The current study aims to explore the shielding properties of multi-component borate-based glass series. Seven glass-samples with composition of (80-y)H3BO3e10ZnOe10Na2OeyBaO where (y ¼ 0, 5, 10, 15, 20,25 and 30 mol.%) were synthesized by melt-quench method. Various shielding features for photons,neutrons, and protons were determined for all prepared samples. XCOM, Phy-X program, and SRIM codewere performed to determine and explain several shielding properties such as equivalent atomicnumber, exposure build-up factor, specific gamma-ray constants, effective removal cross-section (SR),neutron scattering and absorption, Mass Stopping Power (MSP) and projected range. The energy rangesfor photons and protons were 0.015e15 MeV and 0.01e10 MeV, respectively. The mass attenuationcoefficient (m/r) was also determined experimentally by utilizing two radioactive sources (166Ho and 137Cs). Consistent results were obtained between experimental and XCOM values in determining m/r ofthe new glasses. The addition of BaO to the glass matrix led to enhance the m/r and specific gamma-rayconstants of glasses. Whereas the remarkable reductions in SR, MSP, and projected range values werereported with increasing BaO concentrations. The acquired results nominate the use of these glasses indifferent radiation shielding purposes