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대한피부과학회지 update

Korean Journal of Dermatology

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
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수록정보
수록범위 : 1권1호(1960)~59권3호(2021) |수록논문 수 : 9,512
대한피부과학회지
59권3호(2021년 03월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1소아청소년에서 발생한 Sweet 증후군 15예에 대한 임상 및 병리조직학적 고찰

저자 : 신지연 ( Jee Yon Shin ) , 이지연 ( Ji Yeoun Lee ) , 윤태영 ( Tae Young Yoon )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 167-174 (8 pages)

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Background: Sweet syndrome is characterized by tender erythematous plaques and nodules with predominantly dermal neutrophilic infiltrates. Sweet syndrome is relatively rare in children and adolescents. To date, only a few cases have been reported in Korean literature.
Objective: The aim of this study was to investigate the clinical and histopathological features of Sweet syndrome in Korean children and adolescents.
Methods: A retrospective study was conducted on 15 pediatric patients (aged <18 years) who were diagnosed with Sweet syndrome between 1991 and 2019. We reviewed the clinical and histopathological features of Sweet syndrome.
Results: The age of the 15 patients ranged from 4 months to 17 years. Among the 15 patients with Sweet syndrome, nine patients were females and six patients were males. Most patients (80%) had lesions on the upper extremities. Fever and tenderness (60%) were the most commonly associated symptoms. Transient infections such as upper respiratory infection or gastroenteritis were the most common identifiable cause, observed in 40% of patients. Histopathologically, dermal neutrophilic infiltration was observed in all patients. All patients were treated with systemic corticosteroids and showed a good response, although 26.7% of the patients experienced symptom recurrence. During the follow-up period, there were no incidences of any complications or extracutaneous manifestations in the patients.
Conclusion: In contrast to previous reports of pediatric Sweet syndrome, female predominance was observed in this study. Transient infection was the most common factor. All patients responded well to systemic corticosteroid therapy without complications or extracutaneous manifestations during the follow-up period. (Korean J Dermatol 2021;59(3):167∼174)

KCI등재 SCOPUS

2Cyclosporine 저항성 만성 자발성 두드러기환자에서 Omalizumab 치료에 대한 단일기관 후향적 연구

저자 : 김학준 ( Hak-jun Kim ) , 김우일 ( Woo-il Kim ) , 신기혁 ( Kihyuk Shin ) , 손진화 ( Jin-hwa Son ) , 이원구 ( Won-ku Lee ) , 김훈수 ( Hoon-soo Kim ) , 김병수 ( Byungsoo Kim ) , 김문범 ( Moon-bum Kim ) , 고현창 ( Hyun-chang Ko )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 175-180 (6 pages)

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Background: Cyclosporine is a recommended third-line treatment for chronic spontaneous urticaria (CSU) that is resistant to H1-antihistamines according to the EAACI/GA2LEN/EDF/WAO guidelines for management of urticaria. However, some patients with refractory urticaria do not respond to cyclosporine or antihistamines. Omalizumab, a humanized anti-immunoglobulin E antibody, has been shown to be effective and safe for antihistamine-resistant CSU. However, there are few reports on the efficacy of omalizumab in patients with CSU who are resistant to cyclosporine.
Objective: To evaluate the efficacy of omalizumab in patients with cyclosporine-resistant CSU.
Methods: Recalcitrant CSU patients who had symptoms (seven-day urticaria activity score, UAS7≥7) despite being administered cyclosporine (3∼5 mg/kg/day) and H1-antihistamine at up to a four-fold increased dose for 4 weeks were included in this study. Omalizumab was administered at 150 mg or 300 mg by subcutaneous injection every 4 weeks. Efficacy was assessed using UAS7 12 weeks after the initial administration of omalizumab.
Results: A total of 28 patients (18 women, 10 men) with an average age of 43.8 years were included in the study. The mean duration of CSU was 40.0 (2∼288) months, and the mean UAS7 at baseline was 14.2 (9∼35) months. Overall, 22 patients (78.6%) showed a complete (UAS7=0) or partial response (0

KCI등재 SCOPUS

3장미색 비강진에서 마크로라이드계 항생제와 위약의 치료 효과비교: 체계적 문헌고찰 및 메타분석

저자 : 김우일 ( Woo Il Kim ) , 허재영 ( Jae Young Heo ) , 박태흠 ( Taeheum Park ) , 김수영 ( Sooyoung Kim ) , 조문균 ( Moon Kyun Cho )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 181-187 (7 pages)

