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대한소아알레르기호흡기학회> Allergy Asthma & Respiratory Disease

Allergy Asthma & Respiratory Disease

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수록정보
수록범위 : 1권1호(2013)~3권5호(2015) |수록논문 수 : 208
Allergy Asthma & Respiratory Disease
3권5호(2015년 09월) 수록논문
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1EDITORIAL : Clinical features of nonallergic rhinitis in children

저자 : 모지훈 ( Ji Hun Mo )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 311-312 (2 pages)

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2대기 미세먼지가 천식 발생과 조절에 미치는 영향

저자 : 김상헌 ( Sang Heon Kim ) , 양현종 ( Hyeon Jong Yang ) , 장안수 ( An Soo Jang ) , 김상훈 ( Sang Hoon Kim ) , 송우정 ( Woo Jung Song ) , 김태범 ( Tae Bum Kim ) , 예영민 ( Young Min Ye ) , 유영 ( Young Yoo ) , 유진호 ( Jinho Yu ) , 윤종서 ( Jong Seo Yoon ) , 지혜미 ( Hye Mi Jee ) , 서동인 ( D

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 313-319 (7 pages)

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There has been growing concern regarding the effects of ambient air pollution on asthma. Particulate matter (PM) is one of the major air pollutants affecting both general population and the patients with asthma. This paper reviews the recent evidence of the adverse effects of PM on the inception and morbidity of asthma. Epidemiological studies confirmed that short-term exposure to PM aggravated respiratory symptoms and lung function in asthma patients. Furthermore, PM induces acute exacerbations of asthma with increased risk of hospitalization and death. Long-term exposure to PM is responsible for new onset of asthma and lung function decline in both children and adults. Various mechanisms are involved in the effects of PM on airway including oxidative stress, augmentation of inflammation, promotion of allergen sensitization, induction of airway hyperresponsiveness, aggravation of rhinitis and DNA methylation. Special attention and care is needed for the patients with asthma to prevent the detrimental effects of PM. (Allergy Asthma Respir Dis 2015;3:313-319)

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3영유아 식품알레르기 예방을 위한 최신 의견: 수유와 이유식을 중심으로

저자 : 송태원 ( Tae Won Song ) , 안강모 ( Kangmo Ahn ) , 이수영 ( Soo Young Lee )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 320-325 (6 pages)

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Food allergy is common with the prevalence of 5%-7% in Korean children. The development of food allergy is likely to reflect interactions between genetic factors and environmental exposure. To prevent food allergy, early exposure to food allergens through maternal and infant diet have been investigated. Recently, guidelines for primary prevention of food allergy have been updated, and consensus communication on early peanut introduction has been demonstrated. For the first 4-6 months after birth, exclusive breast-feeding is recommended, and if impossible, extensively or partially hydrolyzed infant formula can be recommended in highrisk infants. Introducing complementary foods is recommended between 4 and 6 months of age, even in case of potentially allergenic foods such as egg, milk, and wheat. For the prevention of peanut allergy, early peanut introduction could be better than late peanut introduction in selected high-risk infants. However, infants who developed food allergy should avoid ingestion of specific offending foods. (Allergy Asthma Respir Dis 2015;3:320-325)

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4학동기 및 청소년 천식 소아들의 임상 양상과 천명 시작 시기와의 관련성

저자 : 장광천 ( Gwang Cheon Jang ) , 심정연 ( Jung Yeon Shim ) , 안영민 ( Young Min Ahn ) , 정진아 ( Jin A Jung ) , 김성원 ( Sung Won Kim ) , 정혜리 ( Hai Lee Chung )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 326-333 (8 pages)

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Purpose: We aimed to investigate the clinical characteristics and their relationship with the onset age of wheeze in school-age childrenand adolescents with asthma. Methods: Three hundred twenty-six patients, aged 6 to 19 years, diagnosed with asthma at 6 hospitals from Seoul, Gyeonggi, Daegu, and Busan were enrolled. They were categorized into 3 groups by the onset age of wheeze: group A, early onset (age <3 years); group B, preschool onset (age 3-6 years); group C, late onset (age ≥6 years). Clinical characteristics including atopic sensitization, family history, combined allergic diseases, severity of asthma, and influence of asthma on daily life were examined. A history of hospitalization for early lower respiratory infection (LRI) and environmental tobacco smoking were studied and lung function tests were also performed. Results: There was no difference in demographics, prevalence of atopy, combined allergic diseases, and family history of allergy between 3 groups. A history of sever LRI in early life was more common in groups A and B compared with group C. Sensitization to Dermatophagoides pteronyssinus was more prevalent in groups A and B than in group C. Forced expiratory flow between 25% to 75% (FEF25%-75%) was lower in groups A and B than in group C, and methacholine PC20 (provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second) was lowest in group B. Significantly lower FEF25%-75% and methacholine PC20 were observed in the patients who had been hospitalized with LRI in early life. Conclusion: Our study shows significant difference in lung function and atopic sensitization in relation to the onset age of wheeze in school-age children and adolescents with asthma, and suggests that early LRI might contribute to the development of asthma in early life. (Allergy Asthma Respir Dis 2015;3:326-333)

