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대한피부과학회> 대한피부과학회지> 원저 : 백반증의 감별진단을 위한 조직학적 염색법의 유용성

KCI등재SCOUPUS

원저 : 백반증의 감별진단을 위한 조직학적 염색법의 유용성

Original Article : Value of Histological Staining in Differential Diagnosis of Vitiligo

김형성 ( Hyung Sung Kim ) , 박미선 ( Mei Shan Piao ) , 윤숙정 ( Sook Jung Yun ) , 이지범 ( Jee Bum Lee ) , 김성진 ( Seong Jin Kim ) , 원영호 ( Young Ho Won ) , 이승철 ( Seung Chul Lee )
  • : 대한피부과학회
  • : 대한피부과학회지 46권5호
  • : 연속간행물
  • : 2008년 05월
  • : 569-577(9pages)

DOI


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Background: Vitiligo is a depigmented disorder, causing serious cosmetic problems for patients. In diagnostic and therapeutic aspects, vitiligo should be differentiated from other hypopigmented disorders as the therapeutic approach and prognosis are different for each disease. Objective: This study aimed to compare the usefulness of several markers for melanocytes or melanin in differential diagnosis of vitiligo. Methods: Twenty-eight patients were studied, who were diagnosed clinically as suffering from one of the following diseases: vitiligo, nevus depigmentosus, pityriasis alba, postinflammatory hypopigmentation, and idiopathic guttate hypomelanosis. Skin samples (frozen or paraffin-fixed) were obtained from depigmented patches and normal neighboring skin (control). Histological staining was performed by using Fontana-Masson, S-100, MART-1, and DOPA. The staining level of lesional skin was compared with that of normal skin. Results: When the staining level of vitiligo was compared with that of others, vitiligo was significantly lower in Fontana-Masson (13.3±17.2% vs 44.4±23.7%), S-100 (49.5±14.9% vs 74.7±24.2%), MART-1 (7.4±8.7% vs 68± 33.9%), and DOPA (9.5±11.3% vs 58.2±29.5%) (p<0.0001). Conclusion: MART-1 and DOPA are valuable markers in differential diagnosis of vitiligo. However, Fontana- Masson, a marker of melanin, had some limits in detecting melanocytes, and S-100 showed non-specific staining other than melanocytes. (Korean J Dermatol 2008;46(5):569∼577)

UCI(KEPA)

I410-ECN-0102-2009-510-008686374

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9526


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1원저 : 백반증의 감별진단을 위한 조직학적 염색법의 유용성

저자 : 김형성 ( Hyung Sung Kim ) , 박미선 ( Mei Shan Piao ) , 윤숙정 ( Sook Jung Yun ) , 이지범 ( Jee Bum Lee ) , 김성진 ( Seong Jin Kim ) , 원영호 ( Young Ho Won ) , 이승철 ( Seung Chul Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 569-577 (9 pages)

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Background: Vitiligo is a depigmented disorder, causing serious cosmetic problems for patients. In diagnostic and therapeutic aspects, vitiligo should be differentiated from other hypopigmented disorders as the therapeutic approach and prognosis are different for each disease. Objective: This study aimed to compare the usefulness of several markers for melanocytes or melanin in differential diagnosis of vitiligo. Methods: Twenty-eight patients were studied, who were diagnosed clinically as suffering from one of the following diseases: vitiligo, nevus depigmentosus, pityriasis alba, postinflammatory hypopigmentation, and idiopathic guttate hypomelanosis. Skin samples (frozen or paraffin-fixed) were obtained from depigmented patches and normal neighboring skin (control). Histological staining was performed by using Fontana-Masson, S-100, MART-1, and DOPA. The staining level of lesional skin was compared with that of normal skin. Results: When the staining level of vitiligo was compared with that of others, vitiligo was significantly lower in Fontana-Masson (13.3±17.2% vs 44.4±23.7%), S-100 (49.5±14.9% vs 74.7±24.2%), MART-1 (7.4±8.7% vs 68± 33.9%), and DOPA (9.5±11.3% vs 58.2±29.5%) (p<0.0001). Conclusion: MART-1 and DOPA are valuable markers in differential diagnosis of vitiligo. However, Fontana- Masson, a marker of melanin, had some limits in detecting melanocytes, and S-100 showed non-specific staining other than melanocytes. (Korean J Dermatol 2008;46(5):569∼577)