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Background: Pityriasis rosea is a self-limiting, acute, or subacute inflammatory skin disease that usually starts with a herald patch on the trunk and progresses to a generalized rash over the trunk and limbs. Some clinical trials have suggested that antibiotic macrolides help shorten the duration of skin manifestations in pityriasis rosea; however, the extent of the benefits is unclear.
Objective: To evaluate the effectiveness of antibiotic macrolides compared to placebo in pityriasis rosea.
Methods: A computerized search was performed using different databases, including Cochrane, Embase, and PubMed. Five randomized controlled trials were included. Then, statistical analyses of the outcome data extracted from the studies were performed using Rex Software (version 3.0.1).
Results: Total 160 records were identified by searching databases including Cochrane, Embase, and PubMed. The results of the meta-analysis demonstrated statistical differences between the use of antibiotic macrolides and placebo in the complete and partial resolution of pityriasis rosea (effectiveness) (RR: 1.84, 95% CI: 1.21∼2.78, p=0.004). However, in subgroup analyses, there were no statistical differences compared to placebo in the skin manifestation effectiveness group for azithromycin and clarithromycin, whereas erythromycin showed statistical differences.
Conclusion: Erythromycin was superior to placebo in the treatment of pityriasis rosea. However, this study had some limitations, including insufficient articles and data. Therefore, further investigation is required. (Korean J Dermatol 2021;59(3):181∼187)

KCI등재 SCOPUS

4연골모양 한관종의 발생 위치에 따른 임상 및 병리조직학적 연구

저자 : 이선복 ( Seon Bok Lee ) , 염승돈 ( Seung Dohn Yeom ) , 신정현 ( Jeonghyun Shin ) , 최광성 ( Gwang Seong Choi ) , 변지원 ( Ji Won Byun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 188-195 (8 pages)

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Background: Chondroid syringoma (CS) is an uncommon benign neoplasm of the head and neck seen in middle-aged to elderly individuals. Histopathologically, chondroid syringoma displays nests of cuboidal epithelial cells embedded in a matrix. It is classified as both a tubular branching lumina type and a small tubular lumina type and may exhibit a wide range of differentiation and metaplastic changes in the epithelial and stromal components.
Objective: To investigate the correlation between the clinical and histopathologic features of chondroid syringoma.
Methods: We evaluated the electronic medical records, clinical photographs, and histopathological slides of 17 patients diagnosed with chondroid syringoma.
Results: CS in the terminal hair skin tended to have larger lesions (p=0.036). Tumors in terminal hair skin demonstrated significantly more follicular differentiation (p=0.044) than those in the vellus hair skin. CS arising on the scalp tended to have more osseous metaplasia compared to those arising on non-scalp areas (p=0.022).
Conclusion: This study showed that the clinical and histopathological features of CS can differ depending on its location. (Korean J Dermatol 2021;59(3):188∼195)

KCI등재 SCOPUS

5유아혈관종 환아 375명에서 두 가지 제형의 경구 프로프라놀롤 치료 효과와 안전성에 대한 한국 단일기관에서의 경험

저자 : 이현지 ( Hyun Ji Lee ) , 하기웅 ( Giung Ha ) , 정호윤 ( Ho Yun Chung ) , 이종민 ( Jong Min Lee ) , 이상엽 ( Sang Yub Lee ) , 허승 ( Seung Huh ) , 김지윤 ( Ji Yoon Kim ) , 이석종 ( Seok-jong Lee )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 196-205 (10 pages)

