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대한천식알레르기학회> 천식 및 알레르기> 증례: 가족성 한랭 두드러기 1례

증례: 가족성 한랭 두드러기 1례

이지호 , 박영민 , 김태윤 , 김형옥 , 김정원
  • : 대한천식알레르기학회
  • : 천식 및 알레르기 16권4호
  • : 연속간행물
  • : 1996년 11월
  • : 548-552(5pages)
천식 및 알레르기

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Familial cold urticaria is a rare abnormal cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown etiology. A 21  year  old male patient presented with generalized erythematous macules and papules accompanied by burning, chills and arthralgia after cold exposure since early childhood. Autosomsl dominant inheritance was revealed on the examination of his pedigree. Autosomal dominant inheritance was revealed on the examination of his pedigree. Cold room challenge induced the same lesions after a delay of 20 min. Histopathologic findings showed a perivascular polymorphonuclear leukocytic infiltrstion with some eosinophils. He was treated with several antihistamines, but unsatisfaetory. We report a patient with a familial cold urticaris showing typical cutaneous manifests- tions and general symptoms with a consistent familial history through his five generations.

UCI(KEPA)

I410-ECN-0102-2009-510-005560944

간행물정보

  • : 의약학분야  > 내과학
  • :
  • :
  • : 계간
  • : 1226-8739
  • :
  • : 학술지
  • : 연속간행물
  • : 1981-2012
  • : 1614


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32권4호(2012년 12월) 수록논문
최근 권호 논문
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1종설 : 장기 생존 형질세포

저자 : 이주석 ( Ju Suk Lee )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 203-206 (4 pages)

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Plasma cells are usually considered short-lived plasma cells. This view is changing because plasma cells can survive for a long time in bone marrow. Long-lived plasma cells may be important in allergy because of the persistence of immunoglobulin E in allergic animal models after immune suppression. Allergic therapies efficiently control allergic symptoms but do not provide a cure, especially in adults. Elimination of long-lived plasma cells that secrete specific immunoglobulin E may provide a cure in allergic patients. The purpose of this review is to describe the creation of long-lived plasma cells and their importance in allergic diseases.

2종설 : 알레르기질환에서의 Type 2 Innate Lymphoid Cell의 역할

저자 : 모지훈 ( Ji Hun Mo )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 207-212 (6 pages)

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Innate lymphoid cells have recently been identified to be a cell population that has morphology typical of lymphocytes but lacks rearranged antigen receptors. It can be classified into RORγt innate lymphoid cell, type 2 innate lymphoid cells and natual killer cells. Among them, type 2 innate lymphoid cells plays an important role in type 2 immunity by releasing type 2 cytokines, such as interleukin-5 and interleukin- 13, and makes a match for Th2 cell of the adaptive immune system. Type 2 innate lymphoid cells responses are initiated by interleukin-25 and interleukin-33, which are produced by several cell types, such as epithelial cells, tissue macrophages and dendritic cells. These cytokines strongly activate type 2 innate lymphoid cells, leading to the production of type 2 cytokines, including, interleukin-5 and interleukin- 13. In this review, we will discuss the characteristics and development of type 2 innate lymphoid cells and the role of type 2 innate lymphoid cells in allergic diseases in detail.

3논평 : TARC (CCL17), MDC (CCL22): 알레르기 염증반응의 생체 지표로서의 의의

저자 : 양현종

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 213-215 (3 pages)

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4원저 : 소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성

저자 : 정보현 ( Bo Hyun Chung ) , 이해성 ( Hae Sung Lee ) , 서현석 ( Hyeon Seok Seo ) , 박하늘 ( Ha Neul Park ) , 지그프리드바우어 ( Siegfried Bauer ) , 서성철 ( Sung Chul Seo ) , 윤원석 ( Won Suck Yoon ) , 정지태 ( Ji Tae Choung ) , 유영 ( Young Yoo )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 216-223 (8 pages)

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Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation. Recently many researchers have focused on these mediators, but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22 between children with different manifestation of allergic diseases, such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers. Methods: A total of 49 children (14 bronchial asthma, 13 allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels, blood eosinophils and serum eosinophil cationic protein concentrations. Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17 and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases. Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.

