be greatly enhanced by knowledge of the clinical presentation. (Korean J Dermatol 2022;60(4):228∼234)

KCI등재 SCOPUS

5Anxiety Sensitivity and Psychological Distress in Patients with Rosacea: A Questionnaire-Based Study

저자 : Hyo-eun Kwon , Hye-jin Ahn , Min Kyung Shin

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 235-241 (7 pages)

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Background: Rosacea is a common chronic inflammatory disorder that affects the skin of the central face. Anxiety sensitivity (AS) refers to the fear of sensations and symptoms arising from an expected experience of anxiety. High AS can cause anxiety disorders. Several studies have evaluated depression in patients with rosacea; however, AS has not yet been investigated.
Objective: We aimed to investigate AS, depression, and quality of life in patients with rosacea.
Methods: Eighty-five patients with rosacea and 85 controls (aged>18 years) were enrolled in the study. The severity of rosacea was evaluated according to the standard guidelines of the National Rosacea Society. Patients with rosacea and controls were asked to complete the Korean version of the anxiety sensitivity index-revised (ASI-R), beck depression inventory (BDI), and dermatology life quality index (DLQI).
Results: The ASI, BDI, and DLQI scores were significantly higher in patients with rosacea than in controls (p< 0.001). In particular, the cardiovascular subscale of the ASI was significantly increased in patients with rosacea. The ASI and BDI scores were significantly correlated. DLQI scores were weakly correlated with ASI compared with BDI scores in patients with rosacea.
Conclusion: Our study is the first to report that AS is elevated in patients with rosacea. It is necessary to consider the anxiety-related symptoms of patients with rosacea, as they may benefit from psychological intervention to alleviate distress. (Korean J Dermatol 2022;60(4):235∼241)

KCI등재 SCOPUS

6A Study on the Correlation of Skin Types with Genetic Factors and Environmental Factors in Koreans

저자 : Kui Young Park , Jun Ki Hong , Sun Hye Shin , Young Gue Koh , Hye Sung Han , Nam Ju Moon , Gun Young Ahn , Seong Jun Seo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 242-253 (12 pages)

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Background: The Baumann skin type (BST) classification provides a new approach for clinical care of dermatologic patients.
Objective: To investigate the correlation of skin types with genetic factors and environmental factors that have an important influence on Korean skin by comparing and analyzing the correlation between phenotype and genotype.
Methods: From July to October 2016, 774 adults who visited the one online shopping mall were subjected to skin BST questionnaire and gene single-nucleotide polymorphism (SNP) tests. Oral epithelial cells of the subjects were collected using a Genoplan DNA analysis kit, and 14 genes were analyzed by a genetic analysis agency (Genoplan Inc., Fukuoka, Japan).
Results: The most abundant skin type was OSNT (oily, sensitive, non-pigmented, tight) observed in 205 participants (26.5%). Of the filaggrin (FLG) SNPs, 143 participants (18.5%) had the GG (good) SNP; 391 (50.5%), GA (normal) SNP; and 240 (31.0%), AA (poor) SNP. Among those whose FLG SNP was GG (good), 121 (84.6%) were sensitive and 22 (15.4%) were resistant. Of those whose filaggrin (FLG) SNP was GA (normal), 337 (86.2%) were sensitive and 54 (13.8%) were resistant. Of those whose FLG SNP was AA (poor), 213 (88.8%) were sensitive and 27 (11.3%) were resistant. There was also a statistically significant difference in the fruit-vegetable consumption and use of a sunbathing bed between sensitive and resistant type in the groups that classified the FLG SNP as GA.
Conclusion: This is the first study to investigate the association of BST with genetic factors and environmental factors. (Korean J Dermatol 2022;60(4):242∼253)

KCI등재 SCOPUS

7전완부의 덩이로 발견된 근육내 전이성 투명세포신세포암 1예

저자 : 최연구 ( Yeon-gu Choi ) , 이현주 ( Heun Joo Lee ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee ) , 최영준 ( Young Jun Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 254-257 (4 pages)

