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대한폐경학회지 update

Journal of Menopausal Medicine

  • : 대한폐경학회
  • : 의약학분야  >  산부인과학
  • : KCI등재
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  • : 연속간행물
  • : 연3회
  • : 2288-6478
  • : 2288-6761
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수록정보
수록범위 : 1권1호(1995)~28권1호(2022) |수록논문 수 : 646
대한폐경학회지
28권1호(2022년 04월) 수록논문
최근 권호 논문
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KCI등재

저자 : Sung Wook Choi , Juhee Kim , Jae Hoon Lee , Seul Ki Kim , Sa Ra Lee , Sung Hoon Kim , Hee Dong Chae

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 1-8 (8 pages)

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The coronavirus disease 2019 (COVID-19) pandemic has impacted the medical, social, and reproductive health of millions of people since its outbreak. The causative virus transmits, reproduces, and manifests through the respiratory tract. COVID-19 can invade any system of the body, including the cardiovascular and endocrine systems, through a secondary immune response. In particular, because the fatality rate is high in those over the age of 50 years, special attention is required during the medical care of this population. However, considering the benefit of therapy and the risk of COVID-19, high-quality evidence regarding individualized management in relation to hormone therapy is still insufficient in the field of gynecology. Furthermore, this review aims to serve as a reference for clinical application by analyzing and summarizing the results of studies reported to date regarding female hormone therapy in the context of the COVID-19 pandemic.

KCI등재

저자 : Laura Porterfield , Nyajuok Wur , Zuleica Santiago Delgado , Farha Syed , Amanda Song , Susan C. Weller

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 9-16 (8 pages)

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Genitourinary syndrome of menopause significantly affects the quality of life in postmenopausal women with few evidence-based alternatives to vaginal estrogen for women with contraindications. This systematic review evaluates the evidence for vaginal vitamin E efficacy in reducing patient-reported genitourinary symptoms in healthy postmenopausal women compared to placebo or vaginal control therapy. This systematic review evaluated randomized controlled trials before October 2020 that assessed the efficacy of vitamin E vaginal suppositories in reducing genitourinary symptoms in postmenopausal women compared with a control group of healthy postmenopausal women. Outcomes included patient-perceived genitourinary symptoms. Of the 31 studies, four met the inclusion criteria. One 8-week trial (n = 42) found a significant reduction in vaginal symptoms in the 1 mg vitamin E group than the placebo group (difference in means, 5.3; 95% confidence interval [CI], 4.4 to 6.2). Another 8-week trial (n = 40) found 5 mg vaginal hyaluronic acid superior to 1 mg vitamin E (difference in means -0.50, 95% CI, -0.95 to -0.05). Two 12-week trials (n = 52 in each) found no difference between 0.5 g vaginal estrogen and 100 IU vaginal vitamin E in healthy postmenopausal women (difference in means: -0.19, 95% CI, -4.4 to 4.0, and -3.47, 95% CI, -13.8 to 6.8). Evidence from small, limited studies suggests that vaginal vitamin E may be effective in alleviating symptoms of genitourinary syndrome of menopause; however, additional high-quality studies are needed to determine efficacy, ideal dosing, and long-term safety.

KCI등재

저자 : Camila Oliveira Serra , Paula Mara Gomes Leite , Andráa Beatriz Bezerra , Laura Freitas , Lucas Veras , Marcela Deda Costa , Leila Luiza Conceição Gonçalves , Leonardo Yung Dos Santos Maciel

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 17-24 (8 pages)

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Objectives: This study aimed to compare the climacteric symptoms, quality of life indices, and self-care attitudes in women before and during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: This cross-sectional study was conducted between January 2020 and September 2021. The sample consisted of 342 climacteric women who were divided into two groups: before the pandemic (BP group; n = 62) and during the pandemic (DP group; n = 280). The Menopause Rating Scale and Women's Health Questionnaire were used to measure the health-related quality of life and degree of climacteric symptoms reported by women.
Results: During the COVID-19 pandemic, women were able to decrease their somatic symptoms derived from the climacteric period (BP group: 7.84 ± 4.46, DP group: 5.94 ± 9.20; P = 0.003).
Conclusions: There was no worsening in the self-reported symptoms, quality of life, and self-care attitudes of climacteric women because of the COVID-19 pandemic. Moreover, only somatic symptoms decreased during the pandemic.