5원저 : 군대 훈련 중 흡입항원에 대한 감작률과 알레르기질환 유병률의 변화

저자 : 황세민 ( Se Min Hwang ) , 김희경 ( Hee Kyung Kim ) , 김성화 ( Seoung Hwa Kim ) , 강점숙 ( Jum Sook Kang ) , 주영훈 ( Young Hoon Joo ) , 이상민 ( Sang Min Lee )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 224-230 (7 pages)

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Background: The objective of this study was to evaluate changes in the prevalence of sensitization to inhalant allergens and allergic disease among young army conscripts during a 35-day military training course. Methods: Fifty-four young soldiers who conscripted into the Korean army on April 29, 2011 were enrolled after their informed consent. Their sera were sampled on day 1 to measure total immunoglobulin E and allergen-specific immunoglobulin E to common inhalant allergens using UNICAP(R) and the Multiple Allergen Simultaneous Test(R), respectively. Their sera were sampled again on day 35 to evaluate temporal changes in total immunoglobulin E and allergen-specific immunoglobulin E. Subjects were also requested to respond to the modified International Study of Asthma and Allergies in Childhood questionnaire on day 35 to evaluate the prevalence of allergic diseases. Results: The number of subjects sensitized to birch/alder increased from 1 (1.9%) to 4 (7.4%) during military training; however, the difference was not statistically significant. The status of sensitization to other allergens and serum total immunoglobulin E levels did not change significantly. Of the 54 subjects, 9 (16.7%) experienced new onset or exacerbation of allergic disease. However, most of subjects were not diagnosed with allergic diseases by a physician, nor did they receive proper treatment for their symptoms. Conclusion: A 35-day course of military training was insufficient to change the inhalant allergen sensitization status; however, some young army conscripts suffered from new onset or exacerbation of allergic diseases during military training that were not diagnosed or treated appropriately.

6원저 : MLE12 및 RAW264.7세포에서 Alternaria와 Alternariol Mycotoxin의 알레르기 염증반응 효과

저자 : 최길순 ( Gil Soon Choi ) , 김희규 ( Hee Kyoo Kim )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 231-238 (8 pages)

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Background: Alternaria and their secondary metabolites, alternariol mycotoxins, may cause respiratory symptoms and asthma. Moreover, microbial compounds, such as bacterial endotoxins, act as potential contributors in such situations. Alveolar epithelial cells and macrophages appear to initiate airway inflammation through proinflammatory cytokines after exposure to aeroallergens or toxic materials. The present study investigated the effects of Alternaria and alternariol mycotoxins on inflammatory cytokines secreted from airway epithelial cells and macrophages, especially interleukin-33, interleukin-6 and tumor necrosis factor-α, which were assessed association with lipopolysaccharide. Methods: In vitro MLE12 cells and RAW264.7 cells were treated with Alternaria, alternariol monomethyl ether and alternariol at different doses for 24 hour. The levels of interleukin- 33, interleukin-6, and tumor necrosis factor-α in each cell supernatants were measured by ELISA. Then, each mycotoxin (100 ng/mL) was added to lipopolysaccharide stimulated cells and incubated with them. Cell viability was measured by flow cytometry. Results: Alternaria and alternariol mycotoxin-treated cells released pro-inflammatory cytokines partly in a dose-dependent manner. Moreover, lipopolysaccharide induced the synergic effect of mycotoxins on cytokine production by RAW264.7 cells. However, the different cytokine productions among groups were not related to cell viability. Conclusion: This study suggests that alternariol mycotoxins, such as Alternaria, would provoke airway inflammation through interleukin-33, interleukin-6 and tumor necrosis factor- α uction from epithelial cells and macrophages.