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Cutaneous metastases from renal cell carcinoma (RCC) present as rapidly growing erythematous or purple-round nodules. An 88-year-old male presented with a solitary, deep-seated firm mass on his left forearm that had persisted for 3 years. Ultrasonography revealed an hypervascular mass with rich vessels. Magnetic resonance imaging revealed a 1.6×1.6×3.3 cm sized, high T2-weighted signal intensity mass at brachioradialis muscle. Histopathologic examination revealed cells with atypical, pleomorphic, oval to spindle-shaped nuclei, and clear cytoplasm with an alveolar pattern within an unencapsulated, lobulated mass. Immunohistochemical analysis showed that the tumor cells were positive for PAX8, CD10, epithelial membrane antigen, and vimentin. Ultrasonography of the urinary tract revealed a lesion suspected to be RCC, which was thought to be the primary tumor. As our patient showed peculiar clinical symptoms and the primary tumor was later diagnosed as a metastatic lesion inversely, we report a rare case of metastatic RCC with an intramuscular mass on the forearm. (Korean J Dermatol 2022;60(4):254∼257)

KCI등재 SCOPUS

8가족력이 있으면서 임상적 진단이 어려웠던 결절흑색종 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 윤태진 ( Tae Jin Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 258-261 (4 pages)

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Nodular melanoma is a malignant melanoma which presents as blackish-brown or colorless nodules. Nodular melanoma shows rapid growth compared to other melanoma subtypes, and often exhibits clinical features that do not correspond to the ABCD rules, which is key in differentiating melanoma. This makes nodular melanoma difficult to differentiate from the initially suspected melanoma. As such, diagnosis of nodular melanoma is commonly delayed, and is therefore often identified at an advanced stage. Here, we report a case of nodular melanoma in a young man with a family history of melanoma. We emphasize the importance of early diagnosis through biopsy for malignant melanoma, which is difficult to differentiate based on clinical features. (Korean J Dermatol 2022;60(4):258∼261)

KCI등재 SCOPUS

9면역기능 정상 성인에서 겨드랑 부위에 발생한 모낭염 양상의 전염성 연속종

저자 : 김동성 , 허재영 , 박태흠 , 김우일 , 조문균 , 김수영

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 262-263 (2 pages)

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KCI등재 SCOPUS

10저절로 호전된 원인 불명의 붉은 에크린색한증 1예

저자 : 이상균 , 홍승필

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 4호 발행 연도 : 2022 페이지 : pp. 264-265 (2 pages)

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KCI등재SCOUPUS

1종설 : 피부과 PA (Physician Assistant)의 역할과 한계

저자 : 정영인 ( Young-in Jeong ) , 주민숙 ( Mihn-sook Jue ) , 박향준 ( Hyang-joon Park ) , 최광현 ( Kwang-hyun Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 265-269 (5 pages)

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In Korea, physician assistants (PAs) have emerged owing to the shortage of medical residents, especially in the surgical departments of tertiary hospitals. In addition, the Korean Ministry of Health and Welfare has been planning to reduce the number of medical residents. Hence, training hospitals decided to hire PAs to replace medical residents. PAs can perform a large part of residents' time-consuming job. However, PAs are not a common type of workforce in the field of dermatology. The aim of this study is to compare the roles of dermatology specialist, resident, PAs, and registered nurse (RN), and discuss the limitations and futures of PAs in the field of dermatology. Moreover, in Korea, the legal definition and status of PAs are absent or, if present, inconsistent. Between PAs and other positions such as residents, registered nurses, and nurse specialists, lies an unsettled conflict. Therefore, if PAs are employed, a more precise complement is needed. (Korean J Dermatol 2015;53(4):265∼269)

