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대한피부과학회> 대한피부과학회지> 증례 : Methyl-Aminolevulinate를 이용한 광역동치료로 치료한 단발성 균상식육종 1예

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증례 : Methyl-Aminolevulinate를 이용한 광역동치료로 치료한 단발성 균상식육종 1예

Case Report : A Case of Unilesional Mycosis Fungoides Treated with Photodynamic Therapy Using Methyl-Aminolevulinate

장시혁 ( Sihyeok Jang ) , 황은정 ( Eun Jung Hwang ) , 류형호 ( Hyeong Ho Ryu ) , 조광현 ( Kwang Hyun Cho ) , 조성진 ( Seong Jin Jo )
  • : 대한피부과학회
  • : 대한피부과학회지 53권1호
  • : 연속간행물
  • : 2015년 01월
  • : 58-61(4pages)
대한피부과학회지

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Various treatment modalities are available for mycosis fungoides including topical steroids, topical chemotherapy,phototherapy, and spot radiation therapy. However, these modalities do not always result in optimal effects, withefficacy depending on lesion size, number, and location. Photodynamic therapy (PDT) is a recently introducedtherapeutic modality that proved effective in patients with unilesional mycosis fungoides. A 58-year-old womanpresented with a seven-year history of a pruritic erythematous scaly patch on her right thigh. Through skin biopsy,we verified the lesion as mycosis fungoides. The lesion did not respond well to a topical steroid. We opted fortopical PDT with methyl-aminolevulinate (MAL). MAL cream was applied for 4 hours following irradiation with ared light. Four sessions were administered, separated by five weeks. The lesion clinically improved after treatmentwithout severe side effects. PDT using MAL could be considered an effective and tolerable treatment for mycosisfungoides. (Korean J Dermatol 2015;53(1):58∼61)

UCI(KEPA)

I410-ECN-0102-2015-500-002200133

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
최근 권호 논문
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1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

KCI등재 SCOPUS

2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

KCI등재 SCOPUS

3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

KCI등재 SCOPUS

4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

KCI등재 SCOPUS

5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

KCI등재 SCOPUS

6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

KCI등재 SCOPUS

7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

KCI등재 SCOPUS

8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

KCI등재 SCOPUS

9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

KCI등재 SCOPUS

10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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12
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1주사 환자 278예에 대한 임상적 병리조직학적 고찰

저자 : 정화영 ( Hwa Young Jung ) , 김미리 ( Mi Ri Kim ) , 박영민 ( Young Min Park ) , 박철종 ( Chul Jong Park ) , 김진우 ( Jin Woom Kim ) , 김경문 ( Kyung Moon Kim ) , 이정덕 ( Jeong Deuk Lee ) , 강훈 ( Hoon Kang ) , 조백기 ( Baik Kee Cho ) , 박현정 ( Hyun Jeong Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 1-9 (9 pages)

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Background: Rosacea is characterized by erythema of the central face that persists for several months or longer. Reports of the histological changes in rosacea are scarce, and few attempts have been made to correlate suchchanges with clinical findings and pathophysiology. Objective: This study aimed to elucidate the clinical manifestations of rosacea and investigate its histologicalfeatures. Methods: We performed a retrospective analysis of 278 patients with histologically confirmed rosacea who visitedthe Department of Dermatology at the Catholic Medical Center between January 2008 and May 2013. Clinicalsubtypes, disease severity, and precipitating factors were evaluated. In 115 randomly selected patients, histopathologicalfeatures were evaluated as well. Results: The ratio of males to females was 1:1.8. The age distribution showed a peak incidence in the fifthdecade. The most common subtype was papulopustular rosacea (52.9%) followed by erythematotelangiectatic rosacea(34.9%), ocular rosacea (4.0%), and phymatous rosacea (2.9%). Granulomatous rosacea accounted for 5.4% ofrosacea cases. Precipitating factors included hot weather (54.7%), stress (51.8%), sun exposure (37.4%), alcohol(37.4%), and hot baths (33.1%). Histological analysis of skin biopsies from 115 patients revealed solar elastosis in62 patients (53.9%) and telangiectasia in 85 patients (73.9%).Conclusion: In this study, Korean rosacea patients were predominantly female with a peak age in the fifth decadeand the majority suffered from the papulopustular and erythematotelangiectatic types of rosacea. Histologicalobservations pertaining to each rosacea type were also discussed. (Korean J Dermatol 2015;53(1):1∼9)

KCI등재SCOUPUS

2최근 3년간 피부질환으로 응급실에 내원한 환자에 대한 통계학적 고찰(2010∼2012)

