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대한한방부인과학회지 update

The Journal Of Oriental Gynecology

  • : 대한한방부인과학회
  • : 의약학분야  >  기초한의학
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수록정보
34권3호(2021) |수록논문 수 : 11
간행물 제목
34권3호(2021년 08월) 수록논문
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13종 한약 처방 물 추출물과 황금 에탄올 추출물에 의한 자궁내막과 태반세포 기능조절 연구

저자 : 박서예 ( Seo-ye Park ) , 노의정 ( Eui-jeong Noh ) , 서창섭 ( Chang-seob Seo ) , 이성기 ( Sung-ki Lee ) , 신현규 ( Hyeun-kyoo Shin )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 1-14 (14 pages)

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Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix.
Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells.
Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.

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2맥문동 물 추출물의 선천면역 활성과 염증억제 효과

저자 : 강누리 ( Nu-ri Kang ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 15-28 (14 pages)

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Objectives: This study was designed to examine the anti-cancer activity by innate immunomodulating and anti-inflammatory effects of liriopis tuber water extract (LPE).
Methods: Cell cytotoxicity was tested with 4T1 mouse mammary carcinoma cells, spleen cells, macrophage, and RAW264.7 cells. To investigate innate immunomodulating effects of LPE on macrophage, we measured tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12), and interleukin-10 (IL-10). To investigate innate immunomodulating effects of LPE on RAW264.7 cell, we measured TNF-α, interleukin-6 (IL-6). In addition, TNF-α and nitric oxide (NO) induced by lipopolysaccharide (LPS) were measured after treating with LPE to observe innate immunomodulating effect of LPE on RAW264.7 cell. Also, mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) were examined by western blot analysis.
Results: In an in vitro cytotoxicity analysis, LPE affected tumor cell growth above specific concentration. As compared with the control group, the production of TNF-α, IL-12, and IL-10 were increased in macrophage. As compared with the control group, the production of TNF-α and IL-6 were increased in RAW 264.7 cell. The expression of TNF-α and NO induced by LPS after treating LPE was decreased. In addition, treatment of RAW 264.7 cell with LPE increased the phosphorylation levels of p-extracellular signal-regulated kinase (p-ERK), p-Jun N-terminal kinase (p-JNK), and p-p38.
Conclusions: LPE might have impact on the anti-cancer effect by activation of innate immune system and inflammation control.

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3반총산의 항산화, 항염증, 항소양증, 항균효능에 관한 실험 연구

저자 : 조은진 ( Eun-jin Cho ) , 조성희 ( Seong-hui Jo ) , 양승정 ( Seung-jeong Yang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 29-48 (20 pages)

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Objectives: Banchong-san (BCS) is a herbal formula composed of 13 korean medicinal herbs and is traditionally used to treat inflammatory diseases and pain. The object of this study was to research the antioxidant, anti-inflammatory, antipruritic and antimicrobial effects of the BCS in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Methods: In this experiment, effects of BCS on the following four were measured as follows: (1) Anti-oxidative effects were evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) Radical scavenging activity, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) Radical scavenging activity. (2) Anti-inflammatory effects were evaluated by the production amount of Reactive oxygen species (ROS), Nitric oxide (NO), Interleukin-1β (IL-1β), Interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), Prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2)(the previous two are “mRNA"), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinases (p38), inhibitor of nuclear factor kappa B (IκBα), nuclear factor kappa B (NF-κB) (the previous five are "Protein") in LPS-Stimulated RAW 264.7 cells. (3)Antipruritic effects were evaluated by the production amount of histamine, Leukotriene B4 (LTB4), LeukotrieneC4 (LTC4) Levels in phorbol 12-myristate 13-acetate(PMA)/ionomycin-stimulated MC/9 mast cell. (4) Anti-microbial effects were evaluated by the growth suppression of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Aspergillus niger.
Results: The following results were obtained through each measurement: (1) DPPH Radical Scavenging Activity, ABTS Radical Scavenging Activity evoked a significant concentration-dependent increase. (2) ROS, NO, IL-1β, IL-6, TNF-α, PGE2 production amount, iNOS, COX-2 mRNA expression were significantly reduced in the BCS extraction group compared with the control group and significantly decreased the amount of ERK, JNK, p38, NF-κB Protein expression. The amount of IκB-α Protein Expression have increased significantly. (3) The amounts of histamine, LTB4, LTC4 were significantly decreased. (4) The antibacterial efficacy, BCS inhibited the growth of Escherichia coli, Pseudomonas aeruginosa at concentrations of 5 μg/ml, but did not suppress the growth of staphylococcus aureus and aspergillus niger.
Conclusions: The experimental results show that BCS has anti-oxidant, anti-inflammatory, antipruritic and antimicrobial properties.

