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대한산부인과학회> Obstetrics & Gynecology Science

Obstetrics & Gynecology Science update

  • : 대한산부인과학회
  • : 의약학분야  >  산부인과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 격월
  • : 2287-8572
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  • : 대한산부인과학회지(~2011) → Korean Journal of Obstetrics & Gynecology(2011~) → Obstetrics & Gynecology Science (2013~)

수록정보
수록범위 : 1권0호(1958)~64권4호(2021) |수록논문 수 : 11,062
Obstetrics & Gynecology Science
64권4호(2021년 07월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1Venous thromboembolism associated with combined oral contraceptive use: a single-institution experience

저자 : Yong-Su Jang , Eun Sil Lee , Yang-ki Kim

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 337-344 (8 pages)

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Objective
Combined oral contraceptives (COCs) are used for various reasons. However, venous thromboembolism (VTE), a significant side effect, can be fatal. This study reports the first case series in Korea involving patients with COCassociated VTE registered at a university hospital.
Methods
This study recruited 13 patients diagnosed with COC-associated VTE between June 2006 and May 2018. Risk factors, including age, body mass index, smoking habits, estrogen dosage, type of progestin, and duration of COC use, were evaluated.
Results
Among patients with VTE, 9 showed pulmonary embolism (PE) concomitant with deep vein thrombosis (DVT). However, the remaining patients showed DVT (1 patient), PE (1 patient), and cerebral venous thrombosis (2 patients). The median duration between the onset of symptoms and a hospital visit was 3 days, and it sometimes took as long as 32 days. Among the 10 patients with PE, 1 high-risk group and 2 intermediate-high risk groups were treated with tissue plasminogen activators before anticoagulants. There were no cases of recurrence among patients who continued to take anticoagulants for 3 months.
Conclusion
These findings emphasize that healthcare professionals who prescribe or dispense COCs to women must inform them of the risk of VTE, including the risk factors, differences in risk depending on the type of progestin present in the product, and pertinent signs and symptoms. Efforts should also be made to inform patients of VTE, even through information campaigns such as brochures. Most importantly, women should remain alert for signs and symptoms of VTE when using COCs.

KCI등재 SCOPUS

2Does the timing of cabergoline administration impact rates of ovarian hyperstimulation syndrome?

저자 : Eryn Sara Rubenfeld , Michael Haim Dahan

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 345-352 (8 pages)

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Objective
Does the timing of cabergoline administration impact the rate of mild/moderate ovarian hyperstimulation syndrome in women with a GnRH agonist trigger?
Methods
We conducted a retrospective cohort analysis of 285 in-vitro fertilization patients at risk of OHSS who received a GnRH agonist trigger from 2011 to 2019 at McGill University Health Centre. Group 1 (Trig, n=101) began taking cabergoline 0.5 mg orally for 7 days at the time of GnRH agonist trigger, while Group 2 (Retriev, n=184) started taking cabergoline on the day of oocyte retrieval. The rates of OHSS were then compared between the groups using analysis of variance and chi-square analysis, where appropriate.
Results
The baseline demographic characteristics of the two groups were similar. Trig appeared to be at a slightly higher risk of OHSS based on a significantly higher antral follicle count (20.2±4.2 vs. 19.0±4.3; P=0.02), higher number of stimulated follicles >10 mm at trigger (25.7±7.0 vs. 22.8±8.3, P=0.003), and higher peak serum E2 level (17,325±2,542 vs. 14,822±3,098; P=0.0001). The Trig group had lower rates of mild and moderate OHSS (24% vs. 36%; P=0.045). Neither group had any patients who developed severe OHSS. Trig had fewer patients presenting with pelvic free fluid (13% vs. 23%; P=0.03), lower hematocrit (37.8±4.8% vs. 40.5±4.2%; P=0.0001), higher albumin concentrations (30.4±2.7 vs. 29.5±2.0; P=0.01), and lower potassium concentrations (3.9±0.5 vs. 4.2±0.7; P=0.0002).
Conclusion
Cabergoline at the time of trigger as compared to the time of collection should be investigated to assess its role in reducing the rates of mild/moderate OHSS.

KCI등재 SCOPUS

3Vitamin D supplementation for primary dysmenorrhea: a double-blind, randomized, placebo-controlled trial

저자 : Fatemeh Alsadat Rahnemaei , Ali Gholamrezaei , Maryam Afrakhteh , Farid Zayeri , Mohammad Reza Vafa , Arian Rashidi , Giti Ozgoli

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 353-363 (11 pages)

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Objective
Recent studies have shown a possible association between vitamin D deficiency and the severity of primary dysmenorrhea. The present study aimed to investigate the effect of vitamin D supplementation on pain and systemic symptoms in patients with primary dysmenorrhea.
Methods
This double-blind, randomized, placebo-controlled trial was conducted on female students aged 18 to 32 years with primary dysmenorrhea and vitamin D deficiency (25 [OH]D <30 ng/mL). The participants (n=116) received either 50,000 IU of vitamin D3 (cholecalciferol) or placebo capsules on a weekly basis for eight consecutive weeks. The outcomes were pain intensity (scored 0 to 10), number of days with pain, number of consumed pain-relief medications (per day), and severity of systemic symptoms (fatigue, headache, nausea/vomiting, and diarrhea; total score of 0 to 12).
Results
Compared with baseline, our participants who received vitamin D experienced significant reductions in pain intensity (-1.0 and -1.5 score at weeks 4 and 8, P<0.001), the number of days with pain (-1.0 day at weeks 4 and 8, P<0.001), the number of consumed pain-relief medications (-1.0 at weeks 4 and 8, P<0.001), and systemic symptoms severity (-1.0 score at weeks 4 and 8, P<0.001). No significant improvements were observed in the placebo group in terms of these outcomes.
Conclusion
Vitamin D supplementation in women with primary dysmenorrhea and vitamin D deficiency could improve systemic symptoms and reduce pain intensity, the number of days with pain, and the need for consuming pain-relief medications.

