간행물

대한내과학회> The Korean Journal of Internal Medicine

The Korean Journal of Internal Medicine update

  • : 대한내과학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCI,SCOPUS
  • : 연속간행물
  • : 격월
  • : 1226-3303
  • : 2005-6648
  • :

수록정보
수록범위 : 1권1호(1986)~36권3호(2021) |수록논문 수 : 2,540
The Korean Journal of Internal Medicine
36권3호(2021년) 수록논문
최근 권호 논문
| | | |

KCI등재 SCI SCOPUS

1Single-cell transcriptomics: a novel precision medicine technique in nephrology

저자 : Jisoo Kim , Jihwan Park

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 479-490 (12 pages)

다운로드

(기관인증 필요)

초록보기

Due to the complex structure and function of the kidneys, the mechanism of kidney disease is unclear. In particular, transcriptomics approaches at the bulk level are unable to differentiate primary autonomous responses, which lead to disease development, from secondary cell non-autonomous responses. Single-cell analysis techniques can overcome the limitations inherent in the measurement of heterogeneous cell populations and clarify the central issues in kidney biology and disease pathogenesis. Single-cell sequencing helps in identifying disease-related biomarkers and pathways, stratifying patients, and deciding on appropriate treatment methods. Here we review a variety of single-cell analysis techniques and single-cell transcriptomics studies performed in the field of nephrology. Moreover, we discuss the future prospects of single-cell analysis-based precision medicine in nephrology.

KCI등재 SCI SCOPUS

22020 Korean guidelines for the management of metastatic prostate cancer

저자 : In-ho Kim , Sang Joon Shin , Byung Woog Kang , Jihoon Kang , Dalyong Kim , Miso Kim , Jin Young Kim , Chan Kyu Kim , Hee-jun Kim , Chi Hoon Maeng , Kwonoh Park , Inkeun Park , Woo Kyun Bae , Byeong Seok

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 491-514 (24 pages)

다운로드

(기관인증 필요)

초록보기

In 2017, Korean Society of Medical Oncology (KSMO) published the Korean management guideline of metastatic prostate cancer. This paper is the 2nd edition of the Korean management guideline of metastatic prostate cancer. We updated recent many changes of management in metastatic prostate cancer in this 2nd edition guideline. The present guideline consists of the three categories: management of metastatic hormone sensitive prostate cancer; management of metastatic castration resistant prostate cancer; and clinical consideration for treating patients with metastatic prostate cancer. In category 1 and 2, levels of evidence (LEs) have been mentioned according to the general principles of evidence-based medicine. And grades of recommendation (GR) was taken into account the quality of evidence, the balance between desirable and undesirable effects, the values and preferences, and the use of resources and GR were divided into strong recommendations (SR) and weak recommendations (WR). A total of 16 key questions are selected. And we proposed recommendations and described key evidence for each recommendation. The treatment landscape of metastatic prostate cancer is changing very rapid and many trials are ongoing. To verify the results of the future trials is necessary and should be applied to the treatment for metastatic prostate cancer patients in the clinical practice. Especially, many prostate cancer patients are old age, have multiple underlying medical comorbidities, clinicians should be aware of the significance of medical management as well as clinical efficacy of systemic treatment.

KCI등재 SCI SCOPUS

3Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

저자 : Hong Ki Min , Se-hee Kim , Sang-heon Lee , Hae-rim Kim

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 515-526 (12 pages)

다운로드

(기관인증 필요)

초록보기

Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the criteria for definite autoimmune rheumatic diseases. The classification criteria for IPAF were defined by the European Respiratory Society and American Thoracic Society in 2015. However, further studies to establish IPAF subgroups and treatment modalities for each subgroup are still needed. In this review, we discuss recent advances regarding IPAF and raise critical points for the diagnosis and management of patients with IPAF from the perspective of rheumatologists.

KCI등재 SCI SCOPUS

4Inherited arrhythmia syndrome predisposing to sudden cardiac death

저자 : Yun Gi Kim , Suk-kyu Oh , Ha Young Choi , Jong-il Choi

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 527-538 (12 pages)

다운로드

(기관인증 필요)

초록보기

Inherited arrhythmia (IA) is one of the main causes of sudden cardiac death (SCD) in young people, and is reported to be a more prevalent cause of SCD in Asia than in Western countries. IAs are a group of genetic disorders caused by mutations in genes encoding cardiac ion channels, leading to electrophysiological characteristics that often occur in the absence of structural abnormalities. Channelopathies, such as long QT syndrome and Brugada syndrome, carry a potential risk of life-threatening ventricular tachyarrhythmias that predispose to SCD, although early prediction and prevention of the risk remain challenging. Recent advances in genetic testing have facilitated risk stratification as well as a precise diagnosis for IA, despite ongoing debates about the implications. Herein, we provide epidemiological data, a pathophysiological overview, and the current clinical approach to IAs related to SCD. In addition, we review the general issues arising from genetic testing for IAs.

