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대한피부과학회> 대한피부과학회지> 파종성 표피융해성 극세포종 1예

KCI등재SCOUPUS

파종성 표피융해성 극세포종 1예

Short Report : A Case of Disseminated Epidermolytic Acanthoma

김대석 ( Dae Suk Kim ) , 구본철 ( Bon Cheol Goo ) , 한은천 ( Eun Chun Han ) , 김동현 ( Dong Hyun Kim ) , 이민걸 ( Min Geol Lee )
  • : 대한피부과학회
  • : 대한피부과학회지 45권2호
  • : 연속간행물
  • : 2007년 02월
  • : 209-211(3pages)
대한피부과학회지

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Epidermolytic acanthoma is an uncommon benign tumor characterized histologically by epidermolytic hyperkeratosis. Clinically, the tumor resembles a verruca or seborrheic keratosis and may occur in either isolated or disseminated forms. Herein, we present a case of a 46-year-old male who developed multiple seborrheic keratosis or verruca like papules on his trunk which showed epidermolytic hyperkeratosis upon microscopic examination. Following clinical and histological findings, the patient was diagnosed as having disseminated epidermolytic acanthoma. (Korean J Dermatol 2007:45(2):209~211)

UCI(KEPA)

I410-ECN-0102-2009-510-000037404

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
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KCI등재 SCOPUS

1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

KCI등재 SCOPUS

2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

KCI등재 SCOPUS

3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

KCI등재 SCOPUS

4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

KCI등재 SCOPUS

5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

KCI등재 SCOPUS

6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

KCI등재 SCOPUS

7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

KCI등재 SCOPUS

8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

KCI등재 SCOPUS

9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

KCI등재 SCOPUS

10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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KCI등재SCOUPUS

1원형탈모증 환자에서 병리조직학적 등급과 임상적 예후 인자 및 치료 효과와의 상호 관련성

저자 : 권오언 ( Oh Eon Kwon ) , 구본석 ( Bon Seok Ku ) , 이영규 ( Yeong Kyu Lee ) , 이채욱 ( Chae Wook Lee ) , 김기호 ( Ki Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 111-118 (8 pages)

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Background & Objective: Prognosis of alopecia areata have been attributed to various factors; age of onset, duration before treatment, extent of hair loss, clinical type of alopecia areata, sex, nail changes or accompaniment of atopy. The study on prognostic factors has only been conducted from statistical data of patients and individualized medical conditions. The histopathologic findings of alopecia areata have been investigated by the minute pathologic changes associated with the hair growth cycle in the transverse section. Moreover, these findings were used mainly for diagnostic purpose, but clinical significance of histopathologic severity in prognosis has not been established to date. Methods: A clinical study, including histopathological and clinical evaluation was conducted on 108 alopecia areata patients between July 1997 and August 2005 at the Department of Dermatology, Dong-A University Hospital. The evaluation criteria included; sex, age, age at onset, duration before treatment, clinical types, extent of hair loss, nail changes, accompaniment of atopy, and scalp biopsy finding. The clinical types of alopecia areata were classified as follows; patchy, subtotalis, totalis, and universalis. The extent of hair loss before treatment was classified into 5 grades (S1~S5), according to the method designed by Olsen and Canfield. Clinical improvements after treatment were classified into 5 grades according to degree of regrowth and reduction of the alopecia areata area. Biopsy findings were classified into 4 grades (type I, II, III, and IV) according to classification by Uno and Orecchia. Results: The mean age was 28.6 years, without any sex predominance. The severe histopathologic gradings were significantly associated with early age of onset (p=0.008), a long disease duration before treatment (p=0.003), a greater extent of hair loss (p=0.009), and poor response to treatment (p=0.036). The histopathologic gradings were not significantly associated with sex (p=0.657), clinical types of alopecia areata (p=0.529), nail changes (p=0.746), or accompaniment of atopy (p=0.924). Conclusion: Histopathologic gradings in alopecia areata, using vertical sections are significantly associated with prognostic factors such as age of onset, extent of hair loss, disease duration before treatment, as well as the response to treatment. Therefore we consider that the histopathologic grading system is recommendable as an independent prognostic factor in alopecia areata, in addition to the well-known clinical prognostic factors. They may also be used to predict the response to treatment. (Korean J Dermatol 2007;45(2):111~118)