KCI등재SCOUPUS

2원저 : 건선환자의 말초혈액 내 CD4+CD25+Foxp3+ Regulatory T 세포와 CD4+CD25.Foxp3+ T 세포 수에 관한 연구

저자 : 송상현 ( Sang Hyun Song ) , 김동진 ( Dong Jin Kim ) , 나찬호 ( Chan Ho Na ) , 김민성 ( Min Sung Kim ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 270-276 (7 pages)

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Background: Regulatory T cells (Treg) are able to inhibit the immunological response and maintain cutaneous immunological homeostasis, thus preventing autoimmunity against itself. In several studies, the importance of CD4+CD25+Foxp3+ Treg in psoriasis has been examined, using the peripheral blood of patients. However, limited studies on Treg are available and shows conflicting results. Recently, CD4+CD25.Foxp3+ T cells were identified as being the peripheral reservoir of CD4+CD25+Foxp3+ Treg. Objective: The purpose of this study was to investigate differences in the CD4+CD25+Foxp3+ Treg and CD4+CD25. Foxp3+ T cell counts between patients with psoriasis and normal controls. Methods: For phenotypic analysis, the proportions and absolute cell numbers of CD4+CD25+Foxp3+ Treg and CD4+CD25.Foxp3+ T cells in the peripheral blood were examined by flow cytometry. The correlation between the CD4+CD25+Foxp3+ Treg count and other parameters (age of onset, disease duration, BSA, psoriasis area and severity index score, and clinical stage) was also analyzed. Results: Although the CD4+CD25+Foxp3+ Treg count was slightly increased while the number of CD4+CD25. Foxp3+ T cells was slightly decreased in psoriasis patients than that of the controls, the differences between the groups were not statistically significant (5.27±2.60 vs. 4.70±1.35, p>0.05; 1.56±1.07 vs. 1.93±1.08, p>0.05). The CD4+CD25+Foxp3+ Treg count did not correlate with the tested parameters except for the clinical stage of psoriasis. The mean±SD number of CD4+CD25+Foxp3+ Treg in the stable phase was higher than that in the progressive phase (7.26±2.58 vs. 4.35±2.10, p<0.05). The CD4+CD25.Foxp3+ T cell count did not show any significant correlation with all the parameters tested (p>0.05). Conclusion: These findings suggest that the CD4+CD25+Foxp3+ Treg count alone is insufficient to explain the pathogenesis and severity of psoriasis. However, a decrease in circulating CD4+CD25+Foxp3+ Treg is likely to be correlated with an aggravation of psoriasis. (Korean J Dermatol 2015;53(4):270∼276)

KCI등재SCOUPUS

3원저 : 건선 환자에서 경구 Cyclosporine 치료 후 재발인자에 대한 연구

저자 : 문성훈 ( Seong Hun Moon ) , 김정은 ( Jeong Eun Kim ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 277-283 (7 pages)

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Background: Cyclosporine, which is one of the effective systemic treatments for psoriasis, has a rapid therapeutic effect. However, despite the efficacy of cyclosporine, the recurrence of psoriasis may still occur if treatment with this drug is discontinued. Several studies on the efficacy and safety of cyclosporine for psoriasis have already been conducted. However, studies on the factors causing psoriasis recurrence after cyclosporine treatment are rare. Objective: The aim of this study was to identify the factors that cause recurrence of psoriasis in patients treated with cyclosporine. Methods: We performed a retrospective study of the medical records obtained between January 2007 and March 2014 of 174 patients diagnosed with psoriasis and followed up for at least 6 months after treatment. We analyzed the differences in the demographic characteristics, body surface area, psoriasis area and severity index (PASI) score, psoriasis type, accompanying psoriatic nail, involvement of exposed areas, and several treatment-related factors (starting dose, last dose, maximal dose, cumulative dose, mean daily dose, and treatment duration) between the group that experienced a recurrence and the group that did not. Additionally, we analyzed the effects of these factors on the recurrence and the time to recurrence. Results: Of the 174 patients, 57 (32.8%) reported a recurrence of the disease. There were statistically significant differences between the two groups in terms of their PASI score (p=0.031) and mean daily dose (p=0.014). In the multiple logistic regression analysis, the PASI score (p=0.017, odds ratio=1.057) and treatment duration (p=0.035, odds ratio=0.984) showed a significant relation with relapse. Conclusion: This study suggests that long-term treatment with cyclosporine is necessary for high-severity psoriasis in patients to prevent recurrence. However, as this study is retrospective, further prospective and large-scale studies are necessary to confirm this fact. (Korean J Dermatol 2015;53(4):277∼283)

