간행물

대한본초학회> 대한본초학회지(본초분과학회지)

대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

  • : 대한본초학회
  • : 의약학분야  >  기초한의학
  • : KCI등재
  • :
  • : 연속간행물
  • : 격월
  • : 1229-1765
  • : 2288-7199
  • :

수록정보
수록범위 : 1권0호(1986)~36권6호(2021) |수록논문 수 : 1,655
대한본초학회지(본초분과학회지)
36권6호(2021년 11월) 수록논문
최근 권호 논문
| | | |

KCI등재

1뇌전증 동물 모델에 대한 백출 추출물의 보호 효과

저자 : 강소희 ( Sohi Kang ) , 이수은 ( Su Eun Lee ) , 이아영 ( Ayeong Lee ) , 서윤수 ( Yun-soo Seo ) , 문창종 ( Changjong Moon ) , 김성호 ( Sung Ho Kim ) , 이지혜 ( Jihye Lee ) , 김중선 ( Joong Sun Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 1-8 (8 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : Atractylodis rhizoma Alba has been traditionally used as a medicinal resource that is used for enhancing Qi (氣) in traditional medicine in Korea, China, and Japan. This study investigated the protective effects of Atractylodis rhizoma Alba extract (ARE) against trimethyltin (TMT), a neurotoxin that causes selective hippocampal injury, using both in vitro and in vivo models.
Methods : We investigated the effects of ARE on TMT- (5mM) induced cytotoxicity in primary cultures of mouse hippocampal cells (7 days in vitro ) and on hippocampal injury in C57BL/6 mice injected with TMT (2.6 mg/kg).
Results : We observed that ARE treatment (0 - 50 μg/mL) significantly reduced TMT-induced cytotoxicity in cultured hippocampal neurons in a dose-dependent manner, based on results of lactate dehydrogenase and 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assays. Additionally, this study showed that orally administered ARE (5 mg/kg; between -6 and 0 days before TMT injection) significantly attenuated seizures in adult mice. Furthermore, quantitative analysis of allograft inflammatory factor-1 (Iba-1)- and glial fibrillary acidic protein (GFAP)- positive cells showed significantly reduced levels of Iba-1- and GFAP-positive cell bodies in the dentate gyrus of mice treated with ARE prior to TMT injection. These findings indicate the significant protective effects of ARE against the TMT-induced massive activation of microglia and astrocytes in the hippocampus.
Conclusions : We conclude that ARE minimizes the detrimental effects of TMT-induced hippocampal neurotoxicity, both in vitro and in vivo . Our findings may serve as useful guidelines to support ARE administration as a promising pharmacotherapeutic approach to hippocampal degeneration.

KCI등재

2인삼저온숙성비누의 세안효과 연구

저자 : 구진숙 ( Jin Suk Koo )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 9-16 (8 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : The researcher had investigated the efficacy of ginseng using Microneedle Therapy System (MTS) and confirmed the effect of ginseng Cold Process (CP) soap just before and after washing face. The purpose of this study was to find out what kind of effect appeared through a period of 6 weeks when environmental factors were involved using ginseng CP soap.
Methods : The researcher selected 47 subjects, 37 as the experimental group and 10 as the control group. The researcher asked participants to wash their face twice a day in the morning and evening using ginseng CP soap, and the period was set for 6 weeks. The researcher had the people who selected as the control group use a commercially available foam cleanser. They performed a skin test before the start of the test, and the change status was continuously investigated 2 weeks, 4 weeks, and 6 weeks after using the soap.
Results : In the case of T-zone oil, there was a significant decrease in the use of foam cleansing and ginseng CP soap, and in the case of pores and pigmentation, a significant decrease was observed only in the use of ginseng CP soap. In skin tone change, there was a significant effect in both the experimental group and the control group, but the significance was greatly increased in the case of ginseng CP soap compared to foam cleansing.
Conclusions : Ginseng CP soap is considered to be a more suitable cleanser for skin care compared to foam cleansing.

