간행물

동서의학 update

THE JOURNAL OF EAST - WEST MEDICINES

  • : 대구한의대학교 제한동의학술원
  • : 의약학분야  >  기초한의학
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  • : 연속간행물
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  • : 1225-9535
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  • : 제한동의학술원논문집(~1978)→동서의학(1979~)

수록정보
수록범위 : 1권0호(1973)~46권1호(2021) |수록논문 수 : 968
동서의학
46권1호(2021년 06월) 수록논문
최근 권호 논문
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1우울증 치료의 한의학적 연구 동향

저자 : 안단비 ( Danbi Ahn ) , 김희영 ( Hee Young Kim ) , 김미려 ( Mi Ryeo Kim )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 1-5 (5 pages)

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Objective : The purpose of this study is to the trends of oriental medicine for depression treatment.
Methods : We found articles on depression and herbal medicine or acupuncture and acupoints from 2016 on google scholar (https://scholar.google.co.kr/schhp?hl=ko).
Results and Conclusions : the ratio of ST36 in the spleen meridians was high. We report that the ST36 may be effective in improving depression.

2가미소요산의 2.5시간 간격 7일 반복 병용 투여가 tamoxifen의 약물동력학에 미치는 영향

저자 : 강현구 ( Hyun-Gu Kang ) , 박수진 ( Soo-Jin Park ) , 최성훈 ( Seong-hun Choi ) , 구세광 ( Sae-kwang Ku )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 7-23 (17 pages)

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Objectives : This study aims to elucidate the possible effects on the pharmacokinetics (PK) of tamoxifen after 7-day repeated oral co-administration of Gamisoyo-san (GMSYS) with 2.5 hr-intervals, as a process of the comprehensive and integrative medicine, combination therapy of tamoxifen with GMSYS to achieve synergic pharmacodynamics and reduce toxicity in breast cancer patients.
Materials and methods : Two point five hrs after treatment of tamoxifen 50 mg/kg, GMSYS 100 mg/kg was administered, once a day for 7 days. In tamoxifen single treated rats, 50 mg/kg of tamoxifen was orally administered and 2.5 hrs after treatment, distilled water 5 ml/kg was orally administered, instead of GMSYS solutions. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of last 7th tamoxifen treatment, and plasma concentrations of tamoxifen were analyzed using liquid chromatographic and mass-spectroscopic system. PK of tamoxifen (Tmax, Cmax, AUC, ti/2 and MRTinf) after co-administration of GMSYS 100 mg/kg and tamoxifen 50 mg/kg, was analysis as compared with tamoxifen single administered rats using noncompartmental PK data analyzer programs. Each tamoxifen or GMSYS was orally administered, in a volume of 5 m/kg, dissolved in distilled water, once a day for 7 days.
Results : GMSYS did not influence on the plasma concentrations of tamoxifen as compared with tamoxifen single treated rats and accordingly, no significant changes on the pharmacokinetics profiles, Tmax, Cmax, AUC, t1/2 and MRTinf were observed as compared with tamoxifen single treated rats, when tamoxifen 50 mg/kg and GMSYS 100 mg/kg 2.5 hr-interval co-administered, once aday for 7 days.
Conclusion : Based on the results, co-administration of GMSYS with 2.5 hr-intervals did not critically influenced on the absorption and excretion of tamoxifen, the oral bioavailability. Hence, 2.5 hr-interval co-administration is considered as suitable regime of GMSYS and tamoxifen to achieve synergic pharmacodynamics and reduce toxicity for breast cancer patients as comprehensive and integrative therapy, and further pharmacodynamic studies should be conducted along with tamoxifen and GMSYS 2.5 hr-interval co-administration.

3후각시스템 및 식욕 조절에 영향을 미치는 방향성 식물 및 정유의 항비만 연구 동향

저자 : 김소영 ( So Young Kim ) , 김미려 ( Mi Ryeo Kim )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 25-30 (6 pages)

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Objective : This study was aimed to suggest direction for future research and development of aromatic anti-obese materials through analysis of obesity research trends on aromatic herbal medicine and essential oils in published Korean and abroad articles.
Method : We searched for the papers on the 'Google scholar (https://sch이ar.google.co.kr)', then filtered using keywords, 'appetite', 'olfactory', 'obesity', 'essential oil', 'medicinal herbs', 'aroma' in reported articles for recent 10 years from 2012 to 2021. Among them, we reviewed 10 overseas articles and 2 in Korean that we thought were relevant.
Result and Conclusion : As a results of analyzing the trend of anti-obesity research based on the effects of aromatic plants on the olfactory system, more studies has been conducted abroad than in Korea, and studies has been mainly active. Also, studies of aromatic plant extracts and essential oils has also been studied at the same level. Therefore, it is suggested that the functional extracts and essential oils from various aromatic plants could be a potential anti-obesity treatments with no side effects. This review aimed to provide basic data for the development of obesity treatment by examining anti-obesity research papers on domestic and foreign aromatic plant extracts or essential oils for the past 10 years and classifying research trends.

