간행물

Brain Tumor Research and Treatment update

  • : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회
  • : 의약학분야  >  신경외과학
  • : KCI등재
  • :
  • : 연속간행물
  • : 반년간
  • : 2288-2405
  • : 2288-2413
  • : 대한뇌종양학회지(~2012) → brain tumor research and treatment(2013~)

수록정보
수록범위 : 1권1호(2013)~9권1호(2021) |수록논문 수 : 213
Brain Tumor Research and Treatment
9권1호(2021년 04월) 수록논문
최근 권호 논문
| | | |

KCI등재

1The Korean Society for Neuro-Oncology (KSNO) Guideline for Adult Diffuse Midline Glioma: Version 2021.1

저자 : Hong In Yoon , Chan Woo Wee , Young Zoon Kim , Youngbeom Seo , Jung Ho Im , Yun-sik Dho , Kyung Hwan Kim , Je Beom Hong , Jae-sung Park , Seo Hee Choi , Min-sung Kim , Jangsup Moon , Kihwan Hwang , Ji E

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 1-8 (8 pages)

다운로드

(기관인증 필요)

초록보기

Background There have been no guidelines for the management of adult patients with diffuse midline glioma (DMG), H3K27M-mutant in Korea since the 2016 revised WHO classification newly defined this disease entity. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing guidelines for DMG since 2019.
Methods The Working Group was composed of 27 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of keywords. As 'diffuse midline glioma' was recently defined, and there was no international guideline, trials and guidelines of 'diffuse intrinsic pontine glioma' or 'brain stem glioma' were thoroughly reviewed first.
Results The core contents are as follows. The DMG can be diagnosed when all of the following three criteria are satisfied: the presence of the H3K27M mutation, midline location, and infiltrating feature. Without identification of H3K27M mutation by diagnostic biopsy, DMG cannot be diagnosed. For the primary treatment, maximal safe resection should be considered for tumors when feasible. Radiotherapy is the primary option for tumors in case the total resection is not possible. A total dose of 54 Gy to 60 Gy with conventional fractionation prescribed at 1-2 cm plus gross tumor volume is recommended. Although no chemotherapy has proven to be effective in DMG, concurrent chemoradiotherapy (± maintenance chemotherapy) with temozolomide following WHO grade IV glioblastoma's protocol is recommended.
Conclusion The detection of H3K27M mutation is the most important diagnostic criteria for DMG. Combination of surgery (if amenable to surgery), radiotherapy, and chemotherapy based on comprehensive multidisciplinary discussion can be considered as the treatment options for DMG.

KCI등재

2The Korean Society for Neuro-Oncology (KSNO) Guideline for Antiepileptic Drug Usage of Brain Tumor: Version 2021.1

저자 : Jangsup Moon , Min-sung Kim , Young Zoon Kim , Kihwan Hwang , Ji Eun Park , Kyung Hwan Kim , Jin Mo Cho , Wan-soo Yoon , Se Hoon Kim , Young Il Kim , Ho Sung Kim , Yun-sik Dho , Jae-sung Park , Hong In

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 9-15 (7 pages)

다운로드

(기관인증 필요)

초록보기

Background To date, there has been no practical guidelines for the prescription of antiepileptic drugs (AEDs) in brain tumor patients in Korea. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing guidelines for AED usage in brain tumors since 2019.
Methods The Working Group was composed of 27 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of the keywords.
Results The core contents are as follows. Prophylactic AED administration is not recommended in newly diagnosed brain tumor patients without previous seizure history. When AEDs are administered during peri/postoperative period, it may be tapered off according to the following recommendations. In seizure-naive patients with no postoperative seizure, it is recommended to stop or reduce AED 1 week after surgery. In seizure-naive patients with one early postoperative seizure (<1 week after surgery), it is advisable to maintain AED for at least 3 months before tapering. In seizure-naive patients with ≥2 postoperative seizures or in patients with preoperative seizure history, it is recommended to maintain AEDs for more than 1 year. The possibility of drug interactions should be considered when selecting AEDs in brain tumor patients. Driving can be allowed in brain tumor patients when proven to be seizure-free for more than 1 year.
Conclusion The KSNO suggests prescribing AEDs in patients with brain tumor based on the current guideline. This guideline will contribute to spreading evidence-based prescription of AEDs in brain tumor patients in Korea.

