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한국영양학회> 한국영양학회지> 연구논문 : 폐경 전,후 여성의 골밀도 및 골대사 지표에 영향을 미치는 요인

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연구논문 : 폐경 전,후 여성의 골밀도 및 골대사 지표에 영향을 미치는 요인

Research Articles : The Association between Bone Mineral Density, Bone Turnover Markers, and Nutrient Intake in Pre- and Postmenopausal Women

박지연 ( Ji Youn Park ) , 최미연 ( Mi Youn Choi ) , 이선희 ( Seon Heui Lee ) , 최윤호 ( Yoon Ho Choi ) , 박유경 ( Yook Young Park )
  • : 한국영양학회
  • : 한국영양학회지 44권1호
  • : 연속간행물
  • : 2011년 02월
  • : 29-40(12pages)

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The purpose of this study was to examine the association among bone mineral density (BMD), biochemical bone markers, nutrients, and salt intake in premenopausal and postmenopausal women. We evaluated 431 subjects who visited a health promotion center of a university hospital between January 2008 and July 2009. We excluded those who were taking medications or who had an endocrine disorder affecting osteoporosis. The subjects were divided into premenopausal (n = 283) and postmenopausal (n = 143) women. We evaluated the correlation among BMD of the lumbar spine, femoral neck, and total femoral, as well as biochemical bone markers, hormone, serum profiles, general characteristics, nutrient intakes, and food intake frequencies. From a stepwise multiple regression analysis, lumbar spine BMD was positively correlated with weight (p < 0.001) and negatively correlated with osteocalcin (OC)(p < 0.001), Femoral neck BMD was positively correlated with weight (p < 0.001) and negatively correlated with C-telopeptide (CTx) and alkaline phosphatase (ALP)(p < 0.001, p < 0.05). In premenopausal women, femoral total BMD was positively correlated with BMI (p < 0.001) and negatively correlated with CTx (p < 0.001). In postmenopausal women, lumbar spine BMD was positively correlated with calcium intake (p < 0.01) and negatively correlated with sodium intake (p < 0.01). Femoral neck and femoral total BMD were both positively correlated with weight (p < 0.001), and femoral neck BMD was negatively correlated with age and ALP (p < 0.001, p < 0.05). Femoral total BMD was negatively correlated with age and OC (p < 0.001, p < 0.01). These results suggest that reducing sodium intake may play an important role delaying bone resorption and preventing a decrease in BMD. (Korean J Nutr 2011; 44 (1): 29 ~ 40)

UCI(KEPA)

I410-ECN-0102-2012-590-001780336

간행물정보

  • : 자연과학분야  > 가정
  • : KCI등재
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  • : 격월
  • : 0367-6463
  • :
  • : 학술지
  • : 연속간행물
  • : 1968-2011
  • : 3126


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저자 : 박현서

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 3-4 (2 pages)

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2연구논문 : 임신 쥐의 철 과잉섭취가 조직의 산화적 스트레스에 미치는 영향

저자 : 박미나 ( Mi Na Park ) , 이연숙 ( Yeon Sook Lee )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 5-15 (11 pages)

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Although iron is an essential mineral, excess iron intake during pregnancy may increase oxidative stress in tissues. This study was conducted to investigate the effects of iron overload during pregnancy on iron status and oxidative stress in maternal rats. Ten week-old female Sprague-Dawley rats were mated with male rats. Non-pregnant (control) and pregnant rats were fed diets containing normal Fe (35 mg/kg diet), high Fe (350 mg/kg diet), or excess Fe (1,050 mg/kg diet) during pregnancy. Rats were sacrificed on pregnancy day 19. No significant difference in weight gain, diet intake, or litter size was observed according to iron intake levels. Furthermore, serum iron, hemoglobin, and hematocrit were not different among the rats administered the three levels of Fe both in the control and pregnant groups. However, the iron levels were lower in pregnant rats than those in the control. The liver and spleen iron contents increased significantly in the excess Fe group. An increase in liver ferritin levels with increasing iron intake was observed. Protein carbonyl content, as a marker of oxidative stress, increased significantly in liver with increasing iron intake but not malondialdehyde. Glutathione peroxidase activity in the liver of pregnant rats fed excess iron decreased significantly. Bcl-2 protein expression in the liver declined remarkably with increasing maternal iron intake in pregnant rats. Taken together, iron overload during pregnancy had little effect on hematology. However, the deposits of iron in the liver and the decline in antioxidant enzyme activity implied increased oxidative stress in tissues of the excess Fe group. These results suggest that excess iron intake during pregnancy increases oxidative stress in maternal tissues and may also affect fetal tissues. (Korean J Nutr 2011; 44 (1): 5 ~ 15 )

