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대한피부과학회> 대한피부과학회지> 골수이형성 증후군 환자에서 발생한 조직구양 Sweet 증후군 1예

KCI등재SCOUPUS

골수이형성 증후군 환자에서 발생한 조직구양 Sweet 증후군 1예

Short Report : A Case of Histiocytoid Sweet`s Syndrome with Myelodysplastic Syndrome

이규엽 ( Kyu Yeop Lee ) , 권연숙 ( Yeon Sook Kwon ) , 김도영 ( Do Young Kim ) , 김세훈 ( Se Hoon Kim ) , 이광길 ( Kwang Gil Lee ) , 방동식 ( Dong Sik Bang )
  • : 대한피부과학회
  • : 대한피부과학회지 45권7호
  • : 연속간행물
  • : 2007년 07월
  • : 754-757(4pages)
대한피부과학회지

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Sweet`s syndrome is an acute febrile neutrophilic dermatosis that occurs with malignant disease, mainly myeloid hemopathies, in about 20% of cases. When associated with myelodysplasia, clinical and histologic features of Sweet`s syndrome can be atypical; however its significance is still debated. We encountered a case of Sweet`s syndrome associated with myelodysplastic syndrome in a 63-year-old woman. The clinical presentation strongly suggested Sweet`s syndrome but, histopathologic examination showed dense histiocytic infiltration with prominent upper dermal edema and little neutrophil infiltration. In the evaluation for atypical histopathology and laboratory abnormalities, she was diagnosed with myleodysplastic syndrome by peripheral blood smear and bone marrow biopsy. Histiocytoid Sweet`s syndrome is a currently accepted concept and probably has a close relation with underlying myeloid hemopathies. (Korean J Dermatol 2007;45(7):754∼757)

UCI(KEPA)

I410-ECN-0102-2008-510-002841815

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
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KCI등재 SCOPUS

1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

KCI등재 SCOPUS

2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

KCI등재 SCOPUS

3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

KCI등재 SCOPUS

4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

KCI등재 SCOPUS

5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

KCI등재 SCOPUS

6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

KCI등재 SCOPUS

7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

KCI등재 SCOPUS

8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

KCI등재 SCOPUS

9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

KCI등재 SCOPUS

10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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KCI등재SCOUPUS

1내인성 피부 노화에 따른 Desmoglein 1과 3의 발현

저자 : 최유원 ( You Won Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 645-649 (5 pages)

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Background: Desmogleins are transmembrane glycoproteins of the desmosome which provide mechanical strength to epithelial tissue. Desmogleins have so far, been implicated in several diseases such as pemphigus, striate palmoplantar keratoderma, 4S and squamous cell carcinomas. Skin cancer usually occurs in old age. And there are reports that the expression of desmogleins are increased in squamous cell carcinoma. However the role of desmogleins in skin aging has not yet been reported. Objective: The purpose of this study was to investigate the expression of desmoglein 1 and 3 according to chronologic skin aging. Methods: A total of 6 normal tissue samples from sun-protected skin of different age groups (from 34-year-old to an 84-year-old) and 1 squamous cell carcinoma tissue from a 72-year-old patient were taken. Western blotting and immunohistochemical staining were performed with anti desmoglein 1 and 3 antibodies. The expression of desmoglein 1 and 3 by Western blotting were calculated semiquantitatively by a densitometer. Results: The expression of desmoglein 1 was 0.382 in the 34-year-old, 0.450 in the 45-year-old, 0.369 in the 56-year-old, 0.761 in the 65-year-old, 1.035 in the 77-year-old and 1.329 ODu/mm2 in the 84-year-old. The expression of desmoglein 3 was 0.830 in the 34-year-old, 0.984 in the 45-year-old, 1.029 in the 56-year-old, 1.534 in the 65-year-old, 1.714 in the 77-year-old and 1.878 ODu/mm2 in the 84-year-old. In immunohistochemical staining, the expression of Dsgl increased from the basal layer to the granular layer and Dsg3 was expressed in the basal and suprabasal layers. Conclusion: The expression of desmoglein 1 and 3 were increased according to chronologic skin aging. (Korean J Dermatol 2007;45(7):645~649)

KCI등재SCOUPUS

2보통 천포창의 세포자멸사 기전에 관한 연구

저자 : 노병화 ( Byoung Hwa Roh ) , 황규왕 ( Kyu Uang Whang ) , 조문균 ( Moon Kyun Cho ) , 박영립 ( Young Lip Park ) , 이종석 ( Jong Suk Lee ) , 이창우 ( Chang Woo Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 650-658 (9 pages)