2원저 : 원형 탈모증 환자의 삶의 질

저자 : 백승주 ( Seung Ju Back ) , 박영옥 ( Young Ok Park ) , 김계정 ( Kae Jeung Kim ) , 김창덕 ( Chang Deok Kim ) , 서영준 ( Young Joon Seo ) , 이증훈 ( Jeung Hoon Lee ) , 박장규 ( Jang Kyu Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 578-586 (9 pages)

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Background: Hair constitutes an integral part of our self and our self-identity, which is why hair loss may cause a broad range of psychological problems related to our identity. However, the association between quality of life (QOL) in alopecia areata (AA) patients and their clinical characteristics has not yet been investigated in Korea. Objective: The purpose of this study is to compare the QOL in patients with AA and healthy controls by using Hairdex scale. The relationship between their QOL and their clinical characteristics will be investigated. Methods: 102 AA patients and 82 healthy controls were recruited in this study and compared by use of Hairdex. Correlation analysis was performed to examine the relationship between the QOL and the clinical characteristics of patients with AA. Results: The total Hairdex scores and all domain scores, except those of the symptomatic domain, of the Hairdex scales in AA were higher than those of the healthy controls. Clinical characteristics, including the age, disease duration, AA type, AA area, treatment satisfaction, treatment history, anxiety and depression, showed significant correlation with QOL. Of these characteristics, the depression and treatment satisfaction showed strong association with QOL. Conclusion: AA can a impair patient`s quality of life and has a significant psychological impact. (Korean J Dermatol 2008;46(5):578∼586)

3원저 : 선상 편평태선의 경구 스테로이드 치료

저자 : 강유석 ( Yoo Seok Kang ) , 이운하 ( Un Ha Lee ) , 박현수 ( Hyun Su Park ) , 장상재 ( Sang Jai Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 587-595 (9 pages)

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Background: Lichen planus is a chronic papulosquamous disease characterized by various clinical manifestations of the skin, mucosa, hair, and nails. Various drugs or physical treatments for lichen planus have been proposed, but the efficacies are often disappointing and controversial. Linear lichen planus is a rare variant of lichen planus, which accounts for 0.2∼0.6% of all patients with lichen planus. Systemic corticosteroids remain the most widely used treatment for lichen planus. However, there have been no clinical studies on the effectiveness of this therapy on linear lichen planus despite the fact that linear lichen planus usually lasts for more than 1 year and occasionally results in cosmetic problems. Objective: This study evaluated the efficacy and safety of oral methylprednisolone therapy for linear lichen planus. Methods: Retrospective study was performed by reviewing the medical records and clinical photographs of 12 linear lichen planus patients treated with oral methylprednisolone. The analyses of treatment response to oral methylprednisolone therapy, adverse effects, and recurrence were performed. Results: All the 12 patients who completed the oral methylprednisolone therapy achieved complete response. Most patients showed a marked improvement 1 to 2 weeks after starting oral methylprednisolone therapy. Three of the 12 patients showed recurrence at 9 to 14 weeks after cessation of the treatment. Oral methylprednisolone therapy was generally well-tolerated and no serious adverse effects were observed. Conclusion: Oral methylprednisolone therapy is an efficacious, safe, and tolerable treatment modality for linear lichen planus. (Korean J Dermatol 2008;46(5):587∼595)

4원저 : 이동성 홍반의 피부 병변으로 내원한 환자들에 대한 고찰

저자 : 오윤석 ( Yoon Seok Oh ) , 엄민섭 ( Min Seob Eom ) , 조미연 ( Mee Yon Cho ) , 김종배 ( Jong Bae Kim ) , 최응호 ( Eung Ho Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 596-603 (8 pages)

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Background: Lyme disease, an infection caused by Borrelia(B.) burgdorferi, has been reported in many countries. But in Korea, only 5 cases of serologically diagnosed lyme disease have been reported. Because several strains of B. burgdorferi were isolated from Ixodes ticks which were captured in Kangwon and Chungbuk province, there might be more cases of serologically undiagnosed lyme diseases presenting with erythema migrans. Objective: To understand the clinical patterns and laboratory findings of erythema migrans in Korea. Methods: A clinical survey was retrospectively performed on 9 patients with erythema migrans which occurred after tick bites. Results: Among 9 patients with erythema migrans, 3 patients were male and 6 patients were female. The onset age of erythema migrans ranged from 26 to 71 years old (mean, 51.3 years old). The mean duration of erythema migrans after tick bite was 26.4 days and the diameter of the lesion ranged from 6 to 34 cm (mean, 18.3 cm). All cases developed from May to September and systemic symptoms such as fatigue, fever and/or chills, myalgia, palpitation, headache, arthralgia and dyspnea were present at the time of hospital visits of 3 patients. Clinically, 3 patterns of erythema migrans were seen; typical target pattern, homogenous and erythematous plaque pattern, and linear solitary plaque pattern with central postinflammatory pigmentation. Only 2 of the 7 patients (28.6%) were seropositive for IgM and IgG antibody titers by enzyme-linked immunosorbent assay in consecutive serologic tests. PCR for Borrelia DNA in paraffin-embedded tissue showed full negativity in 6 patients with erythema migrans. Conclusion: Although lyme disease is not endemic in Korea, some patients with erythema migrans might be undiagnosed as lyme disease serologically with erythema migrans. To take into consideration false negative serelogic results in early erythema migrans, early oral tetracycline therapy should be included through clinical and historical diagnosis. (Korean J Dermatol 2008;46(5):596∼603)

