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대한피부과학회지 update

Korean Journal of Dermatology

  • : 대한피부과학회
  • : 의약학분야  >  피부과학
  • : KCI등재
  • : SCOPUS
  • : 연속간행물
  • : 월간
  • : 0494-4739
  • : 2713-7627
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수록정보
35권6호(1997) |수록논문 수 : 35
간행물 제목
60권3호(2022년 03월) 수록논문
최근 권호 논문
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KCI등재 SCOPUS

1악성 흑색종에 대한 한국어 유튜브 동영상의 질 평가

저자 : 허근영 ( Keunyoung Hur ) , 하은서 ( Eun-seo Ha ) , 김동효 ( Dong Hyo Kim ) , 송원지 ( Won Ji Song ) , 문제호 ( Je-ho Mun )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 143-150 (8 pages)

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Background: Disseminating public knowledge on malignant melanoma through YouTube is an important way to bridge the gap between physicians and patients. However, videos recorded on this topic in Korea are yet to be evaluated.
Objective: We aimed to evaluate the quality of YouTube videos on malignant melanoma recorded in Korea. We also investigated whether there was a difference in the quality of videos made by medical professionals (subdivided into dermatologists and non-dermatologists) and non-medical personnel.
Methods: We included all videos recorded in Korean by searching YouTube using the keywords “melanoma” or “malignant melanoma”. The search was performed on March 22, 2021. The inclusion criterion was videos in Korean language that contained medical information about malignant melanoma. The characteristics and content information were collected for each video. Video quality (DISCERN, Global Quality Scale [GQS], Journal of the American Medical Association [JAMA] benchmark criteria) was analyzed.
Results: Eighty-five videos met the inclusion criterion for the analysis. Fifty-six (66%) and 29 videos (34%) were made by medical and non-medical personnel, respectively. The videos made by medical professionals significantly contained more of the following information than those made by non-medical personnel: clinical information (p<0.001), symptoms and signs (p=0.001), risk factors (p<0.05), diagnosis (p<0.001). Videos made by medical professionals, videos with a length of more than 5 minutes, or videos with more than 10,000 views had significantly higher quality scores (DISCERN, GQS, JAMA).
Conclusion: Considering that YouTube is being used as a portal for medical information, the participation of medical professionals is essential for providing more accurate information. (Korean J Dermatol 2022;60(3):143∼150)

KCI등재 SCOPUS

2중등도-중증의 한국인 건선 환자에서 Ustekinumab 장기 투여에 따른 효과 및 안전성 연구

저자 : 김연아 ( Yeona Kim ) , 배경남 ( Kyung-nam Bae ) , 손진화 ( Jin-hwa Son ) , 신기혁 ( Kihyuk Shin ) , 김훈수 ( Hoonsoo Kim ) , 고현창 ( Hyun-chang Ko ) , 김문범 ( Moon-bum Kim ) , 신봉석 ( Bong Seok Shin ) , 김병수 ( Byungsoo Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 151-158 (8 pages)

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Background: Ustekinumab is a humanized monoclonal antibody targeting interleukin (IL)-12 and IL-23. Although popular, data on its long-term efficacy and safety in Korean patients with psoriasis are limited.
Objective: To evaluate the long-term efficacy and safety of ustekinumab in Korean patients with psoriasis.
Methods: A retrospective study in patients with moderate-to-severe psoriasis who had been treated with ustekinumab for at least 5 years was conducted. The sex, age, body mass index, medical records, previous psoriasis therapy, psoriasis area and severity index (PASI) scores, and adverse events were evaluated.
Results: Twenty-five patients (median age 47.00 years) had been treated with ustekinumab for 5 years. The mean duration of psoriasis was 19.12±8.45 years, and the treatment duration with ustekinumab was 285.12±8.48 weeks. The baseline PASI was 17.52±7.38. PASI75 was achieved in 84% of the patients at week 28, and 96% of the patients maintained PASI75 during the 5-year follow-up period. Furthermore, 56% of patients reached PASI90 at 28 weeks, and 48% of patients maintained PASI90 for 5 years. No unexpected adverse events other than herpes zoster, herpes simplex, or elevated liver enzymes were reported.
Conclusion: Ustekinumab demonstrated long-lasting efficacy with an acceptable safety profile in Korean patients with moderate-to-severe psoriasis. (Korean J Dermatol 2022;60(3):151∼158)

