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한국생약학회> Natural Product Sciences

Natural Product Sciences

  • : 한국생약학회
  • : 의약학분야  >  약화학
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수록정보
수록범위 : 1권1호(1995)~28권3호(2022) |수록논문 수 : 1,222
Natural Product Sciences
28권3호(2022년 09월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

저자 : Yee-min Wei , Joo-shun Tan , Hock-wei Tang , Woei-yenn Tong , Chean-ring Leong , Wen-nee Tan

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 93-104 (12 pages)

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Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.

KCI등재 SCOPUS

저자 : Norafiqah Yusof , May P. Y. Goh , Norhayati Ahmad

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 105-114 (10 pages)

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Tinospora crispa (L.) is a medicinal plant traditionally used to treat various ailments including diabetes. The stem has been widely studied for its antidiabetic properties, however the antidiabetic potential of its leaves has not been explored. This study investigates the antidiabetic properties of methanolic T. crispa stem and leaves extracts on alloxan-induced diabetic rats. The stems and leaves were extracted using Soxhlet extraction with methanol as solvent. Crude extracts were administered at 500 mg/kg body weight (BW) (high dose) and 250 mg/kg BW (low dose) via oral route to alloxan induced diabetic rats. T. crispa stem and leaves extracts was found to significantly reduce blood glucose following a twelve-week treatment period. The highest mean difference in blood glucose level was exhibited by animals in the high dose treated stem and low dose leaf extracts. Both extracts showed approximately 75% percentage recovery from hyperglycaemia. The highest regenerative capacity was observed in animals treated with the low dose leaf extract.

KCI등재 SCOPUS

저자 : Ha Sook Chung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 115-120 (6 pages)

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Ten compounds, consisting of neoflavonoids (1-5), isoflavonoids (6 and 7), flavanone (8), and chalcones (9 and 10) were isolated from the ethyl acetate and n-butanol-soluble fractions of the heartwood of Dalbergia melanoxylon. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. Compounds 1-10 were evaluated for cytotoxicity against HCT116 human colorectal cancer, MDA-MB-231 human metastatic breast cancer, and A2058 human melanoma cell lines. Among them, compounds 3 and 10 showed the strongest cytotoxic activity with IC50 values of 11.92 ± 1.07 μM, 10.83 ± 1.02 μM, and 14.37 ± 1.02 μM, 13.62 ± 1.09 μM against HCT116 and MDA-MB-231 cell lines, respectively. Compounds 9 and 10 also had cytotoxic activity with IC50 values of 13.49 ± 1.18 μM and 9.82 ± 0.91 μM against A2058 cell lines, respectively. To the best our knowledge, compounds 2 and 5-10 were isolated from this source for the first time.

KCI등재 SCOPUS

저자 : Sidra Ajmal , Mahwish Shafqat , Laiba Ajmal , Hooria Younas , Raazia Tasadduq , Nasir Mahmood

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 121-129 (9 pages)

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Despite considerable efforts, cancer remains an aggressive killer worldwide. Chemotherapeutic drugs that are currently in use lead to destructive side effects and have not succeeded in fulfilling expectations. For centuries, medicinal plants are used for treating various diseases and are also known to have anticancer activity. The main aim of this research was to evaluate antiproliferative activity of saffron, clove, fenugreek, and green tea on Vero and MDA-MB-231 cell lines and to subsequently analyze the effect of these extracts on IRAK-4, TAK1, IKK-alpha, IKK-beta, NF-Kappa B, IRF3, IRF7 genes in Toll Like Receptors (TLRs) pathway. Antiproliferative assay was done by Neutral Red Dye uptake assay. Methanolic extract of green tea was found to be most effective against both cell lines as IC50 was achieved at least concentration of the extract. For molecular studies, MDAMB- 231 cells were sensitized with methanolic extract of green tea at same IC50, and RT-PCR was performed to determine the relative expression of genes. Expression of IRAK-4, TAK1, IKK-beta, NF-Kappa B, IRF3 genes was down regulated and IRF7 and IKKalpha was upregulated. Green tea has a potential cytotoxic effect on both cell lines which was demonstrated by its effect on the expression of (TLRs) pathway genes.

KCI등재 SCOPUS

저자 : Jayapal Sharath , Rafi Ahmed Shahin Taj , Mahadevaiah Bhagya

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 130-137 (8 pages)

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This study was conducted to characterise phytochemicals and to explore the biological activities of Vitex negundo leaves. The washed, course powder of V. negundo leaves were extracted with different solvents of increasing polarity. All the extracts were characterized and biological activities were compared. The results revealed that the ethanolic and cold water extacts showed the presence of all phytochemicals studied except protein compared to other extracts. Further, the quantitative estimation of phytochemicals showed that the ethanolic extract had highest yield and maximum amount of total polyphenols, flavonoids, and alkaloids with the least amount of tannins compared to other extracts studied. Furthermore, the highest total polyphenol content corresponds with the potent biological activities. Indeed, in vitro antioxidant and antisteroidogenic activities were highest in the ethanolic extract than others. To conclude, the present study is the first to report the characterization and antiaindrogenic property of V. negundo leaf extracts. The ethanolic extract of V. negundo leaves can be used as an antioxidant and antiandrogenic agent. Hence, it can be considered for the treatment of hyperandrogenie conditions like polycystic ovary syndrome, etc.

