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대한피부과학회> 대한피부과학회지> 최근 15년간(1982-1996) 피부 악성 종양과 피부 암전구증에 관한 임상적 관찰

KCI등재SCOUPUS

최근 15년간(1982-1996) 피부 악성 종양과 피부 암전구증에 관한 임상적 관찰

Clinical Observation of Cutaneous Malignant Tumors and Premalignant Lesions over 15 Years(1982-1996)최근 15년간(1982-1996) 피부 악성 종양과 피부 암전구증에 관한 임상적 관찰

정한길(Han Gil Chung) , 문태기(Tae Kee Moon) , 방동식(Dong Sik Bang) , 이민걸(Min Geol Lee)
  • : 대한피부과학회
  • : 대한피부과학회지 37권10호
  • : 연속간행물
  • : 1999년 10월
  • : 1413-1422(10pages)
대한피부과학회지

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UCI(KEPA)

I410-ECN-0102-2009-510-005410854

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2022
  • : 9703


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60권6호(2022년 07월) 수록논문
최근 권호 논문
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1최근 20년간 유방외파젯병의 치료 방법 및 예후에 대한 단일기관 분석: 전이의 위험인자인 암배아항원

저자 : 박준형 ( Jun Hyeong Park ) , 이지범 ( Jee-bum Lee ) , 윤숙정 ( Sook Jung Yun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 343-349 (7 pages)

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Background: Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy of anogenital lesions. Objective: To investigate the long-term prognosis of patients with EMPD and the results of various treatment methods for 20 years.
Methods: We retrospectively reviewed the medical records of 80 patients with biopsy-proven EMPD at Chonnam National University Hospital during the last 20 years from 2000 to 2019.
Results: The most common treatment option was excision in male patients (75.0%). However, for female patients, nonsurgical treatments, such as topical imiquimod (29.1%) or radiation therapy (20.8%), were mostly applied. In the long-term follow-up, 10 patients (12.5%) were diagnosed with systemic metastasis. The most common metastatic site was the lymph nodes, followed by the bone. Among patients with metastasis, 66.7% showed elevated serum carcinoembryonic antigen (CEA) levels, whereas none of the non-metastatic patients showed elevated CEA levels. Negative surgical margins were not associated with systemic metastasis but were associated with local recurrence.
Conclusion: Systemic metastasis of EMPD is significantly associated with serum CEA levels. Therefore, more rigorous follow-up, including imaging studies, is required for patients with a poor prognosis. (Korean J Dermatol 2022;60(6):343∼349)

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2한국 아토피피부염 환자에서 알레르기 항원 감작 추이: 다중 알레르기 항원 검사를 통한 10년간의 후향적 연구

저자 : 한유진 ( Yujin Han ) , 조민아 ( Minah Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 350-363 (14 pages)

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Background: Avoiding causative allergens is important for controlling the clinical course of atopic dermatitis (AD). Allergen sensitization is influenced by many factors, such as the environmental factors. Although socioeconomic development, climate, and lifestyle have changed and the prevalence of allergic diseases has increased in Korea over the past few decades, there is little information about changes in common allergens over time.
Objective: This study aimed to identify the trends of common allergens in patients with AD over a 10-year period based on the results of the multiple allergen simultaneous test (MAST).
Methods: We retrospectively reviewed the medical records of 1,414 patients with AD (603 adults and 811 children) over a period of 10 years. The serum total immunoglobulin E (IgE) and specific IgE levels of 41 allergens were determined using the MAST.
Results: House dust and house dust mites were the most prevalent allergens in both adult and pediatric patients during the 10-year period; however, the percentage of higher-class responses has decreased in recent years. The number of patients sensitized to house dust, cats, and egg whites increased, whereas that of patients sensitized to cockroaches, storage mites, beef, and rice decreased for both adults and children. No significant changes were observed in the total number of sensitizing allergens over time.
Conclusion: Common allergens in patients with AD have change over time. Based on the findings of this study, physicians and patients should consider changing their disease prevention and management strategies. (Korean J Dermatol 2022;60(6):350∼363)

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3연조직염의 예후 예측에서 호중구-림프구 비율의 역할

