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대한피부과학회> 대한피부과학회지> 원저 : 다형 홍반의 임상 및 병리조직학적 특성 - 수장족저부 병변과 비수장족저부 병변의 임상 및 병리조직학적 비교 -

KCI등재SCOUPUS

원저 : 다형 홍반의 임상 및 병리조직학적 특성 - 수장족저부 병변과 비수장족저부 병변의 임상 및 병리조직학적 비교 -

Clinicopathological Characteristics of Erythema Multiforma - A Comparison of Palmoplantar Erythema Multiforme with Erythema Multiforme Involving Other Siers -

홍창의 , 한승경 , 이광길 , 이일주 ( Chang Eui Hong , Seung Kyung Hann , Kwang Gil Lee , Il Joo Lee
  • : 대한피부과학회
  • : 대한피부과학회지 35권6호
  • : 연속간행물
  • : 1997년 12월
  • : 1159-1167(9pages)
대한피부과학회지

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Background: Erythema multiforme is an inflammatory disorder of the skin which may be characterized by erythematous papules, plaques, vesicles, and 'target-like' annular lesions. Mucosal lesions may occur. Symmetric irivolvement of the extrernities, especially the dorsurn of the hands and feet, and face is the classic: pattern of cutaneous distribution. Palmoplantar lesions of erythema multiforme are relatively uricornmon. Objective : Our purpose was to investigate the clinical and histopathological r,haracteristics of erythema multiforme involving the palm and sole. Methods : Thirty  one cases of erythema multiforme involving the palm and sole, and thirty cases involving other sites wer collected and analysed with particular reference to epidemiological data, type and distribution of the skin lesion and histopathological characterist,ics. Results : 1. The median ages of both groups were the early thirties. There were no sexual predominances. 2. The clinical features of erythema multiforme involving the palm and sole were relatively mild and showed atypical skir, lesions including macules and papules compared with erythema multiforme involving the other sites. 3. The histopathological changes of the palmoplantar group were also mild, especially the epidermal changes which included keratinocytes necrosis, subepidermal blisters, focal parakeratosis, extensive epidermal necrosis and xocytosis etc. 4, The most import,ant and consistent histopathological finding of the palmoplantar erythema multiforme group was lymphoc;yte tagging along the basernent membrane, which was found consistently apart from one case. Conclusion : We investigated the clinical and histopathological features of erythema multiforme involving the palm and sole. They showed mild clinical features and atypical skin lesions cornpared with other group. The histopathological spectrum of this group was diverse, and reflected the early stage of pathomecha nisms of erythema multiforme. Among them, lyrnphocyte tagging was the most important and censistent finding in palmoplantar erythema multiforme. (Korean J Dermatol 1997;35(6): 1159-1167)

UCI(KEPA)

I410-ECN-0102-2009-510-005401686

간행물정보

  • : 의약학분야  > 피부과학
  • : KCI등재
  • : SCOPUS
  • : 월간
  • : 0494-4739
  • : 2713-7627
  • : 학술지
  • : 연속간행물
  • : 1960-2021
  • : 9620


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1두경부 기저세포암에서 H-Zone과 비H-Zone에서의 임상 및 조직학적 특성

저자 : 손우리 ( Uri Shon ) , 염규진 ( Kyujin Yeom ) , 윤대관 ( Dea Kwan Yun ) , 김명화 ( Myung Hwa Kim ) , 최미수 ( Mi Soo Choi ) , 박병철 ( Byung Cheol Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 735-741 (7 pages)

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Background: Basal cell carcinoma (BCC) is the most common type of skin cancer. However, limited comparative data on the characteristics and prognosis of BCC in the H-zone and non-H-zone exist.
Objective: We aimed to compare the clinical, histopathological, and surgical characteristics of BCCs in the head and neck region between the H- and non-H-zones.
Methods: We retrospectively reviewed the clinical and histopathological characteristics of 292 head and neck BCC lesions in 275 patients and the characteristics of Mohs micrographic surgery (MMS) of 252 BCC lesions in 239 patients.
Results: In the H-zone, 226 lesions (77.4%) were found. Clinically, patients with H-zone BCC, compared to those with non-H-zone, were significantly older (71.6±11.4 years vs. 64.6±13.5 years) and smaller in diameter (10.1±7.1 mm vs. 12.4±9.9 mm). The noduloulcerative type was more frequent in the H-zone, while the superficial and morpheaform types in the non-H-zone. Histopathologically, the infiltrative subtype was particularly noted in the H-zone than the non-H-zone (7.5% vs. 1.5%). Out of 37 BCC patients with prior treatment history, 31 (83.8%) were in the H-zone. Two out of 252 lesions (0.8%) recurred after MMS at our institution. The mean stages of MMS were comparable between the H- and non-H-zones (1.59 vs. 1.45, p=0.135).
Conclusion: H-zone BCCs were associated with older age and smaller tumor size compared to the non-H-zone BCCs. The noduloulcerative clinical and nodulocystic pathologic subtypes were the most common in both H-zone and non-H-zone BCCs. (Korean J Dermatol 2021;59(10):735∼741)