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4일개한방병원에서 전라북도산후건강지원사업을 이용해 한약치료를 받은 산모에 대한 후향적 연구

저자 : 정서윤 ( Seo-yoon Jeong ) , 이은희 ( Eun-hee Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 49-64 (16 pages)

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Objectives: This study analyzed medical records and online survey of mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Project. Through this, we would like to discuss the proposal of a postpartum questionnaire of korean medicine for the initial examination, and the project direction.
Methods: This study investigated the medical records of 46 mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Program at one korean medical hospital. The mother's general characteristics, past history, symptoms, and herbal medicine prescription were analyzed. In addition, through the 33 mothers who responded to the online survey questionnaire, 13 items including medication satisfaction, lactation, and side effects were investigated.
Results: The average age of the subjects was 34.46±4.27 years. Musculo-skeletal pain was the most common in both medical records and online surveys. The date of visit from the date of delivery was 47.56±57.15 days. Boheo-tang was prescribed the most, and 84.8% of mothers answered positively about their health after taking herbal medicine.
Conclusions: The satisfaction of mothers who received herbal medicine treatment through this project was very high. There were no significant side effects on the mother and the breastfeeding baby who took herbal medicine. In the future, support projects for postpartum korean medical treatment at the national or local level will be necessary.

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5산후 한의진료를 받은 고위험산모와 일반산모의 한의진료 체중변화에 대한 후향적 분석

저자 : 이은희 ( Eun-hee Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 65-78 (14 pages)

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Objectives: This study was aimed to investigate the weight change of the high-risk group and the general maternal group and weight-relating factors in the early postpartum period.
Methods: We retrospectively reviewed the medical records of those who received postpartum care from January 1, 2020, to December 31, 2020, in the postpartum care center affiliated with one Korean Medicine hospital. A total of 257 postpartum women's medical charts were included and divided into the high-risk group and the general maternal group. We investigated the weight changes and Body mass index (BMI) of the postpartum women and compared the difference between the two groups after taking the postpartum care. Finally, we used a Pearson correlation analysis to identify the weight-relating factors in the early postpartum period.
Results: All the postpartum women showed the following results; 33.81±4.03 years old as the mean age; 22.23±3.28 as pre-pregnancy BMI; 58.21±9.18 kg of pre-pregnancy weight increased into 70.75±9.70 kg in the last month of pregnancy. Of the total 257 patients, 149 (58.0%) of high-risk pregnancy experience and 108 (42.0%) of general pregnancy were included. The edema index right after childbirth was significantly higher in the high-risk group than in the general maternal group (p<0.001), but there was no significant difference in BMI. After treatment with Korean medicine treatments, body weight, BMI, and edema index decreased significantly in both groups (p<0.01). As a result of correlation analysis, weight gain during pregnancy had a significant negative correlation with pre-pregnancy weight and pre-pregnancy BMI and a significant positive correlation with weight and BMI of the last month of pregnancy. In particular, pre-pregnancy BMI and body weight showed a significant negative correlation only in the high-risk group. Postpartum weight loss was significantly positively correlated with pre-pregnancy weight, pre-pregnancy BMI, weight & BMI of the pregnancy last month, weight gain during pregnancy, and decrease in edema (p<0.01)
Conclusions: The weight during pregnancy of the high-risk group increased in inverse proportion to the pre-pregnancy BMI. The level of edema right after childbirth was significantly higher than that of the general maternal group, but showed a significant decrease after 2 weeks of Korean medicine treatments. Although it implicates the need for active Korean medicine treatments in the early postpartum period, further studies with controlled groups are needed.

