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대한본초학회지(본초분과학회지) update

The Korea Jounrnal of Herbology

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수록정보
수록범위 : 1권0호(1986)~37권3호(2022) |수록논문 수 : 1,668
대한본초학회지(본초분과학회지)
37권3호(2022년 05월) 수록논문
최근 권호 논문
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KCI등재

1금화규 함유 에센스가 안면피부에 미치는 영향

저자 : 이재원 ( Jae Won Lee ) , 구진숙 ( Jin Suk Koo )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 3호 발행 연도 : 2022 페이지 : pp. 1-8 (8 pages)

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Objectives : The purpose of this study was to investigate the efficacy of Abelmoschus manihot (A-M) on the facial skin by observing the changes in the skin caused by continuous use of the essence containing A-M.
Methods : Fifty-one participants were enrolled, 38 were classified as experimental group and 13 were classified as control group. Before the beginning of the test, the skin condition of the participants was investigated with the facial analyzer. An essence containing A-M was provided to the experimental group, and an essence base not containing Abelmoschus manihot was provided to the control group. Participants were asked to use the product in the morning and evening after washing their face. We checked the skin change status every 2 weeks and performed the test 3 times for 6 weeks.
Results : In the case of t-zone oil and pores, there was a significant decrease in the experimental group. In the case of moisture, a significant increase was observed in the control group, but the significance was significantly increased when the essence containing A-M was used. In the case of elasticity, it was found that the experimental group continued to increase with the period of use.
Conclusion : It is thought that the essence containing A-M will be effective in preventing skin aging through the reduction of t-zone oil, the size of the pores, and the increase in moisture and elasticity.

KCI등재

2당귀(當歸) 추출물이 피부 각질형성세포의 염증반응에 미치는 영향

저자 : 허정 ( Jung Huh ) , 박호연 ( Hoyeon Park ) , 김엄지 ( Eom Ji Kim ) , 김은영 ( Eun-young Kim ) , 손영주 ( Youngjoo Sohn ) , 정혁상 ( Hyuk-sang Jung )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 3호 발행 연도 : 2022 페이지 : pp. 9-19 (11 pages)

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Objectives : Angelicae Gigantis Radix (AG) is a plant of the Ranunculus family. AG have been reported to have various pharmacological effects on human health which include uterine growth promotion, anti-inflammatory, analgesic, and immune enhancement. However, research on dermatitis disease is insufficient. Therefore, we investigated the effects of AG on tumor necrosis factor-α (TNF-α)/interferon-γ (IFN-γ) stimulated HaCaT cell.
Methods : To investigate the effect of AG on HaCaT cell, HaCaT cells were pre-treated with AG for 1 hour and then stimulated with TNF-α/IFN-γ. After 24 hours, media and cells were harvested to analyze the inflammatory mediators. Concentration of human interleukin-1beta (IL-1β), monocyte chemoattractant protein-1 (MCP-1), granulocyte-macrophage colony-stimulating factor (GM-CSF), and TNF-α in the media were assessed by ELISA. mRNA expression of human thymus and activation-regulated chemokine (TARC), IL-6, and IL-8 were analyzed by RT-PCR. Additionally, the mechanisms of mitogen-activated protein kinases (MAPKs) and nuclear factor kappalight- chain-enhancer of activated B cells (NF-κB) signaling pathway were investigated by Western blot.
Results : The treatment of AG inhibited gene expression levels of IL-6, IL-8, and TARC and protein expression levels of IL-1β, MCP-1, and GM-CSF. Also, AG significantly reduced extracellular signal-regulated kinase (ERK) phosphorylation and NF-κB translocation in TNF-α/IFN-γ stimulated HaCaT cell.
Conclusions : Taken together, these results demonstrate that AG can alleviate inflammatory diseases such as atopic dermatitis by regulating the expression of inflammatory cytokines. Also, it suggest that AG may a promising candidate drug for the treatment of inflammatory disease such as atopic dermatitis.

KCI등재

3털부처꽃 물 추출물의 Sprague-Dawley 랫드를 이용한 단회경구투여 독성시험

저자 : 김희영 ( Hee-young Kim ) , 박예진 ( Yea-jin Park ) , 신수 ( Su Shin ) , 최민우 ( Min-woo Choi ) , 홍은진 ( Eun-jin Hong ) , 신영우 ( Young Woo Shin ) , 차윤엽 ( Yun-yeop Cha ) , 안효진 ( Hyo-jin An )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 3호 발행 연도 : 2022 페이지 : pp. 21-27 (7 pages)