KCI등재 SCOPUS

2수지점액낭종 환자에서 유형 및 치료 반응에 대한 후향적 연구

저자 : 정준우 ( Joon Woo Jung ) , 홍은혜 ( Eun Hye Hong ) , 백은주 ( Eun Joo Baek ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 742-748 (7 pages)

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Background: Digital mucous cysts (DMCs) are benign, occurring mainly on the fingers but rarely on the toes. Although the exact cause of DMC has not been identified, it is classified into two different types based on its pathogenesis and location. Surgical and nonsurgical procedures, including aspiration, sclerotherapy, steroid injection, cryotherapy, and CO2 laser, can be used to treat DMC.
Objective: This study aimed to compare treatment response based on DMC type and evaluate its efficacy in surgical and nonsurgical (sclerotherapy) treatments.
Methods: We retrospectively reviewed the electronic medical records of patients with DMC who visited our dermatology department between January 2010 and November 2020.
Results: This study enrolled 39 patients having a mean age of 59.2 years. The proportion of female patients (21/39, 53.8%) was more than male (18/39, 46.2%). The DMC occurrence was more frequent in the fingers (32/39, 82.1%), especially in the index and middle fingers than in the toes (7/39, 17.9%). In sclerotherapy, DMC in the distal interphalangeal joint (DIPJ) required more treatment than that in the proximal nail fold (PNF) (p<0.05). The number of treatments using sclerotherapy was higher compared to that of surgical treatments (p<0.05).
Conclusion: The DIPJ type of DMC patients was more difficult to treat using sclerotherapy than the PNF type. Moreover, surgical treatment has a better response than sclerotherapy. (Korean J Dermatol 2021;59(10):742∼748)

KCI등재 SCOPUS

3혈청 비타민 D 레벨 및 혈중 지질 농도와 건선: 단일 3차 의료기관에 내원한 한국인 건선 환자를 대상으로 한 임상적 고찰

저자 : 박현정 ( Hyeon Jeong Park ) , 이현주 ( Heun Joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 749-760 (12 pages)

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Background: Psoriasis is a chronic inflammatory autoimmune disease. Some studies have demonstrated a relationship of psoriasis with vitamin D (Vit D) deficiency or serum lipid levels.
Objective: We aimed to compare serum levels of Vit D and lipids in patients with active psoriasis and control subjects. Additionally, we analyzed the relationship of disease severity with serum Vit D and lipid levels.
Methods: A total of 243 patients were retrospectively analyzed. Statistical data were evaluated, and the values were considered significant at p<0.05.
Results: Statistically significant difference in Vit D levels between the psoriasis (n=117) and the control groups (n=126) was not found. In addition, an association between Vit D levels and the disease severity, using the psoriasis area and severity index (PASI) was not observed. The proportion of overweight patients (body mass index [BMI]≥ 23 kg/m2) was higher in the psoriasis group than in the control group, and there was a significant relationship between the increase in PASI and the serum triglycerides (TG) levels (p<0.05).
Conclusion: The psoriasis and control groups did not show a statistical difference in serum Vit D levels. In the subgroup analysis of cases with normal BMI, excluding the underlying disease, no significant difference in Vit D levels between the two groups was observed. However, the association of psoriasis with factors, such as BMI and TG, was found to be significant; hence, these could be therapeutic targets in patients with psoriasis to improve their quality of life. Controlled and well-designed studies are required in the future. (Korean J Dermatol 2021;59(10):749∼760)

KCI등재 SCOPUS

4박피 레이저 치료 후 발생하는 염증 후 홍반과 색소 침착에 대한 표피 성장 인자 함유 연고의 효과에 관한 연구

저자 : 송창화 ( Chang Hwa Song ) , 정유진 ( You Jin Jung ) , 고주연 ( Joo Yeon Ko ) , 노영석 ( Young Suck Ro ) , 김정은 ( Jeong Eun Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 761-769 (9 pages)

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Background: Epidermal growth factor (EGF) stimulates wound healing in various skin conditions, and EGFcontaining formulations can promote wound regeneration and help reduce complications after laser treatment.
Objective: To evaluate the effect of EGF-containing ointment on wound regeneration after ablative laser treatment and laser-induced postinflammatory erythema (PIE) and hyperpigmentation (PIH).
Methods: Twenty-five patients who required treatment with ablative laser on both sides of the face were enrolled and underwent one session of laser treatment. Postoperatively, all patients were instructed to apply the EGFcontaining ointment on the randomly assigned-hemifacial side, while gentamicin cream was applied on the opposite side. Investigators' global assessment (IGA), evaluating general wound condition, erythema, pigmentation, and scab shedding, and patient's global assessment (PGA), evaluating patient satisfaction with clinical improvement, were both measured at 1 week and 4 weeks after treatment. Objective assessments, including melanin index (MI), erythema index (EI), skin hydration, and transepidermal water loss (TEWL), were measured before treatment and at 1 week and 4 weeks after treatment.
Results: The EGF-containing ointment showed better outcomes with IGA (1 week; p=0.02, 4 weeks; p=0.002) and PGA (1 week; p=0.04, 4 weeks; p=0.01) scores compared to gentamicin cream. Compared to gentamicin cream, treatment with EGF-containing ointment resulted in significantly lower EI (p=0.044) and MI (p=0.023), but skin hydration and TEWL between the two groups exhibited nonsignificant differences.
Conclusion: EGF-containing ointment could be an effective adjuvant option for wound regeneration after ablative laser treatment and minimizing laser-induced PIE and PIH in Asian patients. (Korean J Dermatol 2021;59(10):761∼769)