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6갱년기 증후군의 약침 치료에 대한 국내 연구 동향 고찰

저자 : 황현지 ( Hyeon-ji Hwang ) , 안수연 ( Soo-yeon Ahn ) , 김동철 ( Dong-chul Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 79-95 (17 pages)

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Objectives: The purpose of this review is to analyze the domestic study trends on climacteric syndrome treated with pharmacopuncture.
Methods: We investigated the studies on pharmacopuncture for climacteric syndrome via searching 6 online databases.
Results: 18 studies were selected. There were 2 case reports, 1 randomised controlled trial, and 15 animal experiments. There were 14 studies about osteoporosis, 1 study about hot flush and sweating, 1 study about abdominal obesity, 1 study about neck pain, and 1 study about learning disability and memory disorder. Nokyong was most frequently used for pharmacopuncture, followed by Honghwa. 陰谷(KI10) was most frequently used for acupuncture point, followed by 腎兪(BL23).
Conclusions: This study shows that pharmacopuncture could be one of the effective treatments for climacteric syndrome. More well-designed clinical studies using pharmacopuncture for climacteric syndrome will be needed.

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7자궁내막증식증에서 한약 치료의 효과에 대한 체계적 문헌 고찰 및 메타분석 - 중국 임상 연구를 중심으로

저자 : 유진실 ( Jin-sil Yu ) , 박경선 ( Kyoung-sun Park ) , 안영태 ( Young-tae Ahn ) , 조유진 ( Yu-jin Cho ) , 강은솔 ( Eun-sol Kang ) , 정성엽 ( Sung-yub Jung ) , 이윤재 ( Yoon-jae Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 96-113 (18 pages)

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Objectives: The purpose of this study is to analyze the effectiveness of herbal medicine that are used for endometrial hyperplasia.
Methods: We searched on three databases [PubMed, China national knowledge infrastructure (CNKI), and Oriental medicine advanced searching integrated system (OASIS)] with keywords for Endometrial hyperplasia(English, Korean, and Chinese) and evaluated the risk of bias. Meta-analysis was performed on the selected studies.
Results: 15 RCTs were finally selected. According to the analysis, Most of the participants were endometrial hyperplasia without atypia. And the combined therapeutic effects of hormonal medicine and herbal medicine were statistically significant (RR 1.21 [95% CI 1.15, 1.28], P<0.00001), The endometrial thickness tended to be thinner when treated combined therapy. And they also showed improvement on levels of pictorial blood assessment chart (PBAC) and hemoglobin. Also, the therapeutic effects of herbal medicine can be identified as similar to Western medicine, and no superior effects have been confirmed (RR 1.05 [95% CI 0.87, 1.28], P=0.60).
Conclusion: The combination Western and herbal medicine was more effective than Western medicine alone treated for endometrial hyperplasia without atypia. Moreover there were also significant improvements in endometrial thickness, PBAC and hemoglobin levels.

