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한국약제학회> 약제학회지> 약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

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약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

Original Articles : The Effects of Laminaria japonica Diet on the Pharmacokinetics of Metformin and Glucose Absorption in Rats

최한곤 ( Choe Han Gon ) , 장보현 ( Jang Bo Hyeon ) , 이종달 ( Lee Jong Dal ) , 김정애 ( Kim Jeong Ae ) , 유봉규 ( Yu Bong Gyu ) , 용철순 ( Yong Cheol Sun )
  • : 한국약제학회
  • : 약제학회지 33권3호
  • : 연속간행물
  • : 2003년 09월
  • : 171-178(8pages)

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Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

UCI(KEPA)

I410-ECN-0102-2009-510-003333038

간행물정보

  • : 의약학분야  > 약품제제
  • : KCI등재
  • : SCOPUS
  • : 격월
  • : 2093-5552
  • :
  • : 학술지
  • : 연속간행물
  • : 1971-2011
  • : 1610


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1약학박사 이진환 교수 정년퇴임 기념호 : 은강 이진환 박사 근영

저자 : 학회자료

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 2-2 (1 pages)

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2약학박사 이진환 교수 정년퇴임 기념호 : 이진환 교수 연보

저자 : 학회자료

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 3-5 (3 pages)

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3약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; [P(AA-co-PEGMM)]공중합체 필름으로부터 Butorphanol Tartrate의 구강점막 투과 특성 및 투과촉진제의 검색

저자 : 김준식 ( Kim Jun Sig ) , 박정숙 ( Park Jeong Sug ) , 정연복 ( Jeong Yeon Bog ) , 한건 ( Han Geon )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 157-162 (6 pages)

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The feasibility of [P(AA-co-PEGMM)] film as a buccal mucoadhesive patch was previously reported by estimating mucoadhesiveness and release characteristics. To find a rational penetration enhancer of [P(AA-co-PEGMM)] film containing butorphanol tartrate (Bt), penetration of Bt from [P(AA-co-PEGMM)] film which contained various additives was estimated by measuring its flux, Pappand lag time in in vitro buccal membrane of porcine. EDTA showed almost no increase of Bt permeability, wherease SGC, STDHF and SLS increased the permeability of Bt with the order of SGC>STDHF>SLS. The rational additive concentration of SGC was 4% and its Papp and lag time were 1.93×10^(-4)±4.21×10^(-6), 126.60±21.88 min (control : Papp 0.45×10^(-4); lag time 211.01±16.77 min), respectively.

4약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 신규 필름형성제를 이용한 경피흡수제제의 설계

저자 : 최양규 ( Choe Yang Gyu ) , 김영소 ( Kim Yeong So ) , 김정주 ( Kim Jeong Ju ) , 심영철 ( Sim Yeong Cheol )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 163-169 (7 pages)

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In order to develop a film-forming transdermal drug delivery system, polyurethane(PU) based on poly(ethylene glycol) and poly(tetramethylene oxide) was synthesized and characterized. The synthesized PU was blended with Gantrez ES225(GT) to improve the adhesion property of film-forming agent to the skin. When film-forming gel formulation containing 3% ketoprofen (KP) was applied, transparent thin film was obtained within 5 minutes and adhered to the skin for 8 hours. In vitro percutaneous absorption studies were performed to determine the rate of ketoprofen absorption through guinea pig skin. A prominent effect of limonene on the skin permeability of ketoprofen was observed among the various skin permeation enhancers investigated. Considering mechanical properties of film and skin permeability of ketoprofen, 2% on limonene was optimal content in the film forming transdermal formulation.

