간행물

BMB Reports update

Biochemistry and Molecular Biology Reports

  • : 생화학분자생물학회
  • : 자연과학분야  >  화학
  • : KCI등재
  • : SCI,SCOPUS
  • : 연속간행물
  • : 월간
  • : 1976-6696
  • : 1976-670X
  • : Korean Biochemical Journal(~1994)→Journal of Biochemistry and Molecular Biology(1995~)→Biochemistry and Molecurar Biology Reports(2008~)

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수록범위 : 1권1호(1968)~54권8호(2021) |수록논문 수 : 4,531
BMB Reports
54권8호(2021년 08월) 수록논문
최근 권호 논문
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KCI등재 SCI SCOPUS

1Proprioception, the regulator of motor function

저자 : Kyeong Min Moon , Jimin Kim , Yurim Seong , Byung-chang Suh , Kyeongjin Kang , Han Kyoung Choe , Kyuhyung Kim

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 393-402 (10 pages)

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In animals, proper locomotion is crucial to find mates and foods and avoid predators or dangers. Multiple sensory systems detect external and internal cues and integrate them to modulate motor outputs. Proprioception is the internal sense of body position, and proprioceptive control of locomotion is essential to generate and maintain precise patterns of movement or gaits. This proprioceptive feedback system is conserved in many animal species and is mediated by stretch-sensitive receptors called proprioceptors. Recent studies have identified multiple proprioceptive neurons and proprioceptors and their roles in the locomotion of various model organisms. In this review we describe molecular and neuronal mechanisms underlying proprioceptive feedback systems in C. elegans, Drosophila, and mice. [BMB Reports 2021; 54(8): 393-402]

KCI등재 SCI SCOPUS

2Perspectives on immune checkpoint ligands: expression, regulation, and clinical implications

저자 : Jihyun Moon , Yoo Min Oh , Sang-jun Ha

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 403-412 (10 pages)

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In the tumor microenvironment, immune checkpoint ligands (ICLs) must be expressed in order to trigger the inhibitory signal via immune checkpoint receptors (ICRs). Although ICL expression frequently occurs in a manner intrinsic to tumor cells, extrinsic factors derived from the tumor microenvironment can fine-tune ICL expression by tumor cells or prompt non-tumor cells, including immune cells. Considering the extensive interaction between T cells and other immune cells within the tumor microenvironment, ICL expression on immune cells can be as significant as that of ICLs on tumor cells in promoting antitumor immune responses. Here, we introduce various regulators known to induce or suppress ICL expression in either tumor cells or immune cells, and concise mechanisms relevant to their induction. Finally, we focus on the clinical significance of understanding the mechanisms of ICLs for an optimized immunotherapy for individual cancer patients. [BMB Reports 2021; 54(8): 403-412]

KCI등재 SCI SCOPUS

3EBP1 regulates Suv39H1 stability via the ubiquitin-proteasome system in neural development

저자 : Byeong-seong Kim , Hyo Rim Ko , Inwoo Hwang , Sung-woo Cho , Jee-yin Ahn

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 413-418 (6 pages)

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ErbB3-binding protein 1 (EBP1) is a multifunctional protein associated with neural development. Loss of Ebp1 leads to upregulation of the gene silencing unit suppressor of variegation 3-9 homolog 1 (Suv39H1)/DNA (cytosine 5)-methyltransferase (DNMT1). EBP1 directly binds to the promoter region of DNMT1, repressing DNA methylation, and hence, promoting neural development. In the current study, we showed that EBP1 suppresses histone methyltransferase activity of Suv39H1 by promoting ubiquitin-proteasome system (UPS)-dependent degradation of Suv39H1. In addition, we showed that EBP1 directly interacts with Suv39H1, and this interaction is required for recruiting the E3 ligase MDM2 for Suv39H1 degradation. Thus, our findings suggest that EBP1 regulates UPS-dependent degradation of Suv39H1 to govern proper heterochromatin assembly during neural development. [BMB Reports 2021; 54(8): 413-418]

KCI등재 SCI SCOPUS

4Nrf2 induces Ucp1 expression in adipocytes in response to β3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice

저자 : Seo-hyuk Chang , Jaeyool Jang , Seungjun Oh , Jung-hoon Yoon , Dong-gyu Jo , Ui Jeong Yun , Kye Won Park

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 419-424 (6 pages)

