간행물

대한간학회> Clinical and Molecular Hepatology(대한간학회지)

Clinical and Molecular Hepatology(대한간학회지) update

Clinical and Molecular Hepatology (CMH)

  • : 대한간학회
  • : 의약학분야  >  내과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 계간
  • : 2287-2728
  • : 2287-285x
  • : 대한간학회지()→Korean Journal of Hepatology(2004~)→대한간학회지(2012~)

수록정보
수록범위 : 1권1호(1995)~28권2호(2022) |수록논문 수 : 4,771
Clinical and Molecular Hepatology(대한간학회지)
28권2호(2022년 04월) 수록논문
최근 권호 논문
| | | |

KCI등재 SCOPUS

1The role of transjugular intrahepatic portosystemic shunt in patients with portal hypertension: Advantages and pitfalls

저자 : Hae Lim Lee , Sung Won Lee

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 121-134 (14 pages)

다운로드

(기관인증 필요)

초록보기

Transjugular intrahepatic portosystemic shunt (TIPS) is an effective interventional procedure to relieve portal hypertension, which is a main mechanism for the development of complications of liver cirrhosis (LC), such as variceal hemorrhage, ascites, and hepatorenal syndrome. However, the high incidence of adverse events after TIPS implementation limits its application in clinical practice. Esophageal variceal hemorrhage is one of the major indications for TIPS. Recently, preemptively performed TIPS has been recommended, as several studies have shown that TIPS significantly reduced mortality as well as rebleeding or failure to control bleeding in patients who are at high risk of treatment failure for bleeding control with endoscopic variceal ligation and vasoactive drugs. Meanwhile, recurrent ascites is another indication for TIPS with a proven survival benefit. TIPS may also be considered as an effective treatment for other LC complications, usually as an alternative therapy. Although there are concerns about the development of hepatic encephalopathy and hepatic dysfunction after TIPS implementation, careful patient selection using prognostic scores can lead to excellent outcomes. Assessments of cardiac and renal function prior to TIPS may also be considered to improve patient prognosis. (Clin Mol Hepatol 2022;28:121-134)

KCI등재 SCOPUS

2Approaches to quantifying hepatitis B virus covalently closed circular DNA

저자 : Henrik Zhang , Thomas Tu

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 135-149 (15 pages)

다운로드

(기관인증 필요)

초록보기

Chronic hepatitis B is a major cause of liver disease worldwide and is currently incurable. Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for all viral transcripts. The field is focussed on methods to clear HBV cccDNA but this been limited by technical difficulties in its quantification due to: identical sequence to other forms of HBV DNA; low copy number per cell; and high resistance to denaturation by heat, leading to difficulty using polymerase chain reaction or hybridization methods for detection. A number of assays have been developed in order to overcome these hurdles either directly or detecting cccDNA levels indirectly via its transcriptional products. In this review, we summarize the approaches to cccDNA quantification that are currently used, and outline key open questions in the cccDNA biology field which remain to be answered due to the limitations of current methods. (Clin Mol Hepatol 2022;28:135-149)

KCI등재 SCOPUS

3MAFLD enhances clinical practice for liver disease in the Asia-Pacific region

저자 : Takumi Kawaguchi , Tsubasa Tsutsumi , Dan Nakano , Mohammed Eslam , Jacob George , Takuji Torimura

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 150-163 (14 pages)

다운로드

(기관인증 필요)

초록보기

Fatty liver is now a major cause of liver disease in the Asia-Pacific region. Liver diseases in this region have distinctive characteristics. First, fatty liver is frequently observed in lean/normal-weight individuals. However, there is no standard definition of this unique phenotype. Second, fatty liver is often observed in patients with concomitant viral hepatitis. The exclusion of viral hepatitis from non-alcoholic fatty liver disease limits its value and detracts from the investigation and holistic management of coexisting fatty liver in patients with viral hepatitis. Third, fatty liver-associated hepatocellular carcinoma (HCC) is generally categorized as non-B non-C HCC. Fourth, the population is aging rapidly, and it is imperative to develop a practicable, low-intensity exercise program for elderly patients. Fifth, most patients and nonspecialized healthcare professionals still lack an awareness of the significance of fatty liver both in terms of intrahepatic and extrahepatic disease and cancer. Recently, an international expert panel proposed a new definition of fatty liver: metabolic dysfunction-associated fatty liver disease (MAFLD). One feature of MAFLD is that metabolic dysfunction is a prerequisite for diagnosis. Pertinent to regional issues, MAFLD also provides its diagnostic criteria in lean/normal-weight individuals. Furthermore, MAFLD is independent of any concomitant liver disease, including viral hepatitis. Therefore, MAFLD may be a more suitable definition for fatty liver in the Asia-Pacific region. In this review, we introduce the regional characteristics of fatty liver and discuss the advantages of MAFLD for improving clinical practice for liver disease in the region. (Clin Mol Hepatol 2022;28:150-163)