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8갑상선기능항진증의 한약 치료에 대한 무작위 대조군 연구의 문헌 고찰

저자 : 이희윤 ( Hee-yoon Lee ) , 황수인 ( Su-in Hwang ) , 박장경 ( Jang-kyung Park ) , 윤영진 ( Young-jin Yoon )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 114-136 (23 pages)

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Objectives: The purpose of this study is to analyze the effectiveness and safety of herbal medicine treatment for treating hyperthyroidism.
Methods: We searched for randomized controlled trials of Hyperthyroidism treated with herbal medicine, published from January 2016 to May 2021, through electronic database such as Pubmed, EMBASE, China Academic Journal (CAJ). Interventions and results of the selected clinical studies were analyzed.
Results: The 25 randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in 2 studies, and with herbal medicine and conventional medicine in 23 studies. Control group was treated with conventional medicine. Outcome measures are total efficacy rate, thyroid function test, Traditional Chinese medicine (TCM) syndrome scores, liver function test, recurrence rate, etc. Prunellae Spica (夏枯草) (60%) was the most frequently used herb in herbal medicine treatment. In all of 25 studies, treatment group was more effective and safer for hyperthyroidism than the control group.
Conclusions: This study indicates that herbal medicine treatment alone or combined with conventional medicine treatment could be helpful in improving the therapeutic effect on hyperthyroidism and reducing side effects as well.

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9한약 복용이 산후 유즙분비에 미치는 효과에 대한 체계적 문헌고찰

저자 : 이혜정 ( Hye-jung Lee ) , 이수정 ( Su-jeong Lee ) , 황덕상 ( Deok-sang Hwang ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang ) , 이진무 ( Jin-moo Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 137-156 (20 pages)

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Objectives: The purpose of this study is to assess the effect of taking herbal medicine for the postpartum lactation.
Methods: We searched 9 databases for recent three years, that contained four english, two chinese, one japanese and two korean database from September 17, 2016 to December 31, 2020. Randomized controlled trials (RCTs) were eligible. Measurement of outcome included total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool.
Results: Total 725 of studies was screened, 11 RCTs were finally selected. Number of participants per study ranged from 60 to 257. The treatment group of taking a herbal medicine is effective for improving total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration compared with control group. Because most of the studies had considerable heterogeneity in terms of type of intervention and comparison for outcome measurement, meta analysis for quantitative analysis was impossible.
Conclusions: This studies showed that taking a herbal medicine is effective on increasing volume of lactation and speeding up the start of the first breastfeeding. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for breastfeeding and reduce the risk of bias.

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10귀비온담탕 가미방을 포함한 한방치료로 호전된 화병 환자 2례 : 증례 보고

저자 : 정소미 ( So-mi Jeong ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang ) , 조성희 ( Seong-hee Cho )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 157-174 (18 pages)

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Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine with Guibiondamtang-gamibang on Hwa-byung patients.
Methods: Case 1 experienced stress at work and complained of chest discomfort, nausea, dizziness, insomnia. Case 2 experienced huge stress about money, and complained of palpitation, chest discomfort, dizziness and insomnia. They received combination treatment of Korean medicine during hospitalization. The treatment included Guibiondamtang-gamibang, acupuncture, moxibustion, pharmacoacupuncture, and fumigation. The effects were evaluated through Hwa-byung scale, instrument of oriental medical evaluation for Hwa-byung, insomnia severity index (ISI) and heart rate variability (HRV) test.
Results: After the treatment, the clinical symptoms such as chest discomfort, palpitation, dizziness, nausea and insomnia were improved.
Conclusions: This case report shows that the combination treatment of Korean medicine with Guibiondamtang-gamibang may be effective for treating Hwa-byung patients.

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13종 한약 처방 물 추출물과 황금 에탄올 추출물에 의한 자궁내막과 태반세포 기능조절 연구

저자 : 박서예 ( Seo-ye Park ) , 노의정 ( Eui-jeong Noh ) , 서창섭 ( Chang-seob Seo ) , 이성기 ( Sung-ki Lee ) , 신현규 ( Hyeun-kyoo Shin )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 1-14 (14 pages)

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Methods: We investigated the ability to induce decidualization of human endometrial stromal cells and invasive ability of human trophoblast cells by water extract of three types herbal medicines (Dangguijakyak-san, Siryung-tang, Antae-eum) and ethanol extract on Scutellariae Radix.
Results: In the process of decidualization of endometrial stromal cells, three herbal medicines including Dangguijakyak-san, Siryung-tang, and Scutellariae Radix increased the production of decidual markers such as prolactin (PRL) and insulin-like growth factor-binding protein 1 (IGFBP1). However, Antae-eum increased mRNA levels of PRL and IGFBP and secretion of IGFBP in decidual stromal cells, but not PRL. Four herbal medicines inhibited the invasion of trophoblast cells.
Conclusions: Four herbal medicines may play a role in implantation in women with reproductive failures. However, further studies are warranted to elucidate whether these medications are helpful in the maintenance of pregnancy.