7원저 : 만성기침에 대한 한국 알레르기 전문의들의 인식과 진료 실태; 설문조사

저자 : 김상헌 ( Sang Heon Kim ) , 김세훈 ( Sae Hoon Kim ) , 송우정 ( Woo Jung Song ) , 권재우 ( Jae Woo Kwon ) , 김민혜 ( Min Hye Kim ) , 김경묵 ( Kyung Mook Kim ) , 정재원 ( Jae Won Jeong ) , 김상훈 ( Sang Hoon Kim ) , 안영민 ( Young Min Ahn ) , 조은정 ( Eun Jung Jo ) , 이승은 ( Seung Eun Lee

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 239-253 (15 pages)

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Background: Chronic cough is a common but disabling respiratory symptom. While patients are frequently referred to allergists for the management of chronic cough, little is known about the perception and clinical practices of allergists on the management of chronic cough. Methods: We performed a questionnaire survey using e-mail and internet platform among the members of the Korean Academy of Asthma, Allergy and Clinical Immunology (n=823). The members were asked to answer the questions regarding the diagnosis and treatment of chronic cough. Results: Questionnaires were completed and returned from 154 subjects (18.7%). There was a heterogeneity in the definitions (durations) of chronic cough, and only 62 subjects (40.3%) defined chronic cough when cough lasted more than 8 weeks. Most subjects (n=131, 85.1%) felt the need for Korean guidelines on chronic cough, while only 89 subjects (57.8%) used the other guidelines in their practice. Various diagnostic tests were used for the evaluations of chronic cough, and chest radiography, paranasal sinus radiography and spirometry were the most frequently performed for the management. Upper airway cough syndrome was perceived as the most common cause of chronic cough, followed by asthma, postinfectious cough and gastroesophageal reflux disease/laryngopharyngeal reflux. Moreover, treatment patterns of these most common clinical conditions differ among studied subjects. Conclusion: There were diverse patterns in the diagnosis and treatment of chronic cough among Korean allergists. Our results could assist in establishing guidelines and health policy on chronic cough management.

8원저 : 만성 자발성 두드러기 환자에서 자가혈청 피부반응검사에 따른 검사실 소견과 증상 조절을 위한 약제의 비교

저자 : 이수경 ( Su Kyoung Lee ) , 조민호 ( Min Ho Cho ) , 김병연 ( Byeong Yeon Kim ) , 강윤성 ( Yun Sung Kang ) , 최승헌 ( Seung Heon Choi ) , 손성욱 ( Seong Wook Sohn )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 254-258 (5 pages)

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Background: The autologous serum skin test is reported to be positive in up to 60% of patients with chronic spontaneous urticaria. However, the clinical role of autologous serum skin test is still poorly understood. Methods: We reviewed the medical records of 166 chronic spontaneous urticaria patients whose symptoms lasted for more than 6 weeks and compared their laboratory findings and medication levels according to autologous serum skin test reactivity. Results: Autologous serum skin test was positive in 69 (41.6%) chronic spontaneous urticaria patients. There were no significant differences between autologous serum skin test-positive and autologous serum skin test-negative groups in laboratory findings, such as anti-microsome antibody, anti- thyroglobulin antibody, anti-nuclear antibody, total immunoglobulin E, complement 4 level levels, rheumatoid factor, erythrocyte sedimentation rate and D-dimer. Autologous serum skin test were not related to medication levels. Eight patients (11.6%) of autologous serum skin test-positive groups and 6 patients (6.2%) of autologous serum skin test-negative groups need level 4 medication (usage of cyclosporine, dapsone or anti-immunoglobulin E monoclonal antibody) to control urticaria without statistical significance. Conclusion: Autologous serum skin test was positive in more than 40% of chronic spontaneous urticaria patients. However, laboratory findings and medication levels were not affected by autologous serum skin test reactivity.