KCI등재 SCOPUS

3흡입 수포의 체액과 혈청에서 측정한 지질들의 상관성 분석

저자 : 권일주 ( Il Joo Kwon ) , 최승재 ( Sung Jay Choe ) , 정승원 ( Seung Won Jeong ) , 전명수 ( Myungsoo Jun ) , 최응호 ( Eung Ho Choi )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 159-166 (8 pages)

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Background: Several biomarkers are measured in the interstitial fluid (IF) obtained from suction blisters that are used by dermatologists. As abnormal lipid levels can cause health problems, several studies have investigated the composition and distribution of lipids and lipoproteins in IF. However, to date, no study has focused on examining lipid profiles in the postprandial state.
Objective: This study aimed to compare postprandial changes in serum lipid profiles and IF obtained from suction blisters and investigated their correlation.
Methods: Fasting and postprandial levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides were measured in paired serum samples. IF was obtained from suction blisters from 20 healthy men using enzymatic-colorimetric methods.
Results: The IF/serum ratios of TC, HDL-C, and LDL-C remained unchanged postoperatively. Postprandial levels of HDL-C and LDL-C decreased in the serum but not in IF. In both fasting and postprandial states, TC, HDL-C, and LDL-C levels in the serum were positively correlated with those in the IF.
Conclusion: The results of this study showed that lipoprotein cholesterol levels measured from suction blister fluids could be used as a biomarker to predict their serum levels regardless of food intake. Therefore, suction blister fluid sampling can be considered as a method to monitor serum lipid concentrations. (Korean J Dermatol 2022;60(3):159∼166)

KCI등재 SCOPUS

4일차성 호중구성 반흔성 탈모의 임상 및 조직학적 소견에 대한 비교 연구

저자 : 백은주 ( Eun Joo Baek ) , 형진혁 ( Jin Hyeok Hyeong ) , 박은주 ( Eun Joo Park ) , 김광중 ( Kwang Joong Kim ) , 김광호 ( Kwang Ho Kim )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 167-172 (6 pages)

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Background: Folliculitis decalvans and dissecting cellulitis are types of primary neutrophilic cicatricial alopecia characterized by permanent hair loss. Clinicopathological differentiation is poorly described in literature.
Objective: This study aimed to determine the clinicopathological distinction between folliculitis decalvans and dissecting cellulitis.
Methods: A retrospective review was conducted in 45 patients diagnosed with dissecting cellulitis and folliculitis decalvans between 2011 and 2021. We reviewed the clinical features using electronic medical records, clinical photographs, and histopathologic features.
Results: Clinically, middle-aged men with folliculitis decalvans showed polytrichia (80%) and papulopustules (55%), while young men with dissecting cellulitis had deeply seated nodules (84%). Histopathologically, follicular plugging was more frequently observed in dissecting cellulitis (80%) than in folliculitis decalvans (50%). There was a difference in the depth of inflammation between the two types.
Conclusion: A difference in clinical manifestations was observed according to the depth of inflammation. These findings may contribute to the differential diagnosis of primary neutrophilic cicatricial alopecia. (Korean J Dermatol 2022;60(3):167∼172)

KCI등재 SCOPUS

5비전형적인 조직소견을 보인 회음부의 색소성 정중솔기낭종 1예

저자 : 김현희 ( Hyun Hee Kim ) , 명기범 ( Ki Bum Myung ) , 권은선 ( Eun Sun Kwon ) , 정승현 ( Seung Hyun Cheong )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 173-177 (5 pages)

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Median raphe cysts (MRCs) are rare benign lesions that occur as a result of congenital defects during the embryological development of the male genitalia in the fetal period. It can develop anywhere along the midline, from the meatus to the anus. Pigmented MRCs are rare subtypes that contain melanin pigments or melanocytes in the epithelium, and there are only eight such cases reported worldwide. We report herein a case of pigmented MRC in the perineum of a 3-year-old boy. The clinical features include a linear tubular structure and foreign body granuloma at the tip of the linear cystic lesion and rare histological findings of pigmented cuboidal epithelium and squamous epithelium. Immunohistochemical staining revealed strong positivity for c-kit in the pigmented cuboidal epithelium. In this report, we discuss a rare case of pigmented MRC with a mixed type of squamous epithelium and pigmented cuboidal epithelium and review the associated literature. (Korean J Dermatol 2022;60(3):173∼177)