저자 : 이현주 ( Heun Joo Lee ) , 정호주 ( Ho Joo Jung ) , 남재희 ( Jae Hui Nam ) , 박지혜 ( Ji Hye Park ) , 이가영 ( Ga Young Lee ) , 김원석 ( Won Serk Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 10-15 (6 pages)

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Background: An increasing number of patients visit the emergency department (ED) for dermatological complaints. However, there is a paucity of data regarding the skin conditions presenting to the ED. Objective: This study aimed to describe the characteristics of skin complaints seen in the ED of a tertiary hospitalin Korea. Methods: We retrospectively reviewed 1,663 new dermatological emergency patients who visited the ED of ourhospital from January 2010 to December 2012. All skin conditions were diagnosed by a dermatologist and not byan emergency medicine specialist. Results: A total of 1,663 patients with skin problem were seen, corresponding to 1.5% of total ED visits. The meanage was 41.8 years and there was a slight female predominance (61.2%). The peak arrival time was between 9 pmand midnight. In terms of visit length, 68.9% of patients stayed less than 2 hours. Patients most commonly presentedwith urticaria/angioedema (53.8%) followed by herpes zoster (14.0%), contact dermatitis (7.2%), drug eruption(6.5%), and cellulitis/erysipelas (4.0%). Urticaria/angioedema patients were most commonly aged 21 to 40 years andherpes zoster patients were most commonly aged 51 to 70 years. Admissions occurred in 8.1% of cases, mostfrequently for herpes zoster. Conclusion: This retrospective study provides insight into the types of cases being evaluated by dermatologists inthe ED of a tertiary hospital. An awareness of these characteristics may assist physicians working in the ED inevaluating patients who present to the ED with skin disease. (Korean J Dermatol 2015;53(1):10∼15)

KCI등재SCOUPUS

3한국인에서 일광노출과 자외선차단제에 대한 인식과 사용 행태 연구

저자 : 장시혁 ( Si Hyeok Jang ) , 박현선 ( Hyun Sun Park ) , 조소연 ( So Yun Cho ) , 윤현선 ( Hyun Sun Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 16-22 (7 pages)

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Background: Although sunscreen is used as a primary strategy for the prevention of sunburn, photoaging, and skincancer, few people regularly use sunscreen. Objective: To investigate awareness regarding the effects of sunlight, the extent of sun exposure, and sunscreen usebehaviors in Korean subjects. Methods: A questionnaire was administered to 467 adult patients who visited the Dermatology Department at SeoulNational University Boramae Hospital. The questionnaire covered demographic characteristics, causes of wrinkles,sunspots, and skin cancer, awareness of the harmful effects of sun exposure, perceived and actual extent of sunexposure, and the use of sun-protective methods including sunscreen. Results: Sun exposure was selected as the major cause of age spots (60.6%), skin cancer (60.9%), and wrinkles(25.9%). Respondents were likely to underestimate the extent of sun exposure. On average, quite a few respondentsstated that they were exposed to sunlight for more than one hour per day (22.7% on weekdays, 52.4% onweekends). However, only 9.4% of respondents thought that their sun exposure was problematic and 62.7% ofrespondents considered moderate sunlight exposure healthy. Respondents`` sun-protective behaviors were inadequate:only 29.8% used sunscreen regularly, and 16.5% have never used sunscreen. SPF was the most important factor inchoosing sunscreen, and 83.3% used a sunscreen with a labeled SPF over 30. By contrast, only 34.6% ofrespondents used PA+++ sunscreen. Conclusion: Despite fairly good knowledge regarding the harmful effects of sunlight, subjects underestimated therisks of their sun exposure and sun-protective behaviors were suboptimal. Education on the risk of UV exposure andeffects of sunscreen is still needed. (Korean J Dermatol 2015;53(1):16∼22)

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4위축성 여드름 흉터의 치료에 따른 피부 확대경 소견의 차이 고찰: Pilot Study

저자 : 채웅석 ( Woong Suk Chae ) , 성준영 ( Jun Young Seong ) , 정하나 ( Ha Na Jung ) , 공숙현 ( Sook Hyun Kong ) , 서호석 ( Ho Seok Suh ) , 최유성 ( Yu Sung Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 23-29 (7 pages)

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Background: Dermoscopy has been suggested as a useful tool for diagnosing various skin diseases. Recently, thepossibility of using dermoscopy to predict the response to treatment has emerged. Objective: The purpose of this study was to determine whether dermoscopic findings corresponded to clinical acnescar types. This study also aimed to discover which dermoscopic findings predict the response to acne scartreatment. Methods: The dermoscopic findings of 39 participants undergoing atrophic acne scar treatment with fractionalphotothermolysis were evaluated. Patients were divided into two groups according to the duration of acne scarpersistence. Results: Patients with a relatively short duration of acne scar persistence usually achieved better treatment outcomes. Dermoscopic findings showed no obvious differences according to clinical acne scar type. But high hair follicledensity can be considered a predictive factor of treatment effects. Conclusion: Our study indicated that acne scar improvements can be predicted by dermoscopically observing hairfollicle density. (Korean J Dermatol 2015;53(1):23∼29)