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Objectives : Single oral dose toxicity test of Lythri Herba water extracts (LHWE) in Sprague-Dawley (SD) rat was performed to determine approximate lethal dose (ALD) of LHWE.
Methods : This test was progressed according to OECD Guidelines for the Testing of Chemicals : acute oral toxicity. After adaptation of 7 days, SD rats were divided into 2 groups : vehicle control and 5000 mg/kg LHWE-treated group. Each group consisted of 5 female rats and 5 male rats. Vehicle or 5000 mg/kg LHWE was orally administrated once a day. Survival rates, general toxicity, and changes of body weight were investigated for 14 days after administration. On the last day of examination, the weight of all animals was measured and an autopsy was performed. All internal organ abnormalities were checked macroscopically and their findings were recorded.
Results : In both groups, dead animals were not observed. During 14 days of administration, abnormal clinical signs were not detected. There was also no significant difference in weight gains between each group. Autopsy analysis showed that one case of the LHWE-treated female group had retention of clear fluid in the uterus; however, it was not considered to be affected by LHWE administration. Moreover, abnormal findings were not discovered in the control male group and the LHWE-treated male group.
Conclusions : These results suggest that the ALD of LHWE exceed 5000 mg/kg and single oral administration of LHWE below 5000 mg/kg is nontoxic.

KCI등재

4미세먼지 유발 폐기능 손상 동물모델에서 RML의 호흡기 보호 효과

저자 : 김수현 ( Soo Hyun Kim ) , 김민주 ( Min Ju Kim ) , 신미래 ( Mi-rae Shin ) , 노성수 ( Seong-soo Roh ) , 김승형 ( Seung Hyung Kim ) , 박해진 ( Hae-jin Park )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 3호 발행 연도 : 2022 페이지 : pp. 29-39 (11 pages)

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Objective : This study is aimed to evaluate the protective effects of Rehmanniae Radix, Mori Folium, and Liriopie Tuber mixture (RML) on lung injury of Particulate matter less than 10 um in diameter and diesel exhaust particles (PM10D) mice model.
Methods : To investigate the anti-inflammatory activity of RML, PM10D was diluted in aluminum hydroxide (Alum) in 7-week-old male mice and induced by Intra-Nazal-Tracheal (INT) injection method. Animal experiments were divided into 5 groups. Nor (normal mice), CTL (PM10D-induced mice with the administration of distilled water), DEXA (PM10D-induced mice with the administration of 3 mg/kg Dexamethasone), RML 100 (PM10D-induced mice treated with RML 100 mg/kg weight), and RML 200 (PM10D-induced mice treated with RML 200 mg/kg body weight). After 11 days administration, mice were sacrificed and inflammation-related immune cells in broncho-alveolar lavage fluid (BALF) were analyzed. Inflammation-related biomarkers were also analyzed in blood and lungs. Lung tissue was observed through histological examination.
Results : In the PM10D induced model, the PML showed decreases in CXCL-1 and IL-17A in BALF. Expression of inflammatory cytokines and cough-related mRNA genes was significantly decreased in serum and lung tissue. The mixture treatment of RML significantly improved the immune related cells in the serum. In addition, histological observations showed a tendency to decrease the severity of lung injury.
Conclusions : Overall, these results confirmed the respiratory protective effect of the RML mixture in a model of lung injury induced by air pollution (PM10+DEP), suggesting that it is a potential treatment for respiratory damage.

KCI등재

5TNF-α/IFN-γ 유도된 각질형성세포 염증에서 가자 추출물의 케모카인 저해 효과

저자 : 조일주 ( Il-joo Jo )

발행기관 : 대한본초학회 간행물 : 대한본초학회지(본초분과학회지) 37권 3호 발행 연도 : 2022 페이지 : pp. 41-47 (7 pages)

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Objectives : Terminalia chebula (TC) has been used as a traditional remedy to treat gastrointestinal infectious and inflammatory diseases. However, its protective effects and mechanisms against skin inflammation have not been well-elucidated. Thus, the aim of this study is to evaluate the protective effects of the TC water extract and also to suggest a putative mechanism of TC against skin injury on human keratinocytes, HaCaT cells.
Methods : HaCaT cells were pre-treated with TC for 1 h and then stimulated with tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) (10 ng/mL each) to induce skin inflammation and injury. After 24 h, the cells were harvested to evaluate the expression of Th2 chemokines, such as C-C motif chemokine ligand 5 (CCL5, also known as RANTES), C-C chemokine ligand 17 (CCL17, also known as TARC) and C-C chemokine ligand 22 (CCL22, also known as MDC). To investigate the regulatory mechanisms of TC, we also assessed the phosphorylation of signal transducer and activator of transcription 1 (STAT1) signaling pathways in HaCaT cells.
Results : Treatment of TC decreased the mRNA levels of RANTES, TARC and MDC with a concentration dependent manner against co-stimulation of TNF-α and IFN-γ. In addition, TC significantly reduced TNF-α and IFN-γ induced phosphorylation of STAT1.
Conclusions : In summary, we propose that TC may be a promising candidate for anti-inflammatory skin protector through the inhibition of chemokines via STAT1 deactivation.

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