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수록정보
수록범위 : 1권1호(1995)~27권1호(2021) |수록논문 수 : 1,165
Natural Product Sciences
27권1호(2021년 03월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Effect of Curcuma xanthorrhiza Gel on Methicillin-Resistant Staphylococcus aureus-Infected Second-Degree Burn Wound in Rats

저자 : Irfan Kesumayadi , Ayyasi Izaz Almas , Ilham Nur Hakim Rambe , Rebriarina Hapsari

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 1-9 (9 pages)

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Methicillin-resistant Staphylococcus aureus (MRSA) infection often complicates burn wounds. Mupirocin is the antibiotic of choice for superficial MRSA infection, and its resistance is on the rise due to its frequent and widespread use. This study aimed to develop and evaluate Curcuma xanthorriza extract (CXE)- containing gel as a topical agent against MRSA-infected second-degree burn wound in rats. CXE was obtained using maceration with 96% ethanol. Xanthorrhizol level, antibacterial, and antioxidant activity were evaluated using a standardized method. In vivo, the wound's healing and bacterial load were evaluated every three days, whereas the histopathology of the wound was examined on day 12 of treatment. One-Way ANOVA and Kruskal- Wallis test were used to analyze the data. In this study, 27.0% and 7.10% of the obtained CXE were xanthorrhizol and curcumin, respectively. Additionally, an IC50 of 64.27 ppm was shown in antioxidant activity measurement, and MIC against MRSA was 5 mg/ml. Treatment with CXE-containing gels showed a significant reduction in bacterial load and proliferation of connective tissue in a dose-dependent manner. In conclusion, CXE-containing gel showed a greater reduction of bacterial load and more advanced wound healing phase than mupirocin.

KCI등재 SCOPUS

2Changes of Prosapogenin Components in Tienchi Seng (Panax notoginseng) by Ultrasonic Thermal Fusion Process

저자 : Jae Bum Lee , Byung Wook Yang , Do Hyeong Kim , Dezhong Jin , Sung Kwon Ko

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 10-17 (8 pages)

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The purpose of this study is to develop a new method of producing tienchi seng (notoginseng, Panax notoginseng) extracts featuring high concentrations of the ginsenoside Rg3, Rg5, and Rg6, special components of Korean red ginseng. The chemical transformation from ginseng saponin glycosides to prosapogenin was analyzed by HPLC. Tienchi seng was heat-processed at 100oC and the optimum conditions were identified. The highest concentrations of total saponin (29.723%) and the ginsenoside Rg3 (1.769%), Rg5 (5.979%), and Rg6 (13.473%) were produced at 48 hours. Also, when tienchi seng was subjected to the ultrasonic thermal fusion (100oC) process, the concentrations of total saponin (30.578%), ginsenoside Rg3 (2.392%), Rg5 (6.614%), and Rg6 (13.017%) were highest at 36 hours. On the other hand, the 2-hour heat-processed extract and 2-hour ultrasonic thermal fusion-processed extract did not contain ginsenoside Rg3, Rg5, and Rg6. The ultrasonic thermal fusion process had an extraction yield that was approximately 1.26 times greater than that of the heat process. These results indicate that the highly functional tienchi seng extracts created through the ultrasonic thermal fusion process are more industrially useful than those produced using the heat process.

KCI등재 SCOPUS

3Cytotoxic Constituents from the Stem Bark of Chisocheton pentandrus

저자 : Rurini Retnowati , Hermin Sulistyarti , Nikmatus Zahro Wahidah , Anisa Lailatusy Syarifah , Suprianto Salam , Nurlelasari , Agus Safari , Desi Harneti , Mulyadi Tanjung , Ace Tatang Hidayat , Rani Maharani , Un

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 18-27 (10 pages)

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Eight cytotoxic constituents, consisting of six triterpenoids, cabralealactone (1), cabraleadiol (2), prototiamin A (3), 23-desmethyllimocin B (5), melianodiol (7) and indicalilacol (8) along with one limonoid, neemfruitins A (4) and one protolimonoid, protoxylocarpin G (6), were isolated from the extract of n-hexane of the stembark of Chisocheton pentandrus. The chemical structures were identified on the basis of spectroscopic evidence and compared to previously reported spectra. These isolated compounds appear for the first time in the plant. Compounds 1 - 8 were evaluated for their cytotoxic effect against MCF-7 breast cancer lines in vitro. Among the isolated compounds, melianodiol (7) showed the strongest cytotoxic activity with IC50 values of 16.8 μM.