KCI등재 SCI SCOPUS

5Can Helicobacter pylori eradication affect long-term mortality?

저자 : Hang Lak Lee

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 539-540 (2 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI SCOPUS

6Urinary angiotensinogen as a marker of elevated blood pressure in patients with chronic kidney disease

저자 : Chan-young Jung , Tae-hyun Yoo

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 541-543 (3 pages)

다운로드

(기관인증 필요)

키워드 보기
초록보기

KCI등재 SCI SCOPUS

7The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2

저자 : Sung Yong Han , Hyun Young Woo , Jeong Heo , Sang Gyu Park , Sung Ik Pyeon , Young Joo Park , Dong Uk Kim , Gwang Ha Kim , Hyung Hoi Kim , Geun Am Song , Mong Cho

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 544-557 (14 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and safety of SOF/RBV in Korean patients with HCV GT2 infection and clinical factors predicting sustained virological response 12 weeks (SVR12) after the end of SOF/RBV treatment.
Methods: A total of 181 patients with HCV GT2 with/without cirrhosis were treated with SOF/RBV for 16/12 weeks. Rapid virological response (RVR) was defined as non-detectable HCV RNA at 4 weeks.
Results: The RVR rate was 80.7% (146/181), the end of treatment response rate was 97.8% (177/181) and the SVR12 rate was 92.8% (168/181). Of eight patients with relapse, four did not achieve RVR. Three patients had a history of hepatocellular carcinoma (HCC). Multivariable analysis showed that RVR (p = 0.015) and no previous history of HCC (p = 0.007) were associated with SVR12. Factors significantly contributing to RVR included cirrhosis, creatinine concentration, and pre-treatment HCV RNA level. SVR12 rate was significantly higher in RVR (+) than RVR (-) patients (95.2% vs. 82.9%, p = 0.011) and also significantly higher in patients without than with a history of HCC (94.1% vs. 72.7%, p = 0.008). During treatment, 80/181 patients (44.2%) experienced mild to moderate adverse events, with 32 (17.7%) requiring RBV dose reductions due to anemia.
Conclusions: SOF/RBV treatment was effective and tolerable in HCV GT2 patients. RVR and no previous history of HCC were positive predictors of SVR12.

KCI등재 SCI SCOPUS

8Impact of nonalcoholic fatty liver disease on the risk of metachronous colorectal neoplasia after polypectomy

저자 : Nam Hee Kim , Yoon Suk Jung , Jung Ho Park , Dong Il Park , Chong Il Sohn

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 557-567 (11 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Metabolic syndrome has been reported to be a risk factor for metachronous colorectal neoplasia (CRN). However, the impact of nonalcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, on the development of metachronous CRN after polypectomy has been rarely examined. We evaluated the association between NAFLD and the development of metachronous CRN after polypectomy.
Methods: Asymptomatic subjects who underwent abdominal ultrasonography and endoscopic removal of ≥ 1 adenomas at the index colonoscopy between 2010 and 2014, and had a follow-up surveillance colonoscopy until 2017 were analyzed.
Results: Of 6,182 participants, 2,642 (42.7%) had NAFLD at the time of the index colonoscopy. Patients with NAFLD had significantly higher cumulative incidence rates of metachronous overall CRN than those without NAFLD in both men (19.4% vs. 18.2% at 3 years and 49.2% vs. 44.0% at 5 years; p = 0.001) and women (18.7% vs. 10.5% at 3 years and 56.1% vs. 29.8% at 5 years; p < 0.001). Even after adjusting for confounders, NAFLD remained independently associated with an increased risk of metachronous overall CRN in both men (adjusted hazard ratio [HR], 1.17; 95% confidence interval [CI], 1.06 to 1.29) and women (adjusted HR, 1.63; 95% CI, 1.27 to 2.07). Additionally, NAFLD was an independent risk factor for metachronous advanced CRN (ACRN) in women (adjusted HR, 2.61; 95% CI, 1.27 to 5.37).
Conclusions: NAFLD is related to an increased risk of metachronous CRN after polypectomy. Especially, women with NAFLD are at an increased risk of developing metachronous ACRN. Our results indicate a possible effect of NAFLD on the pathogenesis of CRN.