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Background: Pemphigus vulgaris is an autoimmune bullous dermatoses of skin and mucosa characterized by loss of adhesion between keratinocytes, a process known as acantholysis. Apoptosis, programmed cell death, may participate in pathogenesis of intercellular detachment and loss of cell-matrix interaction. Objective: This study was designed to investigate the induction of apoptosis in the pemphigus lesional epidermis and to elucidate the mechanism of apoptosis induced by pemphigus sera. Methods: Hoechst 33342 staining was performed to determine the induction of apoptosis in the pemphigus lesional epidermis. In addition, we used HaCaT cells treated with pemphigus sera and analyzed the expression of caspase-3, caspase-8, caspase-9 and bcl-2, bcl-xL, bax, bak by the RT-PCR method. Results: In Hoechst 33342 staining, typical findings of apoptosis were observed in the pemphigus lesional epidermis showing acantholysis. RT-PCR showed the upregulation of caspase group (caspase-3, caspase-8, caspase-9), the downregulation of antiapoptotic bcl-2 family (bcl-2, bcl-xL) and the upregulation of proapoptotic bcl-2 family (bax, bak). Conclusion: These results suggest that apoptosis may be associated with acantholysis of pemphigus lesional epidermis and may play an important role in the pathogenesis of pemphigus. (Korean J Dermatol 2007;45(7):650∼658)

KCI등재SCOUPUS

3한국인 색소성 기저세포암의 Dermoscopy 소견

저자 : 좌승욱 ( Seung Wook Jwa ) , 김문범 ( Moon Bum Kim ) , 고현창 ( Hyun Chang Ko ) , 김병수 ( Byung Soo Kim ) , 김성준 ( Sung Jun Kim ) , 오창근 ( Chang Keun Oh ) , 권경술 ( Kyung Sool Kwon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 659-665 (7 pages)

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Background: Pigmented basal cell carcinomas (PBCC) may be confused with melanoma and other benign pigmented skin lesions. Dermoscopy is a noninvasive technique that is known to increase the diagnostic accuracy of benign versus malignant pigmented skin lesions. Menzies et al recently proposed a simple dermoscopic model for the diagnosis of PBCCs. Objective: To demonstrate whether this criteria was adequate for Korean PBCC patients and seek other characteristic dermoscopic findings in Korean PBCCs. Methods: Dermoscopic images of 50 biopsy-proven PBCCs were examined. Results: Negative features such as a pigment network were not observed in all PBCCs. Positive features - ulceration, large blue-gray ovoid nests, multiple blue-gray globules, maple leaf-like areas, spoke wheel areas and arborizing (treelike) telangiectasia were present in 39 (78.0%), 41 (82.0%), 33 (66.0%), 21 (42.0%), 1 (2.0%) and 32 (64.0%) of 50 PBCCs respectively. All PBCCs satisfied the dermoscopic criteria for diagnosis of PBCC suggested by Menzies et al. Other dermoscopic features were as follows; multiple blue-gray dots (28.0%), milia-like cysts (8.0%), granules (6.0%), diffuse blue-white area (6.0%) and hairpin vessels (2%). Forty-four % of lesions had less than 50% pigmentation of the area and 38.0% of lesions had more than 75% pigmentation. Conclusion: The criteria of PBCC proposed by Menzies et al was useful for dermoscopic diagnosis of Korean PBCCs. Ulceration and pigmentary features such as large blue-gray ovoid nests, multiple blue-gray globules, maple leaf-like areas, multiple blue-gray dots, granules and larger pigmented areas were more frequently observed in Korean PBCCs. However, other specific dermoscopic findings for diagnosis of PBCC in Koreans were not present. (Korean J Dermatol 2007;45(7):659∼665)

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4석회화된 기저세포암의 석회화 관련 인자의 발현

저자 : 도미옥 ( Mi Ok Do ) , 김소영 ( So Young Kim ) , 최유원 ( You Won Choi ) , 명기범 ( Ki Bum Myung ) , 최혜영 ( Hae Young Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 666-672 (7 pages)