저자 : 이기훈 ( Ki Hun Lee ) , 이승연 ( Seung Yeon Lee ) , 오칠환 ( Chil Hwan Oh ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 364-370 (7 pages)

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Background: Cellulitis is an inflammatory disease of the skin and subcutaneous tissue caused by bacterial infection and is one of the most common reasons for admission to the Department of Dermatology. There are many biomarkers to help diagnose inflammatory diseases, and the neutrophil-to-lymphocyte ratio (NLR) has recently been raised as an option.
Objective: This study aimed to evaluate the efficacy of pretreatment NLR for predicting the severity and prognosis of cellulitis.
Methods: We reviewed the medical records of 102 patients diagnosed with cellulitis over the past 5 years. White blood cell count, erythrocyte sedimentation rate, C-reactive protein (CRP) level, procalcitonin level, and NLR were measured on the first day of admission. The associations of CRP, procalcitonin, and NLR ratio with body temperature and number of hospitalization days were assessed.
Results: The CRP level and NLR were positively correlated with body temperature. In addition, positive correlations were found between the number of hospitalization days and biomarkers (p<0.05), with the NLR showing the highest coefficients.
Conclusion: In patients with cellulitis, the NLR is a helpful parameter for evaluating the severity and prognosis of the disease. However, further studies are required to confirm this. (Korean J Dermatol 2022;60(6):364∼370)

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4Efficacy and Safety of Subclinical Sensitization with Diphenylcyclopropenone in Children with Alopecia Areata: A Retrospective Study

저자 : Sang-hoon Lee , Chung Hyeok Lee , Hyun Kang , Won-soo Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 371-377 (7 pages)

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Background: Contact immunotherapy with diphenylcyclopropenone is one of the first-line treatments for extensive alopecia areata, despite its adverse effects (AEs).
Objective: This study aimed to investigate whether a modified contact immunotherapy treatment protocol can safely promote hair regrowth in children.
Methods: Children with alopecia areata who were treated with modified contact immunotherapy with diphenylcyclopropenone were retrospectively reviewed. All patients were sensitized with 0.1% diphenylcyclopropenone and began treatment at subsequent increasing concentrations. The efficacy, AEs, and demographic factors were evaluated.
Results: A total of 32 patients, aged 9 to 17 years (mean age, 14.6 years), were included in the study. The mean disease duration was 26.8 months. Ten (31.3%) and 11 patients (34.4%) showed complete and partial responses, respectively. No AEs were observed after the sensitization. During treatment, 13 patients (40.6%) did not experience any AEs. Sixteen patients (50.0%) showed mild to moderate pruritus, and only three patients (9.4%) had severe pruritus. However, all AEs were well controlled.
Conclusion: A modified diphenylcyclopropenone treatment protocol with subclinical sensitization could induce a favorable therapeutic response and fewer AEs in children. (Korean J Dermatol 2022;60(6):371∼377)

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5다형성 피부 육종 1예 및 World Health Organization 재분류법에 따른 문헌 고찰

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Un Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 378-382 (5 pages)

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Pleomorphic dermal sarcoma (PDS), formerly known as malignant fibrous histiocytoma (MFH), is a rare mesenchymal tissue tumor. A 40-year-old male presented with a 2-month history of a well-defined, solitary, round, palpable protruding mass with central ulceration, 1.5 cm in diameter. Punch biopsy showed tumor cells of variable size and hyperchromatic nuclei with frequent bizarre atypical cells and atypical mitoses arranged in a storiform-pleomorphic pattern in the entire dermis. After complete resection, PDS was diagnosed because the lesion had invaded the deep subcutaneous fat. Because MFH has been renamed according to the World Health Organization new classification system, we reclassified the 10 cases that have been reported as MFH in Korea. Nine cases were renamed undifferentiated pleomorphic sarcoma, with only one being renamed mucofibrosarcoma. Herein, we report a rare case of PDS treated with surgical excision with a review of the literature. (Korean J Dermatol 2022;60(6):378∼382)

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6코로나바이러스감염증-19 백신 접종 후 발생한 결절 홍반