KCI등재SCOUPUS

2여성형 탈모에서 AP-FHG0604T의 유효성 및 안전성 평가에 관한 임상 연구

저자 : 신효승 ( Hyo Seung Shin ) , 이승호 ( Seung Ho Lee ) , 김동현 ( Dong Hyun Kim ) , 안지수 ( Jee Soo An ) , 권오상 ( Oh Sang Kwon ) , 은희철 ( Hee Chul Eun ) , 김규한 ( Kyu Han Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 119-126 (8 pages)

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Background: Hair loss is a very common disorder and the number of patients is known to be increasing. Female pattern hair loss (FPHL) is not only a medical problem but also a very severe psychosocial problem for many female patients. Anti-androgen drugs, mineral supplements and topical minoxidil have all been used for the treatment of FPHL. However they do not always achieve successful results and there is still much need for more effective therapy. Objective: The purpose of this 18-week, double-blind, placebo-controlled, randomized clinical trial was to investigate the efficacy and safety of a new topical agent, AP-FHG0604T, in the treatment of FPHL. Methods: A total of 33 women with FPHL (mean age: 33.4 years old) applied either a topical AP-FHG0604T solution (n=17), or placebo (vehicle for AP-FHG0604T solution; n=16) twice daily. Efficacy was evaluated by phototrichogram, investigator`s photographic and patient`s subjective assessments. All adverse effects were reported during the study. Results: After 18 weeks of therapy, topical AP-FHG0604T treatment showed a significant improvement compared to baseline values of total hair count, non-vellus hair count, and linear hair growth rate. In the placebo group, non-vellus hair count and ratio of anagen hair significantly decreased. The change rates of total hair count and non-vellus hair count in the AP-FHG0604T group were significantly higher than those in the placebo group. Neither investigator`s photographic assessments nor patient`s subjective assessments of hair growth showed statistically significant differences between the AP-FHG0604T group or the placebo group. Some patients who used AP-FHG0604T complained of local irritation during the study, but the irritation was so mild that they did not need any treatment for this. Conclusion: We conclude that AP-FHG0604T is a safe and efficient topical agent which can be used as another treatment of choice for FPHL, as shown by objective assessment with phototrichogram. (Korean J Dermatol 2007; 45(2):119~126)

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3기저세포암에서 국소 광역동요법의 치료 효과

저자 : 김영진 ( Young Jin Kim ) , 강희영 ( Hee Young Kang ) , 이은소 ( Eun So Lee ) , 김유찬 ( You Chan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 127-133 (7 pages)

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Background: Photodynamic therapy has been reported to be useful in treating basal cell carcinoma. However, there have been no clinical trials for the treatment of basal cell carcinoma using photodynamic therapy in Korea. Objective: The purpose of this study was to evaluate the effectiveness and side effects of photodynamic therapy in the treatment of basal cell carcinoma. Methods: Photodynamic therapy, with a 630±50 nm light-emitting diode device and 20% 5-aminolevulinic acid was used to treat 12 lesions of basal cell carcinoma on 12 patients. The light intensity used was 100 mW/cm2 and the light dose was 120 to 280 joules/cm2. The depth of lesions ranged from 0.35 to 1.5 mm. Histopathologic subtypes consisted of 9 nodular, 1 micronodular, 1 infiltrating, and 1 superficial type. Results: Complete clearance was achieved in 2 of 12 lesions after 3 treatment sessions and 5 lesions after 4 treatment sessions. Overall, complete clearance was successful for 7 of 12 lesions (58%). Side effects were negligible in most patients, but two patients reported a moderate burning sensation in the first and second treatment sessions. Conclusion: Photodynamic therapy may be a useful alternative treatment therapy for basal cell carcinoma, especially for those lesions where existing treatment has recognized limitations. (Korean J Dermatol 2007;45(2):127~133)