KCI등재

3바이칼레인(Baicalein)이 indomethacin으로 유발된 생쥐 Leydig세포의 일산화질소 생성에 미치는 영향

저자 : 박완수 ( Wansu Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 17-25 (9 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : Baicalein (3,3′, 4′, 5, 6-pentahydroxyflavone), a type of flavonoid, is a well-known antioxidant and anti-inflammatory ingredient found in Scutellaria baicalensis root. The aim of this study is to investigate the effect of baicalein on nitric oxide (NO) production in TM3 mouse Leydig cells stimulated by indomethacin (IN).
Methods : TM3 cells were treated with IN (0.5 μM) and baicalein at concentrations of 12.5, 25, 50, and 100 μM for 24 hr, 40 hr, 42 hr, 44 hr, and 64 hr. After treatments, cell viabilities were measured with the modified MTT assay. The production of nitric oxide in cells was measured by Griess reagent assay.
Results : Baicalein showed no cytotoxicity on IN-stimulated TM3. NO production in IN-stimulated TM3 treated for 24 hr with baicalein at concentrations of 12.5, 25, 50, and 100 μM was 95.8%, 94.86%, 89.97%, and 81.52% of the control group treated with IN only, respectively; NO production for 40 hr was 97.34%, 97.34%, 95.15%, and 87.42%, respectively; NO production for 42 hr was 89.12%, 90.14%, 89.74%, and 90.26%, respectively; NO production for 44 hr was 83.83%, 84.94%, 85.65%, and 86.85%, respectively; NO production for 64 hr was 94.12%, 95.38%, 94.21%, and 94.12%, respectively. Specifically, baicalein at concentrations of 12.5, 25, and 50 have been shown to most efficiently inhibit NO productions in 48 hr of treatment.
Conclusions : Baicalein might have anti-toxicant effect on Leydig cells related with its inhibition of NO production in Leydig cells stimulated with IN.

KCI등재

4산수유(山茱萸)와 보골지(補骨脂) 복합추출물의 Sprague-Dawley 랫드를 이용한 13 주 반복경구투여 독성시험 및 4 주 회복시험

저자 : 심서아 ( Seo-ah Sim ) , 강성철 ( Sung-chul Kang ) , 진보람 ( Bo-ram Jin ) , 김민정 ( Min-jeong Kim ) , 여수정 ( Sujung Yeo ) , 박인화 ( In-hwa Park ) , 정의민 ( Ui Min Jerng ) , 차윤엽 ( Yun-yeop Cha ) , 안지혜 ( Ji-hye Ahn ) , 안효진 ( Hyo-jin An )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 27-37 (11 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : In the current study, we performed the 13-week repeated oral dose toxicity test and a 4-week recovery test of standardized Cornus officinalis Sieb. et Zucc. and Psoralea corylifolia L. 30 % ethanol extract (SCP) in Sprague- Dawley (SD) rats owing to aims for verifying no observed adverse effect level (NOAEL).
Methods : The animal study was performed according to OECD guidelines for the testing of chemicals section 4 health effects test No.408 repeated dose 90-day oral toxicity study in rodents (03 October 2008). In the repeated dose toxicity study, SCP was orally administered to female and male rats at dose levels of 1,000, 2,000, and 4,000 mg/kg/day for 13-week. The control group and high dose (4,000 mg/kg/day) group were then monitored for 4 extra weeks to determine recovery time after the study period. 1)
Results : Compared with the control group, there were no treatment-related adverse effects in clinical signs, body weight, hematology, serum biochemistry (Aspartate aminotransferase, Alanine aminotransferase, Alkaline phosphatase, γ-Glutamyl transpeptidase, Blood urea nitrogen, Creatinine, Glucose, Total cholesterol, Total protein, Creatine phosphokinase, Albumin, Total bilirubin, Triglyceride, Inorganic phosphorus, Albumin/Globulin ratio, Calcium ion, Sodium ion, Potassium ion, Chloride ion), necropsy findings and organ weight (Ovary, Adrenal gland, Pituitary, Thymus, Prostate, Testis, Epididymis, Spleen, Kidney, Heart, Lung, Brain, Liver) at any dose tested.
Conclusions : Taken together, these results suggest that the NOAEL of SCP in both genders was considered as over 4,000 mg/kg. Results from this study provide scientific evidence for the safety of SCP.

