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대한본초학회> 대한본초학회지(본초분과학회지)

대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

  • : 대한본초학회
  • : 의약학분야  >  기초한의학
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수록정보
수록범위 : 1권0호(1986)~36권2호(2021) |수록논문 수 : 1,625
대한본초학회지(본초분과학회지)
36권2호(2021년 03월) 수록논문
최근 권호 논문
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KCI등재

1면화자 정유의 기억력 손상 완화 효과

저자 : 이지혜 ( Jihye Lee ) , 정은미 ( Eun Mi Jung ) , 이은홍 ( Eunhong Lee ) , 장귀영 ( Gwi Yeong Jang ) , 서경혜 ( Kyung Hye Seo ) , 김미려 ( Mi Ryeo Kim ) , 정지욱 ( Ji Wook Jung )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 2호 발행 연도 : 2021 페이지 : pp. 1-9 (9 pages)

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Objectives : Gossypium arboreum (cotton) is traditionally used to treat various health disorders. However, anti-amnesic effect of G. arboreum has not been reported. The objective of this study was to investigate in-vivo the anti-amnesic effects along with in vitro antioxidant and acetylcholinesterase (AChE) inhibition potential in G. arboreum seed essential oil.
Methods : The essential oil of G. arboreum obtained by solid phase microextraction (SPME) techniques were identified by gas chromatography-mass spectroscopy (GC-MS). 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'- azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay were performed to determine the antioxidant activity at various concentrations (312.5, 625, 1250, 2500, 5000, 10000 ㎍/㎖. Y-maze, passive avoidance and Morris water maze tests were carried out to evaluate improved effect on scopolamine (1 ㎎/㎏)-induced memory dysfunction at the dose level of 50, 100 and 200 ㎎/㎏. Donepezil (5 ㎎/㎏) was used as a positive drug control. We performed acetylcholinesterase (AChE) activity assay in ex vivo.
Results : Five volatile compounds were identified in G. arboreum. The assays of DPPH and ABTS revealed that G. arboreum increased antioxidant activity in a dose-dependent manner. G. arboreum ameliorated the percent of spontaneous alternation in the Y-maze test, shortened step-through latency in the passive avoidance test, and increased swimming time in the target zone in the Morris water maze test. In addition, G. arboreum inhibited the AChE activity.
Conclusions : Based on these findings, G. arboreum may aid in the prevention and treatment of learning and memory-deficit disorders through antioxidant and AChE inhibitory activities.

KCI등재

2목통(木通)이 알코올 투여로 유발된 흰쥐의 간, 비장 및 가슴샘의 손상에 미치는 영향

저자 : 이지혜 ( Ji Hye Lee ) , 서부일 ( Bu-il Seo )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 2호 발행 연도 : 2021 페이지 : pp. 11-17 (7 pages)

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Objective : This study was conducted to investigate the effects of Effects of Akebia quinata (AQ) extract on alcohol-induced damage of liver, spleen and thymus in rats.
Method : Experimental animals were divided in to 4 groups; Normal group, Alcohol group, AQ50 group and AQ200 group. All rats, except for Normal group, were fed 25 % ethanol for 55 days. During experimental period, Normal group and Alcohol group were administrated saline, and AQ50 group and AQ200 group were administrated AQ extract at dose of 50 and 200 ㎎/㎏/day, respectively. We measured organ weight, liver triglyceride contents, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and triglycerid levels in serum. Also, we conducted histomorphometry and histopathological observation of liver, spleen and thymus.
Results : AQ significantly decreased the level of AST, ALT and triglyceride in serum and the liver triglyceride contents induced by ethanol. Also, AQ significantly inhibited lipid droplets accumulation in hepatocytes. The decreased relative organ weight of spleen and thymus by ethanol were increased by AQ administration. In histopathological analysis of spleen, the rats administrated AQ 200 ㎎/㎏ presented significantly increased mean diameters of white pulps, numbers of white pulps and splenic thicknesses. The administration of 200 ㎎/㎏ AQ improved decreased lobular thickness and cortex thickness of thymus, which were decreased by ethanol.
Conclusions : The results of present study indicated that AQ has an ameliorating effect for fatty degeneration of liver and damage of spleen and thymus.