KCI등재 SCOPUS

5The Efficacy of Skin Care Habit Modifications on the Skin Barrier Function in Rosacea Patients

저자 : Jung Eun Seol , Gyeong Je Cho , Sang Woo Ahn , Seong Min Hong , So Hee Park , So Young Jung , Hyojin Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 770-777 (8 pages)

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Background: Patients with rosacea usually suffer from skin irritations, such as itching, stinging, burning, and pain. These symptoms may be related to the skin barrier function disruption.
Objective: We investigated the skin barrier functions in patients with mild to moderate rosacea and the associated improvements based on the skin care habit modifications and treatment modalities.
Methods: We analyzed the data on transepidermal water loss (TEWL) and stratum corneum hydration (SCH) of skin lesions in 27 patients with rosacea and healthy skin of 29 control subjects. We compared the results of TEWL and SCH based on sex, age, type of rosacea, skin care habits, and the treatment modalities.
Results: The skin in the patients with rosacea exhibited increased TEWL and decreased SCH compared with that in control subjects. Male patients showed increased TEWL and decreased SCH compared to female patients. Combination therapy with systemic minocycline and topical metronidazole improved the skin barrier functions. Patients with better skin care habits presented better skin barrier functions and clinical improvement.
Conclusion: Patients with rosacea, especially those with poor skin care habits, showed reduced skin barrier functions. Appropriate skin care habits with cleansers and moisturizers are recommended for the management of rosacea. (Korean J Dermatol 2021;59(10):770∼777)

KCI등재 SCOPUS

6A Clinical Study of Trichotillomania in 198 Cases: An Update and Cross-Time Comparison

저자 : Ji-hoon Lim , Ki-hun Kim , Soon-hyo Kwon , Woo-young Sim , Bark-lynn Lew

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 778-784 (7 pages)

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Background: Trichotillomania (TTM) is characterized by recurrent hair pulling, resulting in hair loss. TTM is typically encountered in dermatology settings; however, few reports on the clinical characteristics of TTM in a large population are available.
Objective: To evaluate the clinical characteristics of TTM.
Methods: We performed a retrospective chart review of patients diagnosed with TTM between 2006 and 2019.
Results: Clinical records of 198 patients were analyzed. The average age of TTM onset was 10.8 years, and 119 patients experienced childhood-onset (at <12 years). Sex prevalence showed a female predominance, and the proportion of females was lower in the childhood-onset TTM than in the late-onset TTM (onset at ≥12 years). Vertex was the most commonly involved site. A history of stressful situations was noted in 48 patients (24.2%). In the group with a poor prognosis, the number of patients with ≥25% scalp invasion was significantly more than the other group. The average duration of hair loss to more than 50% recovery was 4.88 months for childhood-onset TTM cases and 9.83 months for late-onset TTM cases. The prognosis was significantly better in the childhood-onset TTM than in the late-onset TTM. Nail biting and folliculitis were the most common co-occurring repetitive behavior and comorbid disease, respectively.
Conclusion: Unlike previous domestic studies, patients with childhood-onset TTM had a female preponderance. Moreover, the proportion of patients who experienced a stressful situation was higher than that reported in a previous study. In addition, patients with severe disease and late-onset TTM had a significantly poorer prognosis. (Korean J Dermatol 2021;59(10):778∼784)

KCI등재 SCOPUS

7Port-Wine Stains Confined to a Single Cosmetic Unit than on Multiple Cosmetic Units Respond Better to Pulsed Dye Laser Treatment: A Retrospective Study

저자 : Gyoo Huh , Jin Seop Kim , Heun Joo Lee , Young-jun Choi , Ga-young Lee , Won-serk Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 785-792 (8 pages)