저자 : 양나경 ( Na Gyeong Yang ) , 홍정연 ( Jeong Yeon Hong ) , 김재윤 ( Jae Yun Kim ) , 이성열 ( Sung Yul Lee ) , 김정은 ( Jung Eun Kim ) , 유시내 ( Shi Nae Yu ) , 정의현 ( Euy Hyun Chung )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 383-386 (4 pages)

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Erythema nodosum (EN) is the most common form of panniculitis and may be triggered by a variety of stimuli, including infections, drugs, pregnancy, sarcoidosis, inflammatory bowel disease, and malignancies. Rare cases of vaccination-related EN have been reported, but none due to the coronavirus disease 2019 (COVID-19) vaccine of Pfizer have been documented. We report a case of EN associated with the Pfizer vaccine. A 43-year-old woman presented with acute-onset painful nodular lesions that appeared bilaterally on the extensor surface of the lower legs. These lesions appeared 5 days after the first dose of Pfizer vaccination. The patient reported no recent infectious history other than fever for 3 days after vaccination. Skin biopsy revealed inflammation extending into the subcutaneous fat with a septal distribution. It is important for physicians to be aware of the side effects of the COVID-19 vaccine because more people are bound to be vaccinated. (Korean J Dermatol 2022;60(6):383∼386)

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7다운 증후군 환자에서 발생한 뱀모양천공탄력섬유증 1예

저자 : 국형돈 ( Hyung Don Kook ) , 홍나랑 ( Narang Hong ) , 이동헌 ( Dong Heon Lee ) , 정혜정 ( Hye Jung Jung ) , 안지영 ( Jiyoung Ahn ) , 박미연 ( Mi Youn Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 387-389 (3 pages)

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Elastosis perforans serpiginosa (EPS) is a rare condition that belongs to the group of acquired perforating dermatosis. It usually appears as keratotic papules in serpiginous configuration with central atrophy on the head, nape, and extremities. It is characterized by the transepidermal elimination of elastic fibers with clumping and vertical orientation of elastic fibers. In many cases, it is associated with genetic or connective tissue diseases. A 26-year-old female patient with Down syndrome presented with brownish keratotic papules on both arms. The lesion had been present for 2 years, but there were no symptoms. The biopsy specimen showed transepidermal elimination of the degenerated elastic fibers. Verhoeff elastic staining revealed an increased number of thick elastic fibers. Based on these findings, the patient was diagnosed with EPS. Treatment with CO2 laser was performed with a successful outcome. (Korean J Dermatol 2022;60(6):387∼389)

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8Eosinophilic Annular Erythema 1예

저자 : 정서미곤 ( Seo Mi Gon Jeong ) , 강하은 ( Ha Eun Kang ) , 문윤선 ( Yun Sun Moon ) , 김지연 ( Chi Yeon Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 390-394 (5 pages)

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Eosinophilic annular erythema (EAE) is an uncommon, recurrent eosinophilic cutaneous disease, and its etiology has not been clearly elucidated. Clinically, EAE occurs mainly in the form of annular or round erythematous, edematous plaques on the trunk or extremities. Histopathologically, it is characterized by superficial and deep perivascular inflammatory cell infiltration composed of lymphocytes and eosinophils. Based on this, some studies have stated that EAE is not an isolated rare disease but rather a spectrum that shares features similar to Wells syndrome. Herein, we report a case of EAE in a 28-year-old female patient. The clinical features were recurrent annular, erythematous patch on the both extremities. Histopathologic examination demonstrated superficial infiltrates of lymphocytes and eosinophils in the dermis. Based on the clinical and histological features, this case was diagnosed as EAE. (Korean J Dermatol 2022;60(6):390∼394)

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9Rapidly Progressive Myxoinflammatory Fibroblastic Sarcoma with Sudden Onset Treated by Wide Excision: A Case with an Atypical Clinical Course

저자 : Hyeok-jin Kwon , Dong-wha Yoo , Jeong-ho Ryu , Ji-an Choi , Ki-ho Kim , Jung-ho Yoon

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 395-399 (5 pages)

