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대한내과학회> The Korean Journal of Internal Medicine

The Korean Journal of Internal Medicine update

  • : 대한내과학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
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  • : 1226-3303
  • : 2005-6648
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수록정보
수록범위 : 1권1호(1986)~38권1호(2023) |수록논문 수 : 2,791
The Korean Journal of Internal Medicine
38권1호(2023년 01월) 수록논문
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KCI등재 SCOPUS

저자 : 대한내과학회

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 1-1 (1 pages)

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KCI등재 SCOPUS

저자 : Hyoung-chul Oh

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 2-2 (1 pages)

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KCI등재 SCOPUS

저자 : Jongbeom Shin

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 3-4 (2 pages)

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KCI등재 SCOPUS

저자 : Jinho Shin

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 5-6 (2 pages)

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KCI등재 SCOPUS

저자 : Yae Min Park

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 7-15 (9 pages)

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Hypertrophic cardiomyopathy (HCM) is a genetic disease associated with a risk of malignant ventricular tachyarrhythmias and sudden cardiac death (SCD). Assessment of the SCD risk is crucial for its clinical management, and there has been considerable interest in developing risk stratification strategies. An implantable cardioverter-defibrillator (ICD) is a life-saving treatment for patients with HCM who are at a high-risk of ventricular tachyarrhythmias and SCD. However, a substantial number of ICD recipients experience adverse effects arising from inappropriate device therapy and implant-related complications. This has led to numerous investigations of the risk of SCD and the indications for ICD implantation. American guidelines were recently updated to include new risk markers, including left ventricular systolic dysfunction, apical aneurysm, and extensive late gadolinium enhancement, while European guidelines recommend individualized estimated 5-year SCD risk assessment models. Studies evaluating other risk factors for SCD in patients with HCM have also been published. Drawing on recent guidelines and publications on clinical risk factors, we focus this review on updated risk assessments for SCD with ICD therapy in patients with HCM.

KCI등재 SCOPUS

저자 : Sung Cheol Park , Min-seok Kang , Jae Hyuk Yang , Tae-hoon Kim

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 16-26 (11 pages)

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Low back pain (LBP) is a common condition that affects people of all ages and income levels worldwide. The etiology of LBP may be mechanical, neuropathic, systemic, referred visceral, or secondary to other causes. Despite numerous studies, the diagnosis and management of LBP remain challenging due to the complex biomechanics of the spine and confounding factors, such as trivial degenerative imaging findings irrelevant to symptoms and psychological and emotional factors. However, it is imperative to identify the crucial signs (“red flags”) indicating a serious underlying condition. While many recent guidelines emphasize non-pharmacologic management approaches, such as education, reassurance, and physical and psychological care, as the first option, LBP patients in many countries, including South Korea, are prescribed medications. Multidisciplinary rehabilitation combined with prudent use of medications is required in patients unresponsive to first-line therapy. The development of practical guidelines apposite for South Korea is needed with multidisciplinary discussion.

KCI등재 SCOPUS

저자 : Hyuk Yoon , Nam-eun Kim , Jihye Park , Cheol Min Shin , Nayoung Kim , Dong Ho Lee , Jae Yong Park , Chang Hwan Choi , Jae Gyu Kim , Young Soo Park

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 27-39 (13 pages)

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Background/Aims: We evaluated the gut microbiome using extracellular vesicles (EVs) in the urine of patients with colorectal cancer (CRC) to determine whether gut-microbe-derived EVs could be a potential biomarker for the diagnosis of CRC.
Methods: EVs were isolated from the urine of patients with CRC and healthy controls. DNA was extracted from the EVs, and the bacterial composition was analyzed using next-generation sequencing of the 16S rRNA.
Results: A total of 91 patients with CRC and 116 healthy controls were enrolled. We found some specific microbiomes that were more or less abundant in the CRC group than in the control group. The alpha-diversity of the gut microbiome was significantly lower in the CRC group than in the control group. A significant difference was observed in the beta-diversity between the groups. The alpha-diversity indices between patients with early- and late-stage CRC showed conflicting results; however, there was no significant difference in the beta-diversity according to the stage of CRC. There was no difference in the alpha- and beta-diversity of the gut microbiome corresponding to the location of CRC (proximal vs. distal).
Conclusions: A distinct gut microbiome is reflected in the urine EVs of patients with CRC compared with that in the healthy controls. Microbial signatures from EVs in urine could serve as potential biomarkers for the diagnosis of CRC.

