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Natural Product Sciences update

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수록정보
수록범위 : 1권1호(1995)~28권2호(2022) |수록논문 수 : 1,214
Natural Product Sciences
28권2호(2022년 06월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

저자 : Babatunde Bolorunduro Samuel , Wande Michael Oluyemi , Ayoyinka Oluwaseun Okedigba

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 45-52 (8 pages)

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The identification of Plasmodium falciparum enoyl acyl-carrier protein reductase (pfENR) is considered as a potential biological target against malaria. Trema orientalis is considered a rich source of phytochemicals useful in malaria treatment. This study evaluated the in-vitro inhibitory activity of the extract and isolated compounds of T. orientalis leaf; the isolated compounds and the analogues of the most active compound were subjected to in-silico molecular docking studies on pfENR. The methanolic extract of T. orientalis was subjected to repeated chromatographic separation which led to the isolation of some compounds. The isolated compounds from the plant were examined for their antimalarial activity using β-hematin inhibition assay. Virtual screening via molecular docking and ADMET studies were conducted to gain insight into the mechanism of binding of ligand and to identify effective pfENR inhibitors. The isolated compounds and the analogues of the most active isolates were gotten from PubChem library for use in docking study. Hexacosanol and β-sitosterol showed inhibition of the β-hematin formation. The docking results showed that hexacosanol, β-sitosterol and the analogues of β-sitosterol displayed binding energy ranging between -6.1 kcal/mol and -11.6 kcal/mol. Sitosterol glucoside has the highest docking score. Some of the ligands showed more binding affinity than known bioactive compounds used as reference. Analogues of β-sitosterol has been shown to be potential inhibitors of pfENR, therefore, the findings from this study suggest that sitosterol glucoside and ergosterol peroxide could act as antimalarial agents after further lead optimisation investigations.

KCI등재 SCOPUS

저자 : Hai Xuan Nguyen , Truong Nhat Van Do , Tho Huu Le , Phu Hoang Dang , Mai Thanh Thi Nguyen , Nhan Trung Nguyen

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 53-62 (10 pages)

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As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acidcatalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show α- glucosidase inhibitory activity with an IC50 value > 250 μM.

KCI등재 SCOPUS

저자 : Mulyadi Tanjung , Tjitjik Srie Tjahjandarie , Shola Mardhiyyah , Ghinsha Zakatina Rahman , Muhammad Fajar Aldin , Ratih Dewi Saputri , Norizan Ahmat

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 58-71 (14 pages)

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Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1 - 2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 μM.

KCI등재 SCOPUS

저자 : Abdullahi Shehu , Mangala Gowri Ponnapalli , Mohd Mahboob , Pitta Venkata Prabhakar , Gabriel Ademola Olatunji

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 62-88 (27 pages)

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Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1- monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.

KCI등재 SCOPUS

저자 : Hyun Jun Lee , Sang Back Kim , Kyung Jun Boo , Darlene Mae Ortiz , Leandro Val Sayson , Raly James Perez Custodio , Jae Hoon Cheong , Seul Ki Kim , Mikyung Kim , Hee Jin Kim

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 68-74 (7 pages)

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HemoHIM was used as a Korean traditional medicine for anti-inflammatory and antioxidant effects. However, there is no study on the effect of HemoHIM on fatigue. We examined the potential use of HemoHIM to determine whether it can induce anti-fatigue effects. Mice were administered with HemoHIM and VEH for 14 days. On the last day of treatment, mice were subjected to behavioral tests. Subsequently, their plasma and muscle were collected after the treadmill test to measure lactate, lactate dehydrogenase (LDH), ammonia, corticosterone, glycogen, and creatine kinase (CK). We found that HemoHIM moderately increased the running time (s) in the treadmill and mobility duration in the cold swimming tests. In addition, the VEH group showed a significant increase in lactate, LDH, and corticosterone levels in the plasma compared to the group that did not perform the test. However, this was moderately reduced in HemoHIM treatment. Moreover, the HemoHIMtreated group showed significant differences in LDH and glycogen levels, and showed significantly different CK levels in the muscle. HemoHIM is considered to be effective in improving fatigue, given the duration of cold swimming or running time on a treadmill. Also, HemoHIM treatment resulted in reduced concentrations of blood and muscle parameter analysis.

KCI등재 SCOPUS

저자 : Chae Won Kim , Jun Hwi Ko , Do Hyeong Kim , Dezhong Jin , Sung Kwon Ko

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 75-79 (5 pages)

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As a result of comparing the phenolic components of cinnamon medicines, the total phenolic component content of Cinnamomi Cortex in China was about 2.65 times higher than that of Cinnamomi Cortex in Vietnam. In addition, the total phenolic component content of Vietnamese Cinnamomi Cortex Spissus was about 1.80 times higher than that of Chinese Cinnamomi Cortex Spissus. Meanwhile, Vietnamese Cinnamomi Ramulus showed a content about 3.29 times higher than that of Chinese Cinnamomi Ramulus. Cinnamaldehyde, the main component of cinnamon medicines, showed the same tendency as the total phenolic component content. In terms of the average content of the total phenolic components, Cinnamomi Cortex showed the highest content at 23964 μg/g, followed by Cinnamomi Cortex Spissus at 17489 μg/g and Cinnamomi Ramulus at 5435.8 μg/g. These results showed that Cinnamomi Cortex and Cinnamomi Cortex Spissus with stem bark as usage sites had about 3.22 to 4.41 times higher content of phenolic components than Cinnamomi Ramulus with young branches as usage sites.

KCI등재 SCOPUS

저자 : Dan-dan Li , Ying Wang , Zhiran Ju , Eun La Kim , Jongki Hong , Jee H. Jung

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 80-95 (16 pages)

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Colorectal cancer is one of the most common cancers globally, ranking second for the number of cancer-related deaths. Metastasis has been reported as the main cause of death in patients with colorectal cancer. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a transcription factor that functions as a tumor suppressor by inhibiting cellular proliferation, migration, and invasion. In our previous efforts to generate natural product-motivated PPAR-γ ligands, the compounds 1 and 2 were obtained. These compounds activated PPAR-γ and inhibited the migration and invasion of HCT116 colorectal cancer cells, and they were also found to inhibit the epithelial-to-mesenchymal transition, which is a key process in cancer metastasis. Compounds 1 and 2 upregulated expression of the epithelial marker (E-cadherin), and downregulated expression of the mesenchymal marker (N-cadherin) and transcriptional factor (Snail). Therefore, the PPAR-γ agonists 1 and 2 could serve as a valuable model for the study on anti-metastatic leads for the treatment of colorectal cancer.

KCI등재 SCOPUS

저자 : Hyojin Lee , Kyoung Won Jang

발행기관 : 한국생약학회 간행물 : Natural Product Sciences 28권 2호 발행 연도 : 2022 페이지 : pp. 89-92 (4 pages)

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In Asia, the roots of Paeonia lactiflora and Astragalus membranaceus have been used as therapeutic agents for thousands of years. Once the medicinal plants are harvested, they are dried and their ingredients are extracted by heat-mediated reflux extraction. However, the condensed structure of organic products (especially roots) limits the extraction of bioactive components. In this study, we assessed the effect of the puffing method (using high temperature and pressure) before the extraction process in relation to the profile and antioxidant capacity of active ingredients. We demonstrated that the additional puffing process before extraction methods improves the yield of polyphenol concentrations and antioxidant activities from the roots of P. lactiflora and A. membranaceus.

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