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대한갑상선학회> International Journal of Thyroidology

International Journal of Thyroidology update

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수록정보
수록범위 : 1권1호(2008)~15권1호(2022) |수록논문 수 : 373
International Journal of Thyroidology
15권1호(2022년 05월) 수록논문
최근 권호 논문
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KCI등재

저자 : 홍아람 ( A Ram Hong ) , 안화영 ( Hwa Young Ahn ) , 김부경 ( Bu Kyung Kim ) , 안성희 ( Seong Hee Ahn ) , 박소영 ( So Young Park ) , 김민희 ( Min-hee Kim ) , 이정민 ( Jeongmin Lee ) , 조선욱 ( Sun Wook Cho ) , 강호철 ( Ho-cheol Kang )

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 1-16 (16 pages)

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Thyroid hormones have an important physiological role in maintaining adult bone structure and strength. Therefore, thyroid dysfunction is inevitably associated with various degrees of skeletal consequences. Endogenous overt hyperthyroidism is an established cause of high bone turnover with accelerated bone loss, resulting in osteoporosis and an increased risk of fractures. Hyperthyroidism induced by thyroid stimulating hormone suppression therapy in patients with differentiated thyroid cancer also has emerged as a contributing factor to osteoporosis and fragility fractures. While, there is lack of evidence that hypothyroidism negatively affects bone health. Although there is growing clinical evidence of the importance of bone health in hyperthyroidism, clinical guidelines on how to evaluate and manage bone health in these diseases have not yet been published worldwide. The Task Force from the Korean Thyroid Association Committee of Clinical Practice Guideline has developed this position statement for the evaluation and management of bone health in patients with thyroid diseases, particularly focused on endogenous hyperthyroidism and thyroid stimulating hormone suppression therapyassociated hyperthyroidism in patients with differentiated thyroid cancer.

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저자 : 신성찬 ( Sung-chan Shin ) , 서명구 ( Myeonggu Seo ) , 천용일 ( Yong-il Cheon ) , 이병주 ( Byung-joo Lee )

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 17-22 (6 pages)

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Intraoperative neuromonitorng (IONM) has gained wide acceptance as a useful adjunct in identifying and preserving of recurrent laryngeal nerve (RLN) during thyroid surgery. The electromyographic endotracheal tube (EMG-ETT) method is the most widely used and well-validated method for thyroid IONM; however, malpositioning of the tube is a critical shortcoming of the EMG-ETT method. This is the main reason for the low positive predictive value of IONM in thyroid surgery. Needle and skin electrodes can obtain EMG signal regardless of patient position and are easy to apply during surgery and is economical compared to EMG-ETT method. New IONM system using needle or skin electrodes would be an alternative method which can overcome shortcomings of EMG-ETT.

KCI등재

저자 : 김지수 ( Jeesu Kim )

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 23-27 (5 pages)

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Thyroid cancers are commonly diagnosed worldwide with a continuously increasing incident rate. The ultrasonography is the gold standard method for triaging thyroid nodules to biopsy. Although it has successfully triaged cancerous nodules, many benign nodules also have been triaged to be taken an invasive biopsy, which leads to the overdiagnosing issue. Photoacoustic imaging is an emerging biomedical imaging technique that can provide molecular functional information of biological tissues. Recently, there have been trials to investigate thyroid nodules by using clinically relevant photoacoustic imaging systems. In this review, the principles and applications of the photoacoustic imaging systems for analyzing thyroid nodules are overviewed. Although this technique still has a lot of ways to go for clinical translation, its initial results show great potential to be used for triaging thyroid nodules in vivo.

KCI등재

저자 : 이민진 ( Minjin Lee ) , 윤혁준 ( Hyeok Jun Yun ) , 박경아 ( Kyung Ah Park ) , 허지혜 ( Jihye Heo ) , 김한나 ( Hanna Kim ) , 이용상 ( Yong Sang Lee ) , 장항석 ( Hang-seok Chang ) , 박정수 ( Cheong Soo Park )

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 28-35 (8 pages)

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Background and Objectives: Given the major changes in spread of COVID-19 and the contribution of technological innovation, the objective of the current study was to compare the educational needs of thyroid cancer patients between 2012 and 2020. Materials and Methods: The subject of this study were 159 patients in 2012 and 149 patients in 2020 who underwent thyroid cancer surgery. Data were collected from September 2020 to December 2020. Their responses were compared with response for the 2012 survey. The survey contained 36 questions regarding demographics and 5 areas of educational needs (Treatment plan after discharge, Management of the symptom and the complication after surgery, Medication management, Postoperative wound and dietary management, Daily life). Results: The most preferred teaching method for thyroid cancer surgery patients has changed from small group education to self-study with videos. The Internet accounted for the largest proportion of source of information and the preferred educator for the patient were doctors and nurses in both 2012 and 2020. 'Current disease condition and surgical result' was the highest ranked in both 2012 and 2020. Conclusion: It is necessary to develop and utilize an educational method using video centered on medical team including doctors and nurses.

