Objective : The purpose of this study was to report the case of prolonged drug resistance non-small cell lung cancer (NSCLC) with Samchilchoongcho-Jung (HAD-B1) in combining with Gefitinib.
Methods : The patient was diagnosed with Epidermal Growth Factor Receptor mutation (EGFR) NSCLC adenocarcinoma. The patient being treated with Gefitinib was treated with HAD-B1 for prolonged drug resistance. The clinical outcomes were measured by Response Evaluation Criteria in Solid Tumors (RECIST), National Cancer Institute Common Terminology Criteria for Adverse Event (NCI -CTCAE), laboratory findings, etc.
Results : After combining treatment, the drug resistance of Gefitinib was prolonged about 20 months. The tumor marker levels were also maintained. NCI-CTCAE 6.0 showed no adverse events.
Conclusion: This case study suggested that HAD-B1 may prolong the drug resistance of Gefitinib.

Objective: To report the improvement of abdominal pain in patients with bile duct and rectal double cancer with integrative cancer treatment.
Methods : A 59-year-old female patient was diagnosed with bile duct cancer and rectal cancer at ○○ Medical Center in February, mid day, 2020 and applied chemotherapy treatment and Percutaneous catheter drainage (PCD) and percutaneous transhepatic biliary drainage (PTBD) injection from January 31, 2020 to March 11, 2021. Integrated cancer treatment was performed for abdominal pain and fatigue, and evaluations were conducted with numeric rating scores (NRS), Visual Analogue Scale(VAS), the Eastern Cooperative Oncology Group (ECOG), frequency of drug pain medication, liver count, and C-reactive protein (CRP) to improve symptoms.
Results : After integrative cancer treatment, abdominal pain in patients decreased from NRS 8 to 6, Fatigue was maintained between 4 and 5 times without any difference in Vas but sleeping time increased 4 hours to 7 hours, and mid-term awakening decreased from 4 to 2 times. and ECOG improved from 3 to 2, indicating improvement in drug-induced pain medication prevalence, liver count, and CRP.
Conclusion : Integrated cancer treatment may show improvement in abdominal pain in patients with bile duct and rectal double cancer.

Objectives : The purpose of this study is to investigate the therapeutic efficacy of diabetes mellitus using mulberry branch gami saengmaek-san (MBGS). So we researched effects of MBGS on diabetic mouse models.
Methods : Normal groups were not―treated C57BL/6 mice, and the remaining group used db/db mice. Control groups were treated orally with distilled water, glimepiride group were treated orally with glimepiride (1 mg/kg/day), and MBGS groups were treated orally with MBGS (200 mg/kg/day or 400 mg/kg/day). After mice were treated with for 4 weeks, we measured body weight, fasting blood glucose, AST, ALT, ALP, LDH, lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride), insulin, resistin, leptin, and adiponectin.
Results : Body weight, fasting blood glucose, AST, ALT, ALP, and LDH levels of MBGS groups were significantly decreased. Also, MBGS groups were found to have lipid metabolism improvement the levels of ; total cholesterol, LDL cholesterol, and triglyceride were decreased. Finally, while the levels of insulin and resistin were significantly decreased, the levels of leptin and adiponectin were significantly increased by MBGS compared with the control group. However, the effect of MBGS is lower than that of glimepiride.
Conclusions : These results suggest that MBGS may have the control effects on diabetes mellitus by regulating the level of blood glucose and lipid metabolism.

This study aims to investigate the effects of Mulberry Leaves Gami Saengmaek-san (MLGS) on blood glucose and lipid metabolism in type 2 diabetic mellitus mice, and to evaluate its use as a functional material for glycemic control. MLGS consists of Saengmeak-san composed of Liriope platyphylla Wang et Tang, Schisandra chinensis Baillon and Panax ginseng C.A. Meyer with Morus alba Linné added, which have been proven to have antidiabetic properties. We researched the effects of MLGS in type 2 diabetic mellitus mice. C57BL/6 mouse groups had no treatment, db/db mouse randomly assigned to 4 groups, 2 groups of the control group treated with distilled water, 1 mg/kg of glimepiride and 2 groups of the experimental group treated with MLGS (200 and 400 mg/kg/day). After 4 weeks of treatment, blood glucose levels and body weight were checked. Liver function indicators (AST, ALT, ALP and LDH) and lipid metabolites (total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides) were measured with a biochemistry analyzer. Diabetic factors (insulin, resistin, leptin, and adiponectin) were measured with ELISA. MLGS significantly decreased body weight, fasting blood glucose, liver function indicators (AST, ALT, ALP, and LDH), lipid metabolites (total cholesterol, LDL cholesterol, and triglycerides), and diabetic factors (insulin and resistin). Also, leptin and adiponectin were significantly increased in the MLGS group, and HDL-cholesterol was increased, but there was no significant difference with the control group. MLGS may have the potential to improve diabetes mellitus by regulating blood glucose levels and diabetic factors. Also protecting from diabetic complications by adjusting liver function indicators and lipid metabolites. These results suggest that MLGS can be used as a functional food for diabetes.

This study was conducted to suggest the Cinnamomum cassia Presl and Rehmannia glutinosa Liboschitz Complex (CRC) possibility of use as a functional natural material for improved inflammatory response.
Cinnamomum cassia Presl and Rehmannia glutinosa Liboschitz were mixed in a 2:1 ratio, extracted with hot water, and then powdered and used in the study. After, the cytotoxicity of CRC for RAW264.7 cell were evaluated by MTT assay, the anti-inflammatory effect in macrophages was evaluated by ELISA, qRT―PCR, and western blot assay. CRC did not prolilerate macrophages but decreased nitric oxide and prostaglandin E2 production in LPS ―induced RAW264.7 cell. Also, decreased NOS2 and PTGS2 gene expression, and ERK, JNK, and p38 protein phosphorylation in a concentration―dependent manner. As a result, CRC have regulated the production and expression of inflammatory cytokines in LPS ―induced RAW264.7 cell. Therefore, it is thought that CRC can be used as a functional natural material that improving inflammatory response.