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대한피부과학회> Annals of Dermatology

Annals of Dermatology update

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 격월
  • : 1013-9087
  • : 2005-3894
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수록정보
수록범위 : 1권1호(1989)~34권3호(2022) |수록논문 수 : 3,053
Annals of Dermatology
34권3호(2022년 06월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Effects of <10-μm Particulate Matter on Cultured Human Sebocytes and Outer Root Sheath Cells and Usefulness of Siegesbeckia Herba Extract

저자 : Mi Hee Kwack , Nam Gyoung Ha , Weon Ju Lee

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 163-172 (10 pages)

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Background: Particulate matter (PM) is one of the air pollutants that can damage human skin; the recent increase in the amount of PM may be detrimental to skin health.
Objective: We aimed to investigate the effects of PM on cultured human sebocytes and outer root sheath (ORS) cells and the effects of Siegesbeckia Herba extract (SHE) on PM-treated cultured cells.
Methods: Sebocytes and ORS cells were cultured. The cultured cells were treated with various concentrations of PM of <10 μm in size (PM10) (10 μg/ml, 25 μg/ml, 50 μg/ml, and 100 μg/ml) for 24 h. Real-time polymerase chain reaction, measurement of reactive oxygen species (ROS), small interfering (si) RNA transfection, Oil Red O and Nile red staining, and immunofluorescence staining were performed to analyze the presence of inflammatory cytokines, matrix metalloproteinases (MMPs), aryl hydrocarbon receptor (AhR), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), ROS, and lipid production. In addition, PM10 (100 μg/ml)-treated cultured cells were treated with 10 mg/ml of SHE.
Results: PM10 upregulates the expression of inflammatory cytokines, MMPs, AhR, NFkB, and ROS in cultured human sebocytes and ORS cells. The production of ROS was dramatically reduced in AhR siRNA-transfected cells. In addition, PM10 upregulates sebum production in cultured sebocytes. SHE inhibited the upregulation of inflammatory cytokines, MMPs, AhR, NF-kB, ROS, and sebum production in cultured human sebocytes and/or ORS cells by PM10.
Conclusion: Effects of PM10 on cultured human sebocytes and ORS cells can be regulated by SH.

KCI등재 SCOPUS

2Association Between Short-Term PASI90 Achievement and Drug Survival of Biologics in Patients with Psoriasis

저자 : Sungjun Choi , Sohee Oh , Hyun-sun Yoon

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 173-181 (9 pages)

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Background: With accumulating evidence that achieving a 90% improvement in the Psoriasis Area and Severity Index score (PASI90) has better correlation with improved healthrelated quality of life as compared to PASI75 achievement, there has been demand for establishing new treatment goals for psoriasis.
Objective: We investigated whether the short-term PASI90 achievement would predict longer drug survival as compared to PASI75 achievement.
Methods: This single-center retrospective cohort study reviewed 180 treatment series in 128 patients with plaque psoriasis, who were treated with tumor necrosis factor-alpha inhibitors (n=12), ustekinumab (n=88), secukinumab (n=23), guselkumab (n=45), and ixekizumab (n=12). The first effectiveness assessment, usually performed within 12 to 20 weeks, was considered a short-term treatment response to biologics.
Results: After adjustment for covariates, time-dependent Cox proportional hazards regression analysis showed that moderate responders (short-term achievement of ≥PASI75 but 

KCI등재 SCOPUS

3Dieckol Inhibits the Effects of Particulate Matter 10 on Sebocytes, Outer Root Sheath Cells, and Cutibacterium Acnes-Pretreated Mice

저자 : Mi Hee Kwack , Nam Gyoung Ha , Weon Ju Lee

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 182-191 (10 pages)

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Background: Particulate matter (PM) is an air pollutant that can impair the human skin. Antioxidants have been tested to improve PM-induced skin inflammation.
Objective: In this study, we investigated the effects of dieckol on PM-induced inflammation on cultured human sebocytes, outer root sheath (ORS) cells, and mice pretreated with Cutibacterium acnes.
Methods: We cultured and treated the sebocytes and ORS cells with 5 μM of dieckol and 100 μg/ml of PM10 for 24 h. The C. acnes-pretreated mice received 5 μM of dieckol and 100 μg/ml of PM10. We measured cell viability using MTT assay. Real-time PCR and measurement of reactive oxygen species (ROS) and sebum production analyzed the effects.
Results: Dieckol inhibited the upregulation of the gene expression of the inflammatory cytokines, matrix metalloproteinase (MMP), aryl hydrocarbon receptor, and nuclear factor kappa-light-chain-enhancer of activated B cells by PM10 in the cultured sebocytes and ORS cells and inhibited an increase in ROS production by PM10 in the cultured sebocytes. In addition, dieckol decreased the inflammatory cytokines, MMP, and sebum production in C. acnes-pretreated mice.
Conclusion: Dieckol effectively reduced the expression of inflammatory biomarkers and the production of sebum in cultured sebocytes, ORS cells, and C. acnes-pretreated mice.