KCI등재 SCOPUS

6Multiple Spider Angiomas as a Predictive Diagnostic Marker of Alcoholic Liver Cirrhosis

저자 : Jun Ki Hong , Hye Sung Han , Sun Hye Shin , Young Gue Koh , Kapsok Li , Beom Joon Kim , Kwang Ho Yoo

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 178-181 (4 pages)

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Spider angioma (SA) may present as solitary or multiple lesions. Studies have shown that approximately 60% of pregnant women and 38% of healthy children have at least one spider telangiectasia. Hence, solitary SA in an otherwise healthy individual does not warrant further workup. However, multiple spider angiomas (MSAs) are usually suggestive of an underlying systemic disease. Physical examination for MSAs has been reported as the most reliable method to diagnose alcoholic liver cirrhosis; the presence of MSAs is more indicative of liver cirrhosis than just the history of alcohol use because a very low proportion of alcohol drinkers among the general population develop liver cirrhosis. We report a case of MSAs in a 42-year-old alcoholic woman suggesting that MSA is reliable indicator and a warning sign of liver cirrhosis, suggesting that further evaluation and management with the department of hepatology is necessary. (Korean J Dermatol 2022;60(3):178∼181)

KCI등재 SCOPUS

7A Drug-Induced Sarcoidosis-Like Reaction in Lung Cancer Patient Treated with Nivolumab and Ipilimumab: A Case Report and Literature Review

저자 : Soo Hyung Kim , Seo Gyeong Lee , Ji Yoon Kim , Hyun Jeong Ju , Gyong Moon Kim , Ji Hae Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 182-185 (4 pages)

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Immune checkpoint inhibitor (ICI), including programmed cell death protein 1 and cytotoxic T-lymphocyte-associated protein 4 inhibitors, has emerged as a pillar in the management of advanced malignancies. A drug-induced sarcoidosis-like reaction (DISR) is a rare cutaneous adverse event of ICI. A 47-year-old male presented with one-month history of a solitary erythematous nodule on his forehead. He had been diagnosed with metastatic adenocarcinoma of the lung and was treated with nivolumab and ipilimumab for three months. Histological findings revealed multinucleated giant cells forming non-caseating granulomas with moderate peripheral lymphocyte infiltration in the dermis. Also, new hilar lymphadenopathy of the lung was identified in a systemic evaluation. Given the temporal relationship with ICI treatment, the final diagnosis was ICI-induced sarcoidosis-like reaction. To our knowledge, this is the first report of a case of DISR that developed following ICI treatment in the dermatologic literature in Korea. (Korean J Dermatol 2022;60(3):182∼185)

KCI등재 SCOPUS

8Multiple Warty Dyskeratomas of the Scrotum: A Case Report and Review of the Literature

저자 : Joon Ho Son , Yeong Ho Kim , Ju Hee Han , Chul Hwan Bang , Ji Hyun Lee , Young Min Park

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 186-189 (4 pages)

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Warty dyskeratoma (WD) is an uncommon skin tumor that histologically presents as focal acantholysis and dyskeratosis and is a common finding among acantholytic diseases such as Darier's disease. WD most commonly occurs on the head or neck of adults as an isolated papule or nodule. To our knowledge, only 6 cases of WD in the genital area have been previously reported in the literature, and no case have occurred on the scrotum to date. We report the first case of multiple WD that occurred on the scrotum successfully treated with 0.025% tretinoin cream. A 55-year-old male presented with asymptomatic, multiple, 0.1∼0.2-cm-sized, skin-colored papules on the scrotum for the previous 6 months. A skin punch biopsy and human papillomavirus (HPV) polymerase chain reaction test were performed for a clinical suspicion of genital warts or bowenoid papulosis. The histopathologic examination showed cup-shaped epidermal invaginations with central keratotic plug. Prominent villi, acantholytic clefting and corps ronds were also shown. The patient tested negative for HPV and was diagnosed with WD with typical pathologic findings. The patient was treated with 0.025% tretinoin cream for 2 weeks, and the lesions decreased in both size and number. (Korean J Dermatol 2022;60(3):186∼189)