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5Histological Findings in Korean Patients with Rosacea

저자 : Sang Yeon Park , Jin Wook Lee , Sung Ku Ahn

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 30-37 (8 pages)

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Background: Rosacea is characterized by erythema of the face that persists for several months or longer. Rosaceais usually diagnosed based on clinical presentation and a biopsy is rarely performed for diagnostic purposes. However,a biopsy may be helpful when the symptoms are atypical. Objective: We identified commonly appearing histological characteristics of rosacea such as inflammation, sebaceoushyperplasia, granulomatous reaction, epidermal hyperplasia, Demodex, pustules, and fibrosis. In addition, we evaluatedthese according to clinical subtype. Methods: We examined the histological findings of 200 rosacea patients who visited our hospital. Histologicalfindings were evaluated according to clinical subtype. The standard classification and staging method published bythe National Rosacea Society was used for clinical classification. Results: The erythematotelangiectatic and papulopustular types of rosacea were the most common. Mild inflammationwas found in 56.0% of the patients (1 and 1+) and 49.0% showed inflammation greater than 2 degrees. Themost commonly observed histological features across all subtypes were sebaceous hyperplasia followed by epidermalhyperplasia and Demodex. However, sebaceous hyperplasia and Demodex were not observed in ocular rosacea. Conclusion: Some histological findings such as inflammation, granulomatous reaction, sebaceous hyperplasia,pustule, Demodex, epidermal hyperplasia, and fibrosis were commonly observed in rosacea. There were no distinctivesubtype-specific characteristics, but various histological characteristics were observed in a single clinical subtype. (Korean J Dermatol 2015;53(1):30∼37)

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6Immunohistochemical Differentiation between Actinic Cheilitis and Lichen Planus of the Lips

저자 : Soo Eun Jung , Yong Hyun Jang , Hee Young Kang , Eun So Lee , You Chan Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 38-44 (7 pages)

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Background: It is difficult to distinguish between actinic cheilitis and lichen planus histologically, because bothtypes of lesions exhibit variable degrees of epidermal dysplasia and dermal lichenoid inflammation. There iscurrently no consensus on suitable immunohistochemical markers for distinguishing these 2 conditions. Objective: This study aims to determine histological features and immunohistochemical markers that could be usedto differentiate actinic cheilitis from lichen planus. Methods: Fifteen cases of actinic cheilitis and 11 cases of lichen planus of the lips were included in the study. Histological changes such as parakeratosis, hyperkeratosis, atrophy, acanthosis, ulceration, necrosis, dermal solarelastosis, degrees of epidermal dysplasia and dermal inflammatory cell infiltration were examined. Verhoeff-vanGieson stained sections were quantified for the degree of elastosis using computer software. The followingimmunohistochemical markers were stained for: bcl-2, Ki-67, proliferating cell nuclear antigen, indoleamine 2,3-dioxygenase, matrix metalloproteinase-3, matrix metalloproteinase-9, CD4, CD8, c-kit, and prolyl-4-hydroxylase. Results: The only histologically appreciable difference between the diseases was the degree of epidermal dysplasia. No differences were observed with respect to solar elastosis using the Verhoeff-van Gieson stain. We found that cellproliferation markers such as proliferating cell nuclear antigen and Ki-67 were more highly expressed in actiniccheilitis than in lichen planus. In addition, the number of c-kit-positive cells observed in actinic cheilitis wassignificantly higher than in lichen planus. The expression levels of the other tested markers were not significantlydifferent between the 2 diseases. Conclusion: The immunohistochemical markers proliferating cell nuclear antigen, Ki-67, and c-kit may help todifferentiate actinic cheilitis from lichen planus of the lips. (Korean J Dermatol 2015;53(1):38∼44)

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7증례 : 담낭암에서 전이된 Sister Mary Joseph 결절 1예

저자 : 하지민 ( Ji Min Ha ) , 윤종현 ( Jong Hyun Yoon ) , 조은별 ( Eun Byul Cho ) , 박경훈 ( Gyeong Hun Park ) , 박은주 ( Eun Joo Park ) , 권인호 ( In Ho Kwon ) , 김광호 ( Kwang Ho Kim ) , 김광중 ( Kwang Joong Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 45-48 (4 pages)

