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The Journal of Applied Oriental Medicine

  • : 한약응용학회
  • : 의약학분야  >  기초한의학
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  • : 연속간행물
  • : 연간
  • : 1598-5539
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수록정보
수록범위 : 1권1호(2001)~21권1호(2021) |수록논문 수 : 174
한약응용학회지
21권1호(2021년 12월) 수록논문
최근 권호 논문
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저자 : 조창숙 ( Chang Suk Jo ) , 김소영 ( So Young Kim ) , 최문열 ( Moon-yeol Choi ) , 김미형 ( Mi Hyeong Kim ) , 김미려 ( Mi Ryeo Kim ) , 서부일 ( Bu-il Seo )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 21권 1호 발행 연도 : 2021 페이지 : pp. 1-10 (10 pages)

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Objective : Diabetes mellitus (DM) is a chronic metabolic disorder characterized by high blood glucose levels due to the relative or absolute deficiency of insulin action, and has become a major public health and economic problem worldwide. Godjang (GJ) was made by fermentation of soybean with herbal medicine. The purpose of this study was to investigate the effects of Godjang (GJ) water extracts on antidiabetic markers in streptozotocin (STZ, 65 mg/kg of BW, IP injection)-induced type 1 diabetic rats.
Methods : Experimental DM was induced by intraperitoneal injection with a single dose of STZ (65 ㎎/㎏) in Sprague Dawley rats. In other words, animals were divided into 4 groups; NG (normal group + 0.9% saline), COS (diabetic group + 0.9% saline), GJ 200 (diabetic group + Godjang (200 mg/ kg, BW)), GJ 600 (diabetic group + Godjang (600 ㎎/㎏, BW)). Treatments were performed orally administration for 4 weeks. After the experiment of 4 weeks, the blood samples and organs were collected and then serum levels of glucose, BUN, creatinine, TC, TG, ATS and ALT were measured, respectively.
Results : At the 4 weeks of GJ administration, the body weight gain were lower in diabetic groups than normal group. The serum glucose levels were significantly lower in the GJ 200 and 600 group than COS group. In serum, AST and TG levels significantly decreased in GJ 600 group compared to COS group. The serum levels of ALT, TC, BUN and creatinine were decreased in GJ 200 and 600 groups compared to COS group.
Conclusion : Our results suggest that Godjang water extracts would have antidiabetic effects in STZ-induced diabetic rats.

저자 : 이수화 ( Lee Soo Hwa ) , 서부일 ( Seo Bu-il )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 21권 1호 발행 연도 : 2021 페이지 : pp. 11-42 (32 pages)

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Salviae Plebeiae Herba (SP) contains a numberous chemical components and reported to exert various pharmacological activities such as antioxidant, anti-inflammatory, antimicrobial, analgesic, hypoglycemic, antiviral, anti-tumour, and hepatoprotective effects. Even though it has these various effects, its scientific proof remains uncertain the effect and underlying mechanism about joint damage. Accordingly, the present study was designed to evaluate the therapeutic effects and possible underlying mechanism of SP on osteoarthritis. OA models were induced via intra-joint injection of monosodium iodoacetate (MIA) 50 ㎕ with 80 ㎎/㎖ in rats. Excluding the normal group, OA-induced mice were divided into 4 groups (control, INDO, SPL, SPH). The drug concentrations were indomethacin 5 ㎎/㎏, SP 500 ㎎/㎏, and SP 1000 ㎎/㎏, and were administered orally once a day for 2 weeks. After drug supplementation, the effects of SP were measured with serum analysis, western blotting, and histopathological staining.
SP administration improved hind limb overload and it led to relieve pain. Moreover, it suppressed oxidative related factors. The NF-κB inactivation though the inhibition of IκBα phosphorlyation significantly decreased both inflammatory mediators such as COX-2 and iNOS and cytokines such as TNF-α, IL-1β, and IL-6. Whereas, anti-inflammatory cytokines like IL-4 and IL-10 were shown to increase. In addition, SP administration exerted a protective effect on ECM by reducing the expression of collagen degradation factors including MMP-1, -3, -13 and by increasing TIMP-1.
Taken together, SP may possess the effect of delaying the progression of osteoarthritis and protecting cartilage. Accordingly, the present study may provide a scientific basis the chondroprotective effect of SP on MIA induced osteoarthritis.

저자 : 이지혜 ( Ji Hye Lee ) , 문병철 ( Byeong Cheol Moon ) , 최고야 ( Goya Choi )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 21권 1호 발행 연도 : 2021 페이지 : pp. 48-54 (7 pages)

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Processing is a traditional pharmaceutical technique in Korean medicine. Processing is mainly performed to enhance pharmacological effect of herbal medicine depending on specific clinical need. The root of Rehmannia glutinosa (Gaertn.) DC. (RR) is one of major herbal material in Korean medicine. Since nature of RR is altered by processing, the clinical use of RR varies based on processing method. Generally, fresh RR is used to treat blood-heat syndrome, while steamed RR is used to treat Yi-deficiency syndrome. This review summarized the up-to-date studies to investigate how processing affects pharmacological properties of RR. Using electronic database, a total of 13 studies were collected and included in this study. These studies exhibited pharmacological properties of RR including immunostimulatory, hematopoietic, blood-cooling, anti-oxidant, anti-tumor, anti-thrombosis and anti-ulcer effects. All of studies were conducted by using in vitro or in vivo bioassays. This study could help to establish the basis for future research on processing of RR. In order to provide comprehensive data, further study is needed which includes changes in chemical profiles and analysis of relation between chemical profiles changes and pharmacological properties.

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