5약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

저자 : 최한곤 ( Choe Han Gon ) , 장보현 ( Jang Bo Hyeon ) , 이종달 ( Lee Jong Dal ) , 김정애 ( Kim Jeong Ae ) , 유봉규 ( Yu Bong Gyu ) , 용철순 ( Yong Cheol Sun )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 171-178 (8 pages)

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Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

6약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 멜라토닌이 함유된 다층 코팅 펠렛의 방출 및 특성분석

저자 : 강복기 ( Kang Bog Gi ) , 강길선 ( Kang Gil Seon ) , 김종민 ( Kim Jong Min ) , 정상영 ( Jeong Sang Yeong ) , 이해방 ( Lee Hae Bang ) , 조선행 ( Jo Seon Haeng )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 179-185 (7 pages)

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Melatonin (MT) is an indole amide pineal hormone. It has not only very short half-life but also pH-sensitive property. The sustained release dosage form which delivers M in a circadian fashion over 8 h is clinical value. The purpose of this study is to prepare sugar beads using multiple coating methods and enteric-coated in a sustained release to evaluate in vitro release characteristics in simulated gastric and intestinal fluids. The Eudragit^(?) as a polymer, sustained release membrance, and triethylcitrate (TEC) as a plasticizer were used. Multi-coated melatonin delivery system was composed of sugar, various excipients, Eudragit^(?) and enteric materials (e.g. hydorxy propyl methyl celluslose phthalate, HPMCP), and prepared by fluid bed coater. The dissolution test was carried out using the basket method at a stirring speed of 100 rpm at 37℃ in simulated gastric (pH 1.2) and intestinal fluid (pH 7.4). The released amount of MT was determined by High performance liquid chromatography method. The morphologies of surface and cross section of multi-coated beads were observed by scanning electron microscope. Size of multi-coated sugar beads was ranged over 1000∼1300 μm. The release rate of MT from coated beads was limited in simulated gastric fluid (pH 1.2), but it was sustained in intestinal fluid (pH 7.4) during 3∼8 hours. The MT beads may provide small-intestine-targeted device for oral delivery. Studies an animal and relative experiment are in process.

7약학박사 이진화 교수 정년퇴임 기념호 : 원보 ; 계면활성제 함유 인지질 나노입자의 초가변성 연구

저자 : 신지영 ( Sin Ji Yeong ) , 오유경 ( O Yu Gyeong ) , 강민정 ( Kang Min Jeong ) , 권경애 ( Kwon Gyeong Ae ) , 김종국 ( Kim Jong Gug )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 187-193 (7 pages)

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This study was aimed to formulated various phospholipid nanoparticles composed of different surfactants and to evaluate the deformability of the phospholipid vesicles as candidates of useful ultradeformable nanoparticles. In vitro deformability of the hospholipid nanoparticles was studied using an extruder under a certain pressure. The sizes of phospholipid nanoparticles, passed volumes, and concentrations of the phospholipids in suspensions before and after extrusion were measured. The deformability indexes were estimated by using passed volumes, sizes of phospholipid nanoparticles and concentrations of phospholipids. Conventionl liposomes, placed under a certain pressure of an extruder, showed no passed volume indicating little deformability. Similar to conventional liposomes, phospholipid nanoparticles containing surpactants such as sodium taurcholate, Myrj 45, or Myrj 53 showed little deformability. In contrast, phospholipid nanoparticles composed of Tween 20, triton X-100, or sodium deoxycholate showed higher deformability indexes than others. Taken together, the deformability of phospholipid nanoparticles could be significantly affected by the type of surfactants. Moreover, these results suggest that the deformability of phospholipid nanoparticles could be modulated by surfactants.

8약학박사 이진환 교수 정년퇴임 기념호 : 원보 ; 데커시놀추출물의 경구투여후 흰쥐에 있어서의 약물속도론적 연구

저자 : 김지혜 ( Kim Ji Hye ) , 최송암 ( Choe Song Am ) , 김동출 ( Kim Dong Chul )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 195-199 (5 pages)

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The objective of this study is to investigate the pharmacokinetic parameters of decursinol following oral administration in Sprague-Dawley rats. The plasm concentration of decursinol was determined by LC/MS with APCL positive mode. The m/z value of decursinol was observed at 247. Folowing oral administration of decursinol extract, the apparent clearance was 5.3±2.7 ml/hr/rat, the absorption half life was 2.5±0.41 hr, the elimination half life was 3.05±1.57 hr and the apparent volume of distribution was 21±12 ml/rat. The LC/MS method was successfully applied to the phar-macokinetic study of decursinol.