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4연조직염 환자에서 피부 생검 조직 배양을 통한 원인균 검출률 향상에 관한 연구

저자 : 이재영 ( Jae Young Lee ) , 박석돈 ( Seok Don Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 134-139 (6 pages)

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Background: Staphylococcus aureus and group A streptococci are the most common etiologic agents in cellulitis, but occasionally many other bacteria are also identified. The positive rate of bacterial cultures taken from the skin lesion are low. Objective: This study aims to improve the positive culture rate in patients with cellulitis by using skin biopsy specimens in several kinds of media. Methods: Skin biopsy specimens taken from 54 patients with cellulitis were cultured in 4 functionally-different types of media (blood agar, MacConkey agar, chocolate agar, thioglycollate broth). Positive culture rates were evaluated in each medium and cultured bacteria were identified. Clinical characteristics were also studied, including age, sex, affected site, and history of previous treatment. Results: The sex ratio of males to females was 2.9 : 1 and mean age was 49 years. The most commonly-involved site was the lower extremities (42.6%), followed by the upper extremities (13.0%), head and neck (9.3%), and trunk (1.9%). Patients who had received previous antimicrobial treatment numbered 31 cases (57.4%). Of the 23 patients who had received no previous antimicrobial treatment, 13 patients (56.5%) had positive cultures. The most common pathogens were S. aureus and Streptococcus sp. (59.1%), but seven different genus of bacteria were also isolated from 9 patients (40.9%). Thioglycollate broth yielded a high positive culture rate (38.9%) among the 4 types of culture media. Conclusion: It is suggested that the bacterial culture of skin biopsy tissue from four functionally-different types of media is a useful method for improving positive bacterial culture rate in patients with cellulitis. (Korean J Dermatol 2007;45(2):134~139)

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5Hydroxyproline의 안면부 주름 개선 효과에 관한 연구

저자 : 서기석 ( Kee Suck Suh ) , 최수영 ( Soo Young Choi ) , 김상태 ( Sang Tae Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 140-148 (9 pages)

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Background: Many treatment modalities for wrinkle reduction have been developed in the field of dermatology. Hydroxyproline plays a critical role in stabilizing the triple helix of collagen. The triple-helical conformation gives collagen most of its unique properties and is essential for normal fibrillogenesis. Objective: This study was performed to investigate the effect of hydroxyproline on the improvement of wrinkles in vitro and in vivo. Methods: Cultured fibroblasts and 25 human volunteers were used for in vitro and in vivo studies respectively. Hydroxyproline was administered to a fibroblast culture system and was also applied to periorbital wrinkle lesions twice daily for 12 weeks. The effect of hydroxyproline was examined by using an image analysis system with skin replica, and subjective and objective assessment of wrinkles were evaluated. Results: With the in vitro study, the number of cultured fibroblasts did not increase in the 10(-4), 10(-6) and 10(-8)ug/ml hydroxyproline groups compared to the control groups. Procollagen Type 1 C-peptide of cultured fibroblasts did increase in the 10(-8)ug/ml hydroxyproline group compared to the control group (p<0.05). With the in vivo study, there was a significant decrease in wrinkles at 8 and 12 weeks after application in the 0.5% hydroxyproline applied group compared to the control group (p<0.001). In the subjective visual assessment by the investigator and the subjects at 8 and 12 weeks after application, the 0.5% hydroxyproline treated group showed a significant improvement of wrinkles and more personal satisfaction than the control group (p<0.05). Conclusion: 0.5% hydroxyproline had an effect in vivo and in vitro on wrinkle improvement. It is suggested that hydroxyproline might be a candidate compound for treatment or reduction of wrinkles. (Korean J Dermatol 2007;45(2):140~148)

