Objective : The purpose of this study is to the trends of oriental medicine for depression treatment.
Methods : We found articles on depression and herbal medicine or acupuncture and acupoints from 2016 on google scholar (https://scholar.google.co.kr/schhp?hl=ko).
Results and Conclusions : the ratio of ST36 in the spleen meridians was high. We report that the ST36 may be effective in improving depression.

Objectives : This study aims to elucidate the possible effects on the pharmacokinetics (PK) of tamoxifen after 7-day repeated oral co-administration of Gamisoyo-san (GMSYS) with 2.5 hr-intervals, as a process of the comprehensive and integrative medicine, combination therapy of tamoxifen with GMSYS to achieve synergic pharmacodynamics and reduce toxicity in breast cancer patients.
Materials and methods : Two point five hrs after treatment of tamoxifen 50 mg/kg, GMSYS 100 mg/kg was administered, once a day for 7 days. In tamoxifen single treated rats, 50 mg/kg of tamoxifen was orally administered and 2.5 hrs after treatment, distilled water 5 ml/kg was orally administered, instead of GMSYS solutions. The plasma were collected at 30 min before administration, 30 min, 1, 2, 3, 4, 6, 8 and 24 hrs after end of last 7th tamoxifen treatment, and plasma concentrations of tamoxifen were analyzed using liquid chromatographic and mass-spectroscopic system. PK of tamoxifen (Tmax, Cmax, AUC, ti/2 and MRTinf) after co-administration of GMSYS 100 mg/kg and tamoxifen 50 mg/kg, was analysis as compared with tamoxifen single administered rats using noncompartmental PK data analyzer programs. Each tamoxifen or GMSYS was orally administered, in a volume of 5 m/kg, dissolved in distilled water, once a day for 7 days.
Results : GMSYS did not influence on the plasma concentrations of tamoxifen as compared with tamoxifen single treated rats and accordingly, no significant changes on the pharmacokinetics profiles, Tmax, Cmax, AUC, t1/2 and MRTinf were observed as compared with tamoxifen single treated rats, when tamoxifen 50 mg/kg and GMSYS 100 mg/kg 2.5 hr-interval co-administered, once aday for 7 days.
Conclusion : Based on the results, co-administration of GMSYS with 2.5 hr-intervals did not critically influenced on the absorption and excretion of tamoxifen, the oral bioavailability. Hence, 2.5 hr-interval co-administration is considered as suitable regime of GMSYS and tamoxifen to achieve synergic pharmacodynamics and reduce toxicity for breast cancer patients as comprehensive and integrative therapy, and further pharmacodynamic studies should be conducted along with tamoxifen and GMSYS 2.5 hr-interval co-administration.

Objective : This study was aimed to suggest direction for future research and development of aromatic anti-obese materials through analysis of obesity research trends on aromatic herbal medicine and essential oils in published Korean and abroad articles.
Method : We searched for the papers on the 'Google scholar (https://sch이ar.google.co.kr)', then filtered using keywords, 'appetite', 'olfactory', 'obesity', 'essential oil', 'medicinal herbs', 'aroma' in reported articles for recent 10 years from 2012 to 2021. Among them, we reviewed 10 overseas articles and 2 in Korean that we thought were relevant.
Result and Conclusion : As a results of analyzing the trend of anti-obesity research based on the effects of aromatic plants on the olfactory system, more studies has been conducted abroad than in Korea, and studies has been mainly active. Also, studies of aromatic plant extracts and essential oils has also been studied at the same level. Therefore, it is suggested that the functional extracts and essential oils from various aromatic plants could be a potential anti-obesity treatments with no side effects. This review aimed to provide basic data for the development of obesity treatment by examining anti-obesity research papers on domestic and foreign aromatic plant extracts or essential oils for the past 10 years and classifying research trends.