3연구논문 : Glutathione S-transferase (GST) 유전자 다형성에 따른 우리나라 젊은 성인의 항산화 상태, DNA 손상 및 지질 양상

저자 : 조혜련 ( Hye Ryun Jo ) , 이혜진 ( Hye Jin Lee ) , 강명희 ( Myung Hee Kang )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 16-28 (13 pages)

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Oxidative stress leads to the induction of cellular oxidative damage, which may cause adverse modifications of DNA, proteins, and lipids. The production of reactive species during oxidative stress contributes to the pathogenesis of many diseases. Antioxidant defenses can neutralize reactive oxygen species and protect against oxidative damage. The aim of this study was to assess the antioxidant status and the degree of DNA damage in Korean young adults using glutathione s-transferase (GST) polymorphisms. The GSTM1 and GSTT1 genotypes were characterized in 245 healthy young adults by smoking status, and their oxidative DNA damage in lymphocytes and antioxidant status were assessed by GST genotype. General characteristics were investigated by simple questionnaire. From the blood of the subjects, GST genotypes; degree of DNA damage in lymphocytes; the erythrocyte activities of superoxide dismutase, catalase, and glutathione peroxidase; plasma concentrations of total peroxyl radical-trapping potential (TRAP), vitamin C, α- and γ-tocopherol, α- and β-carotene and cryptoxanthin, as well as plasma lipid profiles, conjugated diene (CD), GOT, and GPT were analyzed. Of the 245 subjects studied, 23.2% were GSTM1 wild genotypes and 33.4% were GSTT1 wild genotype. No difference in erythrocyte activities of superoxide dismutase, catalase, or glutathione peroxidase, and the plasma TRAP level, CD, GOT, and GPT levels were observed between smokers and non-smokers categorized by GSTM1 or GSTT1 genotype. Plasma levels of α- and γ-tocopherol increased significantly in smokers with the GSTT1 wild genotype (p < 0.05); however, plasma level of α-carotene decreased significantly in non-smokers with the GSTM1 wild genotype (p < 0.05). DNA damage assessed by the Comet assay was significantly higher in non-smokers with the GSTM1 null genotype; whereas DNA damage was significantly lower in non-smokers with the GSTT1 null genotype. Total cholesterol and LDL cholesterol levels were significantly higher in non-smokers with the GSTT1 null genotype than those with the GSTT1 wild genotype (p < 0.05). In conclusion, the GSTM1 null genotype or the GSTT1 wild genotype in non-smokers aggravated their antioxidant status through DNA damage of lymphocytes; however, the GSTT1 wild type in non-smokers had normal plasma total cholesterol and LDL-cholesterol levels. This finding confirms that GST polymorphisms could be an important determinant of antioxidant status and plasma lipid profiles in non-smoking young adults. Further study is necessary to clarify the antioxidant status and/or lipid profiles of smokers with the GST polymorphism and to conduct a study with significantly more subjects. (Korean J Nutr 2011; 44(1): 16 ~ 28)

4연구논문 : 폐경 전,후 여성의 골밀도 및 골대사 지표에 영향을 미치는 요인

저자 : 박지연 ( Ji Youn Park ) , 최미연 ( Mi Youn Choi ) , 이선희 ( Seon Heui Lee ) , 최윤호 ( Yoon Ho Choi ) , 박유경 ( Yook Young Park )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 29-40 (12 pages)

