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대한상한금궤의학회지 update

The Journal of Korean Medical Association of Clinical Sanghan-Geumgwe (J of KMediACS)

  • : 대한상한금궤의학회
  • : 의약학분야  >  기초한의학
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수록정보
수록범위 : 1권1호(2009)~13권1호(2021) |수록논문 수 : 157
대한상한금궤의학회지
13권1호(2021년 12월) 수록논문
최근 권호 논문
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KCI후보

저자 : 장일웅 ( Jang Il-woong ) , 홍준영 ( Hong Jun-yeong ) , 이숭인 ( Lee Soong-in )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 1-19 (19 pages)

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Purpose : Sayeok-tang (Sini decoction, SND) is a cold-dispelling formula used for cold deficiency syndrome and is composed of Aconiti Lateralis Radix Preperata, Zingiberis Rhizoma, and Glycyrrhizae Radix et Rhizoma. It is used for diseases such as myocardial infarction, heart failure, acute and chronic gastroenteritis, and gastric effusion. This study proposes the possibility of expansion of basic research and clinical applications for ischemic heart disease (IHD) through systematic analysis of domestic and foreign studies on SND.
Methods :We collected studies within the last 10 years on the use of SND in IHD and excluded those lacking relevance. Selected studies were classified by research method and the main themes of the studies were analyzed for each classification.
Result: Out of 15 studies, there were 5 animal studies, 8 metabolite analyses in animals, 1 in vitro study, and 1 systematic review. Our review suggests that SND may be used as an adjuvant to nitroglycerin and percutaneous transluminal coronary angioplasty, and may improve symptoms and quality of life of patients with IHD. Myocardial protective effects through antioxidant, anti-inflammatory, anti-apoptotic, and anti-hypertensive actions were confirmed through these studies. Effects on carbohydrate, protein, and lipid metabolism were also reported.
Conclusions : This study suggests that SND has potential as a treatment for IHD.

KCI후보

저자 : 서영호 ( Young-ho Seo ) , 정태영 ( Hae-yun Choi ) , 김종대 ( Jong-dea Kim ) , 최해윤 ( Tae-young Jung )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 21-44 (24 pages)

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Objective:This study aimed to assess the preventive effect of Bupleuri Radix aqueous extracts (BR) and red koji-fermented BR (fBR) in lipopolysaccharide (LPS)-induced acute lung injury in a rat model.
Methods:Rats were administered 30, 60, or 120 mg/kg/day of fBR for 28 days before LPS treatments. All rats were sacrificed 5 h after LPS treatment (500 μg/head, intratracheal instillation). Body weights, lung weights, pulmonary transcapillary albumin transit, arterial gas parameters (pH, partial pressure [Pa] of O2, PaCO2), bronchoalveolar lavage fluid (BALF) protein, lactate dehydrogenase (LDH), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1 β), total cell numbers, neutrophil/alveolar macrophage ratios, lung malondialdehyde (MDA), and myeloperoxidase (MPO) were measured. In addition, histopathological changes including the luminal surface of alveoli (LSA), thickness of alveolar septum, and number of polymorphonuclear neutrophils (PMNs) were checked.
Results:LPS injection led to increases in lung weights, pulmonary transcapillary albumin transit, BALF protein, LDH, TNF-α and IL-1β contents, total cells, neutrophil and alveolar macrophage ratios, lung MDA, MPO, alveolar septum thickness, and PMNs, and decreases in PaCO2 and pH of arterial blood and LSA. However, these LPS-induced acute lung injuries were inhibited by pretreatment of 30, 60, and 120 mg/kg of fBR. The most favorable effects were seen with 30 mg/kg fBR as compared with 60 mg/kg of α-lipoic acid and BR.
Conclusions:fBR showed preventive effects on LPS-induced acute lung injury, which resembles acute respiratory distress syndrome. The mechanisms of action were likely via antioxidant and anti-inflammatory means.

