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수록정보
수록범위 : 1권1호(1995)~27권4호(2021) |수록논문 수 : 1,199
Natural Product Sciences
27권4호(2021년 12월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Special Issue in Honor of Jinwoong Kim

저자 : Young-won Chin

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 1-2 (2 pages)

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KCI등재 SCOPUS

2Ethnomedicinal Study of Plants in Begumganj, Noakhali, Bangladesh

저자 : Kazi-marjahan Akter , Noor Hassan Sajib , Dong-min Kang , Mi-jeong Ahn , Shaikh Bokhtear Uddin

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 217-227 (11 pages)

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This study is a record of ethnomedicinal knowledge in Begumganj province focussed on medicinal plants and their local uses for primary health care. The aim was to document and preserve the ethnomedicinal knowledge used by traditional healers of Begumganj upazila, Bangladesh, to treat human diseases and evaluate the relative efficacy of the medicinal plants. The uses of medicinal plants were documented as an ethnomedicinal data sheet using direct observation, field interview, plant interview and group interview techniques from December 2012 to January 2014 in the study area. Data were collected from 98 traditional healers through a questionnaire survey and analyzed through informant consensus factor and fidelity level. This study revealed comprehensive relationship among various diseases and families, forms and parts of plants and modes of preparation. Overall, 75 plant species under 71 genera of 47 families were documented, which are used to treat 41 diseases. Data analysis revealed that 41.33%, 14.67%, 36% and 8% of the medicinal plant species were herbs, shrubs, trees, and climbers, respectively. Leaves were the most used parts, followed by stem, root, fruit, bark, latex and rhizome. The most frequently treated diseases were dysentery, rheumatism and skin diseases. This is the first ethnobotanical survey, which recorded the importance of medicinal plants in Begumganj upazila, Bangladesh. This study can contribute to preserving the indigenous knowledge on the traditional use of medicinal plants in this region and new drug development with attracting future generations towards traditional healing practice.

KCI등재 SCOPUS

3Chemical Constituents from Agrimonia pilosa with Inhibitory Activity against Interleukin 1β Production via NLRP3 and NLRC4 Inflammasomes

저자 : Piseth Nhoek , Hee-sung Chae , Chae-yeong An , Pisey Pel , Young-mi Kim , Young-won Chin

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 228-233 (6 pages)

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Bioactivity-guided fractionation by preliminary screening using interleukin-1β production in lipopolysaccharides (LPS)-induced J774A.1 cell line led to the isolation of fourteen structures including chromone, isocoumarins, flavanoids, and triterpenes from the aerial part of Agrimonia pilosa Ledeb. All structures were determined by measuring their spectroscopic data and comparing their spectroscopic data with the literatures. All the isolates were tested for their inhibitory activities against interleukin-1β production in LPSinduced J774A.1 cell. Of the tested compounds, (S)-(+)-5,7-dihydroxy-2-(1-methylpropyl)chromone (1), agrimonolide-6-O-β-D-glucopyranoside (5), agrimonolide-6-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside (6), and catechin (10) were found to be active. Furthermore, compound 1 suppressed the protein expressions of NLRP3 and NLRC4 in murine macrophage.

KCI등재 SCOPUS

4Xanthone and Flavonoid Derivatives from the Leaves of Maclura tricuspidata with Antioxidant and Anti-tyrosinase Activity

저자 : Yang Hee Jo , Solip Lee , Se Hwan Ryu , Sang Won Yeon , Ayman Turk , Bang Yeon Hwang , Mi Kyeong Lee

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 234-239 (6 pages)

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Masclura tricuspidata, also called as Cudrania tricuspidata, is one of the most common Moraceae family plants in East Asia. Its trivial name follows mulberry due to the similar morphology. Investigation of the bioactive constituents of M. tricuspidata leaves yielded a new xanthone derivative along with twenty known compounds through various chromatographic techniques. A new compound was defined as mascluraxanthone (3), a prenylated xanthone glucoside on the basis of 1D and 2D NMR and MS data. Twenty known compounds were identified as four xanthone derivatives (1-2 and 4-5), two flavans (6-7), six flavanol derivatives (8-13), a flavonone (14) and seven flavonol derivatives (15-21). Among the isolated compounds, flavanol and flavonoid derivatives with 3′,4′-OH groups showed antioxidant and anti-tyrosinase activities. Conclusively, the leaves of M. tricuspidata are rich in aromatic compounds including xanthones and flavonoids. In addition, these constituents showed antioxidant and anti-tyrosinase potentials, which might be useful for oxidative stress related diseases.

KCI등재 SCOPUS

5Chemical Constituents from Aegle marmelos Fruits

저자 : Hye Jin Kim , Young Ju Seo , Khin Myo Htwe , Kee Dong Yoon

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 240-249 (10 pages)

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Aegle marmelos (Rutaceae) is a deciduous shrub or tree and typically known as bael throughout Southeast Asia and has been used as a medicinal plant and a food ingredient. In this study eight compounds were determined to be O-(3,3-dimethylallyl) halfordinol (1), (R)-aegeline (2), (R)-marmeline (3), imperatorin (4), xanthotoxol (5), valencic acid (6), vanillic acid (7) and rutin (8). The chemical structures of the isolates were elucidated through spectroscopic evidence including 1D, 2D NMR, ESI-Q-TOF-MS and optical rotation.