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The purpose of this study was to examine the association among bone mineral density (BMD), biochemical bone markers, nutrients, and salt intake in premenopausal and postmenopausal women. We evaluated 431 subjects who visited a health promotion center of a university hospital between January 2008 and July 2009. We excluded those who were taking medications or who had an endocrine disorder affecting osteoporosis. The subjects were divided into premenopausal (n = 283) and postmenopausal (n = 143) women. We evaluated the correlation among BMD of the lumbar spine, femoral neck, and total femoral, as well as biochemical bone markers, hormone, serum profiles, general characteristics, nutrient intakes, and food intake frequencies. From a stepwise multiple regression analysis, lumbar spine BMD was positively correlated with weight (p < 0.001) and negatively correlated with osteocalcin (OC)(p < 0.001), Femoral neck BMD was positively correlated with weight (p < 0.001) and negatively correlated with C-telopeptide (CTx) and alkaline phosphatase (ALP)(p < 0.001, p < 0.05). In premenopausal women, femoral total BMD was positively correlated with BMI (p < 0.001) and negatively correlated with CTx (p < 0.001). In postmenopausal women, lumbar spine BMD was positively correlated with calcium intake (p < 0.01) and negatively correlated with sodium intake (p < 0.01). Femoral neck and femoral total BMD were both positively correlated with weight (p < 0.001), and femoral neck BMD was negatively correlated with age and ALP (p < 0.001, p < 0.05). Femoral total BMD was negatively correlated with age and OC (p < 0.001, p < 0.01). These results suggest that reducing sodium intake may play an important role delaying bone resorption and preventing a decrease in BMD. (Korean J Nutr 2011; 44 (1): 29 ~ 40)

5연구논문 : 우리나라 초등학교 어린이의 식생활 인지,실천 수준 평가지표 구성타당도 평가 및 산정방법 연구

저자 : 권세혁 ( Se Hyug Kwon ) , 김혜영 ( Hye Young Kim ) , 이정숙 ( Jung Sug Lee ) , 곽동경 ( Tong Kyung Kwak ) , 정해랑 ( Hae Rang Chung ) , 최영선 ( Young Sun Choi ) , 강명희 ( Myung Hee Kang )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 41-48 (8 pages)

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Constructs with seven latent evaluation indicators and 18 observable survey questions were developed by food and nutrition experts to calculate a food safety recognition and practice index for children. The purpose of this study was to suggest statistical approaches to test construction validity on the constructs, obtain weights of the evaluation indicators, and develop questionnaires to calculate a children``s food recognition and practice index. Survey data of 2,400 elementary fifth grade students were used as empirical results. Test validity was evaluated by exploratory factor analysis and confirmed to be highly significant by confirmatory factor analysis [i.e., linear structural relations (LISREL) analysis]. Standardized path coefficients of the LISREL analysis were suggested based on weights, and the weights were compared using the AHP and Delphi methods. (Korean J Nutr 2011; 44(1): 41 ~ 48)

6연구논문 : 한국 어린이 식생활 안전지수의 평가 지표 개발

저자 : 정해랑 ( Hae Rang Chung ) , 곽동경 ( Tong Kyung Kwak ) , 최영선 ( Young Sun Choi ) , 김혜영 ( Hye Young Kim ) , 이정숙 ( Jung Sug Lee ) , 최정화 ( Jung Hwa Choi ) , 이나영 ( Na Young Yi ) , 권세혁 ( Se Hyug Kwon ) , 최윤주 ( Youn Ju Choi ) , 이순규 ( Soon Kyu Lee ) , 강명희 ( Myung Hee K

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 49-60 (12 pages)

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This study was performed to develop a children`s dietary life safety index required by the Special Act on Safety Management of Children`s Dietary Life enacted in 2009. An analytical hierarchy process was used to obtain initial weights of dietary life safety evaluation indicators. The Delphi method was applied to develop the weights along with 98 food and nutrition professionals. Three representative policy indicators, nine strategy indicators, 11 main evaluation indicators, and 20 detailed evaluation indicators were selected for the children`s dietary life safety assessment. Three policy indicators and nine strategy indicators were the following: children`s food safety indicator (support level of children`` safety, safety management level of children`s favorite foods, and safety management level of institutional food service), children`s nutrition safety indicator (management level of missing meals and obesity, nutrition management level of children`s favorite foods, and nutrition management level of institutional food service), and children`s perception and practice level indicator ("Dietary Life Law" perception level, perception, and practice level for dietary life safety management, perception, and practice level for nutrition management). Weights of 40%, 40%, and 20% were given for the three representative policy indicators. The relative importance of nine strategic indicators, which were determined by the Delphi method is as follows: For children`s food safety, support level of children`s safety, safety management level of children`s favorite foods, and safety management level of institutional food service were given weights of 12%, 9%, and 19%, respectively. For children`s nutrition safety, the missing meals and obesity management level, nutrition management level of children`s favorite foods, and the nutrition management level of institutional food service were given weights of 13%, 11%, and 16%, respectively. The "Dietary Life Law" perception level, perception and practice level of dietary life safety management, and perception and practice level of nutrition management were given weights of 4%, 7%, and 9%, respectively. (Korean J Nutr 2011; 44(1): 49 ~ 60)