KCI등재

3Delayed Hyponatremia after Transsphenoidal Surgery for Pituitary Adenomas: A Single Institutional Experience

저자 : Yun Gi Hong , Sun Ho Kim , Eui Hyun Kim

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 16-20 (5 pages)

다운로드

(기관인증 필요)

초록보기

Background Hyponatremia is a common complication after transsphenoidal surgery (TSS) for pituitary adenomas. This study retrospectively reviewed various clinical factors of pituitary adenoma patients who underwent TSS and aimed to identify possible risk factors of postoperative hyponatremia.
Methods Total 1,343 patients who underwent TSS for their pituitary adenomas in a single institution were enrolled to this study. We identified and analyzed 93 patients (6.9%) with postoperative hyponatremia and compared them with other 1,250 patients in a control group. Patients' age, sex, tumor extent based on the modified Hardy classification, tumor size and hormonal type of the tumors were analyzed in comparison between two groups. The results of pre- and post-operative combined pituitary function test and their comparison were analyzed to elucidate a possible association between postoperative hyponatremia and hypopituitarism.
Results The onset of postoperative hyponatremia was 7.8 days after surgery (range: postoperative day 3-13). The initial level of serum sodium (Na) level at the start of treatment was 123.5 mmol/L (range: 114-131 mmol/L) and the duration of treatment was 2.7 days (range: 1-9 days). Female predominance was evident in the hyponatremia group (77.4% vs. 61.4%, p=0.02). Preoperative hypopituitarism (58.5% vs. 71.5%, p=0.007) and postoperative hypocortisolism (33.7% vs. 23.4%, p=0.029) were related to postoperative hyponatremia. Other pre- and post-operative clinical factors were not associated with postoperative hyponatremia.
Conclusion Postoperative hyponatremia is a common complication after TSS and is potentially fatal. Female patients were more likely to develop delayed hyponatremia. We demonstrated possible associations of delayed postoperative hyponatremia with preoperative and postoperative pituitary functions, but the mechanism behind it should be further investigated.

KCI등재

4Giant Intradiploic Epidermoid Cyst in the Occipital Bone: A Case Report

저자 : Yoonhee Choo , Youngbeom Seo , Joonhyuk Choi

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 21-25 (5 pages)

다운로드

(기관인증 필요)

초록보기

Epidermoid cysts are uncommon intracranial tumors. As one of the extradural types of epidermoid cysts, intradiploic epidermoid cysts are even rarer tumors and occur in any part of the skull. We herein report a rare case of a giant intradiploic epidermoid cyst of the occipital bone. A 57-year-old woman presented with a 1-year history of localized headache in the occipital area. CT and MRI showed an extradural mass measuring 50×70 mm in the occipital bone with bony destruction. The patient underwent surgical resection. The tumor was completely removed with its capsule. There was no extension to the intradural space. The pathological report confirmed that the tumor was an epidermoid cyst. Follow- up MRI 24 months after the operation showed no recurrence. The headache was well controlled without any medications. We report a rare case of intradiploic epidermoid cyst with clinical and radiologic features and surgical treatment. It is important to consider this diagnosis for a patient with persistent regional headache with or without a growing scalp mass.

KCI등재

5Surgical Experience of Posterior Fossa Meningioma in a Jehovah's Witnesses Patient

저자 : Ki Seong Eom

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 26-30 (5 pages)

다운로드

(기관인증 필요)

초록보기

Unexpected bleeding is a common complication that can occur during surgery. This unexpected bleeding can be managed by checking the patients' preoperative hemodynamic state or by autologous transfusion of an appropriate volume during surgery depending on the amount of blood loss and hemodynamic condition. However, patients like Jehovah's Witnesses, who refuse autologous transfusions for religious reasons even in life-threatening situations, present a predicament for treating physicians. The author reports on a large meningioma on the posterior fossa of a Jehovah's Witness patient who underwent surgery without autologous blood transfusion. There were no major problems other than the fear of unexpected massive bleeding. The surgeon's attention and efforts to minimize bleeding during surgery seemed to be the most important factors for success.