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Background: Cosmetic units are designated based on their similarity in topographic anatomy, texture and color, solar exposure, hair density, and sebaceous features. The difference of such features in facial port-wine stain (PWS) cases can affect the response to pulsed dye laser (PDL) treatment.
Objective: To evaluate the response of facial PWS to PDL treatment based on the underlying cosmetic units.
Methods: A retrospective study was conducted on 18 patients with facial PWS who received PDL treatment. For clinical assessment, three dermatologists evaluated the photographs taken before each treatment session. The response grade was assigned according to the quartile grading scale. The lesion was classified based on the underlying cosmetic units.
Results: The cheek was the most (50%) commonly involved area. All PWS (6/6) confined to one cosmetic unit showed a marked improvement compared with 16% PWS (2/12) affecting two or more units (p<0.05). Patients with PWS within one cosmetic unit required fewer treatment sessions to achieve marked improvement.
Conclusion: PWS confined to a single cosmetic unit than that located in two or more units responded better to PDL treatment. Before PDL treatment for facial PWS, age, initial lesion size, as well as the number of cosmetic units affected by the lesion should be considered. (Korean J Dermatol 2021;59(10):785∼792)

KCI등재 SCOPUS

8크론병 환자에서 발생한 다발성 보웬병 1예

저자 : 조민아 ( Minah Cho ) , 이정덕 ( Jeong Deuk Lee ) , 조상현 ( Sang Hyun Cho ) , 우유리 ( Yu Ri Woo ) , 김혜성 ( Hei Sung Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 793-796 (4 pages)

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A 47-year-old man with a 25-year history of Crohn's disease, presenting asymptomatic erythematous scaly patches (size, 1∼3 cm in diameter) on his back, left hand, right wrist, left ankle, and left sole, visited our clinic. Histopathological examination of the lesions revealed Bowen's disease. Herein, we report a rare case of multiple Bowen's disease in the skin, away from the anogenital region, in a patient with Crohn's disease. (Korean J Dermatol 2021;59(10):793∼796)

KCI등재 SCOPUS

9간찰 부위에서 발생한 전신형 고리 육아종 1예

저자 : 허규 ( Gyoo Huh ) , 이현주 ( Heun-joo Lee ) , 최영준 ( Young-jun Choi ) , 김원석 ( Won-serk Kim ) , 이가영 ( Ga-young Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 797-800 (4 pages)

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Granuloma annulare (GA) is a common non-infectious granulomatous disease. Generalized GA is the second most common variant of GA. It is often associated with recalcitrant disease progression despite treatment. The lesion of generalized GA typically presents widespread papules that coalesce to form annular plaques over the whole body. We report a case of a patient with disseminated papules and coalescing annular plaques, primarily involving the intertriginous area and mimicking tinea corporis or cruris. Histopathological findings confirmed the lesion as GA. This case underscored the unusual clinical presentation of generalized GA. A case of GA localized to the intertriginous area has rarely been reported. Given the recalcitrant nature of the disease, dermatologists should consider generalized GA as a differential diagnosis in patients with an annular lesion involving the intertriginous area. Thus, we report this as an atypical case of generalized GA localized to the intertriginous area. (Korean J Dermatol 2021;59(10):797∼800)

KCI등재 SCOPUS

10A Case of Lyme Disease Followed by Post-Treatment Lyme Disease Syndrome

저자 : Sung Ha Lim , Eung Ho Choi

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 10호 발행 연도 : 2021 페이지 : pp. 801-804 (4 pages)

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Lyme disease caused by Borrelia species is transmitted via infected tick bites. Erythema migrans, a typical skin lesion on the tick-bitten site, is a hallmark of Lyme disease. A 63-year-old female presented an erythematous, semi-circular patch in the left inguinal area. It disappeared spontaneously without treatment. However, after 3 months, an erythematous patch with a diameter of 1 cm recurred on the left thigh. B. burgdorferi antibody testing revealed positive results. At the second visit, doxycycline was prescribed, and the skin lesion was resolved. However, the patient exhibited persistent systemic symptoms, including arthralgia and fatigue, and was diagnosed with post-treatment Lyme disease syndrome (PTLDS). The PTLDS prognosis is associated with delayed diagnosis. Thus, antibiotic treatment should be promptly initiated after suspecting Lyme disease to minimize the associated systemic symptoms. PTLDS diagnosis should be followed by proper medical care to alleviate the symptoms. (Korean J Dermatol 2021;59(10):801∼804)

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KCI등재SCOUPUS

1종설 : UVA , UVB 차단지수 측정방법과 이에 영향을 미치는 요인

저자 : 윤재일 ( Jai Il Youn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1043-1051 (9 pages)

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Recently, exposure to sunlight is increasing due to expanded life time, outdoor leisures, and reduced sun  protective ozone layer. Sunlight can produce not only benefit but also various kinds of harmful effect, such as skin carcinogenesis, photoaging and immunologic alterations, These effects can be minimized by sunscreens. This article reviews the methods to measure a suncreens efficacy and factors influencing the measurement. I. Measurement of photoprctective efficacy 1)The sun protective factor(SPF): The SPF is defined as the ratio of the UVB doses required to produce minimal erythema dose(MED) with sunscreen applied to without it. However, the exact procedures are not estabiished and the value is varied by methods. 2)Photoprotective factor A(FFA): In spite of its clinical improtance, evaluation of UVA protection rernains a problem due to its physiologic features. The methods to measure UVA protection are by the use of erythemal, phototoxic and pigmentary rections. 3)Outdoor measurement: It is ideal to measure the photoprotectiveness outdoor but a wide variation in value results from radiance sources and environmental factors. II. Factors influencing the evaluation The radiance sources, individ zal sensitivity to sunlight, product components and various environmental fact.ors can make differences. Conclusion As more sunlight, exposure, he irnportance of photoprotection is increasing. The exact methods to measure the protectiveness of UVA and UVB should be established, especially adjusted to Korean people (Korean J Dermatol 1997;35(6): 1043-1051)