KCI등재 SCOPUS

9급성 골수성 백혈병 재발과 연관된 결절홍반 1예

저자 : 윤지상 , 배경남 , 손진화 , 김훈수 , 고현창 , 김병수 , 김문범 , 신기혁

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 190-191 (2 pages)

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KCI등재 SCOPUS

10모낭 및 피지선 유도를 동반한 위축성 피부섬유종 1예

저자 : 한유진 , 김혜성 , 조상현 , 이정덕 , 우유리

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 60권 3호 발행 연도 : 2022 페이지 : pp. 192-193 (2 pages)

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KCI등재SCOUPUS

1종설 : UVA , UVB 차단지수 측정방법과 이에 영향을 미치는 요인

저자 : 윤재일 ( Jai Il Youn )

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1043-1051 (9 pages)

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Recently, exposure to sunlight is increasing due to expanded life time, outdoor leisures, and reduced sun  protective ozone layer. Sunlight can produce not only benefit but also various kinds of harmful effect, such as skin carcinogenesis, photoaging and immunologic alterations, These effects can be minimized by sunscreens. This article reviews the methods to measure a suncreens efficacy and factors influencing the measurement. I. Measurement of photoprctective efficacy 1)The sun protective factor(SPF): The SPF is defined as the ratio of the UVB doses required to produce minimal erythema dose(MED) with sunscreen applied to without it. However, the exact procedures are not estabiished and the value is varied by methods. 2)Photoprotective factor A(FFA): In spite of its clinical improtance, evaluation of UVA protection rernains a problem due to its physiologic features. The methods to measure UVA protection are by the use of erythemal, phototoxic and pigmentary rections. 3)Outdoor measurement: It is ideal to measure the photoprotectiveness outdoor but a wide variation in value results from radiance sources and environmental factors. II. Factors influencing the evaluation The radiance sources, individ zal sensitivity to sunlight, product components and various environmental fact.ors can make differences. Conclusion As more sunlight, exposure, he irnportance of photoprotection is increasing. The exact methods to measure the protectiveness of UVA and UVB should be established, especially adjusted to Korean people (Korean J Dermatol 1997;35(6): 1043-1051)

KCI등재SCOUPUS

2원저 : 옻나무에 의한 알레르기성 접촉피부염과 경구복용에 의한 전신성 접촉피부염의 면역조직화학적 비교

저자 : 정소희 , 조상현 , 이상진 , 김시용 ( So Hee Jeong , Sang Hyun Cho , Sang Chin Lee , Si Yong Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1052-1058 (7 pages)

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Background: The rhus has been known to be such a potent allergen that it causes severe contact dermatitis, and mary studies have tried to reveal the mechanism of allergic contact. dermatitis to urushiol. However, the mechanism of systemic contact dermatitis to urushiol is not, well-known, though the consumption of rhus as a health product and for desensitization is not unconmon in Korea. Objective : The purpose of this study was to evaluate the niechanism of systernic contact dermatis, and we carried out irnmunohistochemical stainings un the two strands of dermatitis (systemic arid,llergic contact dermatitis). Methods : The patients of systemir, contact dermatitis were divided into three groups by duration and severity of the illness according to the desired criteria. We perfor med immunohistor,hernical staining of the tissues from the pat.ients with anti CD4, CD8, CDla, ICAM-1, II,-ZR monoclorial antibodies. Results : 1. The results  were as follows. 1. The immunohistochemical staining showed that CD8 positive cell numbers in systemic contact dermatitis(18 -L 1 0) were significantly lower than those of allergic contact der matitis(37 +- 13) ( p< 0.05). 2. The expressions of HLA-DR and ICAM-1 in the keratinocytes were not significantly different. between systemic and allergic contact derrnatitis(p>0.05). Conclusion : The result suggest that lower numbers of CDH positive T cell in systemic contact dermatitis caused a reduation in the suppressor effect to the urushiol  mediated immune rection and CD8 positive T cells play an important role in systemic contact dermatitis due to rhus. (Korean J Dermatol 1997;35(6): 1052-1058)

KCI등재SCOUPUS

3원저 : 멜라닌 세포성 병변에서 화상분석법을 이용한 DNA 배수성에 관한 연구

저자 : 이길주 , 김동준 , 오칠환 ( Gil Ju Yi , Dong Jun Kim , Chil Hwan Oh

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1059-1065 (7 pages)

