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조선대학교 치의학연구원> Oral Biology Research (OBR)

Oral Biology Research (OBR) update

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수록정보
수록범위 : 1권0호(1978)~46권3호(2022) |수록논문 수 : 1,493
Oral Biology Research (OBR)
46권3호(2022년 09월) 수록논문
최근 권호 논문
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KCI등재

저자 : Eun Jeong Kim , Si Young Lee

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 99-105 (7 pages)

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Certain pathogenic bacteria obtain iron for growth through heme or heme compounds. Streptococci are gram-positive bacteria that reside in the mouth and require iron for growth. However, the iron accumulation mechanism in streptococci remains unknown. Therefore, this study investigated the hemin-binding properties of streptococci to confirm the potential of oral streptococci to obtain iron through heme compounds. The hemin-binding ability of streptococci was evaluated by incubation with hemin and subsequent measurement of the optical density of the supernatant to determine the amount of hemin bound by the bacteria using the hemin concentration standard curve. The hemin-binding of streptococci was proportional to the concentration of bacteria (Streptococcus gordonii) and hemin added. However, when a high hemin concentration of up to 60 μg/mL was added, the amount of hemin bound by S. gordonii remained almost unchanged. The incubation temperature had no significant effect on hemin-binding, but pretreatment with trypsin and protease decreased hemin-binding. Additionally, we experimentally confirmed that S. gordonii could use hemin for growth. This study demonstrated that streptococci possess hemin-binding sites and can acquire iron through hemin.

KCI등재

저자 : Si Young Lee , Hye Young Yoon

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 106-110 (5 pages)

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Various disinfectants are used to remove biofilms formed in dental unit waterlines (DUWLs). This study aimed to assess the antibiofilm effects of cetylpyridinium chloride (CPC) on DUWL biofilms formed in a CDC Biofilm Reactor model and evaluate the feasibility of CPC as a novel DUWL disinfectant. For experiments, CPC was used at concentrations of 0.003125% to 0.00039%. Well-established DUWL disinfectants, such as 0.5% sodium hypochlorite (NaOCl), 0.12% chlorhexidine (CHX), and a mixture of 0.12% CHX and 12% ethanol, were used as standards. DUWL biofilms formed in the CDC Biofilm Reactor model were exposed to the disinfecting agents for 15 min. The number of living bacteria in the biofilms before and after exposure to chemicals were compared, and the biofilm reduction rate was calculated. The biofilm reduction rate of CPC at a concentration higher than 0.001562% was greater than that of all other conventional disinfecting agents. These findings suggest that CPC can be used for effective removal of DUWL biofilms.

KCI등재

저자 : Eugene Cho , Hyoun Woo Kim , Da Hye Jeong , Seokmyon Lee , Deuk-sil Oh , Jin Kim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 111-118 (8 pages)

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This study aimed to investigate the antioxidant and anticancer activities of the fermented extract of the dried pericarp of Camellia japonica L. (CJ). The antioxidant activity of the extract after fermentation by Aspergillus oryzae (A. oryzae) at different doses, times, and temperatures was slightly decreased compared with that of the unfermented extract. The total polyphenol content decreased significantly as fermentation time was increased at 30℃, but there was no significant change when the fermentation was performed for 72 hr at different temperatures. The total flavonoid content was not significantly changed by fermentation conditions. Evaluation of the anticancer activity of the A. oryzae-fermented extract revealed that there was no effect on the viability of immortalized 293T cells treated with the extract for 48 hr, but the viability of YD-8 and YD-10B oral cancer cells was significantly reduced. In addition, there was a significant increase in the expression of cleaved PARP and caspase 3, and in apoptotic (annexin V/PI-stained) cells. These results suggest that the water extract of dried pericarp of CJ has no anticancer activity, but gained anticancer activity following fermentation by A. oryzae; furthermore, the fermented extract may be a potential treatment for oral cancer.

KCI등재

저자 : Ho-jin Yun , Min-young Goo , Kyeong-ok Lim , Won-pyo Lee , Byung-ock Kim , Sang-joun Yu

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 119-127 (9 pages)

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This study aimed to compare the vertical and horizontal bone augmentation achieved when using different types of titanium mesh (Ti-mesh) on edentulous atrophic maxilla. Surgical intervention was performed in the maxillary molar area of three patients. One patient received A type Ti-mesh (aTM; pore size: 0.9 mm, thickness: 0.1 mm), and placement of one implant was carried out after 6 months. The remaining two patients received B type Ti-mesh (bTM; pore size: 1.7 mm, 3.37 mm; thickness: 0.3 mm;), and 4 implants were placed after 6 months. The findings showed that both types of Ti-mesh were associated with good feasibility and predictability with regard to vertical and horizontal bone augmentation. Pore size did not affect the amount of bone regenerated for implant placement. However, bTM was associated with several advantages, including decreased operation time and increased convenience during guided bone regeneration surgery.

KCI등재

저자 : Haeni Kim

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 128-134 (7 pages)

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Pulpotomies are usually the treatment of choice for vital primary teeth where the removal of deep caries may lead to pulp exposure. These procedures entail removal of the inflamed coronal pulp, application of a pulp capping material, and preservation of the vitality of the radicular pulp. Inaccurate diagnosis or defective restorations may lead to failure of pulpotomies and consequent apical inflammation and cyst formation. The spread of apical inflammatory lesions affecting deciduous canines to the periodontal tissues can cause displacement and impaction of the permanent successor tooth. As this is a serious side effect of pulpotomies, precise diagnosis and long-term follow-up are required before and after the treatment. This case study presents three patients with canine impaction caused by unsuccessful pulpotomy of the deciduous canine.

KCI등재

저자 : Kyung-min Lee , Min-keun Kim , Young-wook Park

발행기관 : 조선대학교 치의학연구원 간행물 : Oral Biology Research (OBR) 46권 3호 발행 연도 : 2022 페이지 : pp. 135-139 (5 pages)

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This case report presents the 8-year follow-up result of autotransplantation on a healed alveolar ridge, with sinus elevation and autogenous bone grafting. We present a case of a 30-year-old male patient whose maxillary first molar was extracted 1 year ago. Under general anesthesia, after the membrane of the left maxillary sinus was elevated, an artificial socket was prepared on the healed alveolar ridge of the left maxillary first molar area. The left maxillary third molar was extracted and tried on the prepared artificial socket. The autogenous bone was harvested and grafted to the left maxillary sinus floor. The transplanted tooth received root canal therapy 2 months after surgery. During the 8-year follow-up period, no discomforts, periodontal ligament (PDL) widening, or root resorption signs were observed. Desirable bone remodeling signs and regeneration of PDL were observed on the radiograph. Therefore, autotransplantation can be a treatment option for healed and deficient alveolar ridge.

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