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2맥문동 물 추출물의 선천면역 활성과 염증억제 효과

저자 : 강누리 ( Nu-ri Kang ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 15-28 (14 pages)

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Objectives: This study was designed to examine the anti-cancer activity by innate immunomodulating and anti-inflammatory effects of liriopis tuber water extract (LPE).
Methods: Cell cytotoxicity was tested with 4T1 mouse mammary carcinoma cells, spleen cells, macrophage, and RAW264.7 cells. To investigate innate immunomodulating effects of LPE on macrophage, we measured tumor necrosis factor-alpha (TNF-α), interleukin-12 (IL-12), and interleukin-10 (IL-10). To investigate innate immunomodulating effects of LPE on RAW264.7 cell, we measured TNF-α, interleukin-6 (IL-6). In addition, TNF-α and nitric oxide (NO) induced by lipopolysaccharide (LPS) were measured after treating with LPE to observe innate immunomodulating effect of LPE on RAW264.7 cell. Also, mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) were examined by western blot analysis.
Results: In an in vitro cytotoxicity analysis, LPE affected tumor cell growth above specific concentration. As compared with the control group, the production of TNF-α, IL-12, and IL-10 were increased in macrophage. As compared with the control group, the production of TNF-α and IL-6 were increased in RAW 264.7 cell. The expression of TNF-α and NO induced by LPS after treating LPE was decreased. In addition, treatment of RAW 264.7 cell with LPE increased the phosphorylation levels of p-extracellular signal-regulated kinase (p-ERK), p-Jun N-terminal kinase (p-JNK), and p-p38.
Conclusions: LPE might have impact on the anti-cancer effect by activation of innate immune system and inflammation control.

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3반총산의 항산화, 항염증, 항소양증, 항균효능에 관한 실험 연구

저자 : 조은진 ( Eun-jin Cho ) , 조성희 ( Seong-hui Jo ) , 양승정 ( Seung-jeong Yang )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 29-48 (20 pages)

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Objectives: Banchong-san (BCS) is a herbal formula composed of 13 korean medicinal herbs and is traditionally used to treat inflammatory diseases and pain. The object of this study was to research the antioxidant, anti-inflammatory, antipruritic and antimicrobial effects of the BCS in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Methods: In this experiment, effects of BCS on the following four were measured as follows: (1) Anti-oxidative effects were evaluated by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) Radical scavenging activity, 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) Radical scavenging activity. (2) Anti-inflammatory effects were evaluated by the production amount of Reactive oxygen species (ROS), Nitric oxide (NO), Interleukin-1β (IL-1β), Interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), Prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2)(the previous two are “mRNA"), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38 mitogen-activated protein kinases (p38), inhibitor of nuclear factor kappa B (IκBα), nuclear factor kappa B (NF-κB) (the previous five are "Protein") in LPS-Stimulated RAW 264.7 cells. (3)Antipruritic effects were evaluated by the production amount of histamine, Leukotriene B4 (LTB4), LeukotrieneC4 (LTC4) Levels in phorbol 12-myristate 13-acetate(PMA)/ionomycin-stimulated MC/9 mast cell. (4) Anti-microbial effects were evaluated by the growth suppression of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Aspergillus niger.
Results: The following results were obtained through each measurement: (1) DPPH Radical Scavenging Activity, ABTS Radical Scavenging Activity evoked a significant concentration-dependent increase. (2) ROS, NO, IL-1β, IL-6, TNF-α, PGE2 production amount, iNOS, COX-2 mRNA expression were significantly reduced in the BCS extraction group compared with the control group and significantly decreased the amount of ERK, JNK, p38, NF-κB Protein expression. The amount of IκB-α Protein Expression have increased significantly. (3) The amounts of histamine, LTB4, LTC4 were significantly decreased. (4) The antibacterial efficacy, BCS inhibited the growth of Escherichia coli, Pseudomonas aeruginosa at concentrations of 5 μg/ml, but did not suppress the growth of staphylococcus aureus and aspergillus niger.
Conclusions: The experimental results show that BCS has anti-oxidant, anti-inflammatory, antipruritic and antimicrobial properties.