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Backgroutld: In the cutaneou; neoplasms, especially melanocytic skin lesions, the degree of t.he nuclear atypia such as the hyp rchromatism, pleomorphism, and giantism is a very impor tant factor when determining the differntial diagnosis between the malignant. and the benign turnors and the prognosis. Objective : So we measured and cornpared the nuclear atypia of the malignant melanoma, and acquired and congenital melanocytic nevi(AMN and CMN) using the computerized image analysis (IA). Methods : Five micron ser,t ons were cut from each paraffin block. The sections were Feulgen-stained and image analysis was perforrned with an AIC image analysis system. In each case, 50 lymphocytes nuclei fnim the sarne specimen slide were measured as an internal diploid control. Each 100 cells of the MM, CMN and AMN were measured and are referred to in this report as the upper part and the lower part. The morphological parameters such as mean nuclear area, coefficient of variation(CV) of the nuclear area, roundness of the nucleus and CV of the roundness were measured. For the nuclear content, mean ploidy, CV of the mean ploidy ind 2c  Deviation Index(2cI3I) were calculated and then the DNA histograms were produced. Results : Nuclear area, CV of the nuclear area, mean ploidy, CV of the mean ploidy and 2cDI were found to be significantly reat.er for rnalignant melanoma than for CMN and AMN. The nuclear area of AMN is significantly lar ger than that of CMN and there were no significant differences between the uper and the lower part.s of three melanocytic lesions in any of the measured parameters. Conclusion . The results of o ir study suggest that the IA of the melanocytic cells might reflect the biologic behavior rnore sensitively t,han do clinical or histologic criteria, therefore important information for differentiating thi benign and the malignant melanocytic lesions may be obtained by the DNA profile and morphomi try on Feulgen st,ained tissue specirnens using IA.(Korean J Dermatol 1997;35(6): 10591065)

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4원저 : 대상포진 환자에서 T 림프구 아형 및 회상항원에 대한 관찰

저자 : 서석배 , 김광중 , 이종주 ( Suk Bae Suh , Kwang Joong Kim , Chong Ju Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1066-1073 (8 pages)

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Background: The incidence of herpes zoster is higher among patients with impaired cell  mediat,ed immunity. Herpes zoster skin lesions frequently become more severe and run a more protracted course in such patients. Objective : This study aimed to firstly elucidate whether there are changes in cell  mediated immunity, even in immunocompetent, patients with herpes zoster, and secondly to investigate relationships between these change and the clinical appearance of herpes zoster. Methods : T lymphocyte sub;et,s in peripheral blood and delayed hypersensitivity reactions using the Multitest CMI kit were measured in 33 healthy patients with herpes zoster and 28 controls. Results : As compared with controls, there was a slight decrease in percentages of CD4 lym-phocytes, a significant decr eas in percentages of CD8 lyrnphocytes, and a slight increase in CD4/ CD8 ratios in the acute phasr of herpes zoster. The percentages of CD3 lymphocytes were also significantly decreased. Baseg i)n the severit,y of the skin lesion, t.her e was a significant increase in duration of acute herpetic pain. However, there were no signigicant differences in percentages of T lymphocyte subsets based on the severity of skin lesion and duration of acute horpetic pain. In delayed hypersensitivity rea.tions with the Multitest" CMI kit, the intensity and frequencies of positive reactions were signific,intly decreased in the patients group. Conclusions . There are sigr.ificant changes in peripheral blood T lymphocyte subsets and delayed hypersensitivity reactions even in other wise healthy patients. (Korean J Dermatol 1997;35(9): 1066-1073)

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5원저 : 역 모낭성 각화증의 임상적 고찰 및 Human Papillomavirus의 검색에 관한 연구

저자 : 안성구 , 이인욱 , 최응호 , 이원수 , 이승헌 , 이동원 ( In Wook Lee , Eung Ho Choi , Sung Ku Ahn , Won Soo Lee , Seung Hun Lee , Dong Won Lee

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1074-1081 (8 pages)