9증례 : 수은 증기 흡입에 의한 급성 폐손상 및 급성 전신성 발진성 농포증 1예

저자 : 서현정 ( Hyun Jung Seo ) , 명유식 ( Yu Sik Myung ) , 정희재 ( Hee Jae Jung ) , 김민진 ( Min Jin Kim ) , 서유리 ( Yu Ri Seo ) , 박경아 ( Kyong Ah Park ) , 박춘식 ( Choon Sik Park ) , 박재성 ( Jai Soung Park ) , 박종숙 ( Jong Sook Park )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 259-263 (5 pages)

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Background: Inhalation of mercury vapor is very rare, but if it occurs, fatal damage, such as acute lung injury or death, may ensure. In addition, acute generalized exanthematous pustulosis due to mercury hypersensitivity has rarely been reported in the literature. We experienced a 49-year-old male patient who had been exposed to mercury vapor following burning of mercury-containing materials. Case History: The patient complained of dyspnea, fever, and systemic erythema. Physical examination revealed that he had macular erythema with tiny pustules. His body temperature was 38.3oC and a complete blood count revealed elevated leucocytes. Chest radiographs revealed diffuse airspace opacification in both lungs. Results: He was admitted to the intensive care unit and treated with oxygen, intravenous methylprednisolone 125 mg per day, and oral antihistamines. His symptoms improved and his skin lesions resolved completely with desquamation 5 days. On the eighth hospital day, intravenous methylprednisolve was tapered to 62.5 mg methyprednisolone, followed by oral methyprednisolone. He was discharged from the hospital on the 20th hospital day and is currently being followed-up with no aggravation of symptoms or relapse. Conclusion: We report a case of acute lung injury and acute generalized exanthematous pustulosis induced by inhalation of mercury vapor that was successfully treated with early avoidance and steroid therapy.

10증례 : 유전성 혈관부종 환자에서의 성공적인 제왕절개 분만 1예

저자 : 이서영 ( Suh Young Lee ) , 이승은 ( Seung Eun Lee ) , 김민혜 ( Min Hye Kim ) , 송우정 ( Woo Jung Song ) , 강혜련 ( Hye Ryun Kang ) , 민경업 ( Kyung Up Min )

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 32권 4호 발행 연도 : 2012 페이지 : pp. 264-267 (4 pages)

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Background: Hereditary angioedema is a rare disease caused by a deficiency of C1 inhibitor and inherited in an autosomal dominant manner. It leads to episodic abdominal pain and angioedema which can be life-threatening. Associations between hereditary angioedema and pregnancy have been reported in the literature. The frequency of symptoms increases during pregnancy and the postpartum period. While complications during vaginal delivery are generally known to be rare in patients with heterditary angioedema, acute attack of heterditary angioedema may occur during Cesarean section. Case History: A 34-year-old pregnant woman was admitted for the induction of labor with suspected preeclampsia. The patient was diagnosed with hereditary angioedema 5 years ago and treated with tranexamic acid when needed. During the first trimester of pregnancy, the incidence of attacks increased but she did not take any medication. She had prophylactic tranexamic acid for 2 weeks before delivery. Emergency Cesarean section was performed due to fetal deceleration that occurred during labor induction. Results: After injection of a C1 inhibitor in the phase of anesthesia induction, delivery was successful without any complications. Conclusion: We report a case of Cesarean section delivery with a prophylactic use of a C1 inhibitor in a patient with hereditary angioedema.

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1종설: Glucocorticoid의 항염작용의 기전

저자 : 조영주

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 467-475 (9 pages)

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2종설: 진균과 알레르기 질환

저자 : 김규언

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 476-484 (9 pages)

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3원저: Steroid 제제가 호산구 생존율에 미치는 영향

저자 : 최영수 , 이영목 , 김경호 , 김효석 , 임건일 , 문승혁 , 정성환 , 김현태 , 어수택 , 김용훈 , 박춘식

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 485-493 (9 pages)