KCI등재 SCOPUS

4Cost-effectiveness of chronic hepatitis C screening and treatment

저자 : Hye Won Lee , Hankil Lee , Beom Kyung Kim , Young Chang , Jae Young Jang , Do Young Kim

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 164-173 (10 pages)

다운로드

(기관인증 필요)

초록보기

Hepatitis C virus (HCV) infection is the second most common cause of chronic liver disease in South Korea, with a prevalence ranging from 0.6% to 0.8%, and HCV infection incidence increases with age. The anti-HCV antibody test, which is cheaper than the HCV RNA assay, is widely used to screen for HCV infections; however, the underdiagnosis of HCV is a major barrier to the elimination of HCV infections. Although several risk factors have been associated with HCV infections, including intravenous drug use, blood transfusions, and hemodialysis, most patients with HCV infections present with no identifiable risk factors. Universal screening for HCV in adults has been suggested to improve the detection of HCV infections. We reviewed the cost-effectiveness of HCV screening and the methodologies used to perform screening. Recent studies have suggested that universal HCV screening and treatment using direct-acting antivirals represent cost-effective approaches to the prevention and treatment of HCV infection. However, the optimal timing and frequency of HCV screening remain unclear, and further studies are necessary to determine the best approaches for the elimination of HCV infections. (Clin Mol Hepatol 2022;28:164-173)

KCI등재 SCOPUS

5Surgical resection versus ablation for early hepatocellular carcinoma: The debate is still open

저자 : Bo Hyun Kim

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 174-176 (3 pages)

다운로드

(기관인증 필요)

초록보기

KCI등재 SCOPUS

6Leaky gut-derived tumor necrosis factor-α causes sarcopenia in patients with liver cirrhosis

저자 : Takumi Kawaguchi , Takuji Torimura

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 177-180 (4 pages)

다운로드

(기관인증 필요)

초록보기

KCI등재 SCOPUS

7Dyslipidemia in chronic hepatitis B patients on tenofovir alafenamide: Facts and puzzles

저자 : Hung-yao Lin , Tai-chung Tseng

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 181-182 (2 pages)

다운로드

(기관인증 필요)

초록보기

KCI등재 SCOPUS

8Protective association of Klotho rs495392 gene polymorphism against hepatic steatosis in non-alcoholic fatty liver disease patients

저자 : Wen-yue Liu , Xiaofang Zhang , Gang Li , Liang-jie Tang , Pei-wu Zhu , Rafael S. Rios , Kenneth I. Zheng , Hong-lei Ma , Xiao-dong Wang , Qiuwei Pan , Robert J. De Knegt , Luca Valenti , Mohsen Ghanbari ,

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 183-195 (13 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic dysfunction. Among the multiple factors, genetic variation acts as important modifiers. Klotho, an enzyme encoded by the klotho (KL) gene in human, has been implicated in the pathogenesis of metabolic dysfunctions. However, the impact of variants in KL on NAFLD risk remains poorly understood. The aim of this study was to investigate the impact of KL rs495392 C>A polymorphism on the histological severity of NAFLD.
Methods: We evaluated the impact of the KL rs495392 polymorphism on liver histology in 531 Chinese with NAFLD and replicated that in the population-based Rotterdam Study cohort. The interactions between the rs495392, vitamin D, and patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 polymorphism were also analyzed.
Results: Carriage of the rs495392 A allele had a protective effect on steatosis severity (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.42-0.89; P=0.010) in Chinese patients. After adjustment for potential confounders, the A allele remained significant with a protective effect (OR, 0.66; 95% CI, 0.45-0.98; P=0.040). The effect on hepatic steatosis was confirmed in the Rotterdam Study cohort. Additional analysis showed the association between serum vitamin D levels and NAFLD specifically in rs495392 A allele carriers, but not in non-carriers. Moreover, we found that the rs495392 A allele attenuated the detrimental impact of PNPLA3 rs738409 G allele on the risk of severe hepatic steatosis.
Conclusions: The KL rs495392 polymorphism has a protective effect against hepatic steatosis in patients with NAFLD. (Clin Mol Hepatol 2022;28:183-195)