KCI등재 SCOPUS

4The rates of major malformations after gestational exposure to isotretinoin: a systematic review and meta-analysis

저자 : Eun Jeong Choi , NaeRy Kim , Ho-Seok Kwak , Hae Ji Han , Kyoung-chul Chun , Young-ah Kim , Jae-Whoan Koh , Jung Yeol Han , Sung Hong Joo , Ji Sung Lee , Gideon Koren

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 364-373 (10 pages)

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Objective
Isotretinoin is among the most notorious human teratogens, documented originally as causing up to 30% of malformations. This systematic review and meta-analysis aimed to evaluate the rates of major malformation (MM) among isotretinoin-exposed pregnant women over the years through a systematic review and meta-analysis.
Methods
Eligible studies were searched and identified using various databases. Single-arm meta-analysis and meta-analysis of odd ratios among controlled studies were performed using Review Manager version 5.3.
Results
Ten eligible studies that combined 2,783 isotretinoin-exposed women were included in our study. The rate of MM weighted for the sample size was 15%. Three studies that included an unexposed comparison group were eligible for the meta-analysis. The pooled odds ratio of MM for isotretinoin-exposed women was 3.76. After 2006, the pooled odds ratio of MM for isotretinoin exposure was significantly lower at 1.04.
Conclusion
The current rate of MM in isotretinoin-exposed women was substantially lower after 2006.

KCI등재 SCOPUS

5Feasibility and efficacy of modern minilaparoscopy with 2.9 mm laparoscope for diagnostic and level II gynaecological procedure

저자 : Rakhi Rai , Kallol Kumar Roy , Vinod Nair , Garima Kachhawa , Rinchen Zangmo , Deepali Garg , Perumal Vanamail

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 374-382 (9 pages)

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Objective
Laparoscopy has now become a state-of-the-art technique for many diagnostic and therapeutic procedures with known advantages over laparotomy. There is scarce literature from India regarding minilaparoscopy, as per our literature review. Therefore, we performed this study with a 2.9-mm laparoscope to determine its feasibility and efficacy for diagnostic purposes and level II surgeries with the aim of reducing postoperative pain and better cosmesis.
Methods
This was a prospective study conducted from June 2019 to March 2020. Diagnostic modern minilaparoscopy with a 2.9-mm telescope was performed under general anesthesia by a single surgeon. Operative intervention was performed depending on the intraoperative findings.
Results
The mean age was 29.3 years. The most common indication for laparoscopy was infertility (98%). Only diagnostic laparoscopy was performed in 76% of patients, while 24% underwent operative laparoscopy. The various operative procedures performed were cystectomy, salpingectomy, ovarian drilling, and adhesiolysis. The mean visual analog scale scores at 1 hour and 2 hours postoperatively and discharge were 1.57±0.59, 1.41±0.51, and 1.29±0.47, respectively. Mild pain was present in 70 (72.2%) patients at the time of discharge, and only one patient had severe pain. Five or more analgesic tablets were required in only 16.5% of patients in the postoperative period. There was no wound infection or port-site hernia at follow-up.
Conclusion
Modern minilaparoscopy with a 2.9-mm laparoscope is a feasible and safe option for diagnostic laparoscopy and level II gynecological procedures with minimal postoperative morbidity, such as pain and wound infection, and provides good cosmetic outcomes.

KCI등재 SCOPUS

6Gynecological laparoscopic surgeries in the era of COVID-19 pandemic: a prospective study

저자 : Sushmita Saha , Kallol Kumar Roy , Rinchen Zangmo , Anamika Das , Juhi Bharti , Rakhi Rai , Archana Kumari , Gayatri Suresh , Nilofar Noor , Perumal Vanamail

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 383-389 (7 pages)

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Objective
The novel coronavirus pandemic led to the suspension of elective surgeries and the diversion of resources and manpower towards pandemic control. However, gynecological emergencies and malignancies must be addressed despite the restricted resources and the need for protective measures against COVID-19. This study aimed to determine the types of gynecological surgeries performed, difficulties encountered, and their outcomes in the setting of the pandemic.
Methods
We performed a prospective cohort study over 6 months at a single tertiary center, including 60 women with gynecological complaints, categorized as emergencies and semi-emergencies, who underwent further surgery. Their surgical outcomes were measured through various parameters.
Results
We found that 68.3% were emergency cases, while the rest were classified as semi-emergencies. Fibroid and adenomyosis with failed medical management (48.3%), followed by cervical intraepithelial neoplasia (10%), and malignancies (10%) accounted for the semi-emergency cases, while ruptured ectopic pregnancies (13.3%) and torsion and ovarian cysts (18.4%) comprised the emergency cases. The decision to incision time between emergency and semi-emergency cases varied widely due to the safety prerequisites during the pandemic, ranging from 1 hour in emergency cases to 48 hours in semi-emergency cases. In addition, we studied the ease of preoperative preparation, patient satisfaction, and the average number of personnel available to run the operation theaters at these times. No serious perioperative adverse events were observed in the present study.
Conclusion
In conclusion, gynecological surgeries could continue to be safely performed with all precautions in place against COVID-19 infection and related morbidities.

KCI등재 SCOPUS

7The first woman born by in vitro fertilization in Korea gave birth to a healthy baby through natural pregnancy

저자 : Sung Woo Kim , Minhee Lee , Hoon Kim , Seung-yup Ku

발행기관 : 대한산부인과학회 간행물 : Obstetrics & Gynecology Science 64권 4호 발행 연도 : 2021 페이지 : pp. 390-392 (3 pages)

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