KCI등재SCOUPUS

2원저 : 옻나무에 의한 알레르기성 접촉피부염과 경구복용에 의한 전신성 접촉피부염의 면역조직화학적 비교

저자 : 정소희 , 조상현 , 이상진 , 김시용 ( So Hee Jeong , Sang Hyun Cho , Sang Chin Lee , Si Yong Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1052-1058 (7 pages)

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Background: The rhus has been known to be such a potent allergen that it causes severe contact dermatitis, and mary studies have tried to reveal the mechanism of allergic contact. dermatitis to urushiol. However, the mechanism of systemic contact dermatitis to urushiol is not, well-known, though the consumption of rhus as a health product and for desensitization is not unconmon in Korea. Objective : The purpose of this study was to evaluate the niechanism of systernic contact dermatis, and we carried out irnmunohistochemical stainings un the two strands of dermatitis (systemic arid,llergic contact dermatitis). Methods : The patients of systemir, contact dermatitis were divided into three groups by duration and severity of the illness according to the desired criteria. We perfor med immunohistor,hernical staining of the tissues from the pat.ients with anti CD4, CD8, CDla, ICAM-1, II,-ZR monoclorial antibodies. Results : 1. The results  were as follows. 1. The immunohistochemical staining showed that CD8 positive cell numbers in systemic contact dermatitis(18 -L 1 0) were significantly lower than those of allergic contact der matitis(37 +- 13) ( p< 0.05). 2. The expressions of HLA-DR and ICAM-1 in the keratinocytes were not significantly different. between systemic and allergic contact derrnatitis(p>0.05). Conclusion : The result suggest that lower numbers of CDH positive T cell in systemic contact dermatitis caused a reduation in the suppressor effect to the urushiol  mediated immune rection and CD8 positive T cells play an important role in systemic contact dermatitis due to rhus. (Korean J Dermatol 1997;35(6): 1052-1058)

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3원저 : 멜라닌 세포성 병변에서 화상분석법을 이용한 DNA 배수성에 관한 연구

저자 : 이길주 , 김동준 , 오칠환 ( Gil Ju Yi , Dong Jun Kim , Chil Hwan Oh

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1059-1065 (7 pages)

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Backgroutld: In the cutaneou; neoplasms, especially melanocytic skin lesions, the degree of t.he nuclear atypia such as the hyp rchromatism, pleomorphism, and giantism is a very impor tant factor when determining the differntial diagnosis between the malignant. and the benign turnors and the prognosis. Objective : So we measured and cornpared the nuclear atypia of the malignant melanoma, and acquired and congenital melanocytic nevi(AMN and CMN) using the computerized image analysis (IA). Methods : Five micron ser,t ons were cut from each paraffin block. The sections were Feulgen-stained and image analysis was perforrned with an AIC image analysis system. In each case, 50 lymphocytes nuclei fnim the sarne specimen slide were measured as an internal diploid control. Each 100 cells of the MM, CMN and AMN were measured and are referred to in this report as the upper part and the lower part. The morphological parameters such as mean nuclear area, coefficient of variation(CV) of the nuclear area, roundness of the nucleus and CV of the roundness were measured. For the nuclear content, mean ploidy, CV of the mean ploidy ind 2c  Deviation Index(2cI3I) were calculated and then the DNA histograms were produced. Results : Nuclear area, CV of the nuclear area, mean ploidy, CV of the mean ploidy and 2cDI were found to be significantly reat.er for rnalignant melanoma than for CMN and AMN. The nuclear area of AMN is significantly lar ger than that of CMN and there were no significant differences between the uper and the lower part.s of three melanocytic lesions in any of the measured parameters. Conclusion . The results of o ir study suggest that the IA of the melanocytic cells might reflect the biologic behavior rnore sensitively t,han do clinical or histologic criteria, therefore important information for differentiating thi benign and the malignant melanocytic lesions may be obtained by the DNA profile and morphomi try on Feulgen st,ained tissue specirnens using IA.(Korean J Dermatol 1997;35(6): 10591065)

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4원저 : 대상포진 환자에서 T 림프구 아형 및 회상항원에 대한 관찰

저자 : 서석배 , 김광중 , 이종주 ( Suk Bae Suh , Kwang Joong Kim , Chong Ju Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1066-1073 (8 pages)