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Cold-induced norepinephrine activates β3-adrenergic receptors (β3-AR) to stimulate the kinase cascade and cAMP-response element-binding protein, leading to the induction of thermogenic gene expression including uncoupling protein 1 (Ucp1). Here, we showed that stimulation of the β3-AR by its agonists isoproterenol and CL316,243 in adipocytes increased the expression of Ucp1 and Heme Oxygenase 1 (Hmox1), the principal Nrf2 target gene, suggesting the functional interaction of Nrf2 with β3-AR signaling. The activation of Nrf2 by tert-butylhydroquinone and reactive oxygen species (ROS) production by glucose oxidase induced both Ucp1 and Hmox1 expression. The increased expression of Ucp1 and Hmox1 was significantly reduced in the presence of a Nrf2 chemical inhibitor or in Nrf2-deleted (knockout) adipocytes. Furthermore, Nrf2 directly activated the Ucp1 promoter, and this required DNA regions located at -3.7 and -2.0 kb of the transcription start site. The CL316,243-induced Ucp1 expression in adipocytes and oxygen consumption in obese mice were partly compromised in the absence of Nrf2 expression. These data provide additional insight into the role of Nrf2 in β3-AR-mediated Ucp1 expression and energy expenditure, further highlighting the utility of Nrf2-mediated thermogenic stimulation as a therapeutic approach to diet-induced obesity. [BMB Reports 2021; 54(8): 419-424]

KCI등재 SCI SCOPUS

5MUC1-C influences cell survival in lung adenocarcinoma Calu-3 cells after SARS-CoV-2 infection

저자 : Dongbum Kim , Sony Maharjan , Jinsoo Kim , Sangkyu Park , Jeong-a Park , Byoung Kwon Park , Younghee Lee , Hyung-joo Kwon

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 425-430 (6 pages)

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces coronavirus disease 2019 (COVID-19) and may increase the risk of adverse outcomes in lung cancer patients. In this study, we investigated the expression and function of mucin 1 (MUC1) after SARS-CoV-2 infection in the lung epithelial cancer cell line Calu-3. MUC1 is a major constituent of the mucus layer in the respiratory tract and contributes to pathogen defense. SARS-CoV-2 infection induced MUC1 C-terminal subunit (MUC1-C) expression in a STAT3 activation-dependent manner. Inhibition of MUC1-C signaling increased apoptosis-related protein levels and reduced proliferation-related protein levels; however, SARS-CoV-2 replication was not affected. Together, these results suggest that increased MUC1-C expression in response to SARS-CoV-2 infection may trigger the growth of lung cancer cells, and COVID-19 may be a risk factor for lung cancer patients. [BMB Reports 2021; 54(8): 425-430]

KCI등재 SCI SCOPUS

6Acetate decreases PVR/CD155 expression via PI3K/AKT pathway in cancer cells

저자 : Na Ly Tran , In Kyu Lee , Jungkyun Choi , Sang-heon Kim , Seung Ja Oh

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 431-436 (6 pages)

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In recent years, restoring anti-tumor immunity has garnered a growing interest in cancer treatment. As potential therapeutics, immune checkpoint inhibitors have demonstrated benefits in many clinical studies. Although various methods have been applied to suppress immune checkpoints to boost anti-tumor immunity, including the use of immune checkpoint inhibitors, there are still unmet clinical needs to improve the response rate of cancer treatment. Here, we show that acetate can suppress the expression of poliovirus receptor (PVR/CD155), a ligand for immune checkpoint, in colon cancer cells. We demonstrated that acetate treatment could enhance effector responses of CD8+ T cells by decreasing the expression of PVR/CD155 in cancer cells. We also found that acetate could reduce the expression of PVR/CD155 by deactivating the PI3K/AKT pathway. These results demonstrate that acetate-mediated expression of PVR/CD155 in cancer cells might potentiate the anti-tumor immunity in the microenvironment of cancer. Our findings indicate that maintaining particular acetate concentrations could be a complementary strategy in current cancer treatment. [BMB Reports 2021; 54(8): 431-436]

KCI등재 SCI SCOPUS

7Erratum to: Common and differential effects of docosahexaenoic acid and eicosapentaenoic acid on helper T-cell responses and associated pathways

저자 : Jaeho Lee , Yu Ri Choi , Miso Kim , Jung Mi Park , Moonjong Kang , Jaewon Oh , Chan Joo Lee , Sungha Park , Seok-min Kang , Ichiro Manabe , Soo-jin Ann , Sang-hak Lee

발행기관 : 생화학분자생물학회 간행물 : BMB Reports 54권 8호 발행 연도 : 2021 페이지 : pp. 437-437 (1 pages)

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