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Background: Oral propranolol has recently been introduced as a successful treatment for infantile hemangioma (IH). Though, there are limited reports on this treatment including large number of Korean patients with IH covering a long-term powder and solution formulation period.
Objective: We investigated the effectiveness and side effects of two different formulations of oral propranolol treatment in patients with IH at a Korean tertiary university hospital.
Methods: From June 2011 to October 2019, 375 patients were treated with powder- or solution-type oral propranolol starting at 1 mg/kg/day and increasing up to 3 mg/kg/day. Drug effectiveness was evaluated on four scales through sequential photographs by two dermatologists. Side effects were recorded on a medical chart.
Results: Overall, the mean improvement scale was 2.61±0.73 at 3 months after treatment initiation. The scale was higher for solution-type than for powder-type oral propranolol at the 3-month follow-up (2.71±0.79 vs. 2.54±0.67, p<0.05). The patients' mean duration of treatment was 8.56±5.85 months, which was shorter for solution-type than for powder-type oral propranolol (6.0 vs. 10.69 months, p<0.05). Among the total number of patients, 22 reported mild side effects, including loose stools and noticeable sleep disturbance, and few serious side effects such as grunting, while two patients required medical intervention.
Conclusion: The patients in our study were effectively treated for IH with oral propranolol without significant side effects and had a shorter treatment duration with solution-type oral propranolol than with powder-type oral propranolol. (Korean J Dermatol 2021;59(3):196∼205)

KCI등재 SCOPUS

6일광두드러기의 임상 및 광생물학적 분석: 15년간의 후향적 연구

저자 : 홍지윤 ( Ji Youn Hong ) , 이양원 ( Yang Won Lee ) , 최용범 ( Yong Beom Choe ) , 안규중 ( Kyu Joong Ahn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 206-211 (6 pages)

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Background: Solar urticaria (SU) is a rare type of photodermatosis characterized by the appearance of itchy wheals and erythema within minutes after exposure to sunlight or artificial light. Only a few studies have analyzed the clinical and photobiological features of SU in Asia.
Objective: We aimed to analyze the clinical and photobiological characteristics of SU.
Methods: We retrospectively investigated the medical records of patients with SU who visited the Department of Dermatology at the Konkuk University Medical Center between January 2005 and October 2020.
Results: Of the 52 patients, 43 (82.7%) were men, and 9 (17.3%) were women. The mean age at onset was 17.5 years (5∼47 years), and the mean threshold time was 21.2 minutes. Among the 36 patients who underwent phototesting, the action spectrum predominantly responsible for SU was ultraviolet (UV) A only in 14 (38.9%) patients and visible light (415 nm) only in nine (25.0%) patients. Three patients (8.3%) were induced by both UVA and visible light (415 nm). In eight (22.2%) patients, the symptoms were triggered only by natural sunlight. Serum immunoglobulin E (IgE) levels were measured in 39 patients, and 21 (53.8%) patients showed elevated IgE levels. Oral antihistamine (48.1%) was the most widely used treatment, followed by oral cyclosporine (15.4%) and phototherapy (11.5%).
Conclusion: SU is an uncommon type of photodermatosis in Korea, with a greater prevalence in men. In this study, UVA was found to be the predominant action spectrum responsible for SU. (Korean J Dermatol 2021;59(3):206∼ 211)

KCI등재 SCOPUS

7Hypersensitivity Reactions to Contrast Media Used in Computed Tomography in Korea

저자 : Hyun Jin Kang , Kyung Ho Lee , Chul Jong Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 212-216 (5 pages)

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Background: Contrast media have been widely used for the diagnosis of numerous diseases. Although they are generally safe, the reported number of hypersensitivity reactions to contrast media has increased annually.
Objective: We aimed to investigate the incidence of hypersensitivity reactions due to intravenous nonionic contrast media. Also, we investigated whether the risk of contrast media-associated hypersensitivity was increased by specific types of contrast agents.
Methods: We performed a retrospective review of patients who had hypersensitivity reactions after enhanced computed tomography scans at Bucheon St. Mary's Hospital, Bucheon, Korea from January 2016 to December 2019. We classified the hypersensitivity reactions into immediate (<1 hour) or delayed (≥1 hour) reactions. All demographic data and information regarding the hypersensitivity reactions were obtained from the electronic medical records.
Results: The overall incidence of hypersensitivity reactions to contrast media was 0.49% (262 cases resulting from 53,733 exposures). The incidence increased annually from 0.19% in 2016 to 0.86% in 2019. Among the 262 cases, 199 cases (76.0%) were immediate-type while the delayed-type accounted for 63 cases (24.0%). The immediate hypersensitivity reaction incidence was not significantly different among contrast agents. However, the incidence of the delayed-type was significantly different (ranging from 0.02% for iomeprol to 0.25% for iodixanol, p<0.05).
Conclusion: This study found that the hypersensitivity reaction incidence has increased annually. Immediate hypersensitivity reactions occurred at a higher rate than delayed hypersensitivity reactions. The incidence of delayed hypersensitivity reactions was significantly greater in patients who received iodixanol than in those who received the other types. (Korean J Dermatol 2021;59(3):212∼216)