KCI등재 SCOPUS

6Trapping of Methylglyoxal by Sieboldin from Malus baccata L. and Identification of Sieboldin-Methylglyoxal Adducts Forms

저자 : Ji Hoon Kim , Kaixuan Zhang , Juhee Lee , En Mei Gao , Yun Jung Lee , Rak Ho Son , Ahmed Shah Syed , Chul Young Kim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 245-250 (6 pages)

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The methylglyoxal (MGO) trapping constituents from Malus baccata L. were investigated using incubation of MGO and crude extract under physiological conditions followed by HPLC analysis. The peak areas of MGO trapping compounds decreased, and their chemical structures were identified by HPLC-ESI/MS. Sieboldin was identified as a major active molecule representing MGO-trapping activity of the crude extract. After reaction of sieboldin and MGO, remaining MGO was calculated by microplate assay method using imine (Schiff base) formation of 2,4-dinitrophenylhydrazine (DNPH) and aldehyde group. After 4 h incubation, sieboldin trapped over 43.8% MGO at a concentration of 0.33 mM and showed MGO scavenging activity with an RC50 value of 0.88 mM for the incubation of 30 min under physiological conditions. It was also confirmed that sieboldin inhibited the production of advanced glycation end products (AGE) produced by bovine serum albumins (BSA)/MGO. Additionally, MGO trapping mechanism of sieboldin was more specifically identified by 1H-, 13C-, 2D NMR and, confirm to be attached to the position of C-3' (or 5').

KCI등재 SCOPUS

7Inhibition of Interleukin-4 and β-Hexosaminidase Release in RBL-2H3 Cells by Compounds Isolated from Lobelia chinensis

저자 : Tae Young Kim , Beom-geun Jo , No-jun Park , Young-hun Park , Su-nam Kim , Min Hye Yang

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 251-256 (6 pages)

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Lobelia chinensis Lour. has commonly been used in traditional Chinese medicine for the treatment of antidote, diuretic, diarrhea, and inflammation. This study aimed to identify the active compounds in an aqueous extract of L. chinensis responsible for its anti-atopic effect in vitro using RBL-2H3 cells. A chemical investigation of secondary metabolites in an aqueous extract of L. chinensis led to the isolation of nine chemical constituents, which included the four marker compounds, and these were evaluated for their inhibitory effects on IL-4 mRNA expression and the release of β-hexosaminidase in propidium iodide-induced RBL-2H3 cells. We found diosmetin and fraxidin inhibited cellular IL-4 mRNA expression, and that diosmetin and 6,8- dimethoxycoumarin inhibited DNP-specific IgE-induced degranulation in these cells. Our study suggests that diosmetin, fraxidin, and 6,8-dimethoxycoumarin are potential candidates for the treatment of atopic diseases.

KCI등재 SCOPUS

8LC-MS/MS-Based Comparative Investigation on Chemical Constituents of Six Aster Species Occurring in Korea

저자 : Kyo Bin Kang , Dong Young Lee , Sang Hyun Sung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 257-263 (7 pages)

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Aster species (Asteraceae) are widely distributed edible and medicinal plants, known to contain various specialized metabolites including polyphenols and saponins. However, systemic analysis on the chemical profiles of these plants have rarely been made. Here we analyzed the phytochemical constituents in leaves of 6 Aster species occurring in Korea, A. ageratoides, A. altaicus var. uchiyamae, A. glehnii, A. hispidus, A. incisus, and A. yomena, by applying a LC-MS/MS-based untargeted metabolomics approach. The analysis revealed that A. ageratoides, A. hispidus, and A. yomena are relatively rich in saponins most of which are expected to be previously unknown.

KCI등재 SCOPUS

9Analytical Quality by Design Methodology Approach for Simultaneous Quantitation of Paeoniflorin and Decursin in Herbal Medicine by RP-HPLC Analysis

저자 : Min Kyoung Kim , Geonha Park , Seon-pyo Hong , Young Pyo Jang

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 264-273 (10 pages)

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Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C18, 4.6 × 250 mm, 5 μm particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

KCI등재 SCOPUS

10The Extract of Couroupita guianensis Aubl. Ameliorates Benign Prostatic Hyperplasia In Vitro and In Vivo

저자 : Yun Na Kim , Na-hyun Kim , Onevilay Souliya , Salah Uddin , Sang Woo Lee , Soo-yong Kim , Sangho Choi , Jeong-doo Heo , Eun Ju Jeong

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 4호 발행 연도 : 2021 페이지 : pp. 274-279 (6 pages)

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The therapeutic effects of the leaves of Couroupita guianensis, a large tropical tree in the family of Lecythidaceae improving testosterone-induced Benign Prostatic Hyperplasia (BPH) were tested in vitro and in vivo. In BPH rats induced by castration and testosterone treatment, the prostate index was improved in groups administered with the extracts of C. guianensis extracted with 50%-, 100%-ethanol or boiling water, which was comparable with positive control, finasteride. The extract C. guianensis leaves showed significant inhibition on the expressions of type 2 5-alpha reductase (5αR) in RWPE-1 human prostatic epithelial cells, and effectively attenuated the expressions of androgen receptor, type 2 5αR and proliferating cell nuclear antigen in LNCap human prostatic adenocarcinoma cells. The leaves of C. guianensis that exerted evident suppression on BPHrelated biomarkers in vitro and improvement of prostate index in vivo has a potential therapeutic use for the treatment of BPH.

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