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4일개한방병원에서 전라북도산후건강지원사업을 이용해 한약치료를 받은 산모에 대한 후향적 연구

저자 : 정서윤 ( Seo-yoon Jeong ) , 이은희 ( Eun-hee Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 49-64 (16 pages)

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Objectives: This study analyzed medical records and online survey of mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Project. Through this, we would like to discuss the proposal of a postpartum questionnaire of korean medicine for the initial examination, and the project direction.
Methods: This study investigated the medical records of 46 mothers who received herbal medicine treatment using the Jeollabuk-do Postpartum Health Support Program at one korean medical hospital. The mother's general characteristics, past history, symptoms, and herbal medicine prescription were analyzed. In addition, through the 33 mothers who responded to the online survey questionnaire, 13 items including medication satisfaction, lactation, and side effects were investigated.
Results: The average age of the subjects was 34.46±4.27 years. Musculo-skeletal pain was the most common in both medical records and online surveys. The date of visit from the date of delivery was 47.56±57.15 days. Boheo-tang was prescribed the most, and 84.8% of mothers answered positively about their health after taking herbal medicine.
Conclusions: The satisfaction of mothers who received herbal medicine treatment through this project was very high. There were no significant side effects on the mother and the breastfeeding baby who took herbal medicine. In the future, support projects for postpartum korean medical treatment at the national or local level will be necessary.

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5산후 한의진료를 받은 고위험산모와 일반산모의 한의진료 체중변화에 대한 후향적 분석

저자 : 이은희 ( Eun-hee Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 65-78 (14 pages)

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Objectives: This study was aimed to investigate the weight change of the high-risk group and the general maternal group and weight-relating factors in the early postpartum period.
Methods: We retrospectively reviewed the medical records of those who received postpartum care from January 1, 2020, to December 31, 2020, in the postpartum care center affiliated with one Korean Medicine hospital. A total of 257 postpartum women's medical charts were included and divided into the high-risk group and the general maternal group. We investigated the weight changes and Body mass index (BMI) of the postpartum women and compared the difference between the two groups after taking the postpartum care. Finally, we used a Pearson correlation analysis to identify the weight-relating factors in the early postpartum period.
Results: All the postpartum women showed the following results; 33.81±4.03 years old as the mean age; 22.23±3.28 as pre-pregnancy BMI; 58.21±9.18 kg of pre-pregnancy weight increased into 70.75±9.70 kg in the last month of pregnancy. Of the total 257 patients, 149 (58.0%) of high-risk pregnancy experience and 108 (42.0%) of general pregnancy were included. The edema index right after childbirth was significantly higher in the high-risk group than in the general maternal group (p<0.001), but there was no significant difference in BMI. After treatment with Korean medicine treatments, body weight, BMI, and edema index decreased significantly in both groups (p<0.01). As a result of correlation analysis, weight gain during pregnancy had a significant negative correlation with pre-pregnancy weight and pre-pregnancy BMI and a significant positive correlation with weight and BMI of the last month of pregnancy. In particular, pre-pregnancy BMI and body weight showed a significant negative correlation only in the high-risk group. Postpartum weight loss was significantly positively correlated with pre-pregnancy weight, pre-pregnancy BMI, weight & BMI of the pregnancy last month, weight gain during pregnancy, and decrease in edema (p<0.01)
Conclusions: The weight during pregnancy of the high-risk group increased in inverse proportion to the pre-pregnancy BMI. The level of edema right after childbirth was significantly higher than that of the general maternal group, but showed a significant decrease after 2 weeks of Korean medicine treatments. Although it implicates the need for active Korean medicine treatments in the early postpartum period, further studies with controlled groups are needed.