KCI후보

저자 : 윤효중 ( Hyo-joong Yun ) , 하현이 ( Hyun-yee Ha ) , 두인선 ( In-sun Doo ) , 이숭인 ( Sung-in Lee ) , 이성준 ( Sung-jun Lee )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 45-59 (15 pages)

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Objectives: This study was conducted to confirm the reproducibility of the diagnosis of greater yin disease (太陰病) and the efficacy of herbal treatment using Gyejigajakyak-tang or Gyejigadaehwang-tang in somatic symptom disorder (SSD). We also further refined the characteristics of greater yin disease in SSD.
Methods: We analyzed the demographic and treatment data of seven patients with SSD from four Korean medical clinics. The reliability of diagnosis and the efficacy of the treatments were evaluated by the Beck Anxiety Inventory (BAI), a numerical rating scale (NRS), and the patients' statements. Finally, we analyzed patients according to the diagnostic points of Shanghanlun provision 273.
Results: Seven SSD patients took Gyejigajakyak-tang or Gyejigadaehwang-tang. The mean age of the patients was 52.1±15.8 years old, and the herbal medication period was 82.2±38.2 days. At the first visit, the patients showed hypochondriasis, obvious stress, and a severe BAI score (40.4±10.9). The NRS significantly decreased from 8.9±1.6 to 0.7±0.7 after the treatments. There were no side effects reported. As a result of analyzing these 7 cases, hypochondriasis, obvious stress, and anxiety were identified, which had been previously suggested as 自痛, 因爾, and 結硬.
Conclusions: We confirmed the reproducibility of greater yin disease in 7 SSD cases from 4 medical institutions. These results imply that there could be a considerable relation between SSD and greater yin disease as defined by the Shanghanlun provisions.

KCI후보

저자 : 허주 ( Joo Heo ) , 임은교 ( Eun-kyo Lim ) , 이성준 ( Sung-jun Lee )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 61-78 (18 pages)

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Objective : The objective of this study was to explore the meaning of “man (滿)” in Shanghanlun through the analysis of four cases.
Methods : We analyzed four cases treated with modified Soshiho-tang, which is administered when 滿aggravates chief complaints. All cases were diagnosed by the disease pattern identification diagnostic system based on the Shanghanlun provisions.
Results : All 4 patients' chief complaints were improved after administration of modified Soshiho-tang. Swelling symptoms were reduced in all 4 cases. Through the etymological research and clinical treatment results, the clinical meaning of 滿was deduced as “swelling.”
Conclusions : The etymological and clinical analysis suggest that the concept of “滿” may be defined as “swelling” in the Shanghanlun provisions.

KCI후보

저자 : 최운용 ( Woon-yong Choi ) , 이성준 ( Sung-jun Lee )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 81-98 (18 pages)

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Objective : We explored the meaning of “Pyo (表)” in Gangpyeong-Shanghanlun through two cases.
Methods : We analyzed the original form of 表and its context in Shanghanlun. We also analyzed 2 clinical cases of bipolar disorder treated with Mahwang-tang (麻黃湯) according to the newly deduced definition of 表.
Results : 表can be interpreted as “pursuing something high-class seen from the outside.” Both cases had various psychological symptoms including insomnia, mood swings, anxiety, and depression. We determined that the diseases in both cases occurred when 表had not been achieved. We also found that 麻黃湯can improve psychological status.
Conclusions : 表is different from “surface,” which is the most widely used definition. After diagnosing these two patients with bipolar disorder using the Diagnostic and Statistical Manual of Mental Disorders (5th edition), we found that symptoms could be improved by administration of 麻黃湯(46條). Although its potential for neuropsychiatric diagnosis has been suggested through etymological interpretation of 表and analysis of two cases, more advanced clinical studies are needed in the future.

KCI후보

저자 : 조성환 ( Seong-hwan Cho )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 99-110 (12 pages)

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Objective: This study aimed to report the effect of Oryeong-san on Menière's disease.
Methods : A 48-year-old female complained of Menière's disease and daily frequent headache. Based on the Shanghanlun disease pattern identification diagnostic system, the patient was treated with Oryeong-san. The result was evaluated by the Dizziness Handicap Inventory (DHI) and a numerical rating score.
Results : After administration of Oryeong-san for 46 days, the DHI score decreased from 42 to 4. The average number of dizzy spells decreased from 6 to 0.
Conclusions : Some cases of Menière's disease can be treated by Oryeong-san.

