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대한소화기학회지 update

The Korean Journal of Gastroenterology

  • : 대한소화기학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • :
  • : 연속간행물
  • : 월간
  • : 1598-9992
  • : 2233-6869
  • : 대한소화기병학회잡지(~1989) → 대한소화기병학회지(1990~) → 대한소화기학회지(1995~)

수록정보
수록범위 : 1권1호(1968)~77권4호(2021) |수록논문 수 : 5,702
대한소화기학회지
77권4호(2021년) 수록논문
최근 권호 논문
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KCI등재

1기능성 소화불량증에서 프로톤펌프억제제와 위장관 운동 촉진제 병합제의 효과

저자 : 이주엽 ( Ju Yup Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 149-150 (2 pages)

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2내시경 검사실에서 COVID-19 대처방안

저자 : 이은우 ( Eunwoo Lee ) , 조수정 ( Soo-jeong Cho )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 151-155 (5 pages)

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We are now in the middle of an unprecedented coronavirus disease 2019 (COVID-19) pandemic, and efforts to prevent the spread of infections are more important than ever. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, is transmitted through respiratory droplets or contaminated surfaces, and air transmission may be possible during some aerosol-generating procedures, requiring systematic infection control of the surrounding environment. Prior to endoscopy, suspected COVID-19 patients need to be screened, and all workers in the endoscopy room need to wear appropriate personal protective equipment. Isolate and move with a distance of 1-1.8 m or more between patients, and prevent close contact and cross-infection by limiting parental visits and minimizing latency in the waiting room or recovery room. If a COVID-19 infection is suspected or confirmed, it is recommended to postpone the endoscopic examination as much as possible, but if emergency endoscopy is necessary, a minimum number of people shall perform it in the negative pressure room. It is recommended to clean and sterilize the endoscope and accessories based on the current disinfection guidelines, and the treatment room should resume the procedure after a certain period of time after disinfection. In the endoscopy room, thorough infection control will be important for the safety of patients and medical staff, and as new information on SARS-CoV-2 is updated, continuous efforts will be needed to ensure the quality and safety of endoscopy until the end of COVID-19. (Korean J Gastroenterol 2021;77:151-155)

KCI등재

3간질환 환자에서 COVID-19 대처방안

저자 : 이유림 ( Yu Rim Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 156-159 (4 pages)

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Pandemic of coronavirus disease 2019 (COVID-19) has caused many changes in the healthcare system and patients with preexisting advanced liver disease, notably cirrhosis, are associated with a severe course and a high mortality rate of COVID-19. In patients with liver disease, the underlying liver disease severity is closely related to the prognosis, so appropriate management of liver disease will be one of the most important strategies to protect the patient from COVID-19 infection that may occur in the future. The approach to patient care should be individualized and flexible according to the type and severity of patient's underlying liver disease, the prevalence of COVID-19, and availability of medical resource. If possible, standard of care for patients with liver disease should be resumed. In addition, it is necessary to predict and prepare for the wave of liver disease yet to come after the COVID-19 pandemic. (Korean J Gastroenterol 2021;77:156-159)

KCI등재

4염증성 장질환 환자에서 COVID-19 대처방안

저자 : 이유진 ( Yoo Jin Lee )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 160-163 (4 pages)

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Patients with inflammatory bowel disease (IBD) are generally considered to be more vulnerable to coronavirus disease 2019 (COVID-19). In addition, there are many concerns about the risk of severe COVID-19 infection in patients with IBD. Because the uncertainty of COVID-19 can cause confusions for patients with chronic diseases, physicians should be able to provide adequate advice for optimal treatment for patients with IBD. As the COVID-19 pandemic continues, current knowledge of COVID-19 is changing based on numerous empirical guidance and clinical data being updated daily. Based on the latest evidence, we will discuss the appropriate strategy and management of patients with IBD in the era of COVID-19. (Korean J Gastroenterol 2021;77:160-163)

KCI등재

5비유두부 십이지장 표재성 상피 종양의 내시경 치료

저자 : 양효준 ( Hyo-joon Yang )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 164-170 (7 pages)

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Superficial nonampullary duodenal epithelial tumors are considered rare but have been increasingly recognized in recent years. Accordingly, the importance of endoscopic treatment for the lesions are also increasing. An endoscopic resection can be considered for duodenal adenoma and mucosal cancer. The choice of resection method should be made based on the size of the lesion, endoscopic findings, pathologic diagnosis, and risk of procedure-related complication. For small adenomas <10 mm in size, endoscopic mucosal resection (EMR), cold snare polypectomy, and underwater EMR can be considered. An en bloc or piecemeal resection using EMR or underwater EMR can be selected for 10-20 mm sized adenomas. For lesions ≥20 mm in size or suspicious for mucosal cancer, an endoscopic submucosal dissection followed by closure of the mucosal defect conducted by an experienced endoscopist is appropriate. (Korean J Gastroenterol 2021;77:164-170)

KCI등재

6기능성 소화불량증 환자에 대한 서방형 UIC201609/UIC201610 병용요법의 유효성 및 안전성을 비교평가하기 위한 다기관, 무작위배정, 위약대조 임상시험: 예비 보고