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Background : Inverted follicular keratosis has distinctive histopathological features and is infre quently encountered by dermatologists. To date, the pathogenesis of inverted follicular keratosis has not, been concluded. Many authors have suggest,ed several theories for the nature of invert.ed follicular keratosis including vearuca vulgaris with squamous eddies, irritated seborrheic keratosis and dist,inctive follicular tumors. Objective : It is the purpose of this study to observe and compare the clinical features of in verted follicular keratosis with previous studies and evaluate the possible relationship between in verted follicular keratosis and human papillomavirus to clarify the nature of this condition. Methods : We studied 9 patients with inverted follicular keratosis for clinical features including the duratiori of the disease, the location and size of the lesions, the clinical impressions at the first visit and we made a record of the patients age and sex. To evaluate the relationship be tween inverted follicular kerato is and the human papillomavirus, we performed immunohistochvm ical staining using polyclonal antibodies to the human papillomavirus common antigen. We also used the polymerase chain relation to detect hurnan papillomavirus DNA in inverted follicular keratosis from paraffin embedded tissue preparation. 
Results : 1. Seven of the 9 patients,vere male and the ages ranged fiom 36 to 77 years(mean 53 years). The lesions were situat d on the face(4/9),abdomen(1/9), back(1/9), chest(1/9), scapular area(1/9) and leg(1/9). The average size of the lesions was 1.5 cm. Verruca vulgaris was the most common clinical diagnosis(3/9), followed by seborrheic keratosis(2/9), soft fibroma(2/9), pigmented nevi(1/9), and granioloma pyogenicum(1/9). 2. Immunohistochemical stainiiigs using polyclonal antibodies to the human papillomavirus common antigen were negative for all 9 cases. 3. Polymerase chain reaction; using primers for human papillomavirus DNA were negative for all 9 cases. Conclusipn : In general, our linical findings are similar to those of others in previous studies. Our results of immunohistocheriiical staining and the polymerase chain reactions suggest, that in vert,ed follicular keratosis is ncl, related to the human papillomavirus. Further investigat.ions inf'o the nature of invert,ed follicular keratosis, should be centered on initated seborrheic keratosis and distinct follicular tumor s. (Korean J Dermatol 1997;35(6): 1074-1081)

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6원저 : 편평 사마귀에 대한 DNCB와 DPCP 면역요법의 치료 효과에 대한 비교 연구

저자 : 박종혁 , 김성진 , 이승철 , 원영호 , 전인기 ( Jong Hyuk Park , Seong Jin Kim , Seung Chul Lee , Young Ho Won , Inn Ki Chun

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1082-1087 (6 pages)

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This stuc1y was conducted to evaluate the therapeutic effect of immunotherapy on verruca plana. Forty-four patients with verruca plana were tried with dinitrochlorobenzene(DNCB) and diphenylcyclopropenone(DPCP) by topical application on the norinal uninvolved skin of the inner arms for sensitization and challenge. The lesions were challenged in weekly intervals after sensitization. The results obtained in this study are as follows. 1. Mean age of our patients was 20-year-old and sex ratio was about 1:2 (14 of male, 30 of female). 2. Tbe sites of the lesion weve face (60.9%), neck (7.2%), trunk (2.9%), arm (li3.0%), hand (11.6% ), leg (4.3% ). 3. Thirty  two patients (72.7%) from 44 cases were completely cured after DNCB (81.3%) and DPCP (67%) treatment and iesions on younger patients showed a better response than those of of older patients(p<0.05). 4. There were no statistic relationship between duration of the lesions and therapeutic response. 5. Average challenge number after sensitization was 3.77 in DNCB, 2.26 in DPCP, respectively. 6. Sensitization rates in the cured patients were to treat verruca plana 94.7% (18/19) in DNCB, 76.9% (10/13) in DPCP, respectively. (Korean J Dermatol 1997;35(6): 1082-1087)

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7원저 : 레티노이드에 의한 악성 흑색종 세포주의 bcl - 2 발현에 관한 연구

저자 : 방성원 , 박영립 , 황규왕 ( Sung Won Bang , Young Lip Park , Kyu Uang Whang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1088-1094 (7 pages)