KCI등재 SCOPUS

4Anti-inflammatory, Anti-glycation, Anti-tyrosinase and CDK4 Inhibitory Activities of Alaternin (=7-Hydroxyemodin)

저자 : Grishma Bhatarrai , Jeong-wook Choi , Su Hui Seong , Taek-jeong Nam , Hyun Ah Jung , Jae Sue Choi

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 28-35 (8 pages)

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The aim of this study was to anatomize the therapeutic potential of alaternin (=7-hydroxyemodin) against inflammation, advanced glycation end products (AGEs) formation, tyrosinase, and two cyclin-dependent kinases (CDKs), CDK2 and CDK4, and compare its potency with emodin. Alaternin showed lower cytotoxicity and higher dose-dependent inhibition against lipopolysaccharide (LPS) induced nitric oxide (NO) production with half maximal inhibitory concentration (IC50) of 18.68 μM. Similarly, alaternin efficaciously inhibited biotransformation of fluorescent AGEs and amyloid cross-β structure on the bovine serum albumin (BSA)- glucose-fructose system, five times more than emodin. Interestingly, alaternin also showed selective activity against CDK4 at 170 μM, whereas emodin inhibited both CDK2 and CDK4 at a concentration of 17 and 380 μM respectively. In addition, alaternin showed dose-dependent inhibitory activity against mushroom tyrosinase with inhibition percentage of 35.84 % at 400 μM. Altogether, alaternin with pronounced inhibition against inflammatory mediator (NO), glycated products formation, and targeted inhibition towards CDK4 receptor can be taken as an important candidate to target multiple diseases.

KCI등재 SCOPUS

5Volatiles Composition from Aerial Parts of the Insect-Pollinated and the Promising Medicinal Plant Spiraea hypericifolia L. Growing Wild in Northern Kazakhstan

저자 : Vitaliy Kirillov , Tamara Stikhareva , Gayane Atazhanova , Sezai Ercisli , Aigerim Makubayeva , Yana Krekova , Alimzhan Rakhimzhanov , Sergazy Adekenov

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 36-44 (9 pages)

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The essential oils from the aerial parts (leaves and flowers) of Spiraea hypericifolia L. (Rosaceae), collected in Northern Kazakhstan, were obtained by distillation in two dispersion media (distilled water and 15% NaCl solution). The chemical composition of the essential oils was evaluated by GC-MS for the first time. The yield of the essential oil was 0.04% (in fresh growth conditions) and 0.02% (in dry growth conditions) respectively regardless of which dispersion media (H2O or 15% NaCl solution) was used at the isolation of essential oil. The main compounds were aliphatic hydrocarbons (alkanes) (40.6-53.2%), aldehydes (8.4-17.4%), diterpenoids (9.1-16.7%) and ketones (6.2-8.7%). Content of monoterpenoids was depended on dispersion media (2.2-3.6% where H2O was dispersion media and 8.4-8.5% where 15% NaCl solution was dispersion media). n- Heneicosane (17.4-34.1%) and n-tricosane (14.3-19.5%) were the main constituents of the essential oil of S. hypericifolia. There were many insects from different classes in S. hypericifolia at flowering. Important components such as α-methylene-γ-butyrolactone (0.8-2.8%), benzyl cyanide (0.7-1.1%), β-damascenone (1.2- 2.9%), (E,E)-4,8,12-trimethyl-1,3,7,11-tridecatetraene (1.8-2.7%), β-ionone (0.5-1.8%) and others were detected in small amounts.