KCI등재 SCOPUS

저자 : Manh Tuan Ha , Se Eun Park , Jeong Ah Kim , Mi Hee Woo , Jae Sue Choi , Byung Sun Min

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 138-142 (5 pages)

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Alzheimer's disease (AD) is the most common age-related neurodegenerative disease in industrialized countries. It is estimated that about 47 million people living with dementia and the number of cases will be tripled by 2050. However, the exact mechanism of AD is not known, and full therapy has still not been found. Various tryptophan-derived alkaloids have been reported as promising agents for the treatment of AD. In the present study, a series of tryptophan-derived alkaloids were isolated and characterized from the methanol extract of Hedera rhombea fruit. Based on the analysis of their observed and reported spectroscopic data, their structures were identified as N-[4′-hydroxy-(E)-cinnamoyl]-L-tryptophan (1), N-[3′,4′-dihydroxy-(E)-cinnamoyl]- L-tryptophan (2), N-[4′-hydroxy-(E)-cinnamoyl]-L-tryptophan methyl ester (3), and N-[3′,4′-dihydroxy-(E)- cinnamoyl]-L-tryptophan methyl ester (4). These compounds were screened for anti-Alzheimer activity via their inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in vitro. As a result, compounds 3 and 4 showed moderate BChE inhibition with IC50 values of 86.9 and 78.4 μM, respectively, compared to those of the positive control [berberine (IC50 = 11.5 μM)]. However, all four compounds did not show significant inhibition of the AChE enzyme. This is the first time, the AChE and BChE inhibitory activities of these tryptophan-derived alkaloids were investigated and reported.

KCI등재 SCOPUS

저자 : Thi Thanh Le , Manh Tuan Ha , Le Minh Hoang , Ngoc Khanh Vu , Jeong Ah Kim , Byung Sun Min

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 143-175 (33 pages)

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In our study, sixteen known phenolic compounds, including quercetin (1), methyl gallate (2), caesalpiniaphenol C (3), 8S,8′S,7′R-(-)-lyoniresinol (4), 7,3′,5′-trihydroxyflavanone (5), sappanchalcone (6), sappanone A (7), taxifolin (8), fisetin (9), fustin (10), (+)-catechin (11), brazilin (12), 3,4,5-trimethoxyphenyl β-D- glucopyranoside (13), 1-(2-methylbutyryl)phloroglucinol-glucopyranoside (14), (+)-epi-catechin (15), and astragalin (16) and one mixture of two conformers of protosappanin B (17/18) were isolated from the stems of Caesalpinia decapetala var. japonica. Their structures were elucidated based on a comparison of their physicochemical and spectral data with those of literature. To the best of our knowledge, this represents the first isolation of compounds 3, 4, 8, 9, and 10 from C. decapetala and compounds 13 and 14 from the Caesalpinia genus. All the isolated compounds were evaluated for their inhibitory effect against the α-glucosidase enzyme. Among them, two flavonols (1 and 9), one chalcone (6), and one homoisoflavanone (7) exhibited an inhibitory effect on α-glucosidase action with an IC50 range value of 5.08 - 15.01 μM, stronger than that of the positive control (acarbose, IC50 = 152.22 μM). Kinetic analysis revealed that compounds 1 and 9 showed non-competitive α-glucosidase inhibition, while the inhibition type was mixed for compounds 6 and 7.

KCI등재 SCOPUS

저자 : Na-yeon Kim , Min Sung Ko , Chung Hyun Lee , Taek Joo Lee , Kwang-woo Hwang , So-young Park

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 3호 발행 연도 : 2022 페이지 : pp. 153-160 (8 pages)

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Neuroinflammation is known to be associated with brain injury in Alzheimer's disease (AD), and the inhibition of microglial activation, a key player in inflammatory response, is considerd as important target for AD. In this study, the ethanol extract of aerial parts of Forsythia velutina Nakai, a Korean native species, significantly inhibited nitric oxide (NO) production in LPS-stimulated BV2 microglial cells. Thus, the active principles in F. velutina aerial parts were isolated based on activity-guided isolation method. As a result, six compounds were isolated and their structures were elucidated based on NMR data and the comparison with the relevant references as arctigenin (1), matairesinol (2), rengyolone (3), ursolic acid (4), secoisolariciresinol (5), and arctiin (6). Among them, four compounds including arctigenin (1), matairesinol (2), secoisolariciresinol (5), and arctiin (6) significantly inhibited NO production in a dose-dependent manner. In particular, matairesinol (2) and secoisolariciresinol (5) reduced 60% of NO production compared to LPS-treated group. This inhibitory effects of matairesinol (2) and secoisolariciresinol (5) were accompanied with the reduced expression levels of iNOS and COX-2. These results suggest that the extract of F. velutina and its active compounds could be beneficial for neuroinflammatory diseases including AD.

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