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6갱년기 증후군의 약침 치료에 대한 국내 연구 동향 고찰

저자 : 황현지 ( Hyeon-ji Hwang ) , 안수연 ( Soo-yeon Ahn ) , 김동철 ( Dong-chul Kim )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 79-95 (17 pages)

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Objectives: The purpose of this review is to analyze the domestic study trends on climacteric syndrome treated with pharmacopuncture.
Methods: We investigated the studies on pharmacopuncture for climacteric syndrome via searching 6 online databases.
Results: 18 studies were selected. There were 2 case reports, 1 randomised controlled trial, and 15 animal experiments. There were 14 studies about osteoporosis, 1 study about hot flush and sweating, 1 study about abdominal obesity, 1 study about neck pain, and 1 study about learning disability and memory disorder. Nokyong was most frequently used for pharmacopuncture, followed by Honghwa. 陰谷(KI10) was most frequently used for acupuncture point, followed by 腎兪(BL23).
Conclusions: This study shows that pharmacopuncture could be one of the effective treatments for climacteric syndrome. More well-designed clinical studies using pharmacopuncture for climacteric syndrome will be needed.

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7자궁내막증식증에서 한약 치료의 효과에 대한 체계적 문헌 고찰 및 메타분석 - 중국 임상 연구를 중심으로

저자 : 유진실 ( Jin-sil Yu ) , 박경선 ( Kyoung-sun Park ) , 안영태 ( Young-tae Ahn ) , 조유진 ( Yu-jin Cho ) , 강은솔 ( Eun-sol Kang ) , 정성엽 ( Sung-yub Jung ) , 이윤재 ( Yoon-jae Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 96-113 (18 pages)

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Objectives: The purpose of this study is to analyze the effectiveness of herbal medicine that are used for endometrial hyperplasia.
Methods: We searched on three databases [PubMed, China national knowledge infrastructure (CNKI), and Oriental medicine advanced searching integrated system (OASIS)] with keywords for Endometrial hyperplasia(English, Korean, and Chinese) and evaluated the risk of bias. Meta-analysis was performed on the selected studies.
Results: 15 RCTs were finally selected. According to the analysis, Most of the participants were endometrial hyperplasia without atypia. And the combined therapeutic effects of hormonal medicine and herbal medicine were statistically significant (RR 1.21 [95% CI 1.15, 1.28], P<0.00001), The endometrial thickness tended to be thinner when treated combined therapy. And they also showed improvement on levels of pictorial blood assessment chart (PBAC) and hemoglobin. Also, the therapeutic effects of herbal medicine can be identified as similar to Western medicine, and no superior effects have been confirmed (RR 1.05 [95% CI 0.87, 1.28], P=0.60).
Conclusion: The combination Western and herbal medicine was more effective than Western medicine alone treated for endometrial hyperplasia without atypia. Moreover there were also significant improvements in endometrial thickness, PBAC and hemoglobin levels.