KCI등재 SCOPUS

6Macasiamenene V, a New Stilbenoid from the Leaves of Macaranga inermis

저자 : Muhammad Fajar Aldin , Tjitjik Srie Tjahjandarie , Ratih Dewi Saputri , Mulyadi Tanjung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 45-48 (4 pages)

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One new compound, macasiamenene V (1), and two known stilbenes (2 - 3) were isolated from Macaranga inermis Pax & K.Hoffm leaves. The structure of 1 was fully assigned based on the information on high-resolution MS and (1D, 2D) NMR spectra. The cytotoxic of compounds 1 - 3 was evaluated against 4T1 and HeLa cells. Compounds 2 - 3 showed high activity against HeLa cells with an IC50 value of 1.09 and 0.88 μg/mL, respectively.

KCI등재 SCOPUS

7Phenolic Constituents from Balanophora laxiflora with their Anti-inflammatory and Cytotoxic Effects

저자 : Nguyen Thi Hong Anh , Nguyen Thuy Duong , Pham Duc Vinh , Do Thi Ha

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 49-53 (5 pages)

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Balanophora laxiflora Hemsl. (Balanophoraceae) is a traditional medicinal plant with a diverse array of biological activities. In our exploration of new bioactive constituents from B. laxiflora, we isolated five compounds, including a new lignan, balanophorone (5), and four known phenolic compounds (1-4). The chemical structures of these compounds were determined by extensive spectroscopic analyses, including 1D and 2D NMR, HR-ESI-MS, and CD. In addition, we evaluated the effects of each of the isolates (1-5) on the messenger RNA expression levels of tumor necrosis factor (TNF)-α and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and cytotoxicity against MCF-7 and MDA-MB- 231 breast cancer cells. Compound 2 showed significant inhibition of LPS-induced COX-2 and TNF-α expression in RAW 264.7 macrophages, while compound 4 showed moderate cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells, with IC50 values of 18.3 and 30.7 μM, respectively. No significant effects on the viability of normal mammary epithelial cells were observed.

KCI등재 SCOPUS

8Determination of Bergenin in Different Parts of Bergenia ciliata using a Validated RP-HPLC Method

저자 : Ejaz Ali , Khalid Hussain , Nadeem Irfan Bukhari , Najma Arshad , Amjad Hussain , Nasir Abbas , Sohail Arshad , Sajida Parveen , Naureen Shehzadi , Shaista Qamar , Abida Qamar

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 27권 1호 발행 연도 : 2021 페이지 : pp. 54-59 (6 pages)

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Bergenia ciliata (Family: Saxifragaceae) is a folklore remedy for the treatment of various ailments in Asian countries. Bergenin (1) has been isolated as an active constituent in many studies, however, the amount of bergenin has not been determined in all parts of the plant. A simple RP-HPLC method was developed to determine the amount of bergenin in methanol extracts of leaves, rhizomes and roots of the plant. Separation was achieved on an Agilent Eclipse XDB-C18 column maintained at 25 ℃ using isocratic solvent system (water: methanol: acetic acid; 62.5:37:0.5 v/v/v) adjusted at pH 2 0 at a flow rate of 1.0 mL/min. and detected at 275 nm. Correlation coefficient (0.9952) showed linearity of concentration (5-200 μg/mL) and response. The values of LOD (0.00947 μg/mL) and LOQ (0.02869 μg/mL) indicated that method was sensitive. The recovery of bergenin was 99.99-100% indicating accuracy of method. The methanol extract of rhizomes contained higher amount of bergenin (19.4%) than roots (9.2%) and leaves (6.9%). It is concluded that methanol extract of rhizomes is a better source of bergenin than other parts of the plant. The findings are useful for standardization of bergenin containing extracts and herbal preparations.

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부산대학교 중앙대학교(서울) 가천대학교 서울대학교 University of Alberta
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