5원저 : 켈로이드와 비후성 반흔 환자에서 Bleomycin 병변내 주사의 치료 경험

저자 : 박상영 ( Sang Young Park ) , 김성언 ( Seong Eon Kim ) , 윤태진 ( Tae Jin Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 604-610 (7 pages)

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Background: Keloids and hypertrophic scars are benign growths of dermal collagen that usually cause major physical, psychological, and cosmetic problems. Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. Objective: The purpose of this study is to investigate whether bleomycin intralesional injection has an therapeutic effect on both keloids and hypertrophic scars. Methods: Thirteen patients with keloids or hypertrophic scars were administered with intralesional injection of bleomycin (1.5 IU/ml). Scar height was measured, and scar pliability and erythema were scored at baseline and then monthly during the treatment and follow-up period. Patient`s self-assessments of subjective symptoms (pruritus and pain) were also scored. Pre- and post-treatment mean values for scar height, scar pliability, erythema, pruritus and pain were statistically compared. Results: The clinical response was positive in all cases: highly significant flattening in one case, significant flattening in one case, moderate flattening in five cases and minimal flattening in six cases. The mean scores for pruritus and pain also improved. The observed side-effects were hyperpigmentation (two cases), hypopigmentation (one case) and skin infection (one case). No exacerbation was noted during follow-up period of 4 months. Conclusion: Bleomycin intralesional injecton may be one of the effective and safe method of treating keloids and hypertrophic scars. (Korean J Dermatol 2008;46(5):604∼610)

6원저 : 베체트병에서 MIF 발현에 대한 연구

저자 : 인성일 ( Sung Il In ) , 백진아 ( Jin Ah Baek ) , 박경숙 ( Kyung Sook Park ) , 방동식 ( Dong Sik Bang ) , 이은소 ( Eun So Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 611-618 (8 pages)

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Background: Macrophage migration inhibitory factor (MIF) is a unique protein, participating in inflammation, immune response, and cell growth. Previous reports showed that MIF-polymorphisms are associated with an increased risk for various inflammatory diseases. Objective: This study was designed to investigate the effect of MIF polymorphisms on Behcet`s disease (BD). Methods: A total of 362 patients with BD and 290 healthy controls were genotyped. We also performed RT-PCR analysis, ELISA, and immunohistochemical stain for MIF. Results: We could not find statistically significant differences in the genotype frequencies of the MIF-794[CATT]5-8 repeat polymorphism or MIF-173 G>C polymorphism between BD patients and controls. Immunohistochemical analysis showed that MIF protein was diffusely distributed throughout epidermis and subcutaneous fat tissue from the skin lesions of patients with BD and erythema nodosum. Conclusion: Contrary to earlier reports, serum MIF levels were decreased in patients with BD, and the prescence of polymorphisms in the MIF promoter region was not associated with disease susceptibility. Nevertheless, MIF may play a role in cutaneous inflammation in BD. (Korean J Dermatol 2008;46(5):611∼618)

7원저 : 성인기 여드름의 임상양상과 혈청 IGF-1의 상승

저자 : 신민경 ( Min Kyung Shin ) , 김낙인 ( Nack In Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 619-626 (8 pages)