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8갑상선기능항진증의 한약 치료에 대한 무작위 대조군 연구의 문헌 고찰

저자 : 이희윤 ( Hee-yoon Lee ) , 황수인 ( Su-in Hwang ) , 박장경 ( Jang-kyung Park ) , 윤영진 ( Young-jin Yoon )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 114-136 (23 pages)

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Objectives: The purpose of this study is to analyze the effectiveness and safety of herbal medicine treatment for treating hyperthyroidism.
Methods: We searched for randomized controlled trials of Hyperthyroidism treated with herbal medicine, published from January 2016 to May 2021, through electronic database such as Pubmed, EMBASE, China Academic Journal (CAJ). Interventions and results of the selected clinical studies were analyzed.
Results: The 25 randomized controlled trials were finally included according to the inclusion and exclusion criteria. Treatment group was treated with herbal medicine alone in 2 studies, and with herbal medicine and conventional medicine in 23 studies. Control group was treated with conventional medicine. Outcome measures are total efficacy rate, thyroid function test, Traditional Chinese medicine (TCM) syndrome scores, liver function test, recurrence rate, etc. Prunellae Spica (夏枯草) (60%) was the most frequently used herb in herbal medicine treatment. In all of 25 studies, treatment group was more effective and safer for hyperthyroidism than the control group.
Conclusions: This study indicates that herbal medicine treatment alone or combined with conventional medicine treatment could be helpful in improving the therapeutic effect on hyperthyroidism and reducing side effects as well.

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9한약 복용이 산후 유즙분비에 미치는 효과에 대한 체계적 문헌고찰

저자 : 이혜정 ( Hye-jung Lee ) , 이수정 ( Su-jeong Lee ) , 황덕상 ( Deok-sang Hwang ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang ) , 이진무 ( Jin-moo Lee )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 137-156 (20 pages)

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Objectives: The purpose of this study is to assess the effect of taking herbal medicine for the postpartum lactation.
Methods: We searched 9 databases for recent three years, that contained four english, two chinese, one japanese and two korean database from September 17, 2016 to December 31, 2020. Randomized controlled trials (RCTs) were eligible. Measurement of outcome included total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool.
Results: Total 725 of studies was screened, 11 RCTs were finally selected. Number of participants per study ranged from 60 to 257. The treatment group of taking a herbal medicine is effective for improving total curative effective rate, volume of lactation, volume of milk supplement, and serum prolactin concentration compared with control group. Because most of the studies had considerable heterogeneity in terms of type of intervention and comparison for outcome measurement, meta analysis for quantitative analysis was impossible.
Conclusions: This studies showed that taking a herbal medicine is effective on increasing volume of lactation and speeding up the start of the first breastfeeding. However, included studies suffered from incomplete reporting, high or unclear risk of bias and substantial heterogeneity between studies. In the Future, further high-quality RCTs are needed to prove effectiveness of herbal medicine for breastfeeding and reduce the risk of bias.

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10귀비온담탕 가미방을 포함한 한방치료로 호전된 화병 환자 2례 : 증례 보고

저자 : 정소미 ( So-mi Jeong ) , 황덕상 ( Deok-sang Hwang ) , 이진무 ( Jin-moo Lee ) , 이창훈 ( Chang-hoon Lee ) , 장준복 ( Jun-bock Jang ) , 조성희 ( Seong-hee Cho )

발행기관 : 대한한방부인과학회 간행물 : 대한한방부인과학회지 34권 3호 발행 연도 : 2021 페이지 : pp. 157-174 (18 pages)

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Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine with Guibiondamtang-gamibang on Hwa-byung patients.
Methods: Case 1 experienced stress at work and complained of chest discomfort, nausea, dizziness, insomnia. Case 2 experienced huge stress about money, and complained of palpitation, chest discomfort, dizziness and insomnia. They received combination treatment of Korean medicine during hospitalization. The treatment included Guibiondamtang-gamibang, acupuncture, moxibustion, pharmacoacupuncture, and fumigation. The effects were evaluated through Hwa-byung scale, instrument of oriental medical evaluation for Hwa-byung, insomnia severity index (ISI) and heart rate variability (HRV) test.
Results: After the treatment, the clinical symptoms such as chest discomfort, palpitation, dizziness, nausea and insomnia were improved.
Conclusions: This case report shows that the combination treatment of Korean medicine with Guibiondamtang-gamibang may be effective for treating Hwa-byung patients.

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