KCI후보

저자 : 김형섭 ( Hyeong-seop Kim )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 111-119 (9 pages)

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Objectives: This case study aimed to report the effect of Sihogyejigungang-tang (SGGT) on headache with dyspepsia based on the disease pattern identification diagnostic system (DPIDS) based on the Shanghanlun provisions.
Methods: According to the DPIDS based on the Shanghanlun provisions, the patient was diagnosed with Greater Yang Disease Chest Bind and treated with SGGT. The results of treatment were evaluated by a numerical rating scale (NRS), the Korean Headache Impact Test (KHIT-6), and change in clinical symptoms.
Results: After administering SGGT for 160 days, the NRS improved from 9 to 1 and the KHIT-6 improved from 70 to 44. No serious treatment-related adverse events were reported.
Conclusions: This study shows the effective treatment of headache with dyspepsia using SGGT based on the DPIDS based on the Shanghanlun provisions.

KCI후보

저자 : 정재원 ( Jae-won Jeong ) , 이성준 ( Sung-jun Lee )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 121-132 (12 pages)

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Objective: This study aimed to report the improvement in a patient with allergic contact dermatitis treated with Sihogyeji-tang based on the Shanghanlun disease pattern identification diagnostic system (DPIDS).
Methods: According to the Shanghanlun DPIDS, the patient with allergic contact dermatitis was diagnosed with greater yang disease chest bind (Shanghanlun provision 146), and was administered Sihogyeji-tang for 90 days. The results were evaluated using the Dermatological Life Quality Index (DLQI) and a visual analog scale (VAS).
Results: After taking Sihogyeji-tang for 90 days, the DLQI decreased from 28 points to 8 points and the VAS decreased from 10 points to 3 points.
Conclusions: This case shows the potential of treatment through herbal medicine for allergic contact dermatitis using the Shanghanlun DPIDS.

KCI후보

저자 : 이욱제 ( Lee Wookjea )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 133-144 (12 pages)

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Objective : This study aimed to report the improvement of two patients with headache not otherwise classified treated using Saengkangsasim-tang based on the disease pattern identification diagnostic system (DPIDS) based on the Shanghanlun provisions.
Methods : Two patients with headache not otherwise classified were treated using Saengkangsasim-tang according to Shanghanlun provisions, and the effect was also compared with Soshiho-tang. The results were evaluated using a numerical rating scale (NRS) and the Korea Headache Impact Test-6 (KHIT-6). In addition, new clinical implications for the interpretation of Shanghanlun provision 157 were reviewed.
Results : As a result of analyzing the results of the two cases, treatment with Sosiho-tang was ineffective but improved when using Saengkangsasim-tang. After administration of Saengkangsasim-tang, all headaches decreased to the point where they were not uncomfortable in everyday life.
Conclusions : The administration of Saengkangsasim-tang to patients with headache diagnosed according to Shanghanlun provision 157, suggesting that it is clinically effective when applied according to the definitions provided by the Shanghanlun provisions.

KCI후보

저자 : 서영호 ( Young-ho Seo ) , 황보민 ( Hwang-bo Min ) , 최해윤 ( Hae-yun Choi )

발행기관 : 대한상한금궤의학회 간행물 : 대한상한금궤의학회지 13권 1호 발행 연도 : 2021 페이지 : pp. 145-153 (9 pages)

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Objective:This study aimed to report the improvement of a patient with anorexia by treatment with Jinmu-tang (Hyunmu-tang) based on the disease pattern identification diagnostic system (DPIDS) of the Shanghanlun provisions.
Methods:We evaluated the progress of symptoms, patient compliance, and presence of side effects after the patient was administered Jinmu-tang. The clinical response was estimated according to the number of meals a day, the size of meals, the number of complaints of abdominal pain in a week, and a Likert scale.
Results:According to the DPIDS, the patient was diagnosed according to provision 316 with soyinbing. After administration of Jinmu-tang for 45 days, the number of meals a day and the size of meals increased, the number of complaints of abdominal pain in a week decreased, and the Likert scale score decreased from 3 to 0.
Conclusions:This case report suggests that the word “腹痛” (abdominal pain) in the 316th Shanghanlun provision indicates anxiety about abdominal pain, which affected anorexia in this case.

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