9약학박사 이진환 교수 청년퇴임 기념호 : 원보 ; 건강한 한국인 성인 남성에서 레보설피리드 제제의 생체이용률

저자 : 이정민 ( I Jeong Min ) , 최성업 ( Choe Seong Eob ) , 김희규 ( Kim Hui Gyu ) , 윤미경 ( Yun Mi Gyeong ) , 김세희 ( Kim Se Hui ) , 염정록 ( Yeom Jeong Log ) , 최영욱 ( Choe Yeong Ug )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 201-208 (8 pages)

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Pharmacokinetics and oral bioavailability of levosulpiride was determined in Korean healthy male volunteers. Thirty subjects received a single oral dose (25 ㎎) of a tablet in randomized 2×2 cross-over design. The plasma concentratons of levosulpiride were measured by HPLC and compared with those reported in the literature. Pharacokinetic parameters for Isomeric^(??) tablet (levosulpiride 25 ㎎) were revealed as follows: AUC _(inf) 737.1±176.9 ng·hr/ml, C_(max) 56.4±20.1 ng/ml, T_(max) 4.2±1.6hr, K_(a) 1.00±1.09 hr^(-1), K_(el) 0.08±0.02 hr^(-1), and t_(1/2) 8.8±1.9 hr. The rate constant of the absorption phase was obtained based on the first-order kinetics. In the aspect of bioavailability, Isomeric^(??) tablet was bioequivalent to the other product (Levopride^(?)tablet) available in the Korean market. Intersubject variations and race differences were shown in comparison with the published date in the literature, even though there ws a linear relationship between dose and extent of bioavailability.

10약학박사 이진환 교수 정년퇴임 기념호 : 단보 ; 플라스미드 유전자를 함유한 리포좀의 제조 및 특성

저자 : 박효민 ( Park Hyo Min ) , 정수연 ( Jeong Su Yeon ) , 고은정 ( Go Eun Jeong ) , 이화정 ( Lee Hwa Jeong )

발행기관 : 한국약제학회 간행물 : 약제학회지 33권 3호 발행 연도 : 2003 페이지 : pp. 209-213 (5 pages)

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The objective of this study was to construct the pegylated liposomes containing plasmid DNA with optimal encapsulation efficiency. Plasmid DNA (pGL2 clone 753, ∼6 kb) was encapsulated by the freeze/thawing method into liposomes cmposed of 1-palmitoy1-2-oleyl-sn-glycerol-3-phosphocholine (POPC), didodecyl dimethyl ammonium bromide (DDAB), distearoylphosphatidyl ethanolamine polyethylene glycol 2000 (DSPE-PEG 2000) and DSPE-PEG 2000-male-imide. The liposomes containing plasmid DNA entrapped in the liposomes was separated from free plas-mid DNA by Sephadex CL-4B column chromatography. The decreased pore size of polycarbonate filters resulted in the decreased size of liposomes. The encapsulation efficiency was markedly affected by the cationic lipid (DDAB) concentration, but to a low degree by the size of liposomes and by the amount of plasmid DNA.

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25권 0호 ~ 25권 0호

약품개발연구소 연구업적집
26권 0호 ~ 26권 0호

약품개발연구지
24권 0호 ~ 24권 0호

약품개발연구소 연구업적집
25권 0호 ~ 25권 0호

약품개발연구지
23권 0호 ~ 23권 0호

약품개발연구소 연구업적집
22권 0호 ~ 24권 0호

약품개발연구소 연구업적집
22권 0호 ~ 24권 0호

약품개발연구소 연구업적집
21권 0호 ~ 21권 0호

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41권 6호 ~ 41권 6호

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약제학회지
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40권 4호 ~ 40권 4호

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