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Background: Acne has been recognized as a common disorder amongst adolescents but recent studies have documented increased prevalence of post-adolescent acne. Objective: The purpose of this study was to demonstrate insulin resistance in post-adolescent acne by examining insulin, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein-3 (IGFBP-3) compared to those in normal controls. Methods: Twenty-eight patients with acne between 25 and 45 years and 10 control individuals were studied. We classified the post-adolescent acne into persistent and late-onset types according to onset ages. We compared clinical features and the levels of fasting insulin, IGF-1, and IGFBP-3 in persistent and late-onset type of post-adolescent acne. Results: Among the post-adolescent group, there were few patients of metabolic syndrome. But, the mean serum levels of IGF-1 were significantly increased in post-adolescent acne compared to those in controls. Mean serum levels of IGFBP-3 were decreased in post-adolescent acne. Compared to persistent type, late-onset type showed more inflammatory acne lesions. Increased fasting insulin, IGF-1, and decreased IGFBP-3 in late-onset type compared to those in persistent type were observed. Conclusion: Results of this study indicate that insulin resistance could have a role in pathogenesis of post-adolescent acne. (Korean J Dermatol 2008;46(5):619∼626)

8원저 : 기미 병변에서 신경 펩티드와 그 수용체의 발현에 대한 연구

저자 : 이현주 ( Hyun Ju Lee ) , 박하나 ( Ha Na Bak ) , 장성은 ( Sung Eun Chang ) , 최지호 ( Jee Ho Choi ) , 김명남 ( Myeung Nam Kim ) , 김범준 ( Beom Joon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 627-632 (6 pages)

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Background: The pathogenesis of melasma has not yet been clearly demonstrated. But, clinical manifestations such as remarkable lesional symmetry and the distribution related to trigeminal nerves, suggest that the neural system could play a pathogenic role in melasma. Objective: This study was carried out to examine the expression of some neuropeptides and their receptors, which are well known to be major contributors of neuroinflammation in many dermatoses, in melasma lesions. Methods: Skin biopsies were obtained from the lesional and non-lesional facial skin of 6 Korean women with melasma. Immunofluorecence staining and confocal laser scanning microscopy were performed. Results: In our results, no difference could be detected with regard to the intensity of immunoreactivity for vasoactive intestinal peptide (VIP), calcitonin gene-related peptide (CGRP), calcitonin gene-related peptide receptor (CGRPR), substance P (SP), substance P receptor (SPR), somatostatin (SOM), pituitary adenylate cyclase activating peptide (PACAP) and pituitary adenylate cyclase activating peptide receptor (PACAPR) in the lesional skins compared with the non-lesional skins. Conclusion: These results suggest that neuroinflammation induced by neuropeptides such as substance P, calcitonin gene-related peptide, vasoactive intestinal peptide, and somatostatin and their receptors included in this study, are not directly associated with melasma pathogenesis. (Korean J Dermatol 2008;46(5):627∼632)

9원저 : 성기 부위와 성기외 부위 경화 위축성 태선의 임상적, 조직학적 비교

저자 : 오상호 ( Sang Ho Oh ) , 류동진 ( Dong Jin Ryu ) , 이광훈 ( Kwang Hoon Lee ) , 이주희 ( Ju Hee Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 633-640 (8 pages)

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Background: Lichen sclerosus et atrophicus is a persistent inflammatory dermatosis of unknown etiology with a predilection for the genital area. Although there were many case reports in Korea, there are no studies regarding the clinicopathologic comparison of genital and extragenital lichen sclerosus et atrophicus. Objective: The aim of our study was to evaluate the clinicopathologic characteristics and differences between genital and extragenital lichen sclerosus et atrophicus. Methods: Retrospective analysis was performed by reviewing the clinicopatholgic records of 33 patients who were diagnosed with lichen sclerosus et atrophicus from 2000 to 2006 in Yonsei University Severance Hospital. Results: The most common clinical manifestation is a whitish patch with pruritus on labia minor. The ratio of male to female patients in genital and extragenital lichen sclerosus et atrophicus were 1:10.5 and 1:2.3 respectively. Disease onset ages were 49.9 years and 44.2 years respectively. The most common subjective symptom was pruritus. However, no symptom was more significant in extragenital lichen sclerosus et atrophicus compared to genital lichen sclerosus et atrophicus. Most of the lesions presented as whitish patches and plaques but atrophy, erythema and lichenification could also occur. Histopathologic findings of the extragenital lichen sclerosus et atrophicus showed more significant epidermal thinning and cleft formation compared to genital lichen sclerosus et atrophicus, which suggests that extragenital lichen sclerosus et atrophicus shows more evolved lesions. A few cases of genital lichen sclerosus et atrophicus showed spongiotic dermatitis, lichen simplex chronicus-like and lichen planus-like features in addition to typical pathology, which were suspected as secondary features or early lesions. All the patients were treated with high to mid-potency topical corticosteroid which were effective in both the genital and extragenital lichen sclerosus et atrophicus. There was no cases of squamous cell carcinoma arising in lichen sclerosus et atrophicus during the follow-up. Conclusion: Clinically, there were no symptoms significant to extragenital lichen sclerosus et atrophicus and pathologically extragenital lichen sclerosus et atrophicus showed more significant epidermal thinning and cleft formation. Further research regarding the characteristics and differences between genital and extragenital lichen sclerosus et atrophicus should be performed on larger number of cases. (Korean J Dermatol 2008;46(5):633∼640)