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Objectives: To evaluate the inhibitory effect of corticosteroids including hydrocortisone, methyl- prednisolone, dexamethasone on the survival of eosinophils. Method: Eosinophils were purified from allergic patients with peripheral eosinophilia. Survival rate of eosinophils in the presence of IL  5 were measured by using flowcytometer. The inhibitory effect of corticosteroids were compared to spontaneous and IL  5 induced survival of eosinophils rates. Results: 1) Spontaneous survival rates of eosinophils rapidly decreased below 10k at the 3rd day of culture in the absence of IL  5, 2) IL  5 prolonged the survival of eosino- phils dose dependently. 3) Corticosteroids including hydrocortisone, methylprednisolone, dexamethasone did not have any inhibitory effect on the spontaneous survival of eosinophils.  4) Hydrocortisone significantly decreased IL  5  induced prolongation of eosinophil survival dose dependently. The blocking effect became apparent after the 4th day of culture. 5) Biologically equivalent dosages of hyd- rocortisone, methylprednisolone, dexamethasone had the inhibitory potency on the survival of eosinophils in descending order. Conclusion.' Corticosteroids had different effects on survival of eosinophils induced by IL  5 even when used at the concentration of biologically eqivalent dosages. The effect of corticosteroid was not immediate, but delayed upto 4 days or more.

4원저: 데오필린 , 경구 , 베타교감신경자극제 , 경구 스테로이드제가 피부단자시험에 미치는 영향

저자 : 이상록 , 반준우 , 이병재 , 손지웅 , 김우경 , 김윤근 , 지영구 , 조상헌 , 민경업 , 김유영

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 494-501 (8 pages)

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Skin prick test(SPT) is an economic and sensitive test to detect a specific IgE. Theophylline, oral beta2-agonist. Oral corticosteroids, and antihistamines are the commomly prescribed drugs in patients with allergic diseases but there are many situations that SPT are performed while taking those durgs. It has been suggested that theophylline, oral beta2- agonist, and corticosteroid inhibit the release of mediators from mast cells in vitro. To evaluate the effects of theophylline, oral Salbutamol,  and Prednisolone on the results of SPT, we measured skin resgonse to histamine codeine, and allergens before and after the mediestions of therapeutic dosage for 7 days in 10 healthy subjects. The results were as follows. L. In SPT with histamines(lmg/ml), the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistmaine were 4.37+ 0.23 and 4.27+0.20, 4.17 + 0.28 and 3.87 + 0. 28, 4.49 + 0.29 and 3.98 + 0.36, and 4.82 + 0.40 and 1.82+0.35, respectively. Theophylline, bata2-agonist and corticosteroid had no significant effect on the result of SPT with histamine. 2. In SPT with codeine(10mg/ml), the mean wheal sizes(mm+-SE) before and after medications of theophylline, beta2-agonist, corticosteroid, snd antihistamines were 4.00 + 0.37 a,nd 4.05+0.26, 4.51+0.28 and 4.28+0.36 4.31+0.37 and 4.41+0.29, and 4.39+0.30 and 2.05+0.28 respectively. Theophy'Rine, beta2-agonist and corticosteroid had no significant effect on the result of SPT with codeine. 3. In SPT with allergens, the mean wheal sizes(mm +SE) before and after medications of theophylline, beta2-agonist, corticosteroid, and antihistamines were 5.86 + 0.65 and 4.95 +0.97, 6.00+0.79 and 5.58+1.17, 5.12+0.70 and 4.09 + 0.60, and 5.72 + 0.67 and 3.05 + 0. 37, respectively. Theophylline, beta2-agonist and corticosteroid had no significant effect on the result of SPT with allergens. In conclusion, it is suggested that theophyl- line, oral Salbutamol, and Prdnisolone have no significant effect on the result of skin prick  test with histamine, codeine and allergens.