4우슬 추출물의 3T3-L1 지방세포와 고지방식이로 유도된 C57BL/6 마우스에 대한 항비만 효과

저자 : 최정원 ( Jeong Won Choi ) , 노성수 ( Seong-soo Roh )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 31-38 (8 pages)

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Objectives : The objective of this study was to confirm the anti-obesity effect of the Achyranthis Radix 30% EtOH extract (AE).
Methods : The AE treated with 100, 250, and 500 mg/mL on 3T3-L1 cells and then the cell viability was examined through MTT assay. In 3T3-L1 cells, Oil Red O staining was examined to detect triglyceride (TG) accumulation. Oil Red O staining for the examination of lipid accumulation was performed at concentrations 100, 250, and 500 mg/mL. Male C57BL/6 mice were fed on a high-fat diet (45% kcal fat; HFD) to induce obesity. Simultaneously, mice orally received 200 or 400 mg/kg AE for 6 weeks. Also, we measured the body weight gain and liver weight. Moreover, biochemical analyses including AST, ALT, TG, and TC levels were measured in serum.
Results : As a result of Oil Red O staining, both cell differentiation and TG accumulation were inhibited compared with Blank group. In the animal experiment, body weight gain in the AEH treated group was significantly suppressed. Moreover, liver weight gain was markedly suppressed in all drug groups. The increased liver function markers such as AST and ALT significantly decreased by AE treatment. Thus, serum TG and TC levels in AE groups showed a significant reduction compared with Control group.
Conclusion : Taken together, these results suggest that AE treatment showed anti-obesity effects by the inhibition of fat accumulation and the improvement of blood lipids. Therefore, AE could be utilized as a potential therapeutic agent for the prevention and treatment obesity.

5동의수세보원(東醫壽世保元) 중 상한론(傷寒論)에서 인용한 조문 비교 연구

저자 : 박종현 ( Park Jonghyun )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 39-49 (11 pages)

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Objectives : This study is writtern to investigate the biblographical facts on the book 'Dongyisusebowon(東醫壽世保元)' quoted from 'Shanghanlun(傷寒論)'
Methods : It was researched on the comparative and literal study about the relation to 'Dongyisusebowon', 'Shanghanlun' and 'Dongeuibogam'
Results and Conclusions : The number of provisions quoted from 'Shanghanlunᄎ is 65, and 25 prescriptions were quoted. There are different sentences between 'Dongyisusebowon' and 'Shanghanlun'. The sentences of 'Dongyisusebowon' are almost the same as that of 'Dongeuibogam'.

6신경변성질환에서의 한의학적 치료연구에 대한 문헌적 고찰

저자 : 장한별 ( Han Byeol Jang ) , 김희영 ( Hee Young Kim ) , 김미려 ( Mi Ryeo Kim )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 51-55 (5 pages)

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Objective : In this study, we intend to analyze previous studies on herbal medicine and acupuncture in Alzheimer's disease and Parkinson's disease models to help future animal and clinical trials.
Method : Searched several literatures published within the last 5 years using key words such as 'alzheimer', 'parkinson', 'acupuncture', 'herbal medicine', 'oriental medicine', 'Korean medicine', 'Traditional medicine' and 'Medicinal herb' in google scholar (https://scholar.google.co.kr).
Result and Conclusion : A survey of the rates of herbal medicine and acupuncture treatment in the Alzheimer's and Parkinson's disease models found that both diseases had more acupuncture treatments than herbal medicine.

7한방 피부 관련 대한 연구 동향

저자 : 양채영 ( YANG Chaeyoung ) , 송지청 ( Song Jichung )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 57-64 (8 pages)

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Objective : In this day and age with the increasing concern for health and skin aesthetics, there is a demand for comprehensive treatments that utilize the unique methods of Korean medicine for the primary purpose of enhancing physical and cosmetic health. Therefore, to promote the development of various aspects of Korean medicine skin aesthetics and dermatological treatment, the papers that have been published in the last 5 years are categorized and typified.
Method : A total of 130 papers published between 2016 and 2020 were searched using "skin" as the search term. Among them, excluding 12 papers that were not related to skin, 118 papers were selected for the study. The papers were searched from the “Traditional Medicine Specialty Portal", and even if there was an overlap of one paper, it was repeatedly mentioned in various fields.
ResuIt & Concision : 12 research papers, 5 clinical research papers, 24 case study papers, 46 experimental research papers, 2 comparative research papers, and 29 literature research papers. In the course of the data survey, studies related to atopic dermatitis were the most common. Korean medicine skin care is highly stable, with few side effects, good results, and easy methods. Therefore, Korean medicine skin cosmetology has been developed to meet the needs of many people for skin cosmetology.

8우슬의 에탄올 추출물이 모발의 흑화에 미치는 영향

저자 : 이미자 ( Mi-ja Lee ) , 최문열 ( Moon-yeol Choi ) , 김유진 ( Yoo Jin Kim ) , 김미려 ( Mi Ryeo Kim ) , 유왕근 ( Wang Keun Yoo )

발행기관 : 대구한의대학교 제한동의학술원 간행물 : 동서의학 46권 1호 발행 연도 : 2021 페이지 : pp. 65-70 (6 pages)

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Objective : a-MSH (alpha-melanocyte-stimulating hormone) and IBMX (3-lsobutyl-1-methylxanthine) were known as regulating melanogenesis and differentiation, but they were restricted usage because of stability. So, natural products have developed about regulating melanogenesis and differentiation. Therefore, we investigated about effect of Achyramthis Radix (AR) ethanol extract on gray hair.
Methods : a-MSH was used as a positive control. We set up the safe concentration range by MTT assay and conducted melanin contents and tyrosinase activity in mouse melanoma (B16F10) cells.
Results : As results, melanin contents were increased in Achyramthis Radix ethanol extract (AR) group contrast to control group. Also, AR group is higher than control group on tyrosinase activity.
Conclusion : Our results suggest that AR could be used as a potential material for the treatment of gray hair by increasing the melanogenesis of B16F10 cells.

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