KCI등재 SCOPUS

8The Role of Plant Extracts in Alleviating Particulate Matter-induced Inflammation in Barrier-interrupted Skin

저자 : Ji Yeon Hong , Sun Young Choi , Jae Wan Park , Jin O Park , A Reum Kim , Beom Joon Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 217-224 (8 pages)

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Background: The adverse effects of particulate matter (PM) on the skin have been concerning recently.
Objective: We investigated PM induced inflammation on barrier-interrupted skin and relieving effects of plant extracts on PM-induced skin irritation.
Methods: A total of 20 participants were enrolled for the induction of skin irritation. Sodium lauryl sulfate (SLS) patch was affixed to the forearm for 24 hours. After patch removal, total suspended particulates (TSPs) were applied. After inducing skin irritation using SLS and TSP, cream containing 0.1% mixture of plant extracts (Citrus sunki, Sceptridium ternatum (Botrychium ternatum), and Korthalsella japonica) was applied. The a* value, erythema index (EI), and transepidermal water loss (TEWL) were measured.
Results: The a* value was significantly higher at the site where TSPs were applied than that at the site where TSPs were not applied at 1 and 2 days after SLS patch removal. The a* value, EI, and TEWL were significantly low in the cream-applied area 7 days after the introduction of the SLS patch and TSPs.
Conclusion: PM induced skin irritation in a previously disrupted skin barrier. Topical application of plant extracts alleviated skin irritation symptoms caused by dust exposure. (Korean J Dermatol 2021;59(3):217∼224)

KCI등재 SCOPUS

9심부 종양 형태로 발생한 손목의 종양 석회증 1예

저자 : 강홍제 ( Hong Je Kang ) , 김건록 ( Keon Rok Kim ) , 임보라 ( Bo Ra Lim ) , 박건 ( Kun Park )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 225-228 (4 pages)

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Tumoral calcinosis is an ectopic calcification syndrome characterized by an irregular soft tissue mass. It has been reported mainly in large joints such as the hip, shoulder, knee, and elbow, but rarely in the hands. When it occurs on the dorsal side of the wrist, there are no specific symptoms except for localized tenderness. Therefore, it is difficult to differentiate the calcification from other common hand tumors, especially ganglions. We report a case of tumoral calcinosis that occurred on the dorsal side of the wrist with magnetic resonance imaging findings. (Korean J Dermatol 2021;59(3):225∼228)

KCI등재 SCOPUS

10흉부의 둔상 이후 고정된 결절성 병변 형태로 발생한 흉부 피부 누공 1예

저자 : 이선화 ( Seon Hwa Lee ) , 박경덕 ( Kyung Duck Park ) , 장용현 ( Yong Hyun Jang ) , 이원주 ( Weon Ju Lee ) , 이석종 ( Seok-jong Lee ) , 김준영 ( Jun Young Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 59권 3호 발행 연도 : 2021 페이지 : pp. 229-233 (5 pages)

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An 83-year-old man presented with an intermittently bleeding fixed nodule on the left side of the chest for 2 months. Due to the clinical suspicion of metastatic cancer or a ruptured epidermal cyst, a punch biopsy was performed, which revealed granulation tissue. During surgical excision, a connection between the granulation tissue and the deeper structure was confirmed. Based on the clinicopathological findings, a cutaneous fistula was suspected; a detailed history revealed that he had experienced blunt chest trauma in a motorcycle accident 2 months before. Subsequent chest computed tomography showed soft tissue infiltration in the left sixth rib. Finally, the patient was diagnosed with a cutaneous fistula and underwent resection of the left sixth rib and costal cartilage. Cutaneous fistulae rarely occur in the chest. In cases where a recalcitrant inflammatory nodule is observed on the chest, the patient's trauma history and ordinary medical history should be evaluated to rule out a cutaneous fistula. (Korean J Dermatol 2021;59(3):229∼233)

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1연안해역에서 석유오염물질의 세균학적 분해에 관한 연구

(2006)홍길동 외 1명심리학41회 피인용

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(2006)홍길동심리학41회 피인용

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(2006)홍길동41회 피인용

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