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5전국 146개 응급실에 내원한 급성 세기관지염 환자에 대한 통계적 관찰

저자 : 노의정 ( Eui Jung Roh ) , 원연경 ( Youn Kyung Won ) , 이미희 ( Mi Hee Lee ) , 정은희 ( Eun Hee Chung )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 334-340 (7 pages)

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Purpose: This study was aimed to investigate the clinical and epidemiological characteristics of the patients with acute bronchiolitis who visited in 146 Emergency Departments (EDs) in Korea in 2012. Methods: We used the NEDIS (National Emergency Department Information System) database to obtain all children with acute bronchiolitis who visited ED under the age of 3 between January 1, 2012 and December 31, 2012. Results: Totally 18,313 children with acute bronchiolitis were enrolled at this study. The male to female ratio was 1.55:1 and mean age was 10 months. The peak proportion was 17.3% in November during the whole year. The most common chief complaints were fever (38.5%), cough (37.4%), dyspnea (9.5%), gastrointestinal symptom (6.7%), and wheezing (2.5%). The most common accompanying disease was pneumonia (13.3%). The rate of hospital admission and intensive care unit admission were 34.5% and 0.3%, respectively. A predictor for admission via ED was respiratory difficulty. Conclusion: These data expand our understanding of clinical characteristics of patients with acute bronchiolitis who visited all ED in Korea in 2012. (Allergy Asthma Respir Dis 2015;3:334-340)

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6소아에서 알레르기 및 비알레르기비염의 임상 증상 비교

저자 : 안지영 ( Ji Young Ahn ) , 김정은 ( Jung Eun Kim ) , 최봉석 ( Bong Seok Choi )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 341-345 (5 pages)

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Purpose: Children and adolescent have high prevalences of allergic rhinitis (AR) and nonallergic rhinitis (NAR) as well as adult. The purpose of this study was to assess the symptomatic differences between AR and NAR in children. Methods: This study included 138 patients with 2 or more of rhinitis symptoms, including rhinorrhea, nasal obstruction, nasal itching, and sneezing for over 1 hour on most days who visited Kyungpook National University Children's Hospital between March 2013 and June 2014. The levels of total IgE, specific IgE, eosinophil cationic protein, peripheral blood eosinophil count, and the skin prick test were carried out. All the patients or parents were asked to fill out a rhinitis symptom questionnaire and contents were rechecked by physician during the consultation. The symptoms of rhinorrhea, sneezing, nasal itching, nasal obstruction and eye itching were checked. Family history and comorbidity were also evaluated. Results: Ninety-one patients were diagnosed with AR, 47 patients with NAR. Their age ranged from 1 to 16 years. AR patients had more sneezing, nasal pruritus and eye symptoms than NAR patients (P=0.003, P=0.036, and P=0.003, respectively). Conclusion: This study shows that the several symptomatic differences may help to diagnose the AR. It will be helpful in establishing diagnostic and treatment plans for rhinitis patients before allergic tests. (Allergy Asthma Respir Dis 2015;3:341-345)

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7급성 호흡기 감염으로 입원한 소아 환자에서 Chlamydia pneumoniae의 임상 양상: Mycoplasma pneumoniae와의 비교

저자 : 성재진 ( Jae Jin Sung ) , 김은진 ( Eun Jin Kim ) , 선용한 ( Yong Han Sun ) , 전인상 ( In Sang Jeon ) , 차한 ( Hann Tchah ) , 류일 ( Eell Ryoo ) , 손동우 ( Dong Woo Son ) , 조혜경 ( Hye Kyung Cho ) , 조혜정 ( Hye Jung Cho ) , 김나연 ( Na Yeon Kim )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 346-351 (6 pages)

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Purpose: Chlamydia pneumoniae is a common intracellular bacterial pathogen and plays an important role in acute respiratory infections. The purpose of this study was to investigate clinical presentations of C. pneumoniae in children with acute respiratory infections. Methods: We examined the medical records of pediatric patients (age<18 years) admitted with acute respiratory infections of C. pneumoniae to Gachon University Gil Medical Center between March 1, 2011 and August 31, 2014. We compared the clinical features of C. pneumoniae infection with that of Mycoplasma pneumoniae infection. Results: We confirmed acute respiratory infections of C. pneumoniae in 110 patients out of 2,156 patients (5.1%) admitted with acute respiratory infections. The mean age was 37.2±30.1 months. More than half of them (54.5%) had coinfection. C. pneumoniae infection had mild and subacute courses. The mean duration of symptoms prior to admission was 8.5±13.8 days. There were remarkable seasonal variations and prevalence was higher in December and April (P=0.03 and P=0.02, respectively). Although rhinorrhea and pharyngeal injection were more common in C. pneumoniae infection (P<0.05), clinical signs and symptoms were similar between C. pneumoniae and M. pneumoniae. Extrapulmonary manifestations such as skin lesion, Gastrointestinal symptoms, hepatitis, and neurologic symptoms were common (41.0%) in C. pneumoniae infection and, had similar incidence in M. pneumoniae infection. Conclusion: C. pneumoniae is an important infectious agent of acute respiratory infections in children. Clinical pictures of C. pneumoniae are similar to M. pneumoniae, even in extrapulmonary manifestations. C. pneumoniae should be taken into consideration in differential diagnosis of acute respiratory infection in children. (Allergy Asthma Respir Dis 2015;3:346-351)