5원저: 알레르기성 기관지천식 환자의 비점막과민성

저자 : 손지웅 , 이상록 , 김우경 , 김윤근 , 지영구 , 이명현 , 조상헌 , 민경업 , 고영률 , 김유영

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 502-510 (9 pages)

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Backgroued: The relationship between allergic rhinitis and bronchial asthma is controversial although it is well known that one is often accompanied by the other. Some considers these two as pathophysiologically the same, differing only in target organs. Bronchial hyperreactivity of asthma patients has been well documented, but whether they also have nasal hyperreactivity is unknown. Therefore we performed this study to evaluate the nasal reactivity of the patients with  allergic bronchial asthma. Method: 8 patients with allergic bronchial asthma who had no nasal symptoms were tested. 7 patients with allergic rhinitis and 5 healthy normal volunteers were also tested as positive and negative control respectively. To evaluate nasal reactivity, we challenged nasal mucosa with histamine and specific allergen. Before and during challenge, we recorded symptom score and nasal airway resistance by anterior rhinomanometric measurement. Results '. 1. 7 out of 8 asthmatic subjects had negative response and one weakly positive response. None of normal volunteers and all rhinitic patients showed positive response. 2. Mean logarithmic concentration of PCSS4  Histamine(concentration of hista- mine that provokes symptom scores of 4 out of total 6 points) of asthmatic, rhinitic, and normal subjects were 1.89+-0.22, 1.88+-0.16, and 0.75 +- 0.40mg/dl, respectively(Mean +- SE). There was no difference in nasal reactivity between asthmatics and normal subjects although patients with allergic rhinitis showed markedly increased reactivity compared to the other groups. 3. In specific allergen challenge test, all asthmatics showed negative responses. Conclusions . There was no difference in nasal reactivity between normal subjects and the patients with allergic bronchial asthma who had no nasal symptoms.

6원저: 기침형 천식 환자에서의 capsaicin 유발 기침반사의 감수성에 관한 연구

저자 : 지영구 , 김우경 , 김윤근 , 송숙희 , 조상헌 , 민경업 , 김유영

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 511-519 (9 pages)

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Cough, one of the most common respiratory symptoms, is the sole clinical manifestation in cough variant asthma. But the reason why cough develops in cough-variant asthma without showing dyspnea or wheezing is still unknown. Therefore capsaicin, tachykinin related reproducible tussive agent, was used to measure the cough sensitivity in the cough variant asthmatics, t,he classic asthmatics, and the normal control group. Cough sensitivity to capsaicin in the cough variant asthmatics increased significantly as compared to the control group and the classic asthmatics, but there were no differences between the control group and the classic asthmatics. Cough sensitivity to capsaicin showed no signif icant correlation with nonspecific airway hyperresponsiveness measured by methacholine. And correlation between cough sensitivity to capsaicin and base- line PFT was not significant. These results suggest that the cough in cough-variant asthma is related to the increased cough sensitivity to capsaicin and the mechanism of the capsaicin-induced cough is different from that of the nonspecific airway responsiveness t,o methacholine. There may be a role of tachykinin, such as substance P or neurokinin A, to cause cough in cough variant ast.hma.

7원저: 부비동염이 천식 환아의 기도과민성에 미치는 영향

저자 : 송광복 , 심정연 , 홍수종

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 520-525 (6 pages)

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Sinusitis is a common problem in children with bronchial asthma. The sinusitis may exacerbate asthma, but the causal relationship between sinusitis and asthma remains controversial. The aim of this study is to evaluate the influence of sinusitis on bronchial responsiveness in asthmatic children. Bronchial provocation test with methacholine were performed in the ast,hmatics with sinusitis before and after t,reatment of sinusitis and the concoulratins of methecholine causing a 20% fall in forced expiratory volume one second(PC) were determined. The PC was increased significantly in asthmatics with sinusitis after treat,ment of sinusitis. These data suggest that sinusitis may increase the bronchial responsiveness of asthmatics and treatment of sinusitis may be important in the control of asthma.