KCI등재 SCOPUS

4Risk of Psoriasis in Postgastrectomy Gastric Cancer Survivors: A Nationwide Population-Based Cohort Study

저자 : Bo Ri Kim , Dong Ho Lee , Hyun Ik Shim , Jee Woo Kim , Sanghyun Park , Cheol Min Shin , Kyungdo Han , Sang Woong Youn

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 191-201 (11 pages)

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Background: Although patients with psoriasis have an increased risk of cancers, little is known about the risk of psoriasis in cancer patients.
Objective: We aimed to comparatively analyze the incidence and risk factors of psoriasis in gastric cancer patients who underwent gastrectomy and in the general population.
Methods: A nationwide retrospective cohort of 52,608 gastric cancer survivors (2007~2015) was compared to 123,438 matched controls from the general population to estimate the incidence and hazard ratio (HR) of new-onset psoriasis. We also calculated the HRs for psoriasis according to adjuvant cancer treatment, obesity, and vitamin B12 supplementation in gastric cancer survivors.
Results: During a mean follow-up of 6.85 years, 645 of the 52,608 gastric cancer patients developed psoriasis, while 1,806 in the 123,438 matched control group developed psoriasis. Gastric cancer patients had a decreased risk of psoriasis (HR, 0.86; 95% confidence interval, 0.79~0.94), especially those who underwent subtotal gastrectomy. We found that vitamin B12 supplementation for more than 3 years had an additive effect on decreasing the risk of psoriasis in gastric cancer patients who underwent subtotal gastrectomy. Total gastrectomy, radio/chemotherapy, and obesity did not affect the risk of psoriasis in gastric cancer survivors.
Conclusion: The incidence of psoriasis is slightly lower in gastric cancer survivors than in the general population. Our results suggest that the development of psoriasis may be reduced by removing the source of systemic inflammation caused by Helicobacter pylori infection through subtotal gastrectomy in gastric cancer survivors.

KCI등재 SCOPUS

5Comparison of Th1 and Th17 Inflammatory Cytokine Profiles Between Chronic Plaque and Acute Guttate Psoriasis

저자 : Hyun Jeong Ju , Hyo Jin Park , In Hye Choi , Kyung Ho Lee , Mi Yeon Kwon , Chul Jong Park

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 200-205 (6 pages)

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Background: The phenotypic heterogeneity of psoriasis is suspected to reflect differences in its pathogenesis, but not yet completely elucidated. Studies of the Th1 and Th17 cytokines associated with different phenotypes of psoriasis have yielded inconsistent results.
Objective: To investigate the tissue expression levels of Th1 and Th17 cytokines among patients with chronic plaque psoriasis, acute guttate psoriasis, and healthy control.
Methods: A total of 20 patients with psoriasis (10 with chronic plaque type and 10 with acute guttate type) and 5 healthy controls were enrolled. The tissue mRNA and protein levels of following cytokines were measured: interleukin (IL)-12, IL-2, interferon (IFN)-γ, IL-23, IL-17A, and IL-22.
Results: The tissue mRNA levels of IL-12, IFN-γ, IL-23, IL-17A, IL-22 and the protein levels of IL-12, IL-2, IFN-γ, IL-17A, IL-22 were significantly increased in the psoriasis patients compared with the healthy controls. In comparisons of the subtypes, the tissue mRNA level of IFN-γ was increased in acute guttate psoriasis, whereas the protein levels of IL-12 and IL-17A were significantly increased in chronic plaque psoriasis. The cytokine ratios of IL-17A/IL-2 and IL-22/IL-2 were significantly higher in chronic plaque psoriasis than in acute guttate psoriasis.
Conclusion: We confirmed that the tissue levels of Th1 and Th17 cytokines were increased in psoriasis patients compared with healthy controls. The increased IFN-γ mRNA level in acute guttate psoriasis and increased IL-12 and IL-17A protein levels in chronic plaque psoriasis suggest that an imbalance between Th1 and Th17 cytokines may play a role in the phenotypic transition of psoriasis.

KCI등재 SCOPUS

6Inhibitory Effect of Mitoxantrone on Collagen Synthesis in Dermal Fibroblasts

저자 : Kyung-il Kim , Chang-il Kwon , Jeung-hoon Lee , Chang-deok Kim , Tae-jin Yoon

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 206-211 (6 pages)

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Background: Fibroblasts produce collagen molecules that support the structure of the skin. The decrease and hypersynthesis of collagen causes skin problems such as skin atrophy, wrinkles and scars.
Objective: The purpose of this study is to investigate the mechanism of mitoxantrone on collagen synthesis in fibroblasts.
Methods: Cultured fibroblasts were treated with mitoxantrone, and then collagen synthesis was confirmed by reverse transcription-polymerase chain reaction and Western blot.
Results: Mitoxantrone inhibited the expression of type I collagen in fibroblasts at both the mRNA and protein levels. In the collagen gel contraction assay, mitoxantrone significantly inhibited gel contraction compared to the control group. Mitoxantrone inhibited transforming growth factor (TGF)-β-induced phosphorylation of SMAD3. Finally, mitoxantrone inhibited the expression of LARP6, an RNA-binding protein that regulates collagen mRNA stability.
Conclusion: These results suggest that mitoxantrone reduces collagen synthesis by inhibiting TGF-β/SMAD signaling and LARP6 expression in fibroblasts, which can be developed as a therapeutic agent for diseases caused by collagen hypersynthesis.