저자 : 이정원 ( Jung Won Lee ) , 윤영훈 ( Young Hoon Youn ) , 최석채 ( Suck Chei Choi ) , 이광재 ( Kwang Jae Lee ) , 김나영 ( Nayoung Kim )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 171-178 (8 pages)

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목적: 기능성 소화불량증은 상복부 통증, 소화불량과 같은 다양한 상복부 증상을 포괄하는 질환으로서 다양한 병태 생리에서 유래한 다양한 증상의 발현을 찾아볼 수 있는 질환이다. 현재 이에 대해 효과적이면서 순응도가 높은 치료법을 찾기 어려운 상태로, 본 임상시험에서는 기존 기능성 소화불량증 치료의 두 근간인 프로톤펌프억제제인 라베프라졸과 위장관 운동 촉진제인 모사프라이드 서방정 병용요법인 UIC201609 및 UIC201610의 효과 및 안전성을 시험하고자 하였다.
대상 및 방법: 이 연구는 다기관, 이중눈가림, 무작위 배정으로 시행된 연구로 총 30명이 임상시험에 포함되었다. 부작용으로 유효성 평가가 누락된 시험군 1명을 제외한 29명에 대한 결과가 최종 분석되었다. 대조군으로 라베프라졸 10 mg 1일 1회 복용군, 모사프라이드 15 mg 서방정 1일 1회 복용군을 각각 두었으며, 실험군으로 라베프라졸 10 mg 1일 1회 및 모사 프라이드 15 mg 서방정 병용제제인 UIC201609/UIC201610 1일 1회 실험군을 두었다. 연구의 결과변수로 Nepean Dyspepsia Index-Korean 버전의 8가지 항목의 총점 변화량을 투약 시작 2주, 4주 시점에 분석하였고 안전성에 관한 정보를 수집하였다.
결과: 실험군과 대조군 사이의 나이, 성별, 신체계측, 음주 및 흡연에 있어 인구학적인 차이는 관찰되지 않았다. 또한 기능성 소화불량증 아형인 EPS과 PDS 비율에서도 그룹 간 차 이가 관찰되지 않았다. 약물 순응도에서 세 군 모두에서 평균 95% 이상 실험약물 복용이 완료되었다. 이 연구의 1차 유효성 변수인 투약 4주 시점의 증상 점수 변화량에서 모사프라이드 단일군에서 증상 점수(33.4±15.6) 감소, 라베프라졸 단일군(29.4±17.1)에서, 실험군인 UIC201609/UIC201610 병용군(33.4±11.8)에서 감소를 보였으며, 그룹 간 유의미한 자이는 관찰되지 않았다. UIC201609/UIC201610 병용군은 Nepean Dyspepsia Index-Korean의 상복부의 통증 또는, 상복부 쓰림을 호전시키는 비율이 대조군에 비해 높았으나 통계적으로 유의한 변화를 보이지는 못하였다. 안전성 분석에서도 유의미한 차이는 확인되지 않았다.
결론: UIC201609/UIC201610 1일 1회 병용요법에 대한 예비 연구에서 기능성 소화불량증 환자에서 일부 증상의 호전을 보이는 경향이 있으나 유의미한 차이는 없었다. 향후 UIC201609/UIC201610 병용요법의 효능을 확인하기 위한 발전된 설계를 바탕으로 한 추가적인 연구가 필요하다.


Background/Aims: Functional dyspepsia is a disease involving a range of upper gastrointestinal symptoms derived from various pathophysiologies. Tablets containing a combination of rabeprazole and controlled-release (CR) mosapride were recently developed. To investigate a more effective treatment, this trial evaluated the efficacy and safety of UIC201609/UIC201610 as a preliminary study.
Methods: A multicenter, double-blind, randomized study was performed on 30 subjects. UIC201609/UIC201610 (combination of rabeprazole and CR mosapride) was the case group, and the two control groups were rabeprazole 10 mg once a day and mosapride 15 mg CR tablet once a day. As a primary efficacy endpoint of the study, the changes in the total score of eight items of the Nepean Dyspepsia Index-Korean version were analyzed at 2 weeks and 4 weeks. The outcomes regarding safety were collected.
Results: The total symptom score of Nepean Dyspepsia Index-Korean decreased in the rabeprazole single group (29.4±17.1), mosapride CR single group (33.4±15.6), and UIC201609/UIC201610 group (33.4±11.8) at 4 weeks without significant differences. On the other hand, the UIC201609/UIC201610 combination group showed more score reduction of pain in the upper abdomen, burning in the upper abdomen compared to each control group, but it did not reach statistical significance. No difference was found in safety analysis.
Conclusions: UIC201609/UIC201610 once daily showed some improvement in epigastric pain and dyspepsia in patients with functional dyspepsia, but there was no significance. Further study based on the advanced clinical trial design will be needed to confirm the efficacy of UIC201609/UIC201610 combination therapy in the future. (Korean J Gastroenterol 2021;77:171-178)

KCI등재

7대사증후군 요소와 관련된 만성 간질환에서 Biphenyl Dimethyl Dicarboxylate와 Ursodeoxycholic Acid 병합요법의 효과 및 안전성