KCI등재

저자 : Soo Min Kim , Whan Shin , Hyo Jeong Kim , Ji Soo Lee , Yong-ki Min , Byung-koo Yoon

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 25-32 (8 pages)

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Objectives: A retrospective cohort study was conducted to evaluate the effects of combination oral contraceptives (COCs) on bone mineral density (BMD) and metabolism in perimenopausal Korean women.
Methods: The study subjects comprised two groups. The COC group included 55 women who took low-dose COC for at least one year to control vasomotor symptoms. Another 55 women who had annual checkups without history of COC use served as controls. BMD and bone turnover markers were assessed periodically.
Results: In the control group, 12-month BMD values at the lumbar spine (LS) and total hip (TH) significantly decreased with a greater magnitude at LS, and bone resorption (BR) and formation (BF) markers increased concurrently with a larger change in BR. COCs increased BMD at LS after 12 months and prevented BMD decline at TH. Multivariable linear regression revealed a significant difference in LS BMD between groups at 12 months. In the COC group, there were significant negative correlations between baseline BMD and Z-score at LS and corresponding changes at 12 months. COCs did not alter BR markers, whereas BF markers were significantly decreased at 3 months. Group comparison at 12 months, as tested with adjusted linear regression, disclosed significant differences in both BR and BF makers.
Conclusions: Bone loss associated with activated bone turnover is evident during the menopausal transition, and COCs might prevent BMD decrease and suppress bone turnover markers in perimenopausal Korean women. Significant increase in LS BMD and decreases in BF makers suggest underlying mechanisms of greater impact on BF.

KCI등재

저자 : Eliza L. Y. Wong , Annie W. L. Cheung , C. J. Haines , C. C. Wang , Chun-kwok Wong , Karl W. K. Tsim , William K. F. Cheng , Ping-chung Leung

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 33-39 (7 pages)

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Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from menopausal symptoms.
Methods: A third clinical trial to determine the clinical efficacy of high-dose DBT for a period of 12 weeks was carried out. The standard Menopause-Specific Quality of Life (MENQOL) assessment chart was used for the evaluation. Safety was defined as an absence of direct estrogenic effects, serum inflammatory cytokines. Notably, interleukin IL-6, IL-8 and tumor necrosis factor TNF-α, known to be directly related to estrogenic reactions in menopause studies, were monitored.
Results: The third clinical trial indicated an overall improvement in the four domains of MENQOL, offering further proof of the efficacy of DBT demonstrated in the two previous trials. The serial checks of the three cytokines related to estrogen activities did not show either upward or downward trends. The haphazard behavior reactions of the three cytokines offered indirect indications that DBT improved the MENQOL independently from estrogen activities.
Conclusions: The three clinical trials using DBT to relieve menopausal syndrome have offered solid evidence for its efficacy. The uncertainty regarding whether the “phytoestrogen” contained in DBT had bioactivities similar to estrogen was alleviated through the confirmation that no strict estrogenic bioactivities were observed. The issue of safety was further clarified via laboratory platform studies on DBT, which not only showed the lack of similarity with estrogen actions but also confirmed the value of combining the two herbs in the classic formula.

KCI등재

저자 : Christos Iavazzo , Nikolaos Vrachnis , Ioannis D. Gkegkes

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 40-41 (2 pages)

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KCI등재

저자 : Asley Sanchez , Kushal Gandhi , Ben Lee , Jonathan Gomez Garcia , Gary Ventolini

발행기관 : 대한폐경학회 간행물 : 대한폐경학회지 28권 1호 발행 연도 : 2022 페이지 : pp. 42-45 (4 pages)

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Lichen simplex chronicus commonly presents as a distressing vaginal lesion caused by severe, cyclical itch-scratch behavior. Lichen simplex chronicus is diagnosed by obtaining a detailed medical history, performing a physical exam, and recording of selfreported symptoms. Lichen simplex chronicus can be treated by corticosteroids, immunomodulators, antiepileptics, antihistamines, antidepressants, and phototherapy. Our case describes a 55-year-old female patient who presented to a clinic with recurrent vaginal itching, combined with compulsive scratching behavior that disrupted daily functioning. Physical examination revealed hypertrophic nodules located on the labia minora with scaling and hyperpigmentation. And the patient was diagnosed with lichen simplex chronicus. Empirical treatment with behavioral modifications and clobetasol propionate cream with an occlusive dressing produced significant improvements in symptoms at a six-month follow-up. Lichen simplex chronicus can have unusual presentations and; therefore, must be carefully differentiated from infectious and malignant skin lesions.

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