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Background: Although basal cell carcinoma (BCC) is the most common human skin tumor, with calcification reportedly taking place in about 20% of all BCC cases, the pathogenesis of calcification in BCC has not yet been studied. Objective: The purpose of this study was to evaluate factors related to the pathogenesis of calcification in BCC. Methods: We performed immunohistochemical staining for β-catenin, frizzled-2, BMP-4, osteopontin, osteocalcin, and osteonectin using frozen skin tissue from 15 cases of BCC with calcification and 11 cases of BCC without calcification. Results: The expression of β-catenin showed positive in 14 of the 15 cases in BCC with calcification, but negative in all 11 cases of BCC without calcification. The expression of frizzled-2 was observed in 14 of the 15 cases in BCC with calcification, and in 10 of the 11 cases in BCC without calcification. The difference did not reach statistical significance (p=0.236). The expression of BMP-4 was observed in all 26 samples of BCC, but the intensity of expression did not reach statistical significance between the two groups (p=0.293). Furthermore, osteopontin and osteocalcin showed no statistical significance between two the groups (p=0.567, p=0.401). The expression of osteonectin was observed in all of the BCC cases, and was stronger in BCC with calcification than in BCC without calcification (p=0.042). Conclusion: We suggest that the calcification in BCC might be related to the increase of β-catenin expression and that osteonectin might also influence the process of calcification in BCC. (Korean J Dermatol 2007;45(7):666∼672)

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5사춘기 및 성인 아토피피부염 환자에서 스탬프형 배지를 이용한 황색 포도알균의 정량적인 배양

저자 : 성현철 ( Hyun Chul Sung ) , 정홍대 ( Hong Dae Jung ) , 박경덕 ( Kyung Duck Park ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok Jong Lee ) , 김도원 ( Do Won Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 673-679 (7 pages)

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Background: The stratum corneum of the skin of patients with atopic dermatitis (AD) is highly susceptible to colonization by various bacteria, including Staphylococcus (S.) aureus. Because the frequency of bacterial colonization is significantly higher, skin barrier function against bacterial invasion appears to be significantly disrupted in AD. S. aureus colonization in AD is thought to be important in the development and aggravation of eczematous skin lesions. Over the past decades, there have been several quantitative methods of cutaneous bacterial culture from the skin; the swab method, scrub method, tape method and contact plate method. Objective: The purpose of this study was to evaluate the effectiveness of the contact-plate sampling technique as a quantitative culture method of S. aureus in atopic dermatitis. Method: The subjects were 24 patients with AD and 24 age-matched normal controls. S. aureus was sampled at 4 evaluation sites (neck forearm abdomen, popliteal fossa) of AD patients and normal controls using the contact-plate sampling technique. We also checked skin barrier function by measuring the transepidermal water loss (TEWL). Results: Based on the data, we found that the number of S. aureus colonies in the samples from AD patients was significantly higher than from normal controls (p<0.05, 4 sites respectively). Also, TEWL at the 4 evaluation sites of AD patients was significantly higher than in normal controls (p<0.05, 4 sites respectively). However, S. aureus colonization did not usually show significant correlation with TEWL. Conclusion: The contact-plate sampling technique provides a reliable qualitative and quantitative culture method of S. aureus, which is inexpensive and convenient so can be used in both children and within a busy clinic. (Korean J Dermatol 2007;47(7):673∼679)

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6만성 특발성 두드러기 환자에서 저용량 Cyclosporine 치료 효과에 관한 연구

저자 : 김병수 ( Byung Soo Kim ) , 조현호 ( Hyun Ho Cho ) , 고현창 ( Hyun Chang Ko ) , 김성준 ( Sung Joon Kim ) , 오창근 ( Chang Keun Oh ) , 권경술 ( Kyung Sool Kwon ) , 김문범 ( Moon Bum Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 680-686 (7 pages)

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Background: Chronic idiopathic urticaria (CIU) has a major impact on patients` quality of life. However the management of CIU has sometimes been challenging to physicians, with little response to conventional therapy like antihistamines. Objective: This study was aimed to determine the effectiveness and safety of low-dose cyclosporine for the treatment of recalcitrant CIU with a positive autologous serum skin test (ASST). Methods: Thirty CIU patients who were unresponsive to conventional antihistamine therapy were treated for 3 consecutive months with low-dose cyclosporine (2∼3 mg/kg/day) and fexofenadine (180 mg/day). The clinical efficacy was measured at baseline, week 1, 2, and month 1, 2 and 3. CIU sign and symptom scores were assessed using 4-point scales for pruritus, number of hives, size of largest hive, interference with sleep, and interference with daily activities. Global assessment of the severity by patients and any side effects were also measured at every visit. Results: Low-dose cyclosporine significantly improved the total CIU scores. In addition, the interference with sleep was reduced and the performance of daily activities improved in accordance with patient`s global assessment of urticaria severity after 3 month of treatment. Moreover there were no significant side effects to suggest stopping cyclosporine administration. Conclusion: These results show that low-dose cyclosporine therapy might be a good therapeutic alternative in CIU patients who are unresponsive to conventional treatments. (Korean J Dermatol 2007;45(7):680~686)