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Cutaneous metastasis into the umbilicus, known as a Sister Mary Joseph nodule, is quite rare. Gastric adenocarcinoma is the most common primary origin overall, whereas gynecologic tumors such as ovarian cancer are the leading cause in women. In most cases, the nodule manifests after the primary tumor had been diagnosed. In rare cases, however, it serves as the first sign of the underlying malignancy. Here, we report the case of a 59-year-old woman who presented with a nodule on the umbilicus and was diagnosed with metastatic adenocarcinoma originating in the gallbladder. (Korean J Dermatol 2015;53(1):45∼48)

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8증례 : Narrowband Ultraviolet B 광선치료에 의해 치유된 소아의 전신성 색소침착자색반 1예

저자 : 나찬호 ( Chan Ho Na ) , 송상현 ( Sang Hyun Song ) , 김민성 ( Min Sung Kim ) , 신봉석 ( Bong Seok Shin )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 49-52 (4 pages)

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Pigmented purpuric dermatosis (PPD) represents a group of cutaneous lesions exhibiting petechiae, pigmentation, andoccasionally telangiectasia in the absence of an associated venous insufficiency or hematological disorder. PPD mayresolve spontaneously but tends to persist for months to years. Various treatment modalities such as oralgriseofulvin, pentoxifylline, cyclosporine, ascorbic acid, topical corticosteroids, and PUVA therapy have been usedwith unsatisfactory results. Recently, some studies reported that PPD showed a dramatic response to narrowbandultraviolet B (UVB) phototherapy. In these studies, narrowband UVB phototherapy was an effective treatmentmethod with few side effects. Here, we present the case of a 7-year-old boy with generalized PPD that improvedrapidly following narrowband UVB phototherapy. (Korean J Dermatol 2015;53(1):49∼52)

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9증례 : 표피지향성 전이악성흑색종

저자 : 장민수 ( Min Soo Jang ) , 한상화 ( Sang Hwa Han ) , 김준희 ( Joon Hee Kim ) , 이강훈 ( Kang Hoon Lee ) , 박종빈 ( Jong Bin Park ) , 김상태 ( Sang Tae Kim ) , 서기석 ( Kee Suck Suh )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 53-57 (5 pages)

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Cutaneous metastases of malignant melanoma are usually confined to the dermis or subcutaneous fat. In someinstances, however, they may involve the epidermis. A 68-year-old woman with a malignant melanoma on thesubungual area of the right great toe presented with multiple blackish pinhead-sized macules surrounding anulcerative lesion on the right great toe. Histopathological study of the macules showed atypical melanocytes andmelanocytic nests in the papillary dermis and the dermoepidermal junction. A thinning of the epidermis, wideningof the dermal papillae by aggregated atypical melanocytes, epidermal collarette formation, and angiotropism werealso seen. A diagnosis of epidermotropic metastatic malignant melanoma (EMMM) was made. EMMM is a specificform of metastatic malignant melanoma that is associated with epidermotropism of melanoma cells and severalhistopathological features. The differential diagnosis between primary malignant melanoma and EMMM can bedifficult because of their similar clinical and histological features. Here, we report a case demonstrating EMMM. (Korean J Dermatol 2015;53(1):53∼57)

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10증례 : Methyl-Aminolevulinate를 이용한 광역동치료로 치료한 단발성 균상식육종 1예

저자 : 장시혁 ( Sihyeok Jang ) , 황은정 ( Eun Jung Hwang ) , 류형호 ( Hyeong Ho Ryu ) , 조광현 ( Kwang Hyun Cho ) , 조성진 ( Seong Jin Jo )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 53권 1호 발행 연도 : 2015 페이지 : pp. 58-61 (4 pages)

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Various treatment modalities are available for mycosis fungoides including topical steroids, topical chemotherapy,phototherapy, and spot radiation therapy. However, these modalities do not always result in optimal effects, withefficacy depending on lesion size, number, and location. Photodynamic therapy (PDT) is a recently introducedtherapeutic modality that proved effective in patients with unilesional mycosis fungoides. A 58-year-old womanpresented with a seven-year history of a pruritic erythematous scaly patch on her right thigh. Through skin biopsy,we verified the lesion as mycosis fungoides. The lesion did not respond well to a topical steroid. We opted fortopical PDT with methyl-aminolevulinate (MAL). MAL cream was applied for 4 hours following irradiation with ared light. Four sessions were administered, separated by five weeks. The lesion clinically improved after treatmentwithout severe side effects. PDT using MAL could be considered an effective and tolerable treatment for mycosisfungoides. (Korean J Dermatol 2015;53(1):58∼61)

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