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4원저 : 표피낭종의 파열여부 감별에 있어 초음파 검사의 유용성

저자 : 김상태 ( Sang Tae Kim ) , 이강훈 ( Kang Hoon Lee ) , 김준희 ( Joon Hee Kim ) , 한상화 ( Sang Hwa Han ) , 박종빈 ( Jong Bin Park ) , 서기석 ( Kee Suck Suh ) , 장민수 ( Min Soo Jang ) , 김근태 ( Geun Tae Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 284-289 (6 pages)

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Background: An epidermal cyst is a common keratin-filled epithelial-lined cyst. The treatment of choice for epidermal cysts is surgical excision. If the cyst becomes ruptured, inflamed, or infected, then incision and drainage together with oral antibiotic therapy or intralesional steroid injection treatment is required. Identification of ruptured and unruptured cysts is important for treatment decisions. Objective: The purpose of this study was to evaluate the usefulness of ultrasonography in the diagnosis of epidermal cysts, and to analyze distinctive features that can differentiate between ruptured and unruptured epidermal cysts. Methods: We reviewed the clinical and sonographic features of pathologically confirmed epidermal cysts from 2 subgroups of 66 patients: 30 with unruptured cysts and 36 with ruptured cysts. The sonographic features used in the analysis included tumor size, margin, shape, tumor texture, posterior echo, internal debris, and lesion vascularity on color Doppler sonography. Results: The mean long diameter of the cysts was 10.95 mm in the unruptured cyst group and 12 mm in the ruptured cyst group. Some sonographic features, including heterogenous and hypoechoic echo texture, posterior echo enhancement, and internal hyperechoic and hypoechoic debris, showed no significant differences between the groups (p>0.05). The unruptured cyst group showed cysts with significantly higher frequencies of a well-circumscribed margin, an ovoid shape, and no vascular flow (p<0.05). In contrast, the ruptured cyst group usually had cysts with a poorly defined or slightly poorly defined margin, an irregular shape, peripheral vascular flow, and mild or moderate flow vascularity. Conclusion: The results of this study indicate that ultrasonography is helpful in differentiating between ruptured and unruptured epidermal cysts. (Korean J Dermatol 2015;53(4):284∼289)

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5원저 : 혈소판 풍부혈장을 처치한 섬유아세포에서 제 1형 교원질, MMP-1 및 MMP-2 발현 증가

저자 : 한길 ( Gil Han ) , 김상표 ( Sang-pyo Kim ) , 조재위 ( Jae-we Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 290-297 (8 pages)