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Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare neoplasm that is frequently located in the distal extremities. Emerging evidence suggests that MIFS can also affect the proximal limbs, trunk, and scalp, and aggressive clinical courses have been noted. We report a case of MIFS that occurred suddenly in the patient's forearm and grew rapidly within 2 weeks. A level of Ki-67 was observed in the patient's lesion, which constitutes a considerable finding compared with most MIFS cases. The patient underwent surgical tumor removal, and no evidence of recurrence was noted. We highlight this case in view of its sudden occurrence and rapid local progression, which contradicts the usual features of this disease, suggesting that this clinical course might be attributable to the high Ki-67 value. (Korean J Dermatol 2022;60(6):395∼399)

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10피지선 상피종으로 오인된 악성 투명세포 에크린 한공종 1예

저자 : 이재호 ( Jae-ho Lee ) , 어지안 ( Ji-an Uh ) , 김중호 ( Joong-ho Kim ) , 이수경 ( Soo-kyung Lee ) , 김명신 ( Myoung-shin Kim ) , 이운하 ( Un-ha Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 6호 발행 연도 : 2022 페이지 : pp. 400-401 (2 pages)

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1약물오남용 및 부작용에 관한 피부과 영역의 전향적 다기관 임상 역학연구

저자 : 이원수(Won Soo Lee) , 은희철(Hee Chul Eun) , 박한성(Han Sung Park) , 이승헌(Seung Hun Lee) , 문상은(Sang Eun Moon) , 신학철(Hack Chul Shin) , 김홍직(Hong Jig Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1385-1398 (14 pages)

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Background : The abuse, nmisuse, and resultant adverse reactions of various drugs have been widespread due to lack of division of work of medicine and pharmacy in Korea.  Objective : A multicenter, prospective, clinico-epidemiologic evaluation was made from patients with adverse drug reactions who visited 126 dermatologic departments in university hospitals(21) or private clinics(105) nationwide from Iuly 1st to July 31st, 1999.  Results : The prevalence of adverse drug reaction was 10.4% among them 47.9% of the patients had adverse cutaneous effects from external use of topical steroids and 24.1% of the patients had contact dermatitis from external use of various topical agents. The rate(66.3%) of misuse of topical steroids was higher than that(33.7%) of abuse of the drugs. 79.8% of patients had obtained drugs without an accurate diagnosis and prescription from their doctors. Regarding the potency of topical steroids, it was revealed that the lowest potency drugs also caused adverse effects.   Conclusion : The strict grouping of drugs as prescription drugs or over-the-counter drugs based on drug safety is the key factor to avoid the abuse and misuse of drugs, and to protect the public health from harmful drug effects. (Korean J Dermatol 1000;37(10) : 1385∼1398)

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2아토피 피부염 환자에서 임상증상 및 가족력과 면역학적 검사의 상관관계

저자 : 원영호(Young Ho Won) , 이승철(Seung Chul Lee) , 김성진(Sung Jin Kim) , 신삼식(Sham Sik Shin)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1399-1406 (8 pages)

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Background : Atopic dermatitis is an acute, subacute, or chronic pruritic dermatosis related to hereditary factors. However, pathogenesis and immunologic mechanism is not clear. The correlations between clinical status and abnormal immunologic findings have been widely studied. However, different and contrary results were reported according to researchers and environmental conditions.   Objective : This study is to evaluate the relationship between immunologic findings including peripheral blood eosinophil count, IgE level, immediate skin reaction, and clinical status including severity or/and family history.  Methods : Two hundred patients with atopic dermatitis for 4 years(1994-97) were grouped according to clinical severity of skin lesions, and analysed in view of clinical and immunologic findings. Three groups were classified according to modified Rajka`s and Hanifin`s severity grading.   Results : Family history of atopy was recognized in 41.5%(83/200). A high eosinophil count in the blood and a high total serum IgE level were 46.3%(88/190), and 65%(47/72) in patients respectively. Each one tends to be higher in severe clinical status, and both were simultaneously elevated in moderate and severe patient groups. Both of eosinophil count and serum IgE level were significantly correlated in the severe patient group(r=0.284), and patients with(r=0.333) or without(r=0.314) family history. Pin prick test positivity was 70%, and MAST allergen test 53.1%. Atopic dermatitis patients showed relatively higher prevalence in A type of ABO blood groups. Immunohistochemical stains revealed that most of the infiltrated cells in atopic skin lesions were T lymphocytes.   Conclusion : This study supports that clinical severity of atopic dermatitis was closely related to immonologic abnormalities such as elevated perupheral eosinophil count and serum IgE level, especially in patients with familial background. (Korean J Dermatol 1999;37(10) : 1399∼1406)