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저자 : Emil Iskandarov , Nazrin Agayeva

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 36-41 (6 pages)

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Background and Objectives: Hepatic functions in patients with nodular goiter, who received long-term hormonal suppressive treatment was not well enlightened in publications. We studied liver specific enzymes activities in patients with nodular goiter after thyroidectomy. The aim of this study was comparative analysis of treatment outcomes of patients who were previously treated with L-thyroxine and were operated skipping hormonal treatment. Materials and Methods: 88 patients (basic group) with nodular goiter underwent surgical operation without any drug treatment. 86 patients in control group received hormonal suppressive treatment with L-thyroxine for 6-12 months and then underwent thyroidectomy. Liver ultrasound (US) scanning and laboratory tests were comparatively studied 3, 6, 12 months after thyroidectomy. Results: Patients that received long-term hormonal suppressive treatment and then admitted for surgery, suffered from discomfort in upper right abdominal quadrant. The ALT, AST, Alkaline Phosphates and GGT activity of those patients was increased, and steatohepatitis was identified in US investigations. Also, total bilirubin, especially the unconjugated fraction concentration was higher in control group. The hepatocytes functional activity in basic group was slightly affected. Conclusion: Long-term hormone suppressive therapy resulted in dysfunction of hepatocytes. It's highly recommended to the patients with hormonal therapy resistant nodules to undergo surgical treatment.

KCI등재

저자 : Jee Hee Yoon , A Ram Hong , Hee Kyung Kim , Ho-cheol Kang

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 42-48 (7 pages)

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Lenvatinib prolongs the survival of patients with advanced thyroid cancer. At initiation of lenvatinib therapy, advanced thyroid cancer patients frequently have lung metastasis and are vulnerable to pulmonary complications due to concealed lung damage caused by previous therapies including radioactive iodine (RAI) therapy. Among 24 patients treated with lenvatinib, pulmonary events were observed in three patients with lung metastasis, including one with interstitial lung disease (ILD) and two with pneumothorax. One patient who was previously treated with 750 mCi RAI developed uncontrolled ILD after lenvatinib therapy and died of respiratory failure. Two pneumothorax cases had previous cavitation of metastatic lung nodules. Pneumothorax resolved spontaneously in both patients. Pulmonary events in patients with lung metastases treated with lenvatinib are uncommon and manageable in most cases, but may be fatal if detection and management are delayed. Special attention should be given to patients with lung metastasis treated with high cumulative dose of RAI therapy or cavitary changes that develop after lenvatinib therapy.

KCI등재

저자 : Tae Mi Yoon , Kyung-hwa Lee

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 49-53 (5 pages)

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Anthracofibrosis is luminal narrowing with a black anthracotic pigmentation on the bronchial mucosa. Extrapulmonary anthracofibrosis is very rare in head and neck region, and anthracofibrosis associated with adhesion to adjacent tissue can be misdiagnosed to malignancy. We report a rare case of a paraesophageal anthracofibrosis in a patient with advanced papillary thyroid cancer. The paraesophageal anthracofibrosis presented as a black colored hard mass with severe adhesion to the recurrent laryngeal nerve (RLN) during thyroid surgery, suspecting metastatic lymphadenopathy. With intraoperative frozen biopsy, unnecessary aggressive surgery with the injury of RLN can be avoided. Permanent histopathological examination of the mass revealed anthracofibrosis with strong positivity on Masson's trichrome staining. This case highlights that anthracofibrosis should be included in differential diagnosis of paraesophageal masses, and frozen sectional biopsy can help in decision making during surgery. In addition, collagen might be involved in the adhesion of the anthracotic mass to the surrounding tissues.

KCI등재

저자 : Jisu Lee , Sang-gyeom Kim , Arum Oh , Heon-seok Han

발행기관 : 대한갑상선학회 간행물 : International Journal of Thyroidology 15권 1호 발행 연도 : 2022 페이지 : pp. 54-59 (6 pages)

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Dual oxidase maturation factor 2 (DUOXA2) is necessary for the enzymatic activity of dual oxidase 2 (DUOX2) to generate hydrogen peroxide production during thyroid hormone synthesis. We describe two Korean children, who were initially suspected to have transient congenital hypothyroidism (CH), but later confirmed to have permanent CH caused by DUOXA2 mutation. Treatment with levothyroxine was discontinued after confirming thyroid-stimulating hormone (TSH) level to be below 10 μU/mL and normal thyroid scan at the first or second trial-off therapy. However, after therapy cessation, TSH elevated to more than 10 μU/mL, and goiter developed in case 2. As a result, levothyroxine was resumed. Next-generation sequencing showed compound heterozygous mutations of DUOXA2 at Y138X and Y246X in case 1 and homozygous mutations of DUOXA2 at Y246X in case 2. In this report, a longer follow-up is recommended even after treatment termination in transient CH, and genetic studies might help assess the permanence of hypothyroidism in cases of mildly elevated TSH after trial-off therapy.

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