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7증례 : 골수침범을 보인 CD30 양성/ALK 음성 전신성 퇴행성 대세포 림프종 1예

저자 : 이용환 ( Yong Hwan Lee ) , 김수호 ( Soo Ho Kim ) , 서무규 ( Moo Kyu Suh ) , 장태정 ( Tae Jung Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 687-691 (5 pages)

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CD 30 positive anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin`s lymphoma, a tumor that is composed of mostly mast cells expressing CD30 antigens. According to the 2005 World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification, it can be classified as systemic ALCL and primary cutaneous CD30 positive T-cell lymphoproliferative disorder. Systemic ALCL can be subclassified into ALK positive and negative. There have been many cases of primary cutaneous CD30 positive T-cell lymphoproliferative disorder, but reports of systemic ALCL have been rare. We report a case of CD30 positive/ALK negative systemic anaplastic large cell lymphoma involving bone marrow in a 51 year-old-male who showed two pruritic, 1.5×1.0×0.8 cm and 1.0×0.5×0.4 cm sized, erosive, erythematous nodules on the right thigh and calf. (Korean J Dermatol 2007;45(7):687∼691)

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8증례 : 지속적 안와 부종 후에 발생한 연부조직염 양상의 비강 CD56 양성 NK/T 세포 림프종 1예

저자 : 김민정 ( Min Jeong Kim ) , 안석용 ( Seok Yong Ahn ) , 구자웅 ( Ja Woong Goo ) , 이원수 ( Won Soo Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 692-696 (5 pages)

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Recently another distinct subtype of lymphoma has been discovered, the natural killer (NK)T cell lymphoma, which can involve the skin in a primary or secondary fashion. NK/T cell lymphoma is characterized by the biphenotype expression of the T-cell marker and NK cell marker, especially CD56. These CD56+ lymphomas are further subdivided into nasal NK/T-cell lymphomas and non-nasal NK/T-cell lymphomas. We report a case of primary nasal NK/T cell lymphoma, which showed as an atypical cellulites-like lesion on the face. The patient had suffered with recurrent orbital swelling for several years before diagnosis. (Korean J Dermatol 2007;45(7):692∼696)

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9증례 : 류마티스 관절염 환자에서 발생한 울타리모양의 호중구성 육아종성 피부염 1예

저자 : 한예원 ( Ye Won Han ) , 이경호 ( Kyung Ho Lee ) , 이희정 ( Hee Jeong Lee ) , 박철종 ( Chul Jong Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 697-701 (5 pages)

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Palisaded neutrophilic granulomatous dermatitis (PNGD) is an unusual entity that has been described under several different names including, linear subcutaneous bands, interstitial dermatitis with cutaneous cords and arthritis, rheumatoid papules and Churg-Strauss granuloma. The condition is seen in patients with rheumatoid arthritis and other connective tissue diseases. PNGD shows variable clinical manifestations and represents a histologic spectrum, starting with early vasculitic lesions, then palisaded granulomatous lesions and dermal fibrosis with minimal leukocytoclastic debris in the late stage lesions. We report an unusual case of a 49-year old woman with rheumatoid arthritis who presented with multiple acral nodules. The histologic examination revealed palisaded neutrophilic granulomatous dermatitis. (Korean J Dermatol 2007;45(7):697∼701)

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10증례 : B세포 림프종, 식도암, 위암과 동반된 안검외 피지선암 1예 -Muir-Torre 증후군 1 예-

저자 : 이정훈 ( Jeong Hoon Lee ) , 윤숙정 ( Sook Jung Yun ) , 김성진 ( Seong Jin Kim ) , 이승철 ( Seung Chul Lee ) , 원영호 ( Young Ho Won ) , 이지범 ( Jee Bum Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 7호 발행 연도 : 2007 페이지 : pp. 702-705 (4 pages)

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Muir-Torre syndrome (MTS) is a rare autosomal dominant genodermatoses, first described in 1967. It is characterized by the presence of sebaceous tumors and an internal malignancy in the absence of other predisposing factors. The most common internal malignancy associated with MTS is colorectal adenocarcinoma, although a wide tumor spectrum exists including carcinomas of the genitourinary tract, breast, and hematologic malignancy. It is rare for more than two internal malignancies to occur in MTS. We report a rare case of MTS with B-cell lymphoma, esophageal cancer and gastric malignancy in a 63-year-old male. (Korean J Dermatol 2007;45(7):702∼705)

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