Purpose: This study attempted to compare the relationships between self-esteem, family support, and depression in a diploma nursing students. Method: A descriptive research design was used in this study. The participants were 261 nursing students in J city who were surveyed between April 22 and April 30, 2018 using self-report questionnaires. The data were analyzed using SPSS WIN 17.0 Program, which determined frequency, percentage, mean, standard deviation, t-test, One-way ANOVA, Scheffe test, Pearson correlation coefficient. Result: There were positive correlation between self-esteem and family support and negative correlation between depression and self-esteem, family support for nursing students. Conclusion: It is necessary to enhance positive recognition on self-esteem to improve family support and to decrease depression of nursing students. In order to decrease of depression, it is important to consider reform efficient communication skills between professor and nursing students.