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Background: Apoptoss plays a major role in cellular proliferation and differentiation in tumor cells. Bcl-2, proto-oncogene, is known to inhibit apoptotic cell death of tumor cells. The high expression of bcl-2 in human melanoma cells over transforrned keratinocytes has been reported. The Loton group indicated that the growth of human melanoma cells exposed to ret.inoids was inhibit ed and their cellular melanin content incrensed over that of the untreat,ed ce1Ls. The Veis group reported that bcl-2 defieient mice showed hypopigmented hair. Which suggests that bcl-2 may in volve melanogenesis. The Above mentioned findings may suggest that. bcl-2 and retinoids may play a role in melanoms biology. Objective : We under ook this study to elucidate a possible relationship between retinoids and bcl-2 expvessions in human melanoma cell lines. Methods : We analysed bcl-2 expressions from SK 28 cells(melanoma cell lines) after pretreat ment with retinoids using flow cytometry and imtnunoblotting. Results : 1. In the results of the preliminary studies, we found that cultured human keratinocytes, fibro blasts and melanocytes n the resting state showed expressions of bcl-2. The latter showed a four fold expression of bcl-2. 2. Expression of bcl-2 was detected in SK 28, a human melanoma cell line, in the resting state. 3. After incubation with isotretinoin or etretinate treatment at 37'C,  for 48 hours, this treated group showed a more ir creased expression of bcl-2 than the control group. Conclusion : Our data may explain that the mechanism of ret.inoids indur,ing inhibition of mela noma cell growth may be partly due to upregulation of bcl-2 expression. The high base-line ex pression of bcl-2 in melanoma cells may tell us why these pigment cells can survive against oxi dative products generated during melanogenesis. (Korean J Dermatol 1997;35(6): 1088-1094)

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8원저 : 기본첩포검사에서 소실 및 자극반응의 발현빈도

저자 : 김태윤 , 윤두희 , 이준영 , 김형옥 , 김정원 ( Tae Yoon Kim , Dou Hee Yoon , Jun Young Lee , Hyung Ok Kim , Chung Won Kim

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1095-1100 (6 pages)

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Background: The patcl test is widely used for diagnosis of allergic contact dermatitis. However, it is sometimes difficiilt or even impossihle to differentiate between allergic and irritant reactions in patch test readings. The achievernent of valid results from the patch test require intelligent and careful patch testing and physirians with skills and experiences. Objective : The purpos of this study was to assess the frequency, age and sex distr ibution, and the seasonal variatioii of irritant. and lost reactions in standard patch tests. Methods : Patch test records of day 2 and day 4 were reviewed and analysed. Frequency of inritant and lost reactions were analysed by allergen, age, sex and season. Results : A total 212 c ses of standard patch test records(rnale 69, female 143) were analysed. The results were as follovs ; 1. The over  all frequency of lost reactions in the standard patch test were 33.5 percents and that of irritant reactions were 8.0 perr.ents. 2. The frequency of lost reactions was lower in the age groups under twenty(7.7%) than in the older age groups(35.5%). However, there was no significant difference het,ween the age groups over the third dec ide. 3. The seasonal variation was evident in lost reactions. The order of frequency was summer(45. 0% ), winf,er(33.7% ), spri,ig and fall(2l.1% ). 4. The order of frequency of lost reactions in the stclndard patch allergen was captan(5.7%), potassium dichromate(5.2%), cobalt chloride(4.7%), mercury amrnoniurn chloride(3.8%) c3lld wool alcohol(3.8%) Conclusion : Our result, show a relatively high frequency of lost and irritant. reaction in the standird patch test, and uggest second readings in the patch test would he of value. (Korean J Dermatol 1997;35(6): 1095-1100)

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9원저 : 발모벽 28예의 임상소견 및 병리조직학적 연구

저자 : 송일문 , 임철완 ( Il Moon Song , Chull Wan Ihm

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1101-1109 (9 pages)