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Background: The incidence of herpes zoster is higher among patients with impaired cell  mediat,ed immunity. Herpes zoster skin lesions frequently become more severe and run a more protracted course in such patients. Objective : This study aimed to firstly elucidate whether there are changes in cell  mediated immunity, even in immunocompetent, patients with herpes zoster, and secondly to investigate relationships between these change and the clinical appearance of herpes zoster. Methods : T lymphocyte sub;et,s in peripheral blood and delayed hypersensitivity reactions using the Multitest CMI kit were measured in 33 healthy patients with herpes zoster and 28 controls. Results : As compared with controls, there was a slight decrease in percentages of CD4 lym-phocytes, a significant decr eas in percentages of CD8 lyrnphocytes, and a slight increase in CD4/ CD8 ratios in the acute phasr of herpes zoster. The percentages of CD3 lymphocytes were also significantly decreased. Baseg i)n the severit,y of the skin lesion, t.her e was a significant increase in duration of acute herpetic pain. However, there were no signigicant differences in percentages of T lymphocyte subsets based on the severity of skin lesion and duration of acute horpetic pain. In delayed hypersensitivity rea.tions with the Multitest" CMI kit, the intensity and frequencies of positive reactions were signific,intly decreased in the patients group. Conclusions . There are sigr.ificant changes in peripheral blood T lymphocyte subsets and delayed hypersensitivity reactions even in other wise healthy patients. (Korean J Dermatol 1997;35(9): 1066-1073)

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5원저 : 역 모낭성 각화증의 임상적 고찰 및 Human Papillomavirus의 검색에 관한 연구

저자 : 안성구 , 이인욱 , 최응호 , 이원수 , 이승헌 , 이동원 ( In Wook Lee , Eung Ho Choi , Sung Ku Ahn , Won Soo Lee , Seung Hun Lee , Dong Won Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1074-1081 (8 pages)

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Background : Inverted follicular keratosis has distinctive histopathological features and is infre quently encountered by dermatologists. To date, the pathogenesis of inverted follicular keratosis has not, been concluded. Many authors have suggest,ed several theories for the nature of invert.ed follicular keratosis including vearuca vulgaris with squamous eddies, irritated seborrheic keratosis and dist,inctive follicular tumors. Objective : It is the purpose of this study to observe and compare the clinical features of in verted follicular keratosis with previous studies and evaluate the possible relationship between in verted follicular keratosis and human papillomavirus to clarify the nature of this condition. Methods : We studied 9 patients with inverted follicular keratosis for clinical features including the duratiori of the disease, the location and size of the lesions, the clinical impressions at the first visit and we made a record of the patients age and sex. To evaluate the relationship be tween inverted follicular kerato is and the human papillomavirus, we performed immunohistochvm ical staining using polyclonal antibodies to the human papillomavirus common antigen. We also used the polymerase chain relation to detect hurnan papillomavirus DNA in inverted follicular keratosis from paraffin embedded tissue preparation. 
Results : 1. Seven of the 9 patients,vere male and the ages ranged fiom 36 to 77 years(mean 53 years). The lesions were situat d on the face(4/9),abdomen(1/9), back(1/9), chest(1/9), scapular area(1/9) and leg(1/9). The average size of the lesions was 1.5 cm. Verruca vulgaris was the most common clinical diagnosis(3/9), followed by seborrheic keratosis(2/9), soft fibroma(2/9), pigmented nevi(1/9), and granioloma pyogenicum(1/9). 2. Immunohistochemical stainiiigs using polyclonal antibodies to the human papillomavirus common antigen were negative for all 9 cases. 3. Polymerase chain reaction; using primers for human papillomavirus DNA were negative for all 9 cases. Conclusipn : In general, our linical findings are similar to those of others in previous studies. Our results of immunohistocheriiical staining and the polymerase chain reactions suggest, that in vert,ed follicular keratosis is ncl, related to the human papillomavirus. Further investigat.ions inf'o the nature of invert,ed follicular keratosis, should be centered on initated seborrheic keratosis and distinct follicular tumor s. (Korean J Dermatol 1997;35(6): 1074-1081)

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6원저 : 편평 사마귀에 대한 DNCB와 DPCP 면역요법의 치료 효과에 대한 비교 연구

저자 : 박종혁 , 김성진 , 이승철 , 원영호 , 전인기 ( Jong Hyuk Park , Seong Jin Kim , Seung Chul Lee , Young Ho Won , Inn Ki Chun

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1082-1087 (6 pages)