8원저: Toluene diisocyanate(TDI)에 의한 직업성 천식에서의 면역복합체의 역할

저자 : 서창희 , 남동호 , 박해심

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 526-536 (11 pages)

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Tolune diisocynate(TDI) is the most com- mon cause of occupational asthma in Korea as well as other industrialized countries. The pathogenetic mechanism of TDI-induced occu- pational asthma is still unclear. Immunological mechnism, such as IgE-medicated type I hypersensitivity, was thought to be involved in some TDI asthma patients. Other immulogical and non-immunological mechanisms have been suggested. To evaluate a possible role of circulating immune complex(CIC) in the development of TDI asthma, we measured C3- containing CIC in 21 TDI-induced asthmatics, which were confirmed by TDI-bronchoprovocation test, and they were compared with those of14 atopic asthma patients and 26 controls with no exposure history to TDI. Serum specific IgE antibodies to TDI-human serum albumin (HAS) conjugate were detected by RAST technique. The mean level of C3 contsining IgG-CIC tended to be higher in TDI asthma patients than those of atopic asthma and controls with no statistical significance(p=0.42). The IgG- CIC level correlated well with the percent fall of FEV, during the TDI brochoprovocation test(r=0.69, p=0.005), but poorly correlated with methacholine PC20. TDI asthma patients with high TDI-specific IgE antibody showed higher IgG-CIC level than those without specific IgE antibody(p=0.018). These data suggest that C3 containing IgG- CICs have a possible role in induction of inflammatory responses in TDI-induced occupational asthma.

9원저: 곡물분진에 의한 직업성 천식 : 특이 항체 및 호염기구 유리능

저자 : 박해심 , 남동호 , 서창희 , 권오영 , 조상헌 , 김유영

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 537-547 (11 pages)

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Grain dust-induced occupational asthma is commonly found in western countries. To the best of our knowledge, these are the first cases of grain dust-induced occupational asthma in this country. Their pathogenetic mechanisms still remains to be defined. Here we report six cases of occupational asthma induced by grain dust which was confirmed by bronchoprovocation test with grain dust extracts derived from their workplace. In order to further understand pathogenetic mechsnisms of grain dust-induced occupational asthma, we detected serum specific IgE, IgG and IgG antibodies to grain dust, and studied the direct activation of grain dust on basophils from them. Bronchoprovocstioan test showed tat early asthmatic response was the most commonly found one(5 patients) and dual asthmatic  response was noted in one patient. The PC20 methacholine ranged from 2.5 to 40mg/ml. High specific IgE antibodies to grain dust were detected in three(50%) patients. All had high specific IgG antibodies and all but one had high specific IgG, antibody. Basophil histamine release test revealed that grain dust extracts directly released significant amounts of histamirle from basophils as well as IgE- mediated rneohanisms. Minimal amounts of histamine release by anti-IgG antibodies was noted. These results suggested that grain dust can induce IgE-mediated bronchoconstrictions in exposed workers and grain dust may contain some potent active substances that can activate basophil.

10증례: 가족성 한랭 두드러기 1례

저자 : 이지호 , 박영민 , 김태윤 , 김형옥 , 김정원

발행기관 : 대한천식알레르기학회 간행물 : 천식 및 알레르기 16권 4호 발행 연도 : 1996 페이지 : pp. 548-552 (5 pages)

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Familial cold urticaria is a rare abnormal cutaneous and systemic reaction to cold with autosomal dominant inheritance, distinctive clinical features, and unknown etiology. A 21  year  old male patient presented with generalized erythematous macules and papules accompanied by burning, chills and arthralgia after cold exposure since early childhood. Autosomsl dominant inheritance was revealed on the examination of his pedigree. Autosomal dominant inheritance was revealed on the examination of his pedigree. Cold room challenge induced the same lesions after a delay of 20 min. Histopathologic findings showed a perivascular polymorphonuclear leukocytic infiltrstion with some eosinophils. He was treated with several antihistamines, but unsatisfaetory. We report a patient with a familial cold urticaris showing typical cutaneous manifests- tions and general symptoms with a consistent familial history through his five generations.

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