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Background: Platelet-rich plasma (PRP) treatment is a promising tool for dermal tissue regeneration. PRP combined with subcision can synergistically induce dermal tissue regeneration. Objective: The purpose of this study was to investigate the effects of PRP on the proliferation and migration of skin fibroblasts, as well as on the type I collagen, matrix metalloproteinase (MMP)-1, and MMP-2 expression in these skin cells. The effect of PRP with subcision on the expression of TGF-β1 was also investigated in an animal model. Methods: Human skin fibroblasts were treated with various concentrations of PRP. The proliferation and migration rate of the cells were evaluated by the trypan blue exclusion method and scratch assay, respectively. The expression levels of type I collagen, MMP-1, and MMP-2 were analyzed by western blot or RT-PCR. In addition, the activity levels of MMP-1 and MMP-2 were studied by zymography. Finally, we treated the animal back with PRP, subcision, or PRP with subcision. The specimens were evaluated by H&E, Masson-trichrome, and TGF-β1 immunohistochemical staining. Results: Data from this study showed that PRP more effectively promoted the migration and proliferation of cells in a dose-dependent manner. The expression levels of type I collagen, MMP-1, and MMP-2 were increased in PRP-treated fibroblasts at the protein and mRNA levels. The in vivo study revealed that the expression of TGF-β1 was prominently increased by co-treatment with PRP and subcision rather than by treatment with either PRP or subcision alone. Conclusion: PRP treatment promoted fibroblast migration and proliferation, and increased the expression of type I collagen, MMP-1, MMP-2, and TGF-β1. Therefore, PRP co-application with subcision is an effective method for dermal remodeling and can be a good treatment option for depressed acne scars. (Korean J Dermatol 2015;53(4): 290∼297)

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6원저 : 부산지역 여드름 환자를 대상으로 한 인식도 조사

저자 : 박인호 ( In Ho Park ) , 설정은 ( Jung Eun Seol ) , 김효진 ( Hyojin Kim ) , 서종근 ( Jong Keun Seo ) , 이숙경 ( Sook Kyung Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 298-303 (6 pages)

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Background: Acne vulgaris is a common dermatologic disease that can largely affect psychosocial aspects of the patient. Objective: This study was performed to survey the perception of acne vulgaris, including the cause of acne vulgaris, and patient attitude towards the disease, as well as preference for treatment methods in Busan. Methods: A total of 170 patients with acne vulgaris, seeking treatment at 1st-, 2nd-, and 3rd-grade hospitals in Busan, were surveyed by questionnaire. Patient informed consent was obtained. Results: With regards to the cause of acne, increased sebum secretion was the most selected answer, followed by stress and eating habits. Most of the patients believed that all of the acne treatment modalities were effective; however, negative recognition about the safety and durability of each treatment was also reported by a majority of the patients. Acne extraction and laser therapy were the most preferred treatment methods, and the most important reason to choose the treatment method was effectiveness. Conclusion: In this study, we could recognize a patients' overall perception about acne vulgaris. It is suggested that dermatologists should try not only to help patients gain a better understanding about acne but also to cope with their demands. (Korean J Dermatol 2015;53(4):298∼303)

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7증례 : 소세포아형 원발성 피부 CD30 양성 역행성 대세포 림프종 1예

저자 : 민정 ( Jung Min ) , 김한샘 ( Han Saem Kim ) , 황상현 ( Sang Hyeon Hwang ) , 이현주 ( Heun Joo Lee ) , 남재희 ( Jae Hui Nam ) , 정호주 ( Ho-joo Jung ) , 박지혜 ( Ji-hye Park ) , 이가영 ( Ga-young Lee ) , 김원석 ( Won-serk Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 304-309 (6 pages)

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Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare cutaneous T-cell lymphoma. Most cases are composed of large anaplastic cells. However, it presents a wide spectrum of histologic patterns. In the small cell variant, a small-sized pleomorphic cell morphology can be seen. A 74-year-old woman presented with an 8-month history of asymptomatic ulcerative plaque and satellite nodule on the right calf. Her past medical history was not specific. The histologic findings on punch biopsy specimens showed a malignant small round cell tumor on both lesions. The tumor cells had large pleomorphic nuclei with multinucleation and some eosinophilic cytoplasm. We performed immunohistochemical staining to rule out neuroectodermal tumor, neuroendocrine tumor, melanoma, lymphoma, and so on. However, the staining results were negative for pancytokeratin, CD3, CD20, CD99, chromogranin A, synaptophysin, CD56, ALK, HMB45, desmin, kappa, lambda, myoglobin, and S-100 protein. CT, MRI, and PET-CT were negative for extracutaneous involvement. Total excision was done, and additional immunohistochemical staining was performed to confirm the origin of the tumor. Staining results for vimentin, LCA, CD4, and CD30 were positive. We c oncluded that these findings were consistent with the small cell variant CD30+PCALCL, which occurs rarely. (Korean J Dermatol 2015;53(4):304∼309)