KCI등재 SCOPUS

7Bullous Variant of Pyoderma Gangrenosum in a Patient with Acute Myeloid Leukemia

저자 : Chang-il Kwon , Gyeong-won Lee , Chi-yeon Kim

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 212-215 (4 pages)

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Unlike classic pyoderma gangrenosum (PG), the bullous variant of PG is typically represented by a painful erythematous papule, plaque, and superficial bulla that progress into the ulceration with bullous margin. Generally, bullous PG is most commonly associated with myeloproliferative disorders, such as acute myeloid leukemia (AML). Bullous PG in AML patients rarely occurs, but once it does, it suggests a poor clinical prognosis. Although many cases of classic PG in AML patients have been reported, bullous PG is relatively rare. Therefore, we present a case of bullous PG that developed in a patient with AML and was successfully treated with high-dose systemic steroids.

KCI등재 SCOPUS

8Innovative Use of Negative Air Ions As an Alternative Therapy for Acne Vulgaris: A Report of Three Cases

저자 : Hye Sung Han , Guk Jin Jeong , Hae Woong Lee , Joo Hyun Shim , Seong Jun Seo , Kui Young Park

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 216-221 (6 pages)

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Acne vulgaris is a universal skin disease with multifactorial pathogenesis. Although an extensive range of treatment options exist for acne, a substantial number of patients are still struggling for an optimal treatment option due to the side effects or contraindications to the conventional acne treatment. Negative air ions (NAIs) are electrically charged molecules that naturally exist in the atmosphere. Since they are natural component of air, there are no known side effects and contraindications to their application. Furthermore, among the identified benefits of NAIs, certain mechanisms are related to acne pathogenesis, allowing them to be attractive candidates for acne treatment. Here, we describe three patients with acne who showed considerable clinical improvement after NAI therapy. All of the patients had failed to tolerate traditional acne treatment options. In all three cases, considerable improvement was observed in acne severity and the number of total lesions. Based on the three cases and a review of literature underlying the effects of NAIs, we suggest that NAIs may be a safe and effective alternative therapeutic option for acne vulgaris.

KCI등재 SCOPUS

9Diagnostic Pearls of Vulvar Epidermolytic Acanthoma: Case Report

저자 : Navid Farahbakhsh , Colton Nielson , Eric Rudnick , Salma Pothiawala , Vincek Vladimir

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 221-224 (4 pages)

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Epidermolytic acanthomas (EA) are uncommon benign tumors clinically presenting as single to multiple papules. Histologically, EA display hyperkeratosis, hypergranulosis, acanthosis, and epidermal degeneration―also known as epidermolytic hyperkeratosis (EH). EA may be misdiagnosed as condyloma both clinically and histopathologically when located on the genitalia. Thus, this diagnosis carries a significant psychological burden and must remain in the differential when initially considering genital warts. We utilize the case of a 62-year old female referred to dermatology for a 5-year history of multiple pruritic and hypopigmented vulvar papules―misdiagnosed as genital warts―to highlight the impact of differentiating EA from genital warts. This patient was initially misdiagnosed with common genital warts at her gynecologist's office and treated unsuccessfully for years. A shave biopsy was performed and histology revealed EH, consistent with EA.

KCI등재 SCOPUS

10Intralymphatic Histiocytosis Associated with Osteoarthritis: A Case Report

저자 : Taehan Koo , Hyun Ji Kang , Min-soo Kim , Mihn-sook Jue

발행기관 : 대한피부과학회 간행물 : Annals of Dermatology 34권 3호 발행 연도 : 2022 페이지 : pp. 225-227 (3 pages)

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Intralymphatic histiocytosis (ILH) is a rare cutaneous condition with uncertain pathogenesis. It is characterized by dilated lymphatic vessels that contain histiocytes within their lumina. Although the etiology of ILH remains unknown, it has been associated with various inflammatory and neoplastic diseases, such as rheumatoid arthritis (RA), reaction to metal joint implants and Merkel cell carcinoma, breast cancer and colon cancer. An 83-year-old female presented with an erythematous patch on the left forearm that had appeared six months previous. She had suffered from osteoarthritis (OA) and the cutaneous lesion was located in the vicinity of the affected joint. Skin biopsy from the lesion showed dilated dermal vessels and some ectatic vessels that contained many mononuclear histiocytes. Based on the clinical and histopathological findings, we diagnosed her with ILH with OA. Two sessions of intralesional triamcinolone acetonide injection (5 mg/ml) were administered to treat the skin lesion, which gradually improved over a period of a few months. We here report a rare case of ILH associated with degenerative OA.

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