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6피부 악성 흑색종의 임상 및 병리조직학적 소견

저자 : 박경덕 ( Kyung Duck Park ) , 이석종 ( Seok Jong Lee ) , 이원주 ( Weon Ju Lee ) , 김도원 ( Do Won Kim ) , 정호윤 ( Ho Yun Chung ) , 조병채 ( Byung Chae Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 149-158 (10 pages)

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Background: Malignant melanoma is the leading cause of death among skin cancers in western countries. The incidence of melanoma has been steadily increasing over the last 20 years, and age and sex distribution, anatomic location, clinicopathologic subtypes, and prognostic factors of malignant melanoma are also well known. However, various clinicopathologic aspects such as incidence, clinicopathologic subtypes and tumor behaviors are quite different in Asian and black skin. Objective: The purpose of this study was to investigate the clinicopathologic behavior and statistics of malignant melanoma patients of Kyungpook National University Hospital, and to evaluate prognostic predictors. Methods: Of the 97 out of 103 patients diagnosed with malignant melanoma at the Department of Dermatology of Kyungpook National University Hospital over a 14 year period (l992~2006), we analyzed mean age of onset, gender, tumor location, duration, tumor number, color, tumor thickness, Clark`s level, pathologic ulceration, tumor-infiltration lymphocytes, clinicopathologic subtype, and clinical AJCC stage. Univariate analysis and multivariate analyses for survival, according to clinical and histologic tumor settings, were performed by means of the Cox proportional hazard model. Survival curves were plotted by the Kaplan-Meier method. Results: Ninety-seven melanomas were identified and analyzed by both clinical behavior and pathology. Of these, 44 were male and 53 were female patients and the mean age was 59.7 years. Most of the tumors were located on the hands and feet. Thin melanoma was the most common tumor and histologic ulcerations were observed in 37 out of 81 patients who were available for evaluation. For tumor-infiltrating lymphocytes (TIL), 22 out of 76 patients were confirmed with TIL in the pathologic review. Acral lentiginous melanoma was the most common type, followed by nodular melanoma, superficial spreading melanoma, and lentigo maligna melanoma. Univariate analysis for overall survival of melanoma revealed that thickness of tumor, the presence of ulceration, the presence of tumor-infiltrating lymphocytes, clinicopathological subtype, and clinical stage have a tendency for a poorer prognosis. Multivariate analysis demonstrated that advanced stages (III and IV) and tumor thickness were the independent risk factors for poor prognosis. Conclusion: Few similar large studies have been conducted to assess the prognostic factors of melanoma in Korea. Therefore, further prospective studies are needed to assess the biological behavior of malignant melanoma, of which the incidence has been steadily increasing in Korea. (Korean J Dermatol 2007;45(2):149~158)

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7성인 아토피피부염 환자에서 삶의 질 평가의 임상적 유용성

저자 : 이희정 ( Hee Jung Lee ) , 박창욱 ( Chang Ook Park ) , 이주희 ( Ju Hee Lee ) , 이광훈 ( Kwang Hoon Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 159-164 (6 pages)

