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The Journal of Applied Oriental Medicine

  • : 한약응용학회
  • : 의약학분야  >  기초한의학
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  • : 연속간행물
  • : 연간
  • : 1598-5539
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수록정보
수록범위 : 1권1호(2001)~20권2호(2020) |수록논문 수 : 171
한약응용학회지
20권2호(2020년 12월) 수록논문
최근 권호 논문
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1댕댕이나무에 대한 문헌고찰

저자 : 곽민하 ( Min-ha Kwak ) , 이상남 ( Sang-nam Lee ) , 박지하 ( Ji-ha Park )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 20권 2호 발행 연도 : 2020 페이지 : pp. 1-11 (11 pages)

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Objectives : So far, there has been a lot of research on Lonicera caerulea var. edulis in korea. but, There has not been a systematic and comprehensive literature study. In order to use it as a basic data for future research on Lonicera caerulea var. edulis, a literature review was conducted.
Methods : Lonicera caerulea var. edulis is called by various names, the English name is usually called blue honeysuckle, but it is also called honey berry, honeysuckle, edible honeysuckle, and sweetberry. After searching for related words mentioned above at RISS (http://www.riss.kr), DBpia (http://www.dbpia.co.kr), and kiss (http://kiss.kstudy.com), We have summarized the background, experimental method, and conclusion of the paper.
Conclusion & Results : Among 12 selected papers, there were 1 paper on the plant, 2 papers for extraction & commercialization, and 1 paper for toxicity evaluation. The rest were all papers on efficacy evaluation.

2수치방법(修治方法)에 따른 반하(半夏) 추출물(抽出物)의 마우스 단회투여독성실험(單回投與毒性實驗)

저자 : 임영권 ( Young Kwon Lim ) , 이상남 ( Sang-nam Lee ) , 박지하 ( Ji-ha Park )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 20권 2호 발행 연도 : 2020 페이지 : pp. 13-32 (20 pages)

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Objective : The object of this study was to evaluate the single dose toxicity of Pinelliae Rhizoma(PR) according to processing methods in ICR mice.
Methods : In order to observe the change of acute toxicity of PR according to the processing methods, Aqueous extracts of three different processing PR were administered to female and male ICR mice at dose levels of 2000 ㎎/㎏ (body weight) according to the recommendation of Korea Food and Drug Administration (KFDA) Guidelines (2009-116, 2009). The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing, histopathological observations of 12 types of principle organs were examined. In addition, the changes on the serum biochemistry related to the hepatic damages - serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and alkaline phosphatase (ALP) were also observed.
Results : After single oral treatment of three different PR aqueous extracts, we could not find any mortality and toxicological evidences to 2000 ㎎/㎏ in both female and male mice, No remarkable changes on the serum AST, ALT, albumin and ALP levels were also demonstrated in this study.
Conclusion : The results obtained in this study suggest that the toxicity of PR were also reduced by all three different processing methods used in this study. There were no evidences indicating the hepatic damages as well. However, previous study about the not processing PR showed hepatic toxicities. Therefore, it is recommended that the processing PR should be used in clinics as like as suggestions of traditional methods.

3천남성 물 추출물의 마우스 단회투여독성 실험

저자 : 성희정 ( Hui Jeong Seong ) , 이상남 ( Sang-nam Lee ) , 박지하 ( Ji-ha Park )

발행기관 : 한약응용학회 간행물 : 한약응용학회지 20권 2호 발행 연도 : 2020 페이지 : pp. 33-48 (16 pages)

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Objective : The objective of this study was to obtain the primary safety information about AR extracts, lyophilized water extract of Arisaema amurense Maxim. var. serratum Nakai and further clarifies their safety for clinical use.
Methods : In order to observe the 50% lethal dose (LD50), approximate lethal dosage (ALD), maximum tolerance dosage (MTD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) ㎎/㎏ (body weight) according to the recommendation of KFDA Guidelines [2005-60, 2005]. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines [2005-60, 2005] with organ weights and histopathology of 12 types of principle organs.
Results : The LD50 and ALD of AR extracts in both female and male mice were considered as over 2,000 ㎎/㎏ because no mortalities were detected upto 2,000 ㎎/㎏ that was the highest dose recommended by KFDA and OECD Guidelines. Because increases of frequencies of hepatocyte acute cellular swelling and related pale yellow discolorization with increases of liver weights were detected from 1,000 ㎎/㎏ of AR extracts-treated male and from 2,000 ㎎/㎏ in female mice, and the liver is considered as a primary target organ of AR extracts in this study.
Conclusion : The results obtained in this study suggest that the overdose ( ~ 1,000 ㎎/㎏ in male and ~ 2,000 ㎎/㎏ in female) of AR extract has slight reversible hepatotoxicity (acute cellular swelling) in mice and is therefore carefully to be used for clinical use.

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