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This stuc1y was conducted to evaluate the therapeutic effect of immunotherapy on verruca plana. Forty-four patients with verruca plana were tried with dinitrochlorobenzene(DNCB) and diphenylcyclopropenone(DPCP) by topical application on the norinal uninvolved skin of the inner arms for sensitization and challenge. The lesions were challenged in weekly intervals after sensitization. The results obtained in this study are as follows. 1. Mean age of our patients was 20-year-old and sex ratio was about 1:2 (14 of male, 30 of female). 2. Tbe sites of the lesion weve face (60.9%), neck (7.2%), trunk (2.9%), arm (li3.0%), hand (11.6% ), leg (4.3% ). 3. Thirty  two patients (72.7%) from 44 cases were completely cured after DNCB (81.3%) and DPCP (67%) treatment and iesions on younger patients showed a better response than those of of older patients(p<0.05). 4. There were no statistic relationship between duration of the lesions and therapeutic response. 5. Average challenge number after sensitization was 3.77 in DNCB, 2.26 in DPCP, respectively. 6. Sensitization rates in the cured patients were to treat verruca plana 94.7% (18/19) in DNCB, 76.9% (10/13) in DPCP, respectively. (Korean J Dermatol 1997;35(6): 1082-1087)

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7원저 : 레티노이드에 의한 악성 흑색종 세포주의 bcl - 2 발현에 관한 연구

저자 : 방성원 , 박영립 , 황규왕 ( Sung Won Bang , Young Lip Park , Kyu Uang Whang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1088-1094 (7 pages)

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Background: Apoptoss plays a major role in cellular proliferation and differentiation in tumor cells. Bcl-2, proto-oncogene, is known to inhibit apoptotic cell death of tumor cells. The high expression of bcl-2 in human melanoma cells over transforrned keratinocytes has been reported. The Loton group indicated that the growth of human melanoma cells exposed to ret.inoids was inhibit ed and their cellular melanin content incrensed over that of the untreat,ed ce1Ls. The Veis group reported that bcl-2 defieient mice showed hypopigmented hair. Which suggests that bcl-2 may in volve melanogenesis. The Above mentioned findings may suggest that. bcl-2 and retinoids may play a role in melanoms biology. Objective : We under ook this study to elucidate a possible relationship between retinoids and bcl-2 expvessions in human melanoma cell lines. Methods : We analysed bcl-2 expressions from SK 28 cells(melanoma cell lines) after pretreat ment with retinoids using flow cytometry and imtnunoblotting. Results : 1. In the results of the preliminary studies, we found that cultured human keratinocytes, fibro blasts and melanocytes n the resting state showed expressions of bcl-2. The latter showed a four fold expression of bcl-2. 2. Expression of bcl-2 was detected in SK 28, a human melanoma cell line, in the resting state. 3. After incubation with isotretinoin or etretinate treatment at 37'C,  for 48 hours, this treated group showed a more ir creased expression of bcl-2 than the control group. Conclusion : Our data may explain that the mechanism of ret.inoids indur,ing inhibition of mela noma cell growth may be partly due to upregulation of bcl-2 expression. The high base-line ex pression of bcl-2 in melanoma cells may tell us why these pigment cells can survive against oxi dative products generated during melanogenesis. (Korean J Dermatol 1997;35(6): 1088-1094)

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8원저 : 기본첩포검사에서 소실 및 자극반응의 발현빈도

저자 : 김태윤 , 윤두희 , 이준영 , 김형옥 , 김정원 ( Tae Yoon Kim , Dou Hee Yoon , Jun Young Lee , Hyung Ok Kim , Chung Won Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1095-1100 (6 pages)

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Background: The patcl test is widely used for diagnosis of allergic contact dermatitis. However, it is sometimes difficiilt or even impossihle to differentiate between allergic and irritant reactions in patch test readings. The achievernent of valid results from the patch test require intelligent and careful patch testing and physirians with skills and experiences. Objective : The purpos of this study was to assess the frequency, age and sex distr ibution, and the seasonal variatioii of irritant. and lost reactions in standard patch tests. Methods : Patch test records of day 2 and day 4 were reviewed and analysed. Frequency of inritant and lost reactions were analysed by allergen, age, sex and season. Results : A total 212 c ses of standard patch test records(rnale 69, female 143) were analysed. The results were as follovs ; 1. The over  all frequency of lost reactions in the standard patch test were 33.5 percents and that of irritant reactions were 8.0 perr.ents. 2. The frequency of lost reactions was lower in the age groups under twenty(7.7%) than in the older age groups(35.5%). However, there was no significant difference het,ween the age groups over the third dec ide. 3. The seasonal variation was evident in lost reactions. The order of frequency was summer(45. 0% ), winf,er(33.7% ), spri,ig and fall(2l.1% ). 4. The order of frequency of lost reactions in the stclndard patch allergen was captan(5.7%), potassium dichromate(5.2%), cobalt chloride(4.7%), mercury amrnoniurn chloride(3.8%) c3lld wool alcohol(3.8%) Conclusion : Our result, show a relatively high frequency of lost and irritant. reaction in the standird patch test, and uggest second readings in the patch test would he of value. (Korean J Dermatol 1997;35(6): 1095-1100)

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9원저 : 발모벽 28예의 임상소견 및 병리조직학적 연구

저자 : 송일문 , 임철완 ( Il Moon Song , Chull Wan Ihm

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1101-1109 (9 pages)