KCI등재

5LKB1/AMPK 신호 전달 경로의 활성화로 인한 새싹율무 열수 추출물의 항비만 효과

저자 : 김민주 ( Min Ju Kim ) , 이정훈 ( Jeong Hoon Lee ) , 최정원 ( Jeong Won Choi ) , 박해진 ( Hae-jin Park ) , 신미래 ( Mi-rae Shin ) , 노성수 ( Seong-soo Roh )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 39-46 (8 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : AMP-activated protein kinase (AMPK) is a key metabolic regulator that reduces lipogenesis. AMPK is mainly activated via phosphorylation of liver kinase B (LKB) 1 under energy stress. Here, we highlighted the anti-obesity effect and underlying mechanism of Coix lacryma-jobi var. mayuen Stapf sprout water extract (CSW) sprout extract in connection with the LKB1/AMPK signaling pathway.
Methods : C57BL/6 mice (20~25 g) fed HFD to induce obesity and at the same time administered CSW 100 mg/kg (CSWL; (CSWL; CSW low concentration) or CSW 200 mg/kg (CSWH; CSW high concentration) or Garcinia extract (Garcinia) 200 mg/kg orally for 6 weeks. Body weight and food intake were measured at the same time each day. After 6 weeks of CSW administration, liver tissue and serum were obtained through an autopsy. After the end of the experiment, biochemical analysis (triglycerides (TG), total cholesterol (TC), HDL-cholesterol, and LDL-cholesterol) was performed on the serum. And then, protein levels related to TG and TC synthesis were measured through western blot analysis in liver tissue.
Results : As a result, serum TG, TC, and LDL-cholesterol levels were significantly increased in the control group and significantly decreased in the CSW administration group. On the other hand, the HDL-cholesterol level was increased in the CSW-administered group. And as a result of Western blot analysis, CSW significantly increased the phosphorylation of LKB1 & AMPK, and remarkably decreased the expression of factors related to TG and TC synthesis.
Conclusions : Our findings suggest that CSW influences the TG and TC synthesis to positively affect HFD-induced obesity in C57BL/6 mice.

KCI등재

6증폭(蒸曝)에 의한 지황(地黃)의 성분 변화에 대한 고찰

저자 : 정재우 ( Jae Woo Jung ) , 김한영 ( Han Young Kim ) , 류지효 ( Ji Hyo Lyu ) , 김정훈 ( Jung-hoon Kim )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 36권 6호 발행 연도 : 2021 페이지 : pp. 47-61 (15 pages)

다운로드

(기관인증 필요)

초록보기

Objectives : 'Steaming and drying' is a traditional processing method that has been used to produce Suk-ji-hwang (熟地黃; Rehmanniae Radix Preparata) from Ji-hwang (地黃, the fresh root of Rehmannia glutinosa Liboschitz ex Steudel; Rehmanniae Radix). The steaming and drying process, which is proceeded in heating and moisturizing conditions, plays a crucial role in the change of therapeutic effect of Ji-hwang, presumably due to the modification of its chemical constituents. In this article, the chemical influence of the 'Steaming and drying' process was investigated for understanding the underlying mechanism of chemical modification of Ji-hwang.
Methods : The articles regarding the modifications of chemical constituents of Ji-hwang during the 'Steaming and drying' process were collected and analyzed to investigate the influence of the processing to Ji-hwang.
Results : The results indicated that iridoid glycosides were degraded to their aglycones and sugars, and such degradations occurred faster at a high pressure than at an atmospheric pressure during the process. The contents of catalpol, ajugol, and acteoside were decreased, while those of rehmannioside A and D were slightly increased during the repeated processing. The contents of oligosaccharides, namely sucrose, maltose, raffinose, and stachyose (except for manninotriose), were decreased, while those of monosaccharides, glucose and fructose, were increased by the repeated processing.
Conclusions : These results demonstrate that the 'Steaming and drying' process influenced the chemical constituents of Ji-hwang and provide probable basis for the therapeutic modification of Suk-ji-hwang after the processing of Ji-hwang.

1
권호별 보기

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기