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Background: The patients of trichotillomania seem to have received much attent.ion based on patients behavioral psychologic;l aspects, but most of the patients ar e met in dermatological clinics. Dermatological observation of the lesion dose not seem to not sufficient. Qbject: The purpose of this study is to exarnine clinical and histopathological characteristics of the lesion of trichotillomania. Methods : We have observed 28 cases of the trichotillornania and exarnined their cutaneous lesions and histopathological featwres. Histopathological examination with vertical serial sections was done in 21 cases. Because hai folllicles are independent of each other and a usual 5 thickness vertical sect,ion shows only ver y limited numbers of the hair follicles, authors accomplished sectioning of the biopsied scalp tisue to have 300 serial sections cut and 60 representative sections observed to allow the fullest qiiantitative and qualitative examinations of the follicular pathology of the lesion. Results : The important featuies are as follows. 25 cases(89.2%) were under 18 years old with a slight male predorninance(M:F=1.3:1). Only in 2 cases, psychiatric consultation was made. The degree of involvement was vari ble from less than 5%(6 cases) of the scalp up to 100% involvement of the scalp(3 cases). Thr rnean duration of illness was 12.5 months. The involved hair follicles showed one of the following five roots of hairs they are new hairs with tapered ends, broken short hairs, vellus or intermediate hairs, comedone-like hair bodies or empty follicle orifices. Microscopical observation of thr epilat,ed hairs was done in 16 cases, of which in 13 cases there were no telogen roots of terminal hairs, The histopathological results were as follows : 1. Catagen follicles were incr:ased in 20 cases(95.2%). The actual number of catagen follicles was 1386(37.5%) out of a tota 3695 follicles observed in the total examined slides. 2. Trichornalacia were seen ir 11 cases(52.4%). The actual number of hairs with trichomalacia was 195(10.5%) out of a total 1005 hair canals observed. 3. Pigment clumps of the follicular infundibula were seen in 9 cases(42.9%). The actual num- ber of the pigment-laden infundibula was 148(17.9%) out of a total 826 infundibula observed. 4. Destruction of the hair canal wall were seen in 4 cases(19.0% ). The actual number of destructed hair canal wall was 190(10.2%) out of a total 1863 hair canals observed. Hernorrhage around the follicles was not seen. Conclusion : The involved areas of trichotillomania were varied in size up to the whole scalp and showed four different type., of hairs. Histopathologically catagen follicles increased in almost all cases with 37.5% of all follicles examined. Trichomalacia, pigmented clumps, and the destruction of hair canals were seen by less frequently. (KOrean J Dermatol 1997;35(B): 1101-1109)

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10원저 : 비흑색종의 종양과 그 주위 상피 세포에서의 p53 , PCNA , bcl - 2에 대한 면역조직화학 염색 양상

저자 : 김종구 , 윤태영 , 장승호 ( Jong Goo Kim , Tae Young Yoon , Seung Ho Chang

발행기관 : 대한피부과학회 간행물 : 대한피부과학회지 35권 6호 발행 연도 : 1997 페이지 : pp. 1110-1120 (11 pages)

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Background: In both normal tissue development and malignant cell growth, the maintenance of cell numbers reflects a balance between cell proliferation and cell death. Excessive growth may result from uncontrolled cellular proliferation or limited cell death. The growth process of squa mous cell carcinorna(SCC) has recently been reported to differ from that of basal cell carcinoma (BCC). Several reports have suggested that the normal-appearing, overlying epidermis might be a proliferative and be a precursor lesion of BCC. SCCs occur in burn scars, chronic ulcers, and chronic sinus but the najority of SCCs are actinic in origin. It. is possible to develop subsequent. skin cancer from the normal-appearing epidermis adjacent to SCC due to chronic sun-exposure. Objective : The purpose of this study was to investigate growth dynamics of non-melanorna skin cancers and characteristics, including the carcinogenic property, of the normal  appearing epidermis overlying and acljacent to non  rnelanoma skin cancers. Methods : We compared expressions for p53, PCNA, bcl  2, and TGF-a in 21 BCCs and 8 SCCs by irnmunohistochi.mical staining with a labelled strept,avidin  biotin complex(LSAB) method. Results . The results were as follows. 1) Expressions for p53 and PCNA within the tumor remarkably increased and the distribution pattern of expression for p53 was not always consistent with that for PCNA. 2) An expression the bcl-2 was increased in half of the BCCs, but not in all of the SCCs. 3) The epidermis overlying the BCC showed increased expressions for p53, PCNA, and TGF-a. 4) The epidermis adjacent to the SCC showed increased expressions for p53, and PCNA in a few of cases. Conclusion : We suggest that a neoplastic transformatiqn in BCC is caused by extended cell survival rather than ini:reased cell proliferation, but in SCC it. is caused by other mechanisms, and that the proliferativ activity in the epiderrnis overlying BCC is different from the normal epidermis and maybe repr'sents carcinogenic activity of the epidermis. (Korean J Dermatol 19()7;35(6): 1110-1120)

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