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Background: The patients of trichotillomania seem to have received much attent.ion based on patients behavioral psychologic;l aspects, but most of the patients ar e met in dermatological clinics. Dermatological observation of the lesion dose not seem to not sufficient. Qbject: The purpose of this study is to exarnine clinical and histopathological characteristics of the lesion of trichotillomania. Methods : We have observed 28 cases of the trichotillornania and exarnined their cutaneous lesions and histopathological featwres. Histopathological examination with vertical serial sections was done in 21 cases. Because hai folllicles are independent of each other and a usual 5 thickness vertical sect,ion shows only ver y limited numbers of the hair follicles, authors accomplished sectioning of the biopsied scalp tisue to have 300 serial sections cut and 60 representative sections observed to allow the fullest qiiantitative and qualitative examinations of the follicular pathology of the lesion. Results : The important featuies are as follows. 25 cases(89.2%) were under 18 years old with a slight male predorninance(M:F=1.3:1). Only in 2 cases, psychiatric consultation was made. The degree of involvement was vari ble from less than 5%(6 cases) of the scalp up to 100% involvement of the scalp(3 cases). Thr rnean duration of illness was 12.5 months. The involved hair follicles showed one of the following five roots of hairs they are new hairs with tapered ends, broken short hairs, vellus or intermediate hairs, comedone-like hair bodies or empty follicle orifices. Microscopical observation of thr epilat,ed hairs was done in 16 cases, of which in 13 cases there were no telogen roots of terminal hairs, The histopathological results were as follows : 1. Catagen follicles were incr:ased in 20 cases(95.2%). The actual number of catagen follicles was 1386(37.5%) out of a tota 3695 follicles observed in the total examined slides. 2. Trichornalacia were seen ir 11 cases(52.4%). The actual number of hairs with trichomalacia was 195(10.5%) out of a total 1005 hair canals observed. 3. Pigment clumps of the follicular infundibula were seen in 9 cases(42.9%). The actual num- ber of the pigment-laden infundibula was 148(17.9%) out of a total 826 infundibula observed. 4. Destruction of the hair canal wall were seen in 4 cases(19.0% ). The actual number of destructed hair canal wall was 190(10.2%) out of a total 1863 hair canals observed. Hernorrhage around the follicles was not seen. Conclusion : The involved areas of trichotillomania were varied in size up to the whole scalp and showed four different type., of hairs. Histopathologically catagen follicles increased in almost all cases with 37.5% of all follicles examined. Trichomalacia, pigmented clumps, and the destruction of hair canals were seen by less frequently. (KOrean J Dermatol 1997;35(B): 1101-1109)

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10원저 : 비흑색종의 종양과 그 주위 상피 세포에서의 p53 , PCNA , bcl - 2에 대한 면역조직화학 염색 양상

저자 : 김종구 , 윤태영 , 장승호 ( Jong Goo Kim , Tae Young Yoon , Seung Ho Chang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1110-1120 (11 pages)

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Background: In both normal tissue development and malignant cell growth, the maintenance of cell numbers reflects a balance between cell proliferation and cell death. Excessive growth may result from uncontrolled cellular proliferation or limited cell death. The growth process of squa mous cell carcinorna(SCC) has recently been reported to differ from that of basal cell carcinoma (BCC). Several reports have suggested that the normal-appearing, overlying epidermis might be a proliferative and be a precursor lesion of BCC. SCCs occur in burn scars, chronic ulcers, and chronic sinus but the najority of SCCs are actinic in origin. It. is possible to develop subsequent. skin cancer from the normal-appearing epidermis adjacent to SCC due to chronic sun-exposure. Objective : The purpose of this study was to investigate growth dynamics of non-melanorna skin cancers and characteristics, including the carcinogenic property, of the normal  appearing epidermis overlying and acljacent to non  rnelanoma skin cancers. Methods : We compared expressions for p53, PCNA, bcl  2, and TGF-a in 21 BCCs and 8 SCCs by irnmunohistochi.mical staining with a labelled strept,avidin  biotin complex(LSAB) method. Results . The results were as follows. 1) Expressions for p53 and PCNA within the tumor remarkably increased and the distribution pattern of expression for p53 was not always consistent with that for PCNA. 2) An expression the bcl-2 was increased in half of the BCCs, but not in all of the SCCs. 3) The epidermis overlying the BCC showed increased expressions for p53, PCNA, and TGF-a. 4) The epidermis adjacent to the SCC showed increased expressions for p53, and PCNA in a few of cases. Conclusion : We suggest that a neoplastic transformatiqn in BCC is caused by extended cell survival rather than ini:reased cell proliferation, but in SCC it. is caused by other mechanisms, and that the proliferativ activity in the epiderrnis overlying BCC is different from the normal epidermis and maybe repr'sents carcinogenic activity of the epidermis. (Korean J Dermatol 19()7;35(6): 1110-1120)

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