KCI등재 SCI SCOPUS

9Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals

저자 : Weitao Shen , Jiayu Sun , Zhiyang Li , Fen Yao , Kaihuang Lin , Xiaoyang Jiao

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 568-583 (16 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora in healthy and CRC individuals.
Methods: Food intake data were recorded using the Food Frequency Questionnaire (FFQ). The composition and diversity of the intestinal flora detected by 16S rRNA gene sequencing, and the data were analyzed by R version 3.1.1 software.
Results: Higher intake of red meat or pickled foods, and lower intake of white meat, fruits, vegetables, beans, nuts were found in the CRC group compared with the healthy group. Higher levels of Fusobacteria and Proteobacteria, and lower levels of Firmicutes were observed in the CRC group. Partial correlation analysis revealed that the intake of fruits, beans, and nuts was negatively correlated with Proteobacteria and Fusobacteria, but pickled food was positively correlated with Fusobacteria (p < 0.05). Fish, beans, and nuts intake was negatively correlated with Escherichia (p = 0.01). Multiple regression analysis revealed that vegetable oil (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.13 to 0.82), vegetables (OR, 0.26; 95% CI, 0.10 to 0.64), eggs (OR, 0.26; 95% CI, 0.10 to 0.69), pickled foods (OR, 21.02; 95% CI, 6.02 to 73.45), and red meat (OR, 4.23; 95% CI, 1.68 to 10.60) had an impact on CRC risk.
Conclusions: The species and abundance of intestinal flora varies between CRC and healthy individuals and may be affected by their food preference.

KCI등재 SCI SCOPUS

10Effect of Helicobacter pylori treatment on the long-term mortality in patients with type 2 diabetes

저자 : Young-il Kim , Young Ae Kim , Hak Jin Kim , Su-hyun Kim , Yul Hwangbo , Jae Gyu Kim , Jae J. Kim , Il Ju Choi

발행기관 : 대한내과학회 간행물 : The Korean Journal of Internal Medicine 36권 3호 발행 연도 : 2021 페이지 : pp. 584-598 (15 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Meta-analyses of randomized trials reported a non-significant increase in overall mortality risk after Helicobacter pylori eradication. In this study, we investigated whether H. pylori treatment is associated with increased risk of overall mortality in patients with type 2 diabetes.
Methods: In this retrospective population-based cohort study, we identified 66,706 patients treated for type 2 diabetes between 2002 and 2010 from the Korean National Health Insurance Service-National Sample Cohort. Patients who received H. pylori treatment (Hp-treatment cohort, 1,727 patients) were matched to those who did not (non-treatment cohort, 3,454 patients) at a 1:2 ratio. The primary outcome was overall mortality. The secondary outcomes were mortalities due to cardiovascular disease, cerebrovascular disease, or cancers. To estimate hazard ratio (HR) with confidential interval (CI), we used the Cox proportional-hazard model.
Results: During a median follow-up of 4.7 years, the overall mortality was 5.9% (101/1,727 patients) among patients in the Hp-treatment cohort and 7.6% (364/3,454 patients) among patients in the non-treatment cohort. Adjusted HR (aHR) for overall mortality in the Hp-treatment cohort was 0.74 (95% CI, 0.59 to 0.93; p = 0.011). The mortality risks due to cardiovascular disease (aHR, 1.34; 95% CI, 0.54 to 3.30; p = 0.529), cerebrovascular disease (aHR, 0.97; 95% CI, 0.37 to 2.55; p = 0.947), and cancer (aHR, 1.08; 95% CI, 0.68 to 1.72; p = 0.742) were not significantly different between the groups.
Conclusions: In type 2 diabetes patients, overall mortality did not increase after H. pylori treatment.

123
권호별 보기
가장 많이 인용된 논문

(자료제공: 네이버학술정보)

가장 많이 인용된 논문
| | | |
1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

다운로드

2미국의 비트코인 규제

(2006)홍길동심리학41회 피인용

다운로드

가장 많이 참고한 논문

(자료제공: 네이버학술정보)

가장 많이 참고한 논문

다운로드

2미국의 비트코인 규제

(2006)홍길동41회 피인용

다운로드

해당 간행물 관심 구독기관

경상대학교 광주여자대학교 경북대학교 상지대학교 동양미래대학교
 15
 9
 8
 6
 6
  • 1 경상대학교 (15건)
  • 2 광주여자대학교 (9건)
  • 3 경북대학교 (8건)
  • 4 상지대학교 (6건)
  • 5 동양미래대학교 (6건)
  • 6 부산대학교 (5건)
  • 7 연세대학교 (4건)
  • 8 홍익대학교 (3건)
  • 9 고려대학교 (2건)
  • 10 부산가톨릭대학교 (1건)

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기