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3막낭성 변화를 보이는 지방층염에 대한 임상 및 병리조직학적 연구

저자 : 이미우(Mi Woo Lee) , 최지호(Jee Ho Choi) , 성경제(Kyung Jeh Sung) , 문기찬(Kee Chan Moon) , 고재경(Jai Kyoung Koh)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1407-1412 (6 pages)

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Background : Membranocystic change represents a distinctive from of pathology in adipose tissue. It has been oberved in a variety of inflammatory and noninflammatory dermatoses.  Objective : Our purpose was to find the clinical and histopathological features of membranocystic change in the panniculitis and we attempted to review the pathogenesis.  Methods : We reviewed medical records, clinical photographs, and histopatoligic finding of 14 patients having membranocystic changes in biopsy specimen.  Results : ① There was a female predominance (79%). ② The most common primary lesions were the subcutaneous nodules and the most predilection sites were the lower legs. ③ The underlying diseases were varible such as erythema nodosum, lipoatrophy, sparganosis, sportrichosis, accelerated nodulosis, necrobiosis lipoidica, periarteritis nodosa, artery stenosis, dermatomyositis, lupus erythematosus profundus, oil granuloma and nodulocystic fat necrosis. ④ The membranes of cyst were positive with periodic acid-Schiff stain with diastase and sudan black B. Fluorescence examination gave a yellow autofluorescence. These findings indicated the lining materials were ceroid.  Conclusion : Membranocystic change appears to be entirely nonspecific and may be seen in many types of the subcutaneous inflammatory process. Although ischemic insult has received the most attention in dermatololgic literature as the primary cause, it is likely that this change results from various insults to adipose tissue, including infectious, autoimmune, and physical processes. (Korean J Dermatol 1999;37(10) : 1407∼1412)

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4최근 15년간(1982-1996) 피부 악성 종양과 피부 암전구증에 관한 임상적 관찰

저자 : 정한길(Han Gil Chung) , 문태기(Tae Kee Moon) , 방동식(Dong Sik Bang) , 이민걸(Min Geol Lee)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1413-1422 (10 pages)

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5Trichoblastoma와 기저세포아의 감별진단을 위한 면역조직화학염색

저자 : 조광현(Kwang Hyun Cho) , 한광호(Kwang Ho Han) , 문상은(Sang Eun Moon) , 윤재일(Jai Il Youn) , 은희철(Hee Chul Eun) , 김철우(Chul Woo Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1423-1429 (7 pages)

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6피부 질환 치료를 위한 웹 BBS 활용

저자 : 김연수(Youn Soo Kim) , 곽상태(Sang Tae Kwak) , 정회경(Hoe Kyung Jung) , 조인준(In Jun Cho) , 서기범(Gi Bum Suhr) , 이증훈(Jeung Hoon Lee) , 박장규(Jang Kyu Park)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1430-1434 (5 pages)

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7침수가 급성 피부장벽손상 후 장벽회복에 미치는 영향

저자 : 김도원(Do Won Kim) , 이성훈(Sung Hoon Lee) , 전재복(Jae Bok Jun) , 정상립(Sang Lip Chung)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1435-1441 (7 pages)

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8585nm Flashlamp-Pumped Pulsed Dye Laser로 치료한 혈관성 피부질환 216예에 대한 고찰

저자 : 안효현(Hyo Hyun Ahn) , 계영철(Young Chul Kye) , 김수남(Soo Nam Kim)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1442-1449 (8 pages)

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9단자검사와 화학발광법을 이용한 알레르겐 검사성적

저자 : 천태종(Tae Jong Chun) , 이강석(Kang Seok Lee) , 서성준(Seong Jun Seo) , 김명남(Myung Nam Kim) , 홍창권(Chang Kwun Hong) , 노병인(Byung In Ro)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1450-1456 (7 pages)