KCI등재

6Cerebellar Glioependymal Cyst

저자 : El Kim

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 31-34 (4 pages)

다운로드

(기관인증 필요)

초록보기

Glioependymal cyst (GEC) is an uncommonly observed clinical entity in the posterior cranial fossa. A 36-year-old female with cystic lesion in the right cerebellum was hospitalized for evaluating headache and dizziness. Brain images showed a well-defined, ovoid mass adjacent to the fourth ventricle. After drainage and excision of the cyst, the patient became symptom free. Pathology examination disclosed low cuboidal epithelium and glial cells in the cyst wall. The radiological features, neurological manifestations, and the operations for GECs of the present localization are described in this short communication.

KCI등재

7Neuromyelitis Optica Spectrum Disorders Mimicking Multiple Brain Tumors

저자 : Seong-hyun Park , Jeong-hyun Hwang

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 35-39 (5 pages)

다운로드

(기관인증 필요)

초록보기

We report a rare case of neuromyelitis optica spectrum disorders (NMOSD), mimicking multiple brain tumors. A 53-year-old woman presented with weakness and paresthesia in her right arm and leg. Upon admission, brain MRI showed about 10 multiple brain tumors, which had to be differentiated from multiple brain metastases, lymphoma, and high-grade glioma in both hemispheres. No primary cancer was found in the chest-abdomen-pelvis CT. Subsequent spine MRI revealed multifocal cord signal change involving C2-T7, suggesting myelitis. A decrease in visual acuity was noted when taking a medical history, and optic neuritis was diagnosed upon ophthalmologic examination. With clinical and radiological appearances, multiple brain and spinal cord lesions have been diagnosed as NMOSD. Steroid and immunosuppressive drugs were administered. We should consider the possibility of an autoimmune disease, such as NMOSD, involving the optic nerve, spinal cord, and central nervous system when multiple hemispheric tumefactive lesions are observed.

KCI등재

8Arrested Pneumatization of the Sphenoid Sinus in the Skull Base

저자 : Seong-hyun Park , Jeong-hyun Hwang

발행기관 : 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 간행물 : Brain Tumor Research and Treatment 9권 1호 발행 연도 : 2021 페이지 : pp. 40-43 (4 pages)

다운로드

(기관인증 필요)

초록보기

We report 2 cases of arrested pneumatization of the sphenoid sinus, a normal variant commonly misdiagnosed as a serious condition of the skull base. A 65-year-old man visited a local clinic for regular checkups. Brain CT showed a non-expansile lesion of the soft tissue with a well-defined sclerotic margin in the clivus but without destruction or mass effect on the surrounding bony structures. Subsequent brain MRI revealed that the lesion within the clivus was a high-signal lesion on the T2-weighted image, containing a low-signal round mass seen on a high-intensity signal on the T1-weighted image without contrast enhancement. Thus, the lesion was considered to contain internal fat. A 70-year-old woman diagnosed with a tumor in the greater sphenoid bone visited our hospital. Her brain CT revealed a non-expansile lesion of mixed density and a well-demarcated lesion and internal curvilinear calcification in the left greater wing of the sphenoid bone. The margin was osteosclerotic and the adjacent bony structure was intact. Her brain MRI showed that the lesion within the greater sphenoid bone had multiple low-signal lesions within a high-signal lesion on the T2-weighted image, suggesting internal fat contents. The lesions were diagnosed as arrested pneumatization of the sphenoid sinus and no further examination or treatment was performed. Arrested pneumatization of the sphenoid sinus should be considered in the presence of non-expansile lesion with an osteosclerotic boundary and internal fat component in the skull base.

1
권호별 보기

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기