7연구논문 : 식품으로 인한 유해물질 노출평가를 위한 설문지 개발

저자 : 신상아 ( Sang Ah Shin ) , 최슬기 ( Seul Ki Choi ) , 김혜미 ( Hye Mi Kim ) , 이경윤 ( Kyung Youn Lee ) , 신상희 ( Sang Hee Shin ) , 이정원 ( Jung Won Lee ) , 유수현 ( Soo Hyun Yu ) , 남혜선 ( Hye Soen Nam ) , 윤혜정 ( Hae Jung Yoon ) , 정효지 ( Hyo Jee Joung )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 61-73 (13 pages)

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The aim of this study was to develop a reliable dietary questionnaire to assess human exposure to food-borne hazards. Eleven food-borne hazards were chosen as a priority control list through a literature review and advisory committees. The 11 food-borne hazards were phthalate, aflatoxin, bisphenol A, polycyclic aromatic hydrocarbons, dioxin, polychlorinated biphenyls, mercury, lead, cadmium, arsenic, and acrylamide. The characteristics, exposure level, and paths of these hazards were reviewed, and questionnaire items were identified to assess human exposure from the literature. A questionnaire was developed for each selected food based on its characteristics. Based on the items in the individual questionnaires, a comprehensive questionnaire, which contained demographic characteristics, job information, socioeconomic factors, health related lifestyles, and dietary behaviors, was developed. A 99-item food frequency questionnaire (FFQ) to assess food-borne hazard exposure was also developed. The FFQ included frequency of food intake during the previous year, container type for purchasing and storing food, and cooking method. The questionnaire developed in this study could be applied to assess dietary factors during an exposure assessment of food-borne hazards in a large population. A validation study for the questionnaire is needed before applying it to surveys. (Korean J Nutr 2011; 44(1): 61 ~ 73)

8연구논문 : 학교급식 식재료 및 완제품 배송직원의 위생관리 실태 조사

저자 : 김윤화 ( Yun Hwa Kim ) , 이연경 ( Yeon Kyung Lee )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 74-81 (8 pages)

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The purpose of this study was to investigate the sanitation management of school foodstuffs and the sanitation knowledge of delivery company workers. A questionnaire that identified employee``s food safety sanitation management, knowledge, and practices was developed based on a review of the literature. The subjects consisted of 201 delivery company workers from 38 delivery companies in the Daegu and Gyeongbuk area. The workers were 30-39 years of age (41.3%) with 1-3 years of working experience (30.8%). Approximately 62% of the respondents were educated and had 1-2 years of food safety experience, 52.7% of the respondents delivered foodstuffs to two schools in the morning. The total score for delivery company worker sanitation knowledge was 3.75/7.00, which was low. The total mean sanitary performance score for factory workers was 4.58/5.00. They indicated that the most difficult part of the operation is delivering on time. Temperature management was another difficulty. In order to secure the best quality of school food to be supplied safely, the thorough sanitation education must be conducted to the school dieticians and delivery company managers. (Korean J Nutr 2011; 44(1): 74 ~ 81)

9종설 : 한국인의 요오드 섭취와 요오드 상한섭취량

저자 : 이현숙 ( Hyun Sook Lee ) , 민혜선 ( Hye Sun Min )

발행기관 : 한국영양학회 간행물 : 한국영양학회지 44권 1호 발행 연도 : 2011 페이지 : pp. 82-91 (10 pages)

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The present study reviewed the effects of excess iodine intake on thyroid function and the incidence of thyroid disease and discussed the scientific basis for establishing a tolerable upper intake level (UL) of iodine for Koreans. ULs are defined as “the highest level of daily nutrient intake that is likely to pose no risk of adverse effects to almost all individuals in the general population.” Koreans consume excess iodine from seaweed, and iodine intake is strongly influenced by seaweed consumption. However, no dose-response data derived from subjects consuming excess iodine frequently but not continuously during a lifetime are available. Therefore, the Korean DRI committee set the iodine UL to reduce the risk of adverse health effects by excess iodine intake for Koreans with distinctive seaweed-eating habits. (Korean J Nutr 2011; 44(1): 82 ~ 91)

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