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8어머니 우울증과 소아 알레르기 질환과의 관계에 관한 연구

저자 : 류동수 ( Dong Soo Ryu ) , 이주석 ( Ju Suk Lee )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 352-357 (6 pages)

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Purpose: Asthma and atopic dermatitis are common chronic diseases and depression is an important comorbidity in allergic diseases. However, the association between maternal depression and child allergic diseases is little known. This study was performed to find out the association between maternal depression and child allergic diseases. Methods: Data were acquired from 2,737 families who participated in the Fifth Korea National Health and Nutrition Examination Surveys, which was conducted from 2010 through 2012. Results: The prevalence of childhood asthma was 5.3% and that of childhood atopic dermatitis was 14.1%. The prevalence of maternal depression was 3.9%. In univariate analysis, maternal depressions was associated with maternal smoking, lower education level, lower economic state, lower number of household members, maternal asthma, children's asthma (P<0.05), but marital status, maternal employment status, maternal atopic dermatitis, children's sex, children's age, children's atopic dermatitis, residence area were not related to maternal depression. After adjustment, maternal depression was associated with lower house income, maternal asthma, and children's asthma (P<0.05). Conclusion: The present study shows that maternal depression may be associated with childhood asthma, but not childhood atopic dermatitis. These results warrant future studies to explore the mechanisms responsible for the association between maternal depression and childhood asthma. (Allergy Asthma Respir Dis 2015;3:352-357)

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9민들레 화분항원의 교차반응과 주요 알레르겐에 대한 IgE 결합 성분의 규명

저자 : 김지혜 ( Ji Hye Kim ) , 윤문경 ( Moon Kyung Yoon ) , 김미애 ( Mi Ae Kim ) , 신유섭 ( Yoo Seob Shin ) , 예영민 ( Young Min Ye ) , 박해심 ( Hae Sim Park )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 358-364 (7 pages)

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Purpose: The prevalence of pollinosis is increasing, and it is expected to increase further with climate change. Mugwort and ragweed pollens are well known as prevalent allergenic weed pollens in Korea. However, the clinical significance of dandelion pollen as an inhalant allergen has not yet been studied. The purpose of this study was to evaluate the clinical significance and cross allergenicity between dandelion and major weed pollens. Methods: Ninety-seven patients with allergic rhinitis and asthma or with allergic rhinitis alone who were sensitized to dandelion pollens on skin prick tests (allergen/histamine ratio>3) were enrolled between December, 2012 and November, 2013. Serum specific IgE levels to dandelion pollen extracts were measured by using enzyme-linked immunosorbent assay (ELISA). ELISA inhibition tests were performed to evaluate cross allergenecity with other weed pollens. Results: When the positive cutoff value for serum specific IgE was set at the mean±3 standard deviation of absorbance values, 52 patients (53.6%) had a high serum specific IgE antibody level. ELISA inhibition tests showed significant inhibitions with serial addition of dandelion pollen extracts, and 5 different inhibition patterns were noted with addition of 4 weed pollen extracts: significant inhibitions with pollens of mugwort, ragweed, chenopodium and Hop J (25%, 13 of 52), inhibitions with pollens of mugwort, ragweed and chenopodium (17.3%, 9 of 52), inhibitions with 2 pollens of mugwort and ragweed (32.6%, 17 of 52), inhibitions with mugwort pollen (21.1%, 11 of 52), and inhibitions with dandelion pollen alone (4%, 2 of 52). Conclusion: These findings suggest that dandelion pollen may be a causative inhalant allergen to induce pollinosis in the autumn season. Cross-allergenicity with other weed pollens showed individual differences; most patients had cross-reactivity with mugwort, ragweed, and chenopodium pollens, while some with Hop J pollen. Few patients were sensitized to dandelion pollen alone. (Allergy Asthma Respir Dis 2015;3:358-364)

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10기회감염폐렴으로 발현된 Good 증후군

저자 : 김숙연 ( Suk Yeon Kim ) , 김주희 ( Joo Hee Kim ) , 황하원 ( Ha Won Hwang ) , 김광윤 ( Kwang Youn Kim ) , 박성훈 ( Sunghoon Park ) , 황용일 ( Young Il Hwang ) , 장승훈 ( Seung Hun Jang ) , 정기석 ( Ki Suck Jung )

발행기관 : 대한소아알레르기호흡기학회 간행물 : Allergy Asthma & Respiratory Disease 3권 5호 발행 연도 : 2015 페이지 : pp. 365-369 (5 pages)

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Good's syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good's syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement. (Allergy Asthma Respir Dis 2015;3:365-369)

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