KCI등재 SCOPUS

9Prevalence trends of non-alcoholic fatty liver disease among young men in Korea: A Korean military population- based cross-sectional study

저자 : Jaejun Lee , Taeyun Kim , Hyun Yang , Si Hyun Bae

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 196-206 (11 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: Non-alcoholic fatty liver disease (NAFLD) has become a major concern in Korea since its emergence as a dominant cause of chronic liver disease. However, no study has explored its prevalence in adults under 30 years of age. Therefore, we performed a cross-sectional study to investigate the prevalence of NAFLD in Korean men in their early 20s.
Methods: We collected data of 596,359 Korean soldiers who participated in a health examination between January 2015 and July 2021. A total of 571,872 individuals were analyzed after excluding those with missing data and hepatitis B antigen positivity. Hepatic steatosis was determined using the hepatic steatosis index (HSI). Participants with HSI >36 were considered to have NAFLD.
Results: All participants were men, and the mean age was 20.9±1.3 years. Of the 571,872 participants screened, 77,020 (13.47%) were classified as having NAFLD. The prevalence of NAFLD consistently increased from 2015 to 2021 (10.66% vs. 16.44%, P<0.001). Increases from 2015 to 2021 were also noted in the prevalence of hypercholesterolemia, hyperglycemia, and hypertension (P<0.001 for all). The mean body mass index also increased from 23.3±3.0 kg/m2 to 23.9±3.1 kg/m2 between 2015 and 2021 (P<0.001).
Conclusions: The prevalence of NAFLD and of other metabolic dysfunctions in Korean men in their early 20s increased from 2015 to 2021. (Clin Mol Hepatol 2022;28:196-206)

KCI등재 SCOPUS

10Surgery versus radiofrequency ablation in patients with Child- Pugh class-A/single small (≤3 cm) hepatocellular carcinoma

저자 : Jungnam Lee , Young-joo Jin , Seung Kak Shin , Jung Hyun Kwon , Sang Gyune Kim , Young Ju Suh , Yujin Jeong , Jung Hwan Yu , Jin-woo Lee , Oh Sang Kwon , Soon Woo Nahm , Young Seok Kim

발행기관 : 대한간학회 간행물 : Clinical and Molecular Hepatology(대한간학회지) 28권 2호 발행 연도 : 2022 페이지 : pp. 207-218 (12 pages)

다운로드

(기관인증 필요)

초록보기

Background/Aims: We compared the post-treatment overall survival (OS) and recurrence-free survival (RFS) between patients with Child-Turcotte-Pugh (CTP) class-A and single small (≤3 cm) hepatocellular carcinoma (HCC) treated by surgical resection (SR) and radiofrequency ablation (RFA).
Methods: We retrospectively analyzed 391 HCC patients with CTP class-A who underwent SR (n=232) or RFA (n=159) as first-line therapy for single small (≤3 cm) HCC. Survival was compared according to the tumor size (≤2 cm/2-3 cm) and the presence of cirrhosis. Inverse probability of treatment weighting (IPW) method was used to estimate the average causal effect of treatment.
Results: The median follow-up period was 64.8 months (interquartile range, 0.1-162.6). After IPW, the estimated OS was similar in the SR and RFA groups (P=0.215), and even in patients with HCC of ≤2 cm (P=0.816) and without cirrhosis (P=0.195). The estimated RFS was better in the SR group than in the RFA groups (P=0.005), also in patients without cirrhosis (P<0.001), but not in those with HCC of ≤2 cm (P=0.234). The weighted Cox proportional hazards model with IPW provided adjusted hazard ratios (95% confidence interval) for OS, and the RFS after RFA versus SR were 0.698 (0.396- 1.232) (P=0.215) and 1.698 (1.777-2.448) (P=0.005), respectively.
Conclusions: SR was similar for OS compared to RFA, but was better for RFS in patients with CTP class-A and single small (≤3 cm) HCC. The RFS was determined by the presence or absence of cirrhosis. Hence, SR rather than RFA should be considered in patients without cirrhosis to prolong the RFS, although there is no OS difference. (Clin Mol Hepatol 2022;28:207-218)

12
권호별 보기

내가 찾은 최근 검색어

최근 열람 자료

맞춤 논문

보관함

내 보관함
공유한 보관함

1:1문의

닫기