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Background : Prick test is most frequently used in clinical procedures because its simplicity and safety of application and better correlation with clinical history as well as specificity and high reproducibility. The chemiluminescent assay(CLA) is a new in vitro non-radioactive modification of radioallergosorbent test(RAST). The CLA permits quick, simultaneous detection of total and specific IgE in human serum. The CLA has shown good sensitivity, specificity, and a good correlation with the RAST and skin prick test.   Objective : The purpose of this study was to find causative allergens and to evaluate the clinical significance of CLA comparing the results of the CLA with those of the prick test in dermatologic outpatients.  Methods : We performed the prick test with 51 allergens(Bencard Ltd. Brentford, England) in 448 patients, and CLA with 35 allergens(Boehringer mannheim Korea. green cross inc.) in 280 patients with dermatologic disease.  Results : 1. The positive reaction rate was highest in third decade and decreased over the age of 40 in prick and CLA. 2. The positive reaction rate of prick test(52.8%) was higher than that of CLA(25.0%). 3. The positive reaction rate to single allergens and compound allergens was 14.2% and 38.6% in the prick test and 2.5% and 22.5% in the CLA respectively. 4. In the prick test, the positive alleragens, in descending order, were House dust 114(25.4%), D. farinae 88(19.6%), D. pteronyssinus 79(17.6%), Mixed inhalants 61(13.6%), and Threshing 47(10.5%). In the CLA Thistle 35(12.5%), Dandelion 31(11.1%), D. farinae 30(10.7%), D. pteronyssinus 29(10.4%), and Cat fur 12(4.3%). 5. The results of the CLA to common 2 allergens showed a concordance rate of 84.6%, sensitivity of 58.9%, and specificity of 86.1% compared with those of prick test.   Conclusion : CLA may be a useful alternative method and shows a good correlation with the prick test. Combination of the two method results in a high diagnostic accuracy for the cause of allergic disease. (Korean J Dermatol 1999 : 37(10): 1450∼1456)

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10조갑진균증 진단에서 중합효소 연쇄반응 방법의 의의 : 진균배양 및 KONCPA 검사와의 비교

저자 : 권오찬(Oh Chan Kwon) , 백승철(Seung Churl Paik) , 조백기(Baik Kee Cho)

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 37권 10호 발행 연도 : 1999 페이지 : pp. 1457-1465 (9 pages)

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Background : It has been known that the polymerase chain reaction(PCR) test of clinical specimens including blood, sputum, urine, and cerebrospinal fluid collected from patients with systemic fungal infection is a highly sensitive diagnostic method. Recently, the PCR test was applied to the diagnosis of onychomycosis.  Objective : This study was aimed to explore whether the PCR test would be a more sensitive diagnostic tool than the KOH smear, fungus culture and KONCPA(KOH±Nail Clipping+PAS(periodic acid-Schiff) stain) test in diagnosing the onychomycosis.  Methods : Using 50 nail sample from 50 patients with onychomycosis, the result of the PCR test was compared with those of the KOH smear, fungus culture and KONCPA test.  Results : The results were as follows : 1. The positive rates for detecting the causative fungi from the KOH smear, fungus culture, KONCPA test and PCR test were 64.0%, 46.0%, 90.0%, and 100.0% respectively. 2. The fungus culture identified the causative fungi from 23 samples, of which 21(91.2%) were T. rubrum, 1(4.4%) Candida sp. and 1(4.4%) C. albicans. KONCPA test yielded higher positivity by detecting the pathogenic fungi in 45 samples : dermatophytes 2(4.4%). The PCR test yielded the highest positivity by detecting the pathogenic fungi in all samples ; T. rubrum 44(88.0%) and unclassified 6(12.0%). 3. Compared with the results of fungus culture and KONCPA test, that of PCR test showed some differences. The case of Candida sp. in fungus culture was identified as T. rubrum in PCR ; the case of C. albicans in fungus culture as unclassified in the PCR. Five cases of mixed infection and 2 cases of mold infection in the KONPCA test were diagnosed as T. rubrum infection in the PCR test.   Conclusion : The PCR test is useful in dianosing the onychomycosis because of its highest positive rate in detecting the causative fungi compared with fungus culture and the KONCPA test. Furthermore, a more accurate diagnostic method such as the PCR test will be necessary in case (Korean J Dermatol 1999 : 37(10): 1457∼1465)

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