KCI등재 SCOPUS

저자 : Jung Hun Kim , Young Koog Cheon , Tae Yoon Lee , Sang Hoon Lee , Hyunji Chung

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 39-47 (9 pages)

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Background/Aims: Intrahepatic cholangiocarcinoma (iCCA) is a subgroup of cholangiocarcinoma and is the second- most-common primary hepatic tumor. Several predictive and prognostic factors have been analyzed; however, in this study we focused on the influence of age. Our aim was to use real-world results to determine the influence of age in iCCA patients.
Methods: A retrospective analysis of patients treated between 2005 and 2016 at Konkuk University Medical Center. In total, 133 patients with iCCA were identified. The mass-forming, periductal-infiltrating, and intraductal-growth types were included; patients with extrahepatic or hilar-type cholangiocarcinoma were excluded. We defined two groups: a younger group, age < 65 years, and an older group, age ≥ 65 years. Statistical analyses using univariate and multivariate Cox regression analyses, including the Kaplan-Meier method, were conducted.
Results: In total, 114 patients were enrolled. The two groups differed with regard to treatment options such as surgery with adjuvant chemotherapy or palliative chemotherapy (p = 0.012, p < 0.001). The younger group had significantly longer survival than the older group (p = 0.017). In the younger group, patients who received therapy had longer survival than those who did not (hazard ratio, 3.942; 95% confidence interval, 2.053 to 7.569; p < 0.001). Multivariate analysis indicated that younger age, lower bilirubin, low CA 19-9, and no lymph-node involvement were independent factors for improved survival.
Conclusions: Younger patients and those who underwent surgery with adjuvant chemotherapy had longer survival. The younger the patient, the more treatments received, including palliative chemotherapy.

KCI등재 SCOPUS

저자 : Tae-geun Gweon , Yoo Jin Lee , Sung Kyun Yim , Seung Yong Kim , Chang Hwan Choi , Young-seok Cho

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 48-58 (11 pages)

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Background/Aims: Fecal microbiota transplantation (FMT) represents a treatment option for recurrent Clostridioides difficile infection (CDI). Recently, FMT has been investigated in various clinical settings other than CDI. This study examined Korean physicians' recognition of FMT and their attitudes toward this procedure
Methods: An online questionnaire included questions on indications for FMT, the FMT process, physicians' attitudes toward FMT for the treatment of CDI and non-CDI diseases, and possible concerns.
Results: Finally, 107 physicians responded to this survey: 66 (61.7%) had experience of performing FMT, and 86 (80.4%) replied that they were willing to perform FMT for CDI. Two-thirds of physicians (63.6%, n = 68) would perform FMT for recurrent CDI on patients who had at least three recurrences. The most common obstacle to performing FMT for the treatment of CDI was the lack of regulations or guidelines (55.1%, n = 59). Seventy-seven (72.0%) physicians would consider FMT for non- CDI diseases when conventional treatment had failed. The most common obstacle for FMT for the treatment of non-CDI diseases was low treatment efficacy (57.0%, n = 61).
Conclusions: Two-thirds of Korean physicians had experience of performing FMT, and many performed FMT for recurrent CDI. The results of this study will prove useful to researchers and practitioners in FMT in Korea.

KCI등재 SCOPUS

저자 : Jin Young Lee , Jean Kyung Bak , Mina Kim , Ho-gyun Shin , Kyun-ik Park , Seung-pyo Lee , Hee-sun Lee , Ju-yeun Lee , Kwang-il Kim , Si-hyuck Kang , Jang Hoon Lee , Se Yong Jang , Ju-hee Lee , Kye Hun K

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 38권 1호 발행 연도 : 2023 페이지 : pp. 56-79 (24 pages)

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Background/Aims: This study evaluated the long-term cardiovascular complications among Korean patients with hypertension and compared them with that of controls without hypertension.
Methods: The Korean Hypertension Cohort (KHC) enrolled 11,043 patients with hypertension and followed them for more than 10 years. Age- and sex-matched controls without hypertension were enrolled at a 1:10 ratio. We compared the incidence of cardiovascular events and death among patients and controls without hypertension.
Results: The mean age was 59 years, and 34.8% and 16.5% of the patients belonged to the high and moderate cardiovascular risk groups, respectively. During the 10-year follow-up, 1,591 cardiovascular events (14.4%) with 588 deaths (5.3%) occurred among patients with hypertension and 7,635 cardiovascular events (6.9%) with 4,826 deaths (4.4%) occurred among controls. Even the low-risk population with hypertension showed a higher cardiovascular event rate than the population without hypertension. Although blood pressure measurements in the clinic showed remarkable inaccuracy compared with those measured in the national health examinations, systolic blood pressure (SBP) ≥ 150 mmHg was significantly associated with a higher risk of cardiovascular events.
Conclusions: This long-term follow-up study confirmed the cardiovascular event rates among Korean hypertensive patients were substantial, reaching 15% in 10 years. SBP levels ≥ 150 mmHg were highly associated with occurrence of cardiovascular event rates.

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