KCI등재

3추출 용매를 달리한 생강 추출물에 대한 생리활성의 비교 평가 연구

저자 : 김소영 ( So Young Kim ) , 최문열 ( Moon-yeol Choi ) , 도은주 ( Eun Ju Do ) , 김미려 ( Mi Ryeo Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 2호 발행 연도 : 2021 페이지 : pp. 19-29 (11 pages)

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Objective : This study was designed to investigate anti-oxidative, anti-aging and anti-inflammatory activities of Zingiber officinale Roscoe water (ZD) and 50% ethanol extracts (ZE).
Method : The antioxidant capacity of ZD or ZE was analyzed by DPPH, ABTS scavenging activities and reducing power, respectively. The anti-aging efficacy was performed with tyrosinase and collagenase inhibition activities. The anti-inflammatory activities were confirmed through inhibition of nitric oxide production and TNF-α expression in LPStreated Raw 264.7 cells.
Result : As a result of measuring DPPH and ABTS radical scavenging activities, both ZD and ZE extracts increased in concentration-dependent manners. The ABTS radical scavenging activities of water and 50% ethanol extract were similar to that of positive control at high concentration. On reducing power, both ZD and ZE showed higher activities than the positive control at high concentration. On inhibition activities of tyrosinase and collagenase both ZD and ZE showed the large inhibition rates at low concentration. Also, the inhibitory efficacy of ZD on NO and TNF-α production was better than ZE in RAW 264.7 cells.
Conclusion : These results suggest that ZD and ZE have anti-oxidative, anti-aging and anti-inflammatory effects in vitro. Especially, ZD was more effective than ZE. Thus, Ginger extract is considered to be highly useful as a cosmetic or food material with anti-oxidative, anti-aging (prevention of whitening and wrinkle) and anti-inflammatory effects. Also these effects may vary depending on the extraction solvent.

KCI등재

4Thioacetamide로 유발한 간손상 모델에서 계혈등(鷄血藤)의 간보호 효과

저자 : 오민혁 ( Min Hyuck Oh ) , 신미래 ( Mi-rae Shin ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 2호 발행 연도 : 2021 페이지 : pp. 31-42 (12 pages)

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Objectives : This study was undertaken to investigate the hepatoprotective effect of Spatholobi Caulis water extract (SC) to thioacetamide (TAA)-induced acute liver injury (ALI) in rats.
Methods : The rats were injected intraperitoneally with TAA (200 ㎎/㎏ body weight) and orally administered SC (100 or 200 ㎎/㎏ b.w.) daily for 3 days. Liver biomarkers were assessed by serum glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and ammonia levels. Malondialdehyde (MDA) was measured both serum and liver tissue. In addition, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, anti-oxidant, and inflammation-related proteins were investigated by western blot analysis. Histological examination further confirmed though hematoxylin and eosin stain.
Results : The SC treatment reduced liver function markers like GOT and GPT and also remarkably decreased ammonia level. Moreover, the elevated MDA level in TAA-induced group was significantly reduced by SC treatment. NADPH oxidase expression associated with oxidative stress including NOX2, NOX4, and p47phox markedly inhibited by SC administration. SC treatment exerted anti-oxidant effect through the increase of anti-oxidant enzyme including superoxide dismutase (SOD), Catalase, and heme oxygenase-1 (HO-1). The protein expressions of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-6, and IL-1β induced by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor κBα (IκB)α. SC treatment also improved histological alterations.
Conclusion : These findings suggested that SC administration may be a potential candidate for the prevention or treatment of ALI.

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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