10원저 : 광범위한 탈모범위를 지닌 난치성 원형 탈모증 환자의Anthralin 국소 치료의 효과

저자 : 홍원규 ( Won Kyu Hong ) , 신정현 ( Jeong Hyun Shin ) , 최광성 ( Gwang Seong Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 46권 5호 발행 연도 : 2008 페이지 : pp. 641-647 (7 pages)

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Background: Extensive alopecia areata (EAA) is resistant to multiple individual treatment modalities and has poor prognosis for cosmetically adequate regrowth. Anthralin is a widely used topical anti-psoriatic drug that may have an immunomodulating effect on AA as is does in psoriasis. But, there has only been small number of clinical trials of anthralin in the treatment of AA. Objective: The purposes of the study were to evaluate the efficacy, prognostic factor, side effects and recurrence rate of topical anthralin therapy in treatment-resistant EAA. Methods: A total of 16 cases of EAA (>50% scalp hair loss) who had failed in previous treatments were subjected in this study. Anthralin in 0.5% concentrations was applied to alopectic lesions for 1 hour daily over 4 weeks, gradually increasing anthralin concentration until low-grade erythema and pruritus develops. Treatment was withdrawn after complete response or if there were no signs of improvement at 6 months. Responders were followed up for 6 months after discontinuation of therapy. Results: The overall response rate was 62.5%, complete response (>90% regrowth or cosmetically acceptable appearance) was obtained in 25% of cases and, good response (50∼99% regrowth) in 39.5% of cases. In this study, among the investigated prognostic factors, there were no statistically significant factors (p<0.05, Fisher exact test). The most frequent side effects were therapeutically induced mild pruritus (93.8%), erythema (93.8%) and scale (56.3%). Other side-effects were transient folliculitis (31.3%) and regional lymph adenopathy (12.5%). Relapse was observed in 60% of responders after 6 month of follow up. Conclusion: Topical anthralin for treatment-resistant EAA is an effective therapy with tolerable side effects. Therefore, we propose the topical anthralin as a reasonable therapeutic option for treatment-resistant EAA. (Korean J Dermatol 2008;46(5):641∼647)

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주제별 간행물
간행물명 수록권호

KCI등재 SCOUPUS

대한피부과학회지
59권 4호 ~ 59권 4호

프로그램북(구 초록집)
72권 1호 ~ 72권 1호

KCI등재 SCI SCOUPUS

Annals of Dermatology
33권 3호 ~ 33권 3호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
47권 1호 ~ 47권 1호

KCI등재 SCOUPUS

대한피부과학회지
59권 3호 ~ 59권 3호

KCI등재 SCI SCOUPUS

Annals of Dermatology
33권 2호 ~ 33권 2호

KCI등재 SCOUPUS

대한피부과학회지
59권 2호 ~ 59권 2호

KCI등재 SCOUPUS

대한피부과학회지
59권 1호 ~ 59권 1호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 4호 ~ 46권 4호

KCI등재 SCI SCOUPUS

Annals of Dermatology
33권 1호 ~ 33권 1호

프로그램북(구 초록집)
72권 2호 ~ 72권 2호

KCI등재 SCOUPUS

대한피부과학회지
58권 10호 ~ 58권 10호

KCI등재 SCOUPUS

대한피부과학회지
58권 9호 ~ 58권 9호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 6호 ~ 32권 6호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 5호 ~ 32권 5호

KCI등재 SCOUPUS

대한피부과학회지
58권 8호 ~ 58권 8호

KCI등재

대한화장품학회지(J. Soc. Cosmet. Scientists Korea)
46권 3호 ~ 46권 3호

KCI등재 SCOUPUS

대한피부과학회지
58권 7호 ~ 58권 7호

KCI등재 SCI SCOUPUS

Annals of Dermatology
32권 4호 ~ 32권 4호

KCI등재 SCOUPUS

대한피부과학회지
58권 6호 ~ 58권 6호
발행기관 최신논문
자료제공: 네이버학술정보
발행기관 최신논문
자료제공: 네이버학술정보

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