저자 : 허내윤 ( Nae-yun Heo ) , 박승하 ( Seung Ha Park ) , 최준혁 ( Joon Hyuk Choi ) , 김은주 ( Eunju Kim ) , 김태오 ( Tae Oh Kim ) , 박종하 ( Jongha Park ) , 이진 ( Jin Lee ) , 박용은 ( Yong Eun Park ) , 오은혜 ( Eun Hye Oh ) , 황준성 ( Jun Seong Hwang ) , 정수진 ( Su Jin Jeong )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 179-190 (12 pages)

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Background/Aims: Steatohepatitis related to metabolic syndrome is a chronic liver disease prevalent in patients not only with non-alcoholic steatohepatitis but also with alcoholic liver disease and chronic viral hepatitis. On the other hand, there is limited data on the effects of hepatotonic agents in these patients. Therefore, this study evaluated the efficacy of a combined hepatotonic agent in this population.
Methods: Thirty-three adults with chronic hepatitis and one or more components of metabolic syndrome were assigned randomly to receive biphenyl dimethyl dicarboxylate/ursodeoxycholic acid or a placebo for 24 weeks. The primary outcome was the normalization of ALT (≤40 U/L). The secondary outcomes were the change in controlled attenuation parameter, transient elastography, and Chronic Liver Disease Questionnaire score.
Results: The 33 patients were assigned randomly to two groups. Eight (50%) of 16 patients who received the intervention drug showed the normalization of ALT, whereas only one (6%) of 17 patients in the placebo group did so. In contrast, the change in controlled attenuation, transient elastography, and Chronic Liver Disease Questionnaire were similar in the two groups. ALT was changed significantly during the four assessment periods, and this change was affected by the group. The interaction between the group and time was also significant. AST was changed significantly during the same period. This change was not affected by the group.
Conclusions: Biphenyl dimethyl dicarboxylate/ursodeoxycholic acid combination reduced ALT in chronic liver disease related to metabolic syndrome. On the other hand, there is no evidence that this leads to improved hepatic steatosis and fibrosis within 6 months. (Korean J Gastroenterol 2021;77:179-189)

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8간농양 파열로 인한 복막염의 비수술적 치료 증례

저자 : 명희준 ( Hee Jun Myung ) , 류수형 ( Soo Hyung Ryu ) , 유중호 ( Chung Hao Liu ) , 유정훈 ( Jung Hoon Yoo ) , 김서현 ( Seo Hyun Kim ) , 김승혁 ( Seung Hyuk Kim ) , 윤원의 ( Won Eui Yoon ) , 박태영 ( Tae Young Park ) , 문정섭 ( Jeong Seop Moon )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 190-193 (4 pages)

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The rupture of a pyogenic liver abscess (PLA) with peritonitis is a rare occurrence but a surgical emergency with a high mortality rate in the case of gas-forming PLA. Rare cases of ruptured PLA that recovered completely with only medical treatment have been reported. This paper reports a case of a large PLA rupture with peritonitis. In this case, surgical intervention was too risky because of the patient's age and poor general condition. The patient recovered fully with appropriate antibiotic therapy and sufficient percutaneous drainage. Therefore, medical treatment may be considered an alternative option in cases of a ruptured large PLA with peritonitis if surgical intervention is too risky. (Korean J Gastroenterol 2021;77:190-193)

KCI등재

9내혈관 및 내시경적 방법으로 치료한 췌장염을 동반한 췌십이지장동맥류 파열

저자 : 박찬 ( Chan Park ) , 박동은 ( Dong Eun Park )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 194-198 (5 pages)

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Pancreaticoduodenal artery aneurysm (PDAA) is a rare form of abdominal visceral aneurysm that accounts for approximately 2% of all cases. Most cases of PDAA are associated with celiac artery stenosis (CAS). Regardless of the size, there is a risk of rupture. Therefore, treatment should be performed immediately after discovery, even though the need to treat the accompanying CAS, if present, is controversial. The authors report a case of ruptured PDAA and accompanying pancreatitis treated using endovascular and endoscopic methods without treatment of CAS. A 50-year-old man was admitted to the emergency department of Wonkwang University Hospital with epigastric pain and hypovolemic shock. CT revealed a ruptured PDAA and a large volume hemoperitoneum. Emergency angiography was performed, and angioembolization of the PDAA was performed successfully. Follow-up CT revealed infection and pancreatitis, which were treated by surgical drainage and pancreatic duct stenting with ERCP. Because the degree of stenosis was not severe, it was decided to follow-up the accompanying CAS. After discharge, the patient was followed up without complications. (Korean J Gastroenterol 2021;77:194-198)

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10간문맥 내 가스를 동반한 급성 허혈성 위병증

저자 : 이재준 ( Jae Joon Lee ) , 이정섭 ( Jeong Sub Lee ) , 부선진 ( Sun-jin Boo )

발행기관 : 대한소화기학회 간행물 : 대한소화기학회지 77권 4호 발행 연도 : 2021 페이지 : pp. 199-201 (3 pages)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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