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Background: Quantification of quality of life (QOL) related to disease severity is important in patients with atopic dermatitis (AD), because the assessment provides additional information to the traditional objective clinical scoring systems. Objective: We evaluated the association between QOL and severity scoring systems of AD. Methods: We assessed QOL, clinical severity scores, and total IgE in peripheral blood in 41 AD patients at our dermatology clinic over an 8 month period. QOL was assessed at two visits with a monthly interval by a dermatology-specific questionnaire (Dermatology Life Quality Index (DLQI)). Eczema Area and Severity Index (EASI) and Scoring of Atopic Dermatitis (SCORAD) was used to measure disease severity. Visual analogue scale (VAS) of pruritus and loss of sleep (LOS) were also recorded. Results: The mean DLQI was 11.6. For DLQI the dimension with the highest score was 26, and the lowest score was 2. DLQI did not correlate with EASI at visit 1, but correlated well with EASI at visit 2. Changes of DLQI in each patient between visits 1 and 2 were significant (p<0.05) and positively correlated with the severity scoring (EASI, SCORAD). In addition, the sum of VAS of pruritus and loss of sleep a correlated well with the DLQI and EASI at each visit. Conclusion: AD has a great impact on QOL of patients. Although the DLQI is known as an excellent method of measuring QOL in patients with dermatologic disease, correlation between DLQI and disease severity was not definite. However, changes of DLQI during follow-up significantly correlated with clinical course in each patient. Therefore, DLQI can be an important parameter when evaluating the disease course in AD patients. (Korean J Dermatol 2007;45(2):159~164)

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8증례 : BCG 접종 후 발생한 습진양 반응 2예

저자 : 김지웅 ( Jee Woong Kim ) , 최우석 ( Woo Seok Choi ) , 박현수 ( Hyun Su Park ) , 최정철 ( Jung Chul Choi ) , 장상재 ( Sang Jai Jang )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 165-167 (3 pages)

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The adverse effects of BCG vaccination span diversely from systemic to local reactions. However, the adverse effects of BCG vaccination on the skin are rare and these can appear as non-specific or specific skin reactions. We experienced two cases of non-specific skin reaction, which occurred on a vaccine-injected site. Eczematous lesions with the clinical and pathological findings have not previously been report in the English dermatologic literature. Herein, we present two interesting cases of non-specific skin reactions from dermatological complications of BCG vaccination. (Korean J Dermatol 2007;45(2):165~167)

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9증례 : 후경부 섬유종 1예

저자 : 강태원 ( Tae Won Kang ) , 이상은 ( Sang Eun Lee ) , 김수찬 ( Soo Chan Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 168-170 (3 pages)

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Nuchal fibromas are rare, benign fibrous proliferations characterized by hypocellular dense collagen in the dermis and the subcutaneous fat layer. Nuchal fibromas usually develop in the posterior neck as a solitary, soft tissue mass. Herein, we report a case of a nuchal fibroma presenting on the posterior neck of a 60-year-old male. An excisional biopsy was done and showed haphazardly-arranged, dense collagen infiltration throughout the dermis and the subcutaneous fat layer. Moreover, fat lobules, adnexas and nerve fibers were entrapped by collagen bundle infiltrations. Dermatologists should include nuchal fibrma in the differential diagnosis of patients with a posterior neck mass. (Korean J Dermatol 2007;45(2):168~170)

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10증례 : 백혈구 파쇄성 혈관염의 경구 스테로이드 치료 중 발생한 화농성 근염 1예

저자 : 신효승 ( Hyo Seung Shin ) , 원종현 ( Chong Hyun Won ) , 조소연 ( So Yun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 45권 2호 발행 연도 : 2007 페이지 : pp. 171-174 (4 pages)

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Pyomyositis is an acute, suppurative bacterial infection of striated muscle. It occurs primarily, and not from contiguous infection. It is considered rare in temperate climates. There has been no report of pyomyositis in the Korean dermatologic literature to date. We report a case of pyomyositis which developed in a 53-year-old male. The patient was admitted for the treatment of cutaneous leukocytoclastic vasculitis on his entire body. He was treated with oral corticosteroids for approximately three weeks. The skin condition did show improvement; however, the patient developed a persistent fever and a newly-found mass on the right upper back. The mass was diagnosed as an abscess, replacing the striated muscles of the back by sono-guided needle aspiration. After surgical intervention and IV antibiotic treatment, the symptoms and mass on the back disappeared. We speculate that the underlying skin condition and long-term use of oral corticosteroids predisposed the patient to pyomyositis. (Korean J Dermatol 2007;45(2):171~174)

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