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8증례 : 홍반성 판의 양상을 보인 소아기 육아종성 입주위 피부염 2예

저자 : 성준영 ( Jun Young Seong ) , 채웅석 ( Woong Suk Chae ) , 정하나 ( Ha Na Jung ) , 공숙현 ( Sook Hyun Kong ) , 서호석 ( Ho Seok Suh ) , 최유성 ( Yu Sung Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 310-314 (5 pages)

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Childhood granulomatous periorificial dermatitis (CGPD) is a distinctive granulomatous form of perioral dermatitis. It is characterized by papular eruptions located around the mouth, nose, and eyes, and rarely present eczematous patches or plaques. Histopathologic examination shows upper dermal and perifollicular granulomatous infiltrates. Herein, we report two cases of CGPD that were presented with erythematous plaques. One patient was treated with 0.03% topical tacrolimus and the other patient with oral metronidazole. The patients responded well to their respective therapies, showing resolution of the lesions. (Korean J Dermatol 2015;53(4):310∼314)

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9증례 : 1064 nm Nd:YAG Laser와 595 nm Pulsed Dye Laser로 치료한 철분 주사 후 색소침착

저자 : 임은화 ( Eun Hwa Lim ) , 김수정 ( Sue-jeong Kim ) , 이영 ( Young Lee ) , 서영준 ( Young Joon Seo ) , 김창덕 ( Chang-deok Kim ) , 이증훈 ( Jeung Hoon Lee ) , 임명 ( Myung Im )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 315-318 (4 pages)

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Ferric carboxymaltose is a non-dextraniron complex used in patients with iron deficiency. However, iron injections may lead to long-lasting brown discoloration secondary to extravasation at the injection site. We herein report a case involving a patient who developed pigmentation after intravenous iron injection and was successfully treated with combined laser therapy. A 36-year-old woman presented with circumscript pigmentation on her left arm after having undergone intravenous iron injection for the treatment of iron deficiency anemia. Histopathologic examination revealed basal hypermelanosis and dermal infiltration of siderophages. Combined therapy with 1064 nm Nd:YAG laser and 595 nm pulsed dye laser was performed to treat the lesion, and marked improvement was noted after five sessions. (Korean J Dermatol 2015;53(4):315∼318)

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10증례 : 류마티스 관절염 환자에서 Adalimumab 사용 후 발생한 심부홍반루푸스

저자 : 한길 ( Gil Han ) , 김성애 ( Sung-ae Kim ) , 조재위 ( Jae-we Cho ) , 이규석 ( Kyu-suk Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 4호 발행 연도 : 2015 페이지 : pp. 319-323 (5 pages)

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The clinical manifestations and immunohistologic findings of drug-induced lupus erythematosus (DILE) are similar to those of idiopathic lupus. However, DILE is different from idiopathic lupus because it is induced after continuous drug exposure and resolves after discontinuation of the causative drug. DILE can be divided into systemic lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus (CCLE). Lupus erythematosus profundus is a subtype of CCLE, and drug-induced CCLE is very rarely reported in the literature. Herein, we report a rare case of adalimumab-induced lupus erythematosus profundus developed in a rheumatoid arthritis patient. The patient is a 43-year-old Korean woman who had multiple tender nodules and plaques on her face, trunk, and both extremities after using adalimumab for rheumatoid arthritis. She was diagnosed with adalimumab-induced lupus erythematosus profundus, and her condition improved after discontinuation of adalimumab. (Korean J Dermatol 2015;53(4):319∼323)

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