Objectives : The objective of this study was to confirm the anti-obesity effect of the Achyranthis Radix 30% EtOH extract (AE).
Methods : The AE treated with 100, 250, and 500 mg/mL on 3T3-L1 cells and then the cell viability was examined through MTT assay. In 3T3-L1 cells, Oil Red O staining was examined to detect triglyceride (TG) accumulation. Oil Red O staining for the examination of lipid accumulation was performed at concentrations 100, 250, and 500 mg/mL. Male C57BL/6 mice were fed on a high-fat diet (45% kcal fat; HFD) to induce obesity. Simultaneously, mice orally received 200 or 400 mg/kg AE for 6 weeks. Also, we measured the body weight gain and liver weight. Moreover, biochemical analyses including AST, ALT, TG, and TC levels were measured in serum.
Results : As a result of Oil Red O staining, both cell differentiation and TG accumulation were inhibited compared with Blank group. In the animal experiment, body weight gain in the AEH treated group was significantly suppressed. Moreover, liver weight gain was markedly suppressed in all drug groups. The increased liver function markers such as AST and ALT significantly decreased by AE treatment. Thus, serum TG and TC levels in AE groups showed a significant reduction compared with Control group.
Conclusion : Taken together, these results suggest that AE treatment showed anti-obesity effects by the inhibition of fat accumulation and the improvement of blood lipids. Therefore, AE could be utilized as a potential therapeutic agent for the prevention and treatment obesity.

Objectives : This study is writtern to investigate the biblographical facts on the book 'Dongyisusebowon(東醫壽世保元)' quoted from 'Shanghanlun(傷寒論)'
Methods : It was researched on the comparative and literal study about the relation to 'Dongyisusebowon', 'Shanghanlun' and 'Dongeuibogam'
Results and Conclusions : The number of provisions quoted from 'Shanghanlunᄎ is 65, and 25 prescriptions were quoted. There are different sentences between 'Dongyisusebowon' and 'Shanghanlun'. The sentences of 'Dongyisusebowon' are almost the same as that of 'Dongeuibogam'.

Objective : In this study, we intend to analyze previous studies on herbal medicine and acupuncture in Alzheimer's disease and Parkinson's disease models to help future animal and clinical trials.
Method : Searched several literatures published within the last 5 years using key words such as 'alzheimer', 'parkinson', 'acupuncture', 'herbal medicine', 'oriental medicine', 'Korean medicine', 'Traditional medicine' and 'Medicinal herb' in google scholar (https://scholar.google.co.kr).
Result and Conclusion : A survey of the rates of herbal medicine and acupuncture treatment in the Alzheimer's and Parkinson's disease models found that both diseases had more acupuncture treatments than herbal medicine.

Objective : In this day and age with the increasing concern for health and skin aesthetics, there is a demand for comprehensive treatments that utilize the unique methods of Korean medicine for the primary purpose of enhancing physical and cosmetic health. Therefore, to promote the development of various aspects of Korean medicine skin aesthetics and dermatological treatment, the papers that have been published in the last 5 years are categorized and typified.
Method : A total of 130 papers published between 2016 and 2020 were searched using "skin" as the search term. Among them, excluding 12 papers that were not related to skin, 118 papers were selected for the study. The papers were searched from the “Traditional Medicine Specialty Portal", and even if there was an overlap of one paper, it was repeatedly mentioned in various fields.
ResuIt & Concision : 12 research papers, 5 clinical research papers, 24 case study papers, 46 experimental research papers, 2 comparative research papers, and 29 literature research papers. In the course of the data survey, studies related to atopic dermatitis were the most common. Korean medicine skin care is highly stable, with few side effects, good results, and easy methods. Therefore, Korean medicine skin cosmetology has been developed to meet the needs of many people for skin cosmetology.

Objective : a-MSH (alpha-melanocyte-stimulating hormone) and IBMX (3-lsobutyl-1-methylxanthine) were known as regulating melanogenesis and differentiation, but they were restricted usage because of stability. So, natural products have developed about regulating melanogenesis and differentiation. Therefore, we investigated about effect of Achyramthis Radix (AR) ethanol extract on gray hair.
Methods : a-MSH was used as a positive control. We set up the safe concentration range by MTT assay and conducted melanin contents and tyrosinase activity in mouse melanoma (B16F10) cells.
Results : As results, melanin contents were increased in Achyramthis Radix ethanol extract (AR) group contrast to control group. Also, AR group is higher than control group on tyrosinase activity.
Conclusion : Our results suggest that AR could be used as